Urologiia最新文献

{"title":"[Evaluation of hormonal status and sperm parameters in reproductive-age men after COVID-19 infection].","authors":"G Antonov A, I Gamylin K, V Gordeev V","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The symptoms of novel coronavirus infection (SARS-CoV-2), observed in the long-term period after COVID-19 and collectively referred to as post-COVID syndrome, include not only pulmonary complications but also damage to other target organs, particularly the male reproductive system. Most published studies are based on data obtained during the acute phase of the disease, while reports on long-term reproductive complications are scarce. Therefore, assessment of post-COVID effects on male reproductive function remains a relevant clinical issue.</p><p><strong>Aim: </strong>To evaluate hormonal status and semen parameters in men of reproductive age after recovery from COVID-19 in the long-term period.</p><p><strong>Materials and methods: </strong>A prospective study included 120 men aged 21-44 years. Group 1 comprised 60 patients who had COVID-19 complicated by viral pneumonia, and Group 2 included 60 patients with COVID-19 presenting as an acute respiratory viral infection (ARVI). Peripheral blood and semen samples were collected on the 15th and 90th days after disease onset. The following blood parameters were analyzed: total testosterone (TT), follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, estradiol, and sex hormone-binding globulin (SHBG).</p><p><strong>Results: </strong>Analysis of hormonal profiles showed a decrease in total testosterone relative to the diagnostic threshold on day 15 from disease onset by 46% in patients with COVID-19 complicated by pneumonia and by 17% in patients with ARVI-like COVID-19. A significant positive trend in TT level was observed in both groups by day 90: an increase of 20% in Group 1 (p less or equal 0.05) and 33% in Group 2 (p less or equal 0.05). Compared with reference values, SHBG levels exceeded the upper limit by 24% and 25% in Groups 1 and 2, respectively, on day 15, and remained elevated on day 90 (by 16% and 11%, respectively), despite a significant decline over time (p less or equal 0.05 in both groups). Level of pituitary hormones and estradiol remained within the reference range at all time points. A decrease in total sperm motility relative to reference values was recorded in both groups due to a reduction in progressively motile sperm. However, a significant improvement in progressive motility was noted by day 90, resulting in higher total sperm motility in Group 1 (p less or equal 0.05) and a 14% increase in the proportion of morphologically normal sperm in Group 2 (p less or equal 0.05).</p><p><strong>Conclusion: </strong>Men recovering from COVID-19, both with and without pneumonia, showed significant alterations in total testosterone and SHBG levels on day 15 and by the end of the third month of observation. Microscopic semen analysis revealed reduced total sperm motility relative to reference values on days 15 and 90 after disease onset, primarily due to a decrease in progressive motility. Nevertheless, a significant improvement was obser","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 5","pages":"53-58"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145763856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical significance of the biomarker KIM-1 IN assessing kidney injury after contact ureterolithotripsy].","authors":"E Belyi L, V Klochkov A, V Klochkov V, G Shmyrin A","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Relevance: </strong>Transurethral ureterolithotripsy (TULT) is considered as a first-line treatment method in patients with ureteral stones. TULT is associated with its high efficacy and low incidence of complications. However, the effect of TULT on kidney function has not been sufficiently studied. The aim was to explore the possibility of using the biomarker KIM-1 (Kidney Injury Molecule-1) in the assessment of kidney injury after TULT in patients with occlusive ureteral calculi.</p><p><strong>Materials and methods: </strong>of research. The clinical data of 28 patients with ureteral stones who underwent surgery were analyzed. Before and after TULT serum creatinine levels were determined, glomerular filtration rate (GFR) was calculated, KIM-1 was quantified in urine, and dopplerography of renal blood flow was performed with the calculation of the resistance index in the interlobular arteries of the kidneys (Ri). The size, density of the stone and its localization in the ureter were determined using computed tomography. A day after TULT, computed tomography was performed repeatedly to identify residual stones and assess the position of the ureteral catheter.