Vestnik otorinolaringologii最新文献

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[Hamman syndrome in the practice of an otorhinolaryngologist]. [耳鼻喉科医生的哈曼综合征]。
Vestnik otorinolaringologii Pub Date : 2025-01-01 DOI: 10.17116/otorino20259001178
M V Komarov, O I Goncharov, A A Valkova, E D Kuznetsova
{"title":"[Hamman syndrome in the practice of an otorhinolaryngologist].","authors":"M V Komarov, O I Goncharov, A A Valkova, E D Kuznetsova","doi":"10.17116/otorino20259001178","DOIUrl":"https://doi.org/10.17116/otorino20259001178","url":null,"abstract":"<p><p>Spontaneous pneumomediastinum or Hamman syndrome is a rare clinical entity that emergency physicians may encounter. It is characterized by the presence of free air in the mediastinum unrelated to overt trauma. The cause of this condition is rupture of terminal alveoli as a result of increased intra-alveolar pressure against the background of chronic lung disease. Hamman syndrome presents with nonspecific symptoms such as: chest pain, difficulty breathing, neck puffiness, rhinolalia, dyspnea, vomiting, fever, dysphagia, hoarseness, tachycardia, tachypnea, and restlessness. This condition most often has a favorable prognosis, but in rare cases can lead to compression of the main vessels and trachea. The main method of diagnosis is chest radiography in two projections. Otorhinolaryngologists should be aware of Hamman syndrome, since the main complaint of the patient may be complaints from the ENT organs. In this case, a detailed collection of history will help to establish a correct diagnosis and choose the right tactics for the management of the patient. This article presents a clinical case of spontaneous pneumomediastinum in a patient with a long history of smoking, diagnosis and treatment of the condition in an urban multidisciplinary hospital.</p>","PeriodicalId":23575,"journal":{"name":"Vestnik otorinolaringologii","volume":"90 1","pages":"78-83"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Risk of developing occupational hearing loss among uranium mining workers]. [铀矿工人职业性听力损失的风险]。
Vestnik otorinolaringologii Pub Date : 2025-01-01 DOI: 10.17116/otorino20259001115
V B Pankova, I N Phedina, P V Serebryakov
{"title":"[Risk of developing occupational hearing loss among uranium mining workers].","authors":"V B Pankova, I N Phedina, P V Serebryakov","doi":"10.17116/otorino20259001115","DOIUrl":"https://doi.org/10.17116/otorino20259001115","url":null,"abstract":"<p><p>Underground working conditions of uranium mining production are characterized by the predominance of industrial noise, determining a high occupational risk of hearing loss.</p><p><strong>Objective: </strong>To perform the analysis of occupational risk of hearing loss in uranium mining workers.</p><p><strong>Material and methods: </strong>The indicators of working conditions of uranium mining production of the «Rosatom» state corporation and tonal threshold audiometry data of 113 staff members as a part of preventive medical examination were used; a priori and a posteriori occupational risks of hearing loss were determined.</p><p><strong>Results: </strong>The highest levels of industrial noise and the highest noise dose have been noted in stope miners (SMs), that determines a priori risk of their hearing function impairment. The mean length of service in persons of SMs group is over 25 years. Indicators of a posteriori risk of occupational sensorineural hearing loss are predominant in SMs with long service period (25 years and more) - 50%.</p><p><strong>Conclusion: </strong>The highest occupational risk of hearing loss is identified in stope miners, that means the need to optimize preventive measures to preserve their hearing function.</p>","PeriodicalId":23575,"journal":{"name":"Vestnik otorinolaringologii","volume":"90 1","pages":"15-19"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[On possible causes of discrepancy between the results of auditory brainstem responses (ABR) and auditory steady-state responses (ASSR) recordings]. [关于听觉脑干反应(ABR)和听觉稳态反应(ASSR)记录结果不一致的可能原因]。
Vestnik otorinolaringologii Pub Date : 2025-01-01 DOI: 10.17116/otorino20259001164
A V Pashkov, L S Namazova-Baranova, N V Ustinova, I V Naumova, M T Fatakhova, K I Voevodina, A E Pashkova, V I Popadyuk, V G Kunitsyna, P A Rubinshtein
