Vascular MedicinePub Date : 2024-10-01Epub Date: 2024-09-01DOI: 10.1177/1358863X241268727
Santiago Callegari, Kim G Smolderen, Jacob Cleman, Carlos Mena-Hurtado, Gaëlle Romain
{"title":"Competing risk analysis to estimate amputation incidence and risk in lower-extremity peripheral artery disease.","authors":"Santiago Callegari, Kim G Smolderen, Jacob Cleman, Carlos Mena-Hurtado, Gaëlle Romain","doi":"10.1177/1358863X241268727","DOIUrl":"10.1177/1358863X241268727","url":null,"abstract":"<p><p><b>Background:</b> Patients with peripheral artery disease face high amputation and mortality risk. When assessing vascular outcomes, consideration of mortality as a competing risk is not routine. We hypothesize standard time-to-event methods will overestimate major amputation risk in chronic limb-threatening ischemia (CLTI) and non-CLTI. <b>Methods</b>: Patients undergoing peripheral vascular intervention from 2017 to 2018 were abstracted from the Vascular Quality Initiative registry and stratified by mean age (⩾ 75 vs < 75 years). Mortality and amputation data were obtained from Medicare claims. The 2-year cumulative incidence function (CIF) and risk of major amputation from standard time-to-event analysis (1 - Kaplan-Meier and Cox regression) were compared with competing risk analysis (Aalen-Johansen and Fine-Gray model) in CLTI and non-CLTI. <b>Results</b>: A total of 7273 patients with CLTI and 5095 with non-CLTI were included. At 2-year follow up, 13.1% of patients underwent major amputation and 33.4% died without major amputation in the CLTI cohort; 1.3% and 10.7%, respectively, in the non-CLTI cohort. In CLTI, standard time-to-event analysis overestimated the 2-year CIF of major amputation by 20.5% and 13.7%, respectively, in patients ⩾ 75 and < 75 years old compared with competing risk analysis. The standard Cox regression overestimated adjusted 2-year major amputation risk in patients ⩾ 75 versus < 75 years old by 7.0%. In non-CLTI, the CIF was overestimated by 7.1% in patients ⩾ 75 years, and the adjusted risk was overestimated by 5.1% compared with competing risk analysis. <b>Conclusions</b>: Standard time-to-event analysis overestimates the incidence and risk of major amputation, especially in CLTI. Competing risk analyses are alternative approaches to estimate accurately amputation risk in vascular outcomes research.</p>","PeriodicalId":23604,"journal":{"name":"Vascular Medicine","volume":" ","pages":"496-506"},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11575932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vascular MedicinePub Date : 2024-09-12DOI: 10.1177/1358863x241278092
{"title":"Original Research Abstracts Presented at the 2024 Vascular Scientific Sessions of the Society for Vascular Medicine","authors":"","doi":"10.1177/1358863x241278092","DOIUrl":"https://doi.org/10.1177/1358863x241278092","url":null,"abstract":"","PeriodicalId":23604,"journal":{"name":"Vascular Medicine","volume":"28 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142205638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vascular MedicinePub Date : 2024-09-12DOI: 10.1177/1358863x241278093
{"title":"Clinical Case Abstracts Presented at the 2024 Vascular Scientific Sessions of the Society for Vascular Medicine","authors":"","doi":"10.1177/1358863x241278093","DOIUrl":"https://doi.org/10.1177/1358863x241278093","url":null,"abstract":"","PeriodicalId":23604,"journal":{"name":"Vascular Medicine","volume":"71 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142205637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vascular MedicinePub Date : 2024-09-12DOI: 10.1177/1358863x241281872
Joshua Newman,Elizabeth Bruno,Sorcha Allen,Jonathan Moore,Robert Zilinyi,Asma Khaliq,Fahad Alkhafan,Clara Vitarello,Robert Lookstein,Brent Keeling,C Michael Gibson,Kenneth Rosenfield,Eric A Secemsky,Rachel P Rosovsky,Amir Darki