</p><p><strong>Results: </strong>The average size of the stones was 46,9+/-5,0 mm2, and the duration of the TULT was 31,9+/-5,5 minutes. The size of the renal pelvis significantly decreased in the postoperative period (17,3+/-1,6 mm before surgery and 11,4+/-0,9 mm after, p<0,05). The urinary excretion level of KIM-1 was significantly higher in patients with occlusive ureteral stones than in patients of the control group with kidney stones without urinary stasis. Different pathogenetic scenarios of the course of the postoperative period were observed. A significant decrease in Ri and a simultaneous significant increase in the concentration of KIM-1 in urine were found in 10 patients a day after TULT, 6 hours after removal of the ureteral catheter. The reovery of urine outflow from a kidney that has recently been in a state of ischemia leads to normalization of renal hemodynamics and is accompanied by increased urinary excretion of KIM-1. This phenomenon is obviously related with the \"washing\" of the renal tubules. In the remaining 18 patients, Ri did not decrease and there was no increase in the concentration of KIM-1 in urine. In our opinion, there is a continuation of obstructive uropathy due to local swelling of the ureteral mucosa. The duration of the endoscopic intervention and the size of the concretion were not factors, determining the severity of renal hemodynamic disorders and damage to the renal tubulointerstitium. Multidirectional changes in Ri in the postoperative period were accompanied by a significant decrease in serum creatinine and an increase in GFR. This makes it impossible to use these indicators to assess kidney injury after surgery.</p><p><strong>Conclusion: </strong>A study of the urinary excretion level of KIM-1 before and after TULT in combination with a me","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 5","pages":"32-38"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145763911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Results of histological evaluation of glandular epithelium in BPH in hypo- and eugonadal men].","authors":"M -H Uzhakhov M, I Lemeshko S, S Ibishev Kh","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Benign prostatic hyperplasia (BPH), despite advances in pharmacotherapy and surgical treatment, remains a pressing problem in modern urology. The success of therapy depends on the condition of the prostate epithelial compartment.</p><p><strong>Objective: </strong>To conduct a histological assessment of glandular epithelium in BPH in hypo- and eugonadal men.</p><p><strong>Materials and methods: </strong>The results of morphological examination of the resected prostate tissue of 188 men with BPH were analyzed, who were divided into two groups: Group I - 71 patients with testosterone (Tc) deficiency, group II (control) - 117 patients with testosterone levels above 12.1 nmol/L.</p><p><strong>Results: </strong>In patients with Tc deficiency, morphological examination of resected prostate tissue samples revealed a stromal pattern of BPH, combined with cystic deformation of the acini, with flattened and non-secretory epithelium. In patients with normal Tc levels, all patients had a glandular pattern of hyperplasia, and the epithelial cells of the acini were tall, columnar, and showed signs of active secretion.</p><p><strong>Conclusions: </strong>In patients with testosterone deficiency, morphological examination of resected prostate tissue samples revealed atrophic, flattened, and non-secretory epithelium. In patients with Tc levels within the reference range, all epithelial cells were tall, columnar, and showed signs of active secretion.</p>","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 5","pages":"84-88"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145763977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Endocrine and metabolic changes in prostate cancer patients after radical prostatectomy].","authors":"L Polishchuk D, V Amosova M, A Amosov N, V Fadeev V, V Amosov A, V Vasilieva I, L Demidko Yu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>It has been established that women who undergo hysterectomy, even in cases where the ovaries are preserved, frequently experience premature ovarian insufficiency syndrome, which can lead to various endocrine and metabolic disorders. A comparable inquiry emerges in the context of radical prostatectomy (RP) in males: whether the extraction of the prostate gland itself influences testicular function and the emergence of polymetabolic disorders in the absence of androgen deprivation therapy (ADT). Radical prostatectomy has been recognized as an effective treatment for localized prostate cancer (PCa), providing high survival rates for patients diagnosed with this disease. The primary focus of specialists in this field has historically centered on the surgical consequences of RP, such as erectile dysfunction and stress urinary incontinence. However, mounting evidence suggests that prostate removal itself can also result in a transient decrease in testosterone levels, manifesting as biochemical or manifest hypogonadism, along with moderate metabolic disturbances, though not to the same extent as observed with adjuvant hormone therapy. In some cases, patients already in the preoperative period may have risk factors for metabolic syndrome, osteopenia, and other perioperative complications, which makes it difficult to objectively assess the direct effect of RP. A more profound comprehension of the pathophysiologic mechanisms underlying these changes appears to be a pivotal element in facilitating timely diagnosis, prevention, and treatment of potential endocrine-metabolic complications associated with RP.