Is lipedema a progressive disease?

IF 3 3区医学 Q2 PERIPHERAL VASCULAR DISEASE

Vascular Medicine Pub Date : 2025-01-20 DOI:10.1177/1358863X241306415

Isabel Forner-Cordero, José Muñoz-Langa

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引用次数: 0

Abstract

Background: It is not yet known whether lipedema is a progressive chronic disease or not. The aim of this paper is to describe the long-term changes in the volume of the lower limbs.

Methods: The primary endpoint of this prospective cohort study of patients with lipedema was the percentage of volume change (PVC) during follow up. Progression was defined as when the PVC was > 10% from the baseline, whereas improvement was defined as when the PVC was < -10%, and stability as PVC -10% to 10%.

Results: A cohort of 100 patients with lipedema were included in the study. The average follow-up period from the start of this study was 4.6 years. The average PVC was 2.8%. Stability was observed in 62% of the patients, progression in 28%, and improvement in 10%. In the univariate analysis, a significant positive association was observed between PVC and both BMI-change and waist-to-height ratio (WHtR)-change. The more the BMI increased, the more the lipedema progressed (p < 0.0001), as did the WHtR (p < 0.0001). In the adjusted regression analysis, age was not seen to be an influencing factor for PVC. Regarding maintenance therapies, no associations were observed.

Conclusion: Lipedema was seen to be stable in two-thirds of the patients. Age was not related to progression. Progression was related to WHtR increase, which is an indicator of abdominal fat gain. This demonstrates the relationship between fat gain and lipedema progression.

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脂水肿是一种进行性疾病吗？

背景：目前尚不清楚脂水肿是否是一种进行性慢性疾病。本文的目的是描述长期的变化在下肢的体积。方法：这项前瞻性队列研究的主要终点是脂水肿患者在随访期间的体积变化百分比（PVC）。进展被定义为当PVC比基线低10%时，而改善被定义为当PVC < -10%时，稳定被定义为PVC -10%至10%。结果：研究纳入了100例脂水肿患者。从研究开始的平均随访时间为4.6年。平均PVC为2.8%。62%的患者病情稳定，28%的患者进展，10%的患者改善。在单变量分析中，观察到PVC与bmi变化和腰高比（WHtR）变化之间存在显著的正相关。BMI越高，脂水肿进展越严重（p < 0.0001）， WHtR也是如此（p < 0.0001）。在校正回归分析中，年龄并不是PVC的影响因素。关于维持治疗，没有观察到任何关联。结论：三分之二的患者脂肪水肿是稳定的。年龄与进展无关。进展与WHtR增加有关，WHtR是腹部脂肪增加的指标。这证明了脂肪增加和脂水肿进展之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Vascular Medicine 医学-外周血管病

CiteScore

5.70

自引率

5.70%

发文量

158

审稿时长

>12 weeks

期刊介绍： The premier, ISI-ranked journal of vascular medicine. Integrates the latest research in vascular biology with advancements for the practice of vascular medicine and vascular surgery. It features original research and reviews on vascular biology, epidemiology, diagnosis, medical treatment and interventions for vascular disease. A member of the Committee on Publication Ethics (COPE)