{"title":"[On possible causes of discrepancy between the results of auditory brainstem responses (ABR) and auditory steady-state responses (ASSR) recordings].","authors":"A V Pashkov, L S Namazova-Baranova, N V Ustinova, I V Naumova, M T Fatakhova, K I Voevodina, A E Pashkova, V I Popadyuk, V G Kunitsyna, P A Rubinshtein","doi":"10.17116/otorino20259001164","DOIUrl":"https://doi.org/10.17116/otorino20259001164","url":null,"abstract":"<p><p>Auditory brainstem responses (ABR) and auditory steady-state responses (ASSR) are the most widely used tests for objective hearing assessment. These tests are included in clinical guidelines for sensorineural hearing loss and other protocols. The literature sources describe examples of inconsistency between the results of these two tests, which are suggested to be interpreted in favor of ABR as the test with the highest values of sensitivity and specificity. Also, in a number of cases, discrepancy between the results of ABR and ASSR recordings in patients with neurological pathology was revealed. Given the expanding indications for auditory evoked potentials recording in groups of patients with neurological or psychiatric pathologies (for example, ABR and ASSR are recommended for use in clinical guidelines for the management of patients with autism spectrum disorders in 2020), an attempt has been made to assess the diagnostic value of these research methods in relation to conditions unrelated to hearing impairment.</p><p><strong>Material and methods: </strong>A diagnostic search of domestic and foreign literature was conducted on the combined interpretation of the results of ABR and ASSR recording was carried out. Literature on the use of these tests in groups of patients without sensorineural hearing loss was also reviewed.</p><p><strong>Results: </strong>The review includes the results of a literature search that provides a comparative analysis of ABR and ASSR results, including in patients with neurologic/psychiatric pathology. The analysis showed that ASSR recording results may significantly differ from the ABR response, which should be taken into account in patients with comorbidities.</p>","PeriodicalId":23575,"journal":{"name":"Vestnik otorinolaringologii","volume":"90 1","pages":"64-68"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Modern approaches to rational combination pharmacotherapy of allergic rhinitis]. [过敏性鼻炎合理联合药物治疗的现代方法]。
Vestnik otorinolaringologii Pub Date : 2024-01-01 DOI: 10.17116/otorino20248904168
S K Zyryanov, A V Vozzhaev
{"title":"[Modern approaches to rational combination pharmacotherapy of allergic rhinitis].","authors":"S K Zyryanov, A V Vozzhaev","doi":"10.17116/otorino20248904168","DOIUrl":"https://doi.org/10.17116/otorino20248904168","url":null,"abstract":"<p><p>Allergic rhinitis (AR) can significantly reduce the quality of life of patients leading to increased fatigue, mood changes, cognitive impairment, and depression. In clinical practice, insufficient effectiveness of initial AR monotherapy is often noted, and a significant proportion of patients referring for medical care have moderate-severe AR. In this regard, the issues of optimization of combined pharmacological treatment of AR are becoming more and more urgent. This paper provides analysis of the opportunities of combined pharmacotherapy within the framework of current management strategy of AR. Based on the results of some studies and known pharmacological properties of medications it is being discussed the advantages of combined use of intranasal corticosteroids and leukotriene receptor antagonists, in particular mometasone furoate and montelukast, in the therapy of AR, including such comorbidities as bronchial asthma, chronic polyposis rhinosinusitis and pharyngeal tonsil hyperplasia. Some aspects of combination therapy with montelukast and second-generation systemic antihistamines as an alternative approach in case of inability to take intranasal corticosteroids, including the reasonability of using a fixed combination of montelukast and levocetirizine, are analyzed from the perspective of rational pharmacotherapy. The problem of interchangeability of brand-name and generic drugs for the treatment of AR is discussed, considering the almost complete absence of studies of their therapeutic equivalence.</p>","PeriodicalId":23575,"journal":{"name":"Vestnik otorinolaringologii","volume":"89 4","pages":"68-77"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Optimization of the puncture treatment method for acute bacterial maxillary sinusitis]. [急性细菌性上颌窦炎穿刺治疗方法的优化]。
Vestnik otorinolaringologii Pub Date : 2024-01-01 DOI: 10.17116/otorino20248902115
A I Kryukov, A S Tovmasyan, A A Lapchenko, A Ya Bolgar, A E Kishinevskii, M G Timofeeva, A V Artemyeva-Karelova, D S Ogorodnikov
