Urologiia最新文献

{"title":"[Stent-associated urosepsis, personalized bacteriophage therapy].","authors":"S Perepanova T, V Kazachenko A, A Mesropyan S, E Antonova V, R Nazirov M, A Malova Yu, N Lyubchenko L","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the era of antibiotic resistance, strict control of foci of infection (for example, a long-term stent) and adherence to the timing of drainage removal are necessary. The spread of pan-resistant pathogens requires the development of effective alternative antimicrobial measures, in particular, bacteriophage therapy. A clinical case of a 42-year-old patient with a closed spinal cord injury, lower paraplegia, pelvic organs dysfunction, post-traumatic right ureteral stricture, and right kidney stones is presented in the article. The patient developed stent-associated urosepsis due to pan-resistant Klebsiella pneumonia after endoscopic removal of a long-term right ureteral stent (over 3 months) with endotoxic shock, disseminated intravascular coagulation syndrome and wound sepsis, which was treated using personalized local bacteriophage therapy.</p>","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 4","pages":"97-102"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[New Prospects for Conservative Treatment of Chronic Recurrent Cystitis in Women: Experience with the Drug Superlymph].","authors":"P Tevlin K, V Tevlina E, V Khanaliev B, V Sudilovskaya V, V Gankovskaya L, D Nasaeva E, M Khasanova E","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Chronic recurrent cystitis is a common and difficult problem of modern urology. Traditional use of antimicrobial drugs often cannot lead to the long-term remission.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To evaluate the efficacy and safety of using different dosages and routes of the drug Superlymph in rectal and vaginal suppositories 10 U and 25 U in patients with chronic recurrent cystitis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;A randomized comparative clinical study in parallel groups included 60 patients aged from 18 to 80 years with a diagnosis of chronic recurrent bacterial uncomplicated cystitis. All study participants were randomized into three groups. In Group 1 (n=25), Superlymph suppositories 25 U were prescribed rectally once a day for 20 days. In group 2 (n=25), Superlymph suppositories 10 U were administered vaginally 2 times a day, for 20 days. In accordance with the prescription information, Superlymph 10 U/25 U can be used vaginally or rectally depending on the gender. In addition, it is possible to change the route of administration, for example, Superlymph 25 U one suppository once a day or Superlymph 10 U, one suppository 2 times a day in the morning and in the evening. The duration of the course is from 10 to 20 days. The main aim of the study was to compare an influence of various route of administration of Superlymph in women with frequent relapses of cystitis on the urothelium according to biopsy results, as well as on the symptoms of recurrent cystitis. The reparative effect of Superlymph was evaluated as well. In the control group (n=10), standard therapy was administered (fosfomycin trometamol 3.0 g once, and then, on the next day from the start of therapy, nitrofurantoin 100 mg three times a day for 5 days). The study consisted of screening, therapy and follow-up stages. The duration of therapy was 20 days. All groups did not differ significantly in the main baseline characteristics.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The drug Superlymph demonstrated efficacy as monotherapy of uncomplicated lower urinary tract infection in women compared with standard treatment. Rectal administration of the drug was more effective than vaginal. This was primarily manifested by a decrease in the level of urothelial metaplasia by the end of the study by 41% in the group of rectal suppositories and by 9% for the vaginal suppositories. In the control group, no changes in the level of metaplasia were found. A symptom scale showed an improvement of 36% in the group of rectal suppositories, 25% in the group of vaginal suppositories, and 19% in the control group. Improvements in the quality-of-life score were 50.8%, 33.9%, and 31.1%, respectively. The mean pelvic pain symptom scale score improved by 30%, 23%, and 13%, while a decrease in the mean leukocytes level in urine was most significant in the group of vaginal suppositories, by 39%. The respective indicators in the group of rectal suppositories and the control","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 4","pages":"48-57"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Study of the pharmacokinetics of extended release sildenafil].","authors":"B Kurta I, V Zakharova A, F Guranda D, I Kuzmin A, V Isakov F, I Shaburov R, G Belolipetskaya V","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose of the study: </strong>Comparison of the pharmacokinetic characteristics of the drug Vildegra registered in the Russian Federation with literature data for the original drug Viagra.</p><p><strong>Materials and methods: </strong>Study design: prospective, open-label in healthy volunteers with a single oral dose on an empty stomach. The study included 48 male volunteers aged 18 to 45 years with a verified diagnosis of \"healthy.