{"title":"The influence of patient sex on pulmonary embolism evaluation, treatment modality, and outcomes.","authors":"Joshua Newman,Elizabeth Bruno,Sorcha Allen,Jonathan Moore,Robert Zilinyi,Asma Khaliq,Fahad Alkhafan,Clara Vitarello,Robert Lookstein,Brent Keeling,C Michael Gibson,Kenneth Rosenfield,Eric A Secemsky,Rachel P Rosovsky,Amir Darki","doi":"10.1177/1358863x241281872","DOIUrl":"https://doi.org/10.1177/1358863x241281872","url":null,"abstract":"BACKGROUNDPulmonary embolism (PE) is the third-leading cause of cardiovascular mortality, accounting for 100,000 deaths per year in the United States. Although sex-based disparities have previously been described in this population, it is unclear if these differences have persisted with the expansion of PE evaluation and treatment approaches. The purpose of this study is to investigate sex-based differences in the evaluation, management, and outcomes of patients with acute PE.METHODSWe performed a retrospective analysis of patients enrolled in the national Pulmonary Embolism Response Team (PERT) Consortium database between October 2015 and October 2022. We evaluated patient demographics, clinical characteristics, diagnostic imaging performed, treatment at several phases of care (pre-PERT, PERT recommendations, and post-PERT), and clinical outcomes.RESULTSA total of 5722 patients with acute PE (2838 [49.6%] women) from 35 centers were included. There were no differences in PE risk category between male and female patients. Women were less likely to undergo echocardiography (76.9% vs 73.8%) and more likely to receive no anticoagulation prior to PERT evaluation (35.5% vs 32.9%). PERT teams were more likely to recommend catheter-based interventions for men (26.6% vs 23.1%), and men were more likely to undergo these procedures (21.9% vs 19.3%). In a multivariable analysis, female sex was a predictor of in-hospital mortality (OR 1.53, 95% CI 1.06 to 2.21).CONCLUSIONSIn this analysis, we identified sex-based differences in the evaluation and management of patients presenting with acute PE. Subsequently, women presenting with acute PE were at higher risk of in-hospital mortality.","PeriodicalId":23604,"journal":{"name":"Vascular Medicine","volume":"10 1","pages":"1358863X241281872"},"PeriodicalIF":3.5,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142205639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vascular MedicinePub Date : 2024-08-01Epub Date: 2024-07-29DOI: 10.1177/1358863X241258957
Mateo Porres-Aguilar, Belinda Rivera-Lebron, Nick H Kim, Alexandra L Solomon, Elizabeth V Ratchford, Gustavo A Heresi
{"title":"Post-pulmonary embolism syndrome, CTEPD, and CTEPH.","authors":"Mateo Porres-Aguilar, Belinda Rivera-Lebron, Nick H Kim, Alexandra L Solomon, Elizabeth V Ratchford, Gustavo A Heresi","doi":"10.1177/1358863X241258957","DOIUrl":"10.1177/1358863X241258957","url":null,"abstract":"","PeriodicalId":23604,"journal":{"name":"Vascular Medicine","volume":" ","pages":"457-461"},"PeriodicalIF":3.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141793589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vascular MedicinePub Date : 2024-08-01Epub Date: 2024-06-03DOI: 10.1177/1358863X241256299
Maitri Patel, Robertino M Mera, Denisse A Rumbea, Oscar H Del Brutto
{"title":"Changes in the ankle-brachial index and progression of white matter hyperintensities of presumed vascular origin in community-dwelling older adults: A prospective population study.","authors":"Maitri Patel, Robertino M Mera, Denisse A Rumbea, Oscar H Del Brutto","doi":"10.1177/1358863X241256299","DOIUrl":"10.1177/1358863X241256299","url":null,"abstract":"","PeriodicalId":23604,"journal":{"name":"Vascular Medicine","volume":" ","pages":"438-440"},"PeriodicalIF":3.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141200509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vascular MedicinePub Date : 2024-08-01Epub Date: 2024-04-01DOI: 10.1177/1358863X241236774