</p>","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 5","pages":"144-150"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145763829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Evaluation of the possibility of using the Androscan-MIT device for diagnosis and minimally invasive assessment of conservative therapy outcomes in patients with vasculogenic erectile dysfunction].","authors":"R Aliev R, I Neymark A, V Davydov A","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Erectile dysfunction (ED) remains one of the important issues in modern urology, as it affects not only the quality of life but also the psychological and reproductive health of patients. Diagnostic challenges persist, as there is still no universal, minimally invasive method to evaluate the quality of erection and the efficiency of therapy in patients with a confirmed diagnosis of ED.</p><p><strong>Aim: </strong>To assess the feasibility of using the Androscan-MIT device as a minimally invasive tool for monitoring the efficiency of conservative treatment in patients with vasculogenic erectile dysfunction.</p><p><strong>Materials and methods: </strong>The study included 80 men aged 37 to 61 years with mild to moderate ED and 20 healthy volunteers as a control group. Patients were divided into four groups: group 1 (n=30): patients received local negative pressure therapy (LOD-therapy), low-intensity shockwave therapy (LiSWT), and Avantron chair stimulation (10 sessions); group 2 (n=30): patients received daily phosphodiesterase type 5 inhibitor (PDE5i) therapy at a dose of 5 mg for 2 months; group 3 (n=20): patients received combined therapy including LOD-therapy, LiSWT, Avantron chair stimulation, and platelet-rich plasma (PRP) injections (5 sessions); group 4 (n=20): control group of healthy volunteers. Therapeutic efficacy was assessed using the IIEF-5 questionnaire (International Index of Erectile Function) and Androscan-MIT measurements before and after treatment.</p><p><strong>Results: </strong>In Group 3, a significant improvement was observed after therapy: the IIEF-5 score increased to 21.1+/-2.1, corresponding to a 39.7% rise from baseline. Repeat nocturnal penile tumescence (NPT) monitoring demonstrated erectile function parameters comparable to those in the control group. The absolute increase in penile diameter reached 12.5+/-0.4 mm (+48.8% from baseline). The average number of effective nocturnal erections increased to 4.6+/-0.4 (+67.6%), and the average duration of each effective erection reached 20.9+/-1.5 minutes (+36.6%). The total erection time per night was 81.8+/-5.3 minutes (+74.8% from baseline). In Groups 1 and 2, no statistically significant changes in these parameters were recorded compared to baseline.</p><p><strong>Conclusion: </strong>The use of the Androscan-MIT device allowed for effective diagnosis of vasculogenic erectile dysfunction and minimally invasive assessment of therapeutic outcomes. The observed improvements following treatment confirm the potential of Androscan-MIT for both diagnostic evaluation and monitoring of conservative therapy efficiency in patients with vasculogenic ED.</p>","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 5","pages":"72-76"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145763907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Risk assessment scale for the development of acute pyelonephritis in women at different stages of pregnancy].","authors":"M Konyrov E, U Shalekenov B, B Shalekenov S, E Apenova A","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The authors consider gestational pyelonephritis as a relevant clinical problem requiring timely diagnosis and a well-grounded choice of treatment strategy.</p><p><strong>Aim: </strong>To develop and validate a scale for stratifying the risk of acute pyelonephritis in pregnant women, allowing determination of the optimal management strategy (conservative therapy or upper urinary tract drainage) at various gestational stages.</p><p><strong>Materials and methods: </strong>A retrospective analysis was performed on 161 cases of urinary tract infection in pregnant women: 73 patients observed in 2024 using the proposed scale and 88 patients from 2023, who formed the control group.</p><p><strong>Results: </strong>Implementation of the scale in 2024 increased the frequency of ureteral stenting (32.8% vs. 17% in 2023) and reduced the number of cases with kidney decapsulation (2.9% vs. 3.5%). A statistically significant increase was observed in the proportion of hospitalizations during the third trimester (20.6% vs. 6.8% in the first trimester), indicating more accurate risk stratification and timely selection of treatment tactics.