\" All subjects of the clinical study took 1 tablet of Vildegra once on an empty stomach. Blood samples to determine the concentrations of active substances were taken before taking the study drug and then after 0.25; 0.5; 0.75; 1; 1.5; 2; 2.5; 3; 3.5; 4; 4.5; 5; 5.5; 6; 7; 8; 10; 12; 16; 24; thirty; 36; 48 and 72 hours after taking the drug. Dynamic monitoring was carried out throughout the study, including clinical examination, measurement of vital signs, monitoring of laboratory parameters and monitoring of adverse events (AE). The concentrations of sildenafil and its active metabolite N-desmethylsildenafil in the blood plasma of volunteers were determined by high-performance liquid chromatography with tandem mass spectrometric detection. Pharmacokinetic parameters were calculated using a model-free method using the specialized program PK Solution2.0.</p><p><strong>Results: </strong>The AUC0-t, AUC0- and Cmax values for sildenafil and its active metabolite when taking the drug Vildegra are in good agreement with the literature data for the original drug Viagra. The values of tmax and t1/2 of the drug Vildegra are slightly higher than those of the original drug, which is apparently explained by the extended-release dosage form in the case of Vildegra. In 10 of 48 volunteers (21%), 20 AE were recorded, which resulted in complete recovery. No serious or unexpected AE were noted.</p><p><strong>Conclusion: </strong>The results obtained allow us to conclude that the pharmacokinetics, good tolerability and satisfactory safety profile of the drug Vildegra are comparable with the published data for the original drug Viagra.</p>","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 4","pages":"22-28"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Laparoscopic retropubic adenomectomy in patients with giant prostate adenoma].","authors":"A Podoynicin A, A Mamedov E, A Amosov N, V Romanov D, A Kuznecova D, F Kurkayakov I","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A clinical case of operative treatment of a 71-year-old patient with diagnosis \"Prostate hyperplasia. Cystoma from 26.06.2023\" is described. According to the MRI of the small pelvis with intravenous contrast, the prostate volume was 557 cm3. The patient underwent a laparoscopic ovarian adenomectomy. Intraoperative blood loss was 500 ml, and the operation time was 3 hours and 25 minutes.The postoperative period passed without complications due to conservative therapy. The maximum urination rate reached 33 ml/cek. The patient was discharged for the sixth day after the operation in a satisfactory condition under the supervision of the urologist at the place of residence.</p>","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 4","pages":"94-96"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Psychological aspects of surgical treatment in women with stress urinary incontinence].","authors":"A Sazonova N, G Kiseleva M, Yu Gvozdev M, V Krasavtseva Y","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Urinary incontinence is a socially significant disease affecting millions of women around the world. High efficiency of modern treatment methods and short hospital stay contribute to lower psychological discomfort of patients.</p><p><strong>Aim: </strong>To assess the psychological state of patients suffering from stress urinary incontinence before and after surgical treatment in a day patient department and while staying in the hospital for 3-4 days.</p><p><strong>Materials and methods: </strong>A total of 133 patients aged from 34 to 69 years were included, who underwent surgical treatment in the City Clinical Hospital named after. S.I. Spasokukotsky from 2021 to 2022 in a day patient department and a standard hospital.</p><p><strong>Results: </strong>In homogeneous groups, there was a decrease in the level of anxiety and depression, as well as an increase quality of life after surgery, which was more pronounced in those treated in a day patient department.</p>","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 4","pages":"35-40"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Parameters of nocturnal penile tumescence monitoring as potential predictors of the coronary heart disease].","authors":"A Kamalov A, A Orlova Y, E Chalyi M, A Okhobotov D, A Strigunov A, Yu Nesterova O, A Makeeva E","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Aim: </strong>To determine the possibilities of nocturnal penile tumescence (NPT) monitoring in the detection of coronary heart disease (CHD).</p><p><strong>Materials and methods: </strong>A total of 100 patients were included in the study, of them 50 men had a confirmed diagnosis of CHD and 50 patients consisted the control group. In all patients, flow-dependent vasodilation of the brachial artery and pulse wave velocity were evaluated. The assessment of the quality of erection was carried out using IIEF-15 questionnaire (erectile domain) and Androscan NPT monitoring device. The relative increase in the diameter of the penis (rIn), the duration of NPT with rIn greater than or equal to 30% and 20%, respectively (dNPT with rIn more or equal 30% and dNPT with rIn more or equal 20%) were estimated.</p><p><strong>Results: </strong>The age of the patients in both groups was comparable with a median of 58.0 years. Patients with CHD had a higher body mass index (BMI) than patients without CHD (29.2 kg/m2 vs. 26.9 kg/m2, respectively; p=0.011). In those without CHD, erectile function was better, both according to the IIEF-15 questionnaire and according to the monitoring of NPT. The model with the maximum coefficient of determination (R2 =32.1%) predicting the probability of having CHD included age, BMI, rIn and dNPT with rIn more or equal 20%. The chance of having CHD increased by 10.5% and 1.6% with a decrease in rIn by 1% and a decrease in dNPT with rIn more or equal 20% for 1 minute. The sensitivity and specificity of the model was 74% and 65.3%, respectively.