Veterinary Record Open最新文献

{"title":"Students' acceptance of case-based blended learning in mandatory interdisciplinary lectures for clinical medicine and veterinary public health.","authors":"Veronica Duckwitz, Lena Vogt, Claudia Hautzinger, Alexander Bartel, Sebastian Haase, Mechthild Wiegard, Marcus G Doherr","doi":"10.1002/vro2.14","DOIUrl":"10.1002/vro2.14","url":null,"abstract":"<p><strong>Background: </strong>In German veterinary education interdisciplinary lectures (ILs) are an important and mandatory part of the curriculum as their merging character builds a useful preparation for the future profession as a veterinarian. These lectures should enable students to work on practically-relevant and interdisciplinary cases, which should ideally be defined jointly by lecturers from different disciplines.</p><p><strong>Methods: </strong>In order to give students the opportunity to work on these cases and at the same time have contact with their lecturers and fellow students, the Faculty of Veterinary Medicine, Freie Universität Berlin, has converted its former in-class ILs (face-to-face delivery format) into a blended learning format. The mandatory lectures comprise 196 curricular hours and are delivered over the course of three semesters within the veterinary curriculum. The new concept was developed over a period of three academic years and extensively evaluated (old-new-comparison) with regard to its acceptance and compliance with national requirements for interdisciplinary teaching.</p><p><strong>Results: </strong>A total of 306 students were asked to evaluate different aspects of the newly implemented format. Overall, more than 79% of the students attending the newly implemented blended learning format responded positively, and the evaluation showed a significant improvement of learning motivation and acceptance when compared to the traditional teaching format.</p><p><strong>Conclusion: </strong>The results indicated that blended learning is a suitable option for teaching mandatory ILs in clinical medicine and veterinary public health.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2021-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39255195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low occurrence of <i>Salmonella</i> spp. in wild birds from a Swiss rehabilitation centre.","authors":"Barbara R Vogler, Katrin Zurfluh, Prisca Mattmann, Kira Schmitt, Sarah Albini","doi":"10.1002/vro2.17","DOIUrl":"10.1002/vro2.17","url":null,"abstract":"<p><strong>Background: </strong><i>Salmonella</i> are bacteria of the family <i>Enterobacteriaceae</i> with a wide host range. Infection in birds causes subclinical disease to mass mortality events. Wild birds may act as healthy carriers posing a hazard to livestock and humans. The present study investigated the occurrence of <i>Salmonella</i> in wild birds admitted to a rehabilitation centre in order to assess the exposure of the staff to this zoonotic pathogen.</p><p><strong>Methods: </strong>Faecal swabs of 552 avian patients (68 species) were collected over the course of 12 months. Each sample was propagated in enrichment broth and subsequently incubated on a RAPID'<i>Salmonella</i> plate. <i>Salmonella</i> isolates were serotyped, and antimicrobial susceptibility testing was performed.</p><p><strong>Results: </strong>Six <i>Salmonella enterica</i> subsp. <i>enterica</i> serovar Typhimurium (<i>S</i>. Typhimurium) and 1 <i>S</i>. Schleissheim were detected; all were pansusceptible to the antibiotics tested.</p><p><strong>Conclusion: </strong>Despite the low positive rate in the tested population, the authors recommend applying protective equipment and hygiene measures when handling wild birds.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2021-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39255196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of dietary fish oil supplementation on DNA damage in peripheral blood lymphocytes of nine healthy dogs.","authors":"Francisco J Pellegrino, Analía Risso, Yanina Corrada, Rocío C Gambaro, Analía I Seoane","doi":"10.1002/vro2.12","DOIUrl":"10.1002/vro2.12","url":null,"abstract":"<p><strong>Background: </strong>Fish oil (FO) supplementation as a source of omega 3 fatty acids is associated with beneficial effects on health. However, high unsaturated fatty acid content in the diet could result in increased lipid peroxidation and damage to proteins, lipids and DNA. We evaluated the effect of dietary FO supplementation on DNA damage in peripheral blood lymphocytes of dogs. Additionally, we determined the effect of FO supplementation on lipid peroxidation and lipid profile of these dogs.</p><p><strong>Methods: </strong>Healthy male dogs (<i>n</i> = 9) were randomly assigned to one of two diets during 90 days: control (CG, <i>n</i> = 4), based on a commercial food, and FO (FOG, <i>n</i> = 5), the same food supplemented with 1000 mg FO. Blood samples were collected on days -1, 30, 60 and 90. DNA damage was assessed with the comet assay, and the damage index was obtained. Malondialdehyde (MDA) levels were determined as an indicator of lipid peroxidation. Lipid profile determination included serum triglyceride, cholesterol, low-density lipoprotein and high-density lipoprotein levels (HDL).