</p><p><strong>Conclusion: </strong>The developed scale facilitates objectification of clinical decisions in managing pregnant women with gestational pyelonephritis, ensures timely drainage in high-risk patients, and reduces the frequency of unnecessary invasive interventions.</p>","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 5","pages":"66-71"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145763991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Pharmacological treatment of overactive bladder: the potential of anticholinergic therapy].","authors":"V Kuzmin I","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The management of overactive bladder (OAB) involves drugs from several pharmacological classes, among which anticholinergic agents occupy an important place. The choice of therapy should be strictly individualized, taking into account not only the expected efficacy but also potential drug interactions, age-related pharmacokinetic and pharmacodynamic changes, comorbidities, the overall anticholinergic burden, and the risk of adverse effects. Trospium chloride (Spasmex) is considered the drug of choice for patients with OAB. Its pharmacological properties ensure both clinical efficacy and good tolerability, along with proven cognitive safety. Trospium chloride does not cross the blood-brain barrier and therefore does not cause central nervous system adverse effects. Another advantage of trospium chloride is the flexible dosing regimen, which allows for individualized dose titration according to patient response and tolerability.</p>","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 5","pages":"130-136"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145764012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Multicenter open prospective randomized study on the efficacy and safety of Canephron N in preventing recurrences of uncomplicated lower urinary tract infection in women].","authors":"E Amdiy R, R Bayguzin R, O Darienko R, S Trufanov G, Kh Al-Shukri S","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;In women, urinary tract infections (UTIs) rank second in morbidity after acute respiratory viral infections. Therefore, issues of non-antibacterial prevention and treatment of UTIs are of great relevance. Particular interest is focused on evaluating the efficacy of the herbal medicinal product Canephron N in UTI prevention under conditions of rapidly increasing antibiotic resistance among uropathogenic bacterial strains, as well as the growing frequency of microbial associations and multidrug-resistant pathogens.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To assess and update data on the efficacy and safety of Canephron N for the prevention of recurrent UTIs in outpatient practice.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;A total of 72 female patients with a clinical diagnosis of acute cystitis or exacerbation of chronic cystitis, for whom empirical antibiotic therapy (ABT) was indicated according to the Russian clinical guidelines, were enrolled in a multicenter, open, prospective, randomized study. Thirty-six patients were assigned to the main group, receiving ABT in combination with Canephron N (2 tablets three times daily) followed by prophylactic monotherapy with the herbal product for 1 month. Thirty-one patients, receiving ABT only (contact was lost with 5 patients after randomization, and they were excluded from further analysis), were included in the control group. Treatment efficiency and recurrence rates were evaluated for 12 months after completion of therapy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The mean age of the patients was 37,4 years: 35,1 years in the main group and 39,7 years in the control group. Acute cystitis was diagnosed in 36 (53,7%) patients, and recurrent cystitis in 31 (46,2%). When Canephron N was administered at the onset of the disease together with antibiotic therapy and subsequently for one month, recurrences of uncomplicated lower urinary tract infections (LUTIs) within one year were observed in 13,9% of patients, compared with 38,7% in the control group. Among patients with acute cystitis, a recurrent episode during the year occurred in 5% of those treated with ABT and Canephron N, compared with 31,2% in the group without phytotherapy. In patients with recurrent cystitis, the recurrence rate within one year was 25% in the Canephron N group versus 46,7% in the control group.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion: &lt;/strong&gt;Currently, Canephron N is one of the herbal medicinal products with the most convincing evidence base, a high safety profile, and a broad range of therapeutic effects. The components of this phytomedicine are included in the 2024 Russian Ministry of Health Clinical Guidelines \"Cystitis in Women\" as an agent for both the prevention and treatment of recurrent cystitis. Our study demonstrated that the combination of antibiotic therapy with Canephron N reduced the recurrence rate by almost threefold (from 38.7% in the control group to 13.9% in the main group) and prolonged the recurrence-free","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 5","pages":"24-31"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145764019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Evidence-Based Study of Kidney Transplantation: Renal Arterial Resistance and Rejection].","authors":"Zahra Tolou-Ghamari Zahra Tolou-Ghamari","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>To decrease the high morbidity and mortality of patients with end-stage renal disease kidney transplantation is the most effective management. This study aimed to investigate changes in clinical, biochemical, inflammation, rejection, and its association with the renal arterial resistive index after kidney transplantation.