</p><p><strong>Conclusion: </strong>Monitoring of the NPT is an important tool for the diagnosis of vascular ED. Based on the results, it is possible to assess the probability of CHD. In contrast to the IIEF-15 questionnaire, NPT, dNPT with rIn more or equal 20% and rIn are more likely to suggest the presence of CHD. The lower the OP and dNPT with rIn more or equal 20%, the higher the probability of having CHD.</p>","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 4","pages":"16-21"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[MRI-Ultrasound Fusion Targeted Transperineal Prostate Biopsy Under Local Anaesthesia Patient-Reported and Biopsy Outcomes: A Single Centre Cohort Study].","authors":"G Khairul-Asri M, E A Jaharudin M, Khor V Khor V, R Yusof M, F Mohamad Sharin M, Jagwani A Jagwani A, Y Lee F, S K Lee C, Fahmy O Fahmy O","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To compare the tolerability and feasibility of transrectal(TR) versus transperineal (TP) routes for prostate biopsy under local anaesthesia(LA). To assess the functional outcome and the complication of both procedures.</p><p><strong>Method: </strong>s. A prospective cohort observational study was performed on patients who underwent prostate biopsy under LA. Visual Analogue Scale (VAS) was used during the procedure. International Prostate Symptoms Score (IPSS) and International Index of Erectile dysfunction (IIEF) were assessed before the procedure and in 14 days after the procedure. Complication for each procedure was recorded.</p><p><strong>Result: </strong>A total of 128 patients with 64 patients for each group underwent prostate biopsy by TP and TR under LA. TP targeted biopsy group had comparable pain scores to those who underwent the procedure using the TR routes. The median pain score for the TP group was 2 and TR was 3, (IQR=2, range 0-10 for both groups)with no significant pain difference between both groups (P=0.48). Furthermore, there was no significant difference in urinary function(p=0.68) and sexual function (p=0.19) between the two groups post-procedure. Both groups have similar rates of complications, with no significant difference observed. Urinary tract infection incidents that did occur were rare and did not significantly differ between the groups (p=0.21). None of the patients experienced sepsis postoperatively. AUR was reported in both groups, slightly higher with 9.4%(N=6) in the TP group and 6.3%(N=4) in the TR group however no significant difference(p=0.112) was noted. Haematuria is common in both groups with TP (66%) and TR (59%) but self-limiting with Clavien-Dindo grade I without significant difference (p=0.589).</p><p><strong>Conclusion: </strong>Our results showed that both Transperineal and transrectal approaches have similar tolerability with no significant difference in functional outcome or complications. Further studies are mandatory to verify our results.</p>","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 4","pages":"87-93"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Overactive bladder in the elderly].","authors":"G Krivoborodov G, S Efremov N, A Gontar A, A Shirin D, N Tkacheva O","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Overactive bladder (OAB) is a syndrome consisting of urgency, usually accompanied by urinary frequency and nocturia, with or without urgent incontinence, in absence of a causative infection or pathological conditions. The prevalence of OAB is approximately 11-19% in both men and women, and leads to a significant negative effect on health-related quality of life. The prevalence of OAB increases with age. The elderly population is unique, with increased medical comorbidities and the possibility for cognitive and functional deficits. Anticholinergics should be avoided in older adults as this class of drugs is associated with an increased risk of cognitive decline. Unfortunately, there is little data on the possibility of using intradetrusor injections of botulinum toxin, as well as tibial and sacral neuromodulation in elderly patients with OAB.</p>","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 4","pages":"103-109"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Combined prevention of infectious complications of minimally invasive procedures in urology].","authors":"V Esipov A, G Martov A, G Kochetov A, A Musailov V, G Ragimov I","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The available literature data on the prevention of infectious and inflammatory complications after minimally invasive urological procedures based on current knowledge about urobiome as the main point of application of preventive measures are summarized in the article. The main risk factors for the occurrence of inflammatory complications at all stages of the perioperative process are analyzed. The role of antibacterial prophylaxis is emphasized, and its features and the importance of finding ways to overcome one of the main problems of modern medicine, which is antibiotic resistance, are discussed.</p>","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 4","pages":"110-115"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Arterial priapism: the current state of the problem].","authors":"K Yarovoy S, A Khromov R","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A review of literature on the etiology, clinical course, prognosis and differential diagnostics of arterial (non-ischemic) priapism is provided in the article. Indications and techniques of surgical treatment are considered in detail. Published data are supplemented by the results of our own observations.</p>","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 4","pages":"144-148"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}