</p><p><strong>Results: </strong>Damage index values (arbitrary units) were lower in FOG on day 30 (CG, 13.7 ± 2.5; FOG, 6.5 ± 2.5), 60 (CG, 14.7 ± 2.5; FOG, 3.5 ± 2.5) and 90 (CG, 15.5 ± 2.5; FOG, 3.0 ± 2.5) compared with CG (treatment × time interaction, <i>p</i> < 0.01). Serum MDA and HDL concentrations were lower in FOG compared with CG on day 60 and 90 (treatment × time interaction, <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>These findings suggest that dietary FO supplementation did not induce DNA damage in peripheral blood lymphocytes of healthy dogs, but rather reduced it.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2021-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39040666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nasal hyperkeratosis in Griffon breeds: Clinical, histopathological features and the prevalence in the Swedish population compared to a control group and other brachycephalic breeds.","authors":"Robert Cikota, Liselotte Åberg, Erika Karlstam, Arman Shokrai, Susanne Åhman","doi":"10.1002/vro2.10","DOIUrl":"10.1002/vro2.10","url":null,"abstract":"<p><strong>Background: </strong>In the Griffon breeds (GB) nasal hyperkeratosis is common and develops already in early adulthood. Breed-related features and prevalence have not previously been documented.</p><p><strong>Hypothesis/objectives: </strong>To describe clinical and histopathological features of nasal hyperkeratosis in GB and to document the prevalence.</p><p><strong>Materials and methods: </strong>Seven GB dogs with nasal hyperkeratosis were examined. Three histopathological samples were analysed. Owners of 107 GB and 493 control dogs completed a questionnaire distributed via social media.</p><p><strong>Results: </strong>Typical features of nasal hyperkeratosis in GB included varying degrees of dry, firm, excessive proliferation of keratin, affecting the dorsal or dorsolateral aspect of the planum nasale. Histopathology was characterized by severe, lamellar orthokeratotic and focal parakeratotic hyperkeratosis and multiple small serum lakes. Thirty-four of 107 GB dogs (31.8%) and 65 of 493 (13.2%) control dogs had varying degree of nasal hyperkeratosis. No sex predisposition was noted. Median age of onset was 3 years for GB, similar to brachycephalic control dogs whereas non-brachycephalic control dogs had a significantly later age of onset (<i>p</i> = 0.0053).</p><p><strong>Conclusions and clinical importance: </strong>Idiopathic nasal hyperkeratosis is very common in GB dogs and other brachycephalic breeds with nearly one third being affected, often already a young age.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2021-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38974718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drivers of canine distemper virus exposure in dogs at a wildlife interface in Janos, Mexico.","authors":"Rocío Almuna, Andrés M López-Pérez, Rosa E Sarmiento, Gerardo Suzán","doi":"10.1002/vro2.7","DOIUrl":"10.1002/vro2.7","url":null,"abstract":"<p><strong>Background: </strong>Human population expansion has increased the contact between domestic animals and wildlife, thereby increasing the transmission of infectious diseases including canine distemper virus (CDV). Here, we investigated the risk factors associated with CDV exposure in domestic and wild carnivores from the Janos Biosphere Reserve (JBR), Mexico.</p><p><strong>Methods: </strong>A cross-sectional household questionnaire study was performed in four rural towns to investigate the risk factors associated with the presence of CDV in domestic and wild carnivores from the JBR, Mexico. In addition, we tested serum samples from 70 dogs and three wild carnivores, including one bobcat (Lynx rufus), one striped skunk (<i>Mephitis mephitis)</i> and one gray fox (<i>Urocyon cinereoargenteus</i>) for CDV antibodies using immunochromatographic and viral neutralization assays.</p><p><strong>Results: </strong>Overall, 62% of domestic dogs were seropositive for CDV, and the presence of antibodies was significantly higher in free-roaming owned dogs than dogs with restricted movement. Among the wild carnivores, only the bobcat was seropositive. The rate of vaccination against CDV in dogs was low (7%), and there was a high rate of direct interactions between domestic dogs and wild carnivores.</p><p><strong>Conclusion: </strong>Our serological assays show that CDV is circulating in both domestic dogs and wild carnivores, suggesting cross-species transmission. Our finding of low vaccination rates, high number of unrestrained owned dogs and direct interactions between wildlife and domestic animals reported in the region may be perpetuating the high prevalence of the virus and increasing the risk of CDV transmission between wild and domestic carnivores. Therefore, long-term longitudinal studies are recommended in order to monitor infectious diseases at the domestic-wildlife interface in this highly biodiverse region.