{"title":"[Optimization of the puncture treatment method for acute bacterial maxillary sinusitis].","authors":"A I Kryukov, A S Tovmasyan, A A Lapchenko, A Ya Bolgar, A E Kishinevskii, M G Timofeeva, A V Artemyeva-Karelova, D S Ogorodnikov","doi":"10.17116/otorino20248902115","DOIUrl":"10.17116/otorino20248902115","url":null,"abstract":"<p><strong>Objective: </strong>Optimization of the method of puncture treatment of acute bacterial maxillary sinusitis (ABMS) through the development of original devices for drainage of the maxillary sinus (MS).</p><p><strong>Material and methods: </strong>Registration and comparative analysis of the results of puncture methods of treatment of 120 patients with ABMS using developed new original devices for drainage of MS with one channels and with two channels in comparison with the Kulikovsky's needle (KN) was carried out. Based on the results of the analysis, the effectiveness of the original devices was assessed. During the clinical study, patients were divided into two groups: in group I, patients underwent of the MS puncture using KN, in group II, using original devices. Groups I and II, depending on the absence or presence of a block of the natural anastomosis MS, was divided into subgroups A and B, respectively. After puncture of the MS, the pain syndrome was assessed by patients using Visual Analogue Scale (VAS) and by doctors - using Touch Visual Pain (TVP) scale.</p><p><strong>Results: </strong>Our study showed that when puncturing the upper jaw with an original needle with one channels and with two channels, compared with the use of KN, there is a decrease in pain (the average VAS score was 1.5±0.3 and 1.7±0.3 points, respectively; the average TVP scale score was 0.9±0.2 and 1.8±0.3 points, respectively, the difference is significant, <i>p</i>≤0.05). Patients of subgroup IB were manipulated with two KN, patients of subgroup IIB manipulated using the original device with two channels without an additional needle (the average VAS score was 3.0±0.4 and 1.3±0.3 points, respectively; the average TVP scale score was 2.7±0.4 and 1.0±0.2 points, respectively, the difference is significant, <i>p</i>≤0.05). The doctors also assessed the devices used for puncture of the upper jaw. As a result of the study, the high efficiency and safety of using new original devices was established.</p>","PeriodicalId":23575,"journal":{"name":"Vestnik otorinolaringologii","volume":"89 2","pages":"15-20"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Audiological aspects of rehabilitation after cochlear implantation in patients with inner ear malformations]. [内耳畸形患者人工耳蜗植入术后康复的听力学方面]。
Vestnik otorinolaringologii Pub Date : 2024-01-01 DOI: 10.17116/otorino2024890614
V V Dvorianchikov, S B Sugarova, D S Kliachko, A S Lilenko, D D Kaliapin
{"title":"[Audiological aspects of rehabilitation after cochlear implantation in patients with inner ear malformations].","authors":"V V Dvorianchikov, S B Sugarova, D S Kliachko, A S Lilenko, D D Kaliapin","doi":"10.17116/otorino2024890614","DOIUrl":"https://doi.org/10.17116/otorino2024890614","url":null,"abstract":"<p><p>The article is devoted to the problem of the rehabilitation stage of cochlear implantation in patients with inner ear abnormalities. It provides a detailed analysis of the audiological characteristics of such patients and draws conclusions about approaches to interpreting diagnostic data and speech processors fitting.</p><p><strong>Material and methods: </strong>The track records of 80 patients with abnormalities of the inner ear development were retrospectively studied, of which 10 had abnormal structure of the auditory nerve. At the surgical and rehabilitation stages, patients underwent analysis of the results of implant telemetry, neural response telemetry, speech processor fitting maps, and the results of subjective audiological testing. The results were compared with those of 50 patients (control group) with normal inner ear anatomy and congenital deafness etiology.</p><p><strong>Results: </strong>The resistance figures of the electrode circuit in patients with abnormalities of the inner ear and normal anatomy did not differ statistically significantly (T=0.86, <i>p</i>>0.05). The ability to register the eCAP turned out to be significantly lower in patients with cochlear malformations and had a pattern with the degree of pathological development of the organ (T=10.2; <i>p</i><0.05). The distinctive features of the fitting maps of speech processors in different groups were also revealed, as well as the results of audiological testing.