</p><p><strong>Methods: </strong>In this study, we assessed changes in clinical, biochemical, and renal arterial resistive (RRI) index measured by doppler ultrasound and its association with graft rejection after kidney transplantation in 60 adult recipients. Data included; gender, age, hospital stay, living or deceased donor, evidence of acute tubular necrosis, donor (living or cadaver), preference of vessel anastomosis (first artery- second vein; FASV or FVSA), preference of arterial anastomosis (as end-to-end to hypogastric artery or end-to-side to common or external iliac artery), evidence for acute tubular necrosis (ATN), in addition to biochemical variables were noted analyzed by SPSS.</p><p><strong>Results: </strong>With a minimum of 16 and a maximum of 68, the mean+/-SD was 42,3+/-13,7 years old. Of the total population studied 52% received kidneys from cadaver donors. Although acute tubular necrosis versus acute rejection was reported at 32% versus 60%, the value of RRI in the total population was 0,76+/-0,11. There was a significant difference in rejected versus non-rejected (p=0,001) and living versus cadaver donors regarding the values of reported RRI (=0,018).</p><p><strong>Conclusion: </strong>In this study, the recorded RRI suggested respected information regarding changes within intraparanchymal vascularization linked to rejection after kidney transplantation. Further evidence-based studies regarding RRI with more sample size are recommended.</p>","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 5","pages":"39-43"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145763859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Experience with Domestic local Nitinol Stents in Patients with Benign Ureteral Obstruction].","authors":"S Serikov S, G Martov A, M Pshikhachev A, V Dutov S, S Andronov A","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy and safety of intraluminal nitinol ureteral stents (\"MIT\", Russia) in patients with benign ureteral strictures who experience a significant decline in their quality of life due to standard drainage systems and have contraindications to radical surgical treatment.</p><p><strong>Materials and methods: </strong>Between 2021 and 2025, a total of 27 MIT nitinol stents were implanted in 25 patients with benign ureteral obstruction. In the first stage, all the patients underwent an endoscopic assessment of the stricture determining its length, followed by a temporary placement of a double J stent. In the second stage, an intraluminal stent was implanted. The effectiveness was evaluated based on technical and clinical success, as well as changes in quality of life assessed by the Visual Analogue Scale (VAS).</p><p><strong>Results: </strong>The mean operative time was 35 [30; 41] minutes. Technical success was achieved in 92% of the patients. A significant improvement in quality of life was observed in most patients, with the median VAS score increasing from 21 [20; 26] to 86 [77; 90] points 3 months after the implantation. Mild stent-related symptoms persisted in 6 patients. Additional interventions were required in 6 patients (8 interventions). In 4 cases, stent encrustations had to be removed endoscopically; in 2 cases, endoscopic correction of stent position was performed; in 2 cases, additional drainage was required due to mucosal hyperplasia at the contact points of the stent ends.</p><p><strong>Discussion: </strong>Intraluminal nitinol stents demonstrate high clinical efficacy and may serve as a viable alternative to standard drainage systems in patients who are not candidates for reconstructive surgery. Their use is associated with fewer side effects and a significant improvement in quality of life. However, stent implantation carries a risk of complications such as encrustation, migration, and mucosal hyperplasia. Therefore, careful patient selection, adherence to technical standards of implantation, and regular follow-up are essential.</p><p><strong>Conclusion: </strong>The introduction of MIT nitinol ureteral stents into clinical practice shows promising results in patients with benign ureteral strictures. Further studies involving larger patient cohorts and longer follow-up periods are needed to refine indications and optimize patient management strategies.</p>","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 5","pages":"97-103"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145763948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}