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2021-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38974715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recombinant human interferon-α14 for the treatment of canine allergic pruritic disease in eight dogs.","authors":"Breno C B Beirão, Aline C Taraciuk, Carolina Trentin, Max Ingberman, Luiz F Caron, Chris McKenzie, William H Stimson","doi":"10.1002/vro2.6","DOIUrl":"10.1002/vro2.6","url":null,"abstract":"<p><strong>Background: </strong>Allergic pruritic diseases are increasingly common in dogs. This group of conditions hampers life quality as pruritus progressively interferes with normal behaviours. Therefore, new treatment modalities for canine allergic pruritic diseases are necessary. While novel drugs have recently reached the market, there is still the need for other therapeutic approaches. Some dogs are refractory even to the newer compounds, and cost is also an important issue for these. Older therapeutic modalities are only moderately successful or have considerable secondary effects, as is the case with glucocorticoids.</p><p><strong>Objectives: </strong>Report on the use of recombinant human interferon-α14 (rhIFN-α14) for the treatment of canine allergic pruritus. Following the experience with a similar compound in the Japanese market, it was expected that rhIFN-α14 could alter the Th1/Th2 disbalance that drives these diseases.</p><p><strong>Methods: </strong>Here, we present an uncontrolled trial in which eight dogs with clinical diagnosis of allergic pruritus were treated with rhIFN-α14, either orally or via subcutaneous injections. Skin condition, microbiota and anti-interferon antibody levels were assessed.</p><p><strong>Results: </strong>The parenteral use of interferon induced hypersensitivity in two of the three dogs in which it was used. The oral administration was consistently safe and could reduce signs of the allergic condition in three of the five treated animals. Treatment also altered the skin microbiota, as verified by next-generation sequencing.</p><p><strong>Conclusion: </strong>The present results indicate that rhIFN-α14 is a viable candidate for the treatment of canine allergic pruritus. Future controlled studies are needed, and the oral route is indicated for further trials.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2021-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38974714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of high-intensity interval training compared with moderate-intensity continuous training on maximal aerobic potency in dogs: Trial protocol for a randomised controlled clinical study.","authors":"Sonia C Orozco, María P Arias, Pablo A Carvajal, Jaime Gallo-Villegas, Martha Olivera-Angel","doi":"10.1002/vro2.4","DOIUrl":"10.1002/vro2.4","url":null,"abstract":"<p><strong>Background: </strong>High-intensity interval training (HIIT) is a more efficient method to improve exercise capacity than moderate-intensity continuous training (MICT) because of its greater physiological stimulus.</p><p><strong>Objective: </strong>The aim of this protocol is to evaluate the efficacy of HIIT on maximal aerobic potency in dogs as compared to MICT.</p><p><strong>Methods: </strong>This protocol is for a randomised, blinded controlled clinical trial, with three parallel groups for the purpose of demonstrating superiority. Thirty dogs aged between 12 and 84 months of both sexes and different breeds will be included. Dogs, before initiating and after finalising the training will perform an incremental exercise test on a treadmill to obtain maximal speed and lactate threshold; resting parameters of heart and respiratory rate, left ventricle chamber and systolic function will be measured. Dogs assigned to each intervention will endure a 42-min session of HIIT or MICT during 12 weeks. HIIT comprises four intervals of 4 min each at a load of 85%, alternating with a 4-min resting period. MICT group will have a continuous load of 60%. The control group will remain in a cage. An intention-to-treat statistical analysis will be implemented. Analysis of covariance will be used to estimate the effect of HIIT compared with MICT training on maximal aerobic potency, aerobic resistance, systolic function at rest, left ventricle chamber measurements and indexes, respiratory rate and HR at rest.</p><p><strong>Conclusion: </strong>Significant time and effort are invested into training sports/working dogs, which could benefit from improving physical capacity by means of the HIIT methodology.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2021-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/vro2.4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38906174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Faecal proteome in clinically healthy dogs and cats: Findings in pooled faeces from 10 cats and 10 dogs.","authors":"Matteo Cerquetella, Andrea Marchegiani, Sara Mangiaterra, Giacomo Rossi, Alessandra Gavazza, Beniamino Tesei, Andrea Spaterna, Gianni Sagratini, Massimo Ricciutelli, Valeria Polzonetti, Stefania Pucciarelli, Silvia Vincenzetti","doi":"10.1002/vro2.9","DOIUrl":"10.1002/vro2.9","url":null,"abstract":"<p><strong>Background: </strong>In the scientific literature, there are only a few manuscripts available on small animal faecal proteomics.</p><p><strong>Methods: </strong>In the present pilot study, this evaluation was performed using pooled faecal samples from 10 clinically healthy dogs and, for the first time, in 10 clinically healthy cats by mean of two-dimensional electrophoresis followed by liquid chromatography-tandem mass spectrometry.