</p><p><strong>Conclusions: </strong>Patients with abnormalities in the development of the inner ear have distinctive electrophysiological characteristics that are important during the rehabilitation stage of cochlear transplantation. When configuring speech processors, it makes sense to resort to using CIS coding strategies, reducing the dynamic range by increasing the minimum stimulation threshold, and increasing compression.</p>","PeriodicalId":23575,"journal":{"name":"Vestnik otorinolaringologii","volume":"89 6","pages":"4-9"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pediatric sensorineural hearing loss related COVID-19. Clinical cases]. [与 COVID-19 有关的小儿感音神经性听力损失临床病例]。
Vestnik otorinolaringologii Pub Date : 2024-01-01 DOI: 10.17116/otorino20248903164
Kh M-A Diab, K L Meshcheryakov, V N Sokolova, A A Plyakina, V E Mamedov
{"title":"[Pediatric sensorineural hearing loss related COVID-19. Clinical cases].","authors":"Kh M-A Diab, K L Meshcheryakov, V N Sokolova, A A Plyakina, V E Mamedov","doi":"10.17116/otorino20248903164","DOIUrl":"10.17116/otorino20248903164","url":null,"abstract":"<p><p>COVID-19 is an acute respiratory coronavirus infection in 2019 caused by the SARS-CoV-2 virus. Currently, the number of neurological complications in the acute or delayed period of coronavirus disease is increasing, including peripheral disorders of the auditory analyzer.</p><p><strong>Objective: </strong>To present clinical cases of sensorineural hearing loss in children under 5 years of age after a novel coronavirus infection.</p><p><strong>Material and methods: </strong>We report 3 cases of unilateral and 1 case of bilateral acquired deep sensorineural hearing loss, while the association with SARS-CoV-2 has been confirmed anamnetically and/or laboratory.</p><p><strong>Results: </strong>The SARS-CoV-2 virus can have a depressing effect on the cochlea on its own or enhance the toxic effect of viruses during the recovery period after COVID-19. The true frequency of acute sensorineural hearing loss of infectious origin in childhood and, as its outcome, the formation of persistent hearing impairment has not been determined.</p><p><strong>Conclusion: </strong>Viruses are volatile, contagious, and clinically dangerous due to their complications. Vaccination is the most effective measure for the prevention of infectious diseases.</p>","PeriodicalId":23575,"journal":{"name":"Vestnik otorinolaringologii","volume":"89 3","pages":"64-68"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141894486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Vestibular rehabilitation for peripheral vestibular hypofunction: an interdisciplinary consensus]. [外周前庭功能减退的前庭康复:跨学科共识]。
Vestnik otorinolaringologii Pub Date : 2024-01-01 DOI: 10.17116/otorino20248901152
N L Kunelskay, G E Ivanova, E V Baybakova, A L Guseva, V A Parfenov, M V Zamergrad, O V Zaitseva, O A Melnikov, A A Shmonin, M N Maltseva
{"title":"[Vestibular rehabilitation for peripheral vestibular hypofunction: an interdisciplinary consensus].","authors":"N L Kunelskay, G E Ivanova, E V Baybakova, A L Guseva, V A Parfenov, M V Zamergrad, O V Zaitseva, O A Melnikov, A A Shmonin, M N Maltseva","doi":"10.17116/otorino20248901152","DOIUrl":"https://doi.org/10.17116/otorino20248901152","url":null,"abstract":"<p><p>The literature review presents approaches to the management of patients with vestibular disorders. The principles of organization of vestibular rehabilitation in peripheral vestibular hypofunction, indications for appointment, factors influencing its implementation, technique, methods of evaluating effectiveness are considered in detail. Attention is drawn to the fact that the selection of exercises and the duration of vestibular rehabilitation is carried out individually and depends on many factors, including the nature of vestibular deficiency and the specific characteristics of the patient. The possibilities of using additional pharmacological therapy with histamine preparations, which can accelerate the onset of vestibular compensation, are shown. It is noted that vestibular rehabilitation is a safe and effective method of treating peripheral vestibular hypofunction and should be recommended to patients of all ages with vestibular disorders leading to limited social and physical activity.</p>","PeriodicalId":23575,"journal":{"name":"Vestnik otorinolaringologii","volume":"89 1","pages":"52-63"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cervicogenic dysphagia: a case report]. [颈源性吞咽困难:病例报告]。
Vestnik otorinolaringologii Pub Date : 2024-01-01 DOI: 10.17116/otorino202489021109