Shantum Misra, Aaron Hakim, Martin P Smith, Vikram Deshpande, Jacqueline L Wolf, Brett J Carroll
{"title":"Enterocolic lymphocytic phlebitis as a rare vascular cause of colitis.","authors":"Shantum Misra, Aaron Hakim, Martin P Smith, Vikram Deshpande, Jacqueline L Wolf, Brett J Carroll","doi":"10.1177/1358863X241236774","DOIUrl":"10.1177/1358863X241236774","url":null,"abstract":"","PeriodicalId":23604,"journal":{"name":"Vascular Medicine","volume":" ","pages":"451-453"},"PeriodicalIF":3.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140336999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vascular MedicinePub Date : 2024-08-01DOI: 10.1177/1358863X241262723
Kevin P Cohoon, Mateo Porres-Aguilar, Roger T Tomihama, Sneha E Thomas, Anthony Buckley, Everett Rogers, Nichole E Brunton, Stanislav Henkin, Deborah Hornacek, Eric A Secemsky
{"title":"Steering the multidisciplinary landscape of vascular medicine: Collaboration as the key to success for aspiring vascular medicine specialists.","authors":"Kevin P Cohoon, Mateo Porres-Aguilar, Roger T Tomihama, Sneha E Thomas, Anthony Buckley, Everett Rogers, Nichole E Brunton, Stanislav Henkin, Deborah Hornacek, Eric A Secemsky","doi":"10.1177/1358863X241262723","DOIUrl":"10.1177/1358863X241262723","url":null,"abstract":"","PeriodicalId":23604,"journal":{"name":"Vascular Medicine","volume":"29 4","pages":"462-466"},"PeriodicalIF":3.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Five-year outcomes of the GORE VIABAHN Endoprosthesis for the treatment of complex femoropopliteal lesions from a Japanese postmarket surveillance study.","authors":"Osamu Iida, Takao Ohki, Yoshimitsu Soga, Nobuhiro Suematsu, Tatsuya Nakama, Terutoshi Yamaoka, Kazuki Tobita, Shigeo Ichihashi","doi":"10.1177/1358863X241233528","DOIUrl":"10.1177/1358863X241233528","url":null,"abstract":"<p><p><b>Introduction:</b> The safety and effectiveness of the GORE VIABAHN Endoprosthesis for treatment of symptomatic patients with peripheral artery disease (PAD) and complex femoropopliteal (FP) lesions was assessed in a real-world Japanese practice setting. <b>Methods</b>: A prospective, multicenter, postmarket surveillance study was conducted from 2016 to 2017 at 64 sites in Japan. Symptomatic patients with PAD and FP lesions ⩾ 10 cm and reference vessel diameters ranging from 4.0 to 7.5 mm were eligible for enrollment. Outcome measures evaluated at 5 years were primary patency (PP), primary-assisted patency (PAP), secondary patency (SP), freedom from target lesion revascularization (fTLR), occurrence of device- or procedure-related serious adverse events (SAEs), and stent fractures. <b>Results</b>: A total of 321 patients were enrolled and were a mean age of 73.9 ± 8.7 years; 77.3% were men and 26.5% had chronic limb-threatening ischemia (CLTI). The mean lesion length was 23.6 ± 6.6 cm and the frequency with TASC II C/D lesions and chronic total occlusions was 86.6% and 70.4%, respectively. The Kaplan-Meier estimated PP, PAP, SP, and fTLR at 5 years was 62.4%, 74.1%, 82.3%, and 75.9%, respectively. The mean ankle-brachial index was 0.92 ± 0.15 and the mean improvement in Rutherford class was 2.3 ± 1.4, which was maintained through 5 years. The rate of cumulative device- or procedure-related SAEs through 5 years was 19.9% with only 9.3% of those occurring after the first year. No stent fractures were observed through 5 years by x-ray evaluation. <b>Conclusion</b>: The 5-year safety and efficacy outcomes of the endoprosthesis were clinically acceptable for treating complex FP lesions in a real-world cohort of Japanese patients with PAD. (<b>ClinicalTrials.gov Identifier: NCT04706273)</b>.</p>","PeriodicalId":23604,"journal":{"name":"Vascular Medicine","volume":" ","pages":"416-423"},"PeriodicalIF":3.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11323428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140307093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}