</p><p><strong>Results: </strong>Our results showed the presence of nine (albumin, alkaline phosphatase, chymotrypsin-C-like, cytosol aminopeptidase, elastase-3B/proteinase E, immunoglobulins and nuclear pore membrane glycoprotein 210) and 14 (albumin, caspase recruitment domain-containing protein, chymotrypsin-like, deleted in malignant brain tumours 1 protein-like, hypothetical protein LOC107375, immunoglobulin, kallikrein-1, superoxide dismutase, transthyretin precursor, interstitial collagenase-like) different proteins in canine and feline faeces, respectively.</p><p><strong>Conclusion: </strong>These preliminary findings document the presence of a range of proteins in the faeces of apparently healthy dogs and cats and may serve as a basis for larger, prospective studies to establish reference proteomic data against which diseased populations can be compared.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2021-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38974717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of autopsy imaging-computed tomography in the post-mortem study of farm animals.","authors":"Kazutaka Yamada, Taiki Yokoyama, Naoyuki Aihara, Yumi Une, Reiichiro Sato","doi":"10.1002/vro2.1","DOIUrl":"10.1002/vro2.1","url":null,"abstract":"<p><strong>Background: </strong>Autopsy imaging (Ai) is used to determine the cause of death, providing pre-dissection information. Ai is often used in the field of human forensic medicine but has never been applied on farm animals.</p><p><strong>Methods: </strong>Ai-computed tomography (CT) was performed before necropsy for farm animals (one goat, one ox, one cow and three calves) that died or were euthanised.</p><p><strong>Results: </strong>Ai-CT findings of rib fractures (case 1), urethral calculi (case 2), multiple osteolytic bone lesions (case 3 and 4) and hair balls (case 4) were confirmed by dissection. However, a tentative diagnosis of actinomycosis was made in an ox (case 5) using antemortem radiography and Ai-CT, and the mass was identified as ameloblastic fibro-odontoma on histological examination. A tentative diagnosis of maxillary abscess was made from antemortem radiography in a cow (case 6); however, the lesion was shown to be maxillary neoplasia on Ai-CT. The mass was identified as hemangiosarcoma on histopathological examination.</p><p><strong>Conclusion: </strong>Ai is helpful in pathological examination because the specific findings are known before the dissection, the lesions can be pinpointed in the pathological dissection, facilitating workflow; furthermore, the oversight of lesions can be reduced. In addition, Ai-CT images, including three-dimensional images and a three-dimensional printed model, allowed an easy understanding of pathology among students and farmers. Ai-CT for farm animals represents a novel option for veterinary education.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2021-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38906171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of protective level of rabies antibodies in vaccinated dogs in Chennai, India.","authors":"Gowri Yale, Sampada Sudarshan, Shaheen Taj, Ganesan Irulappan Patchimuthu, Bharathi Vijaya Mangalanathan, Ashwin Yajaman Belludi, Madhusudana Narayan Shampur, Tirumurugaan Gopalan Krishnaswamy, Stella Mazeri","doi":"10.1002/vro2.8","DOIUrl":"10.1002/vro2.8","url":null,"abstract":"<p><strong>Background: </strong>Rabies is still endemic in India causing an estimated 20,000 human deaths a year. Free roaming dogs and unvaccinated owned dogs play a major role in the maintenance of the disease. Dog vaccination is the most crucial aspect of rabies prevention and control strategies; therefore vaccine immunogenicity and longevity are important determinants of the efficiency of rabies control efforts.</p><p><strong>Methods: </strong>In this study at Madras Veterinary College, India, a total of 297 serum samples were collected from owned dogs that were vaccinated against rabies. Data regarding age, gender, breed, neuter status and last date of vaccination were collected at the time of blood collection. The level of rabies virus neutralising antibodies in the sera of these dogs was measured through rapid focus fluorescence inhibition test. The factors associated with protective level of rabies antibodies in vaccinated dogs were investigated through multivariable regression analysis.</p><p><strong>Results: </strong>This cross-sectional investigation shows that only 40% (119/297) of the all the dogs in the study showed presence of protective level of anti-rabies antibodies, and 40% (72/180) of the dogs vaccinated within the last year showed presence of protective levels of antibodies causing concern about rabies vaccine quality and its impact on rabies control. The study also shows that older and neutered dogs are more likely to have protective titre among vaccinated dogs, while non-descript breed dogs are less likely to have a protective titre compared to pure breeds.</p><p><strong>Conclusion: </strong>In this study 60% (108/180) of young prima dogs and adult dogs did not show protective levels of antibodies within the year of last rabies vaccination, although they had previous vaccination history. This high percentage of apparent non-responders is a cause of concern of administration, distribution, storage, potency and quality management of vaccines in India.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2021-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38974716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}