A B Perminov, S L Kabak, N O Zhizhko-Mikhasevich, Yu M Melnichenko, A R Sakovich
{"title":"[Cervicogenic dysphagia: a case report].","authors":"A B Perminov, S L Kabak, N O Zhizhko-Mikhasevich, Yu M Melnichenko, A R Sakovich","doi":"10.17116/otorino202489021109","DOIUrl":"10.17116/otorino202489021109","url":null,"abstract":"<p><p>The article presents a case of pharyngeal dysphagia and obstructive sleep apnea syndrome caused by degenerative-dystrophic changes in the cervical spine with the formation of large cervical osteophytes at the C3-C6 level. Osteophytes caused deformation of the posterior wall of the hypopharynx and narrowing of its lumen by 20-25% from the level of the arytenoid cartilages to the upper parts of the epiglottis. CT scan also showed the intervertebral disc heights lost, as well as osteophytes at the posterolateral margins of the vertebral bodies (disc osteophyte complex). Osteosclerosis in combination with facet arthrosis caused spinal and foraminal stenosis.</p>","PeriodicalId":23575,"journal":{"name":"Vestnik otorinolaringologii","volume":"89 2","pages":"109-112"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Closing of nasal septum perforation using adipose stromal vascular fraction: an experimental study]. [利用脂肪基质血管部分闭合鼻中隔穿孔:一项实验研究]。
Vestnik otorinolaringologii Pub Date : 2024-01-01 DOI: 10.17116/otorino20248902121
V M Svistushkin, P S Timashev, V V Lobacheva, A V Zolotova, M V Svistushkin, N V Kosheleva, E A Shevchik, G N Nikiforova, A I Shpichka, A N Nikiforova, I A Tychkina
{"title":"[Closing of nasal septum perforation using adipose stromal vascular fraction: an experimental study].","authors":"V M Svistushkin, P S Timashev, V V Lobacheva, A V Zolotova, M V Svistushkin, N V Kosheleva, E A Shevchik, G N Nikiforova, A I Shpichka, A N Nikiforova, I A Tychkina","doi":"10.17116/otorino20248902121","DOIUrl":"10.17116/otorino20248902121","url":null,"abstract":"<p><p>Nasal septal perforation (NSP) is a complex problem in otorhinolaryngology, which leads to impaired nasal breathing and dryness in the nose. This reduces the patient's quality of life and leads to psychological discomfort. The treatment of nasal septum perforation is selected taking into account the clinical manifestations, perforation parameters and general condition of the patient. Currently, a large number of different surgical methods have been described in order to closing the defect of nasal septum. To date, there is no universally accepted method for closing NSP, which stimulates the search and development of new treatment options.</p><p><strong>Objective: </strong>Under experimental conditions, to study a new method for closing nasal septum perforation using a collagen scaffold together with adipose stromal vascular fraction containing multipotent mesenchymal stromal cells.</p><p><strong>Material and methods: </strong>The experiment was carried out on a model of nasal septum perforation in 24 male rabbits divided into four groups, depending on the construct, implanted into the defect zone: the 1st group was the control group - without the introduction of implantation material; the 2nd group - collagen scaffold without adipose stromal vascular fraction; the 3rd group - collagen scaffold with xenogenic adipose stromal vascular fraction; the 4th group - collagen scaffold with allogeneic adipose stromal vascular fraction with further dynamic evaluation of endoscopic control on day 14, after 1 month, 3 months, and 6 months. At month 6, the animals were removed from the experiment, followed by morphological examination in color with hematoxylin and eosin, as well as safranin and methyl green.</p><p><strong>Results: </strong>As a result of the experiment using adipose stromal vascular fraction of allogeneic and xenogenic origin, closing of perforation of the nasal septum of a rabbit for 3 months of dynamic endoscopic control, as well as according to morphological research, was demonstrated.</p><p><strong>Conclusion: </strong>Our study showed that the use of adipose stromal vascular fraction containing not only endothelial cells and pericytes, but also multipotent mesenchymal stromal cells in combination with a collagen scaffold closes the perforation of the nasal septum in a rabbit, without increasing the risk of violations of habitual vital activity.</p>","PeriodicalId":23575,"journal":{"name":"Vestnik otorinolaringologii","volume":"89 2","pages":"21-27"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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