Urologiia最新文献

{"title":"[Dystrophic diseases of the penile skin: modern approaches to therapy].","authors":"V Ignatovskii A","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Dystrophic diseases of the penile skin represent a heterogeneous group of conditions requiring different therapeutic approaches. These processes may result in irreversible changes in the genital skin that adversely affect patients quality of life. This publication presents a series of clinical cases in which Flamena gel coating was used as part of combination therapy. In a small group of patients with penile lichen sclerosus, steroid balanoposthitis, and plasma cell balanitis, the liposomal antioxidant-phospholipid complex Flamena demonstrated beneficial therapeutic effects.</p>","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 4","pages":"131-138"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148971335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Genes determining virulence factors of Escherichia coli strains isolated from prostate secretions patients with chronic bacterial prostatitis].","authors":"D Kuzmin M, A Kapustina O, P Popova L, M Pashkova T, A Gritsenko V, L Kartashova O","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of the work is to characterize virulence genes of E. coli strains isolated from prostate secretions patients with chronic bacterial prostatitis.</p><p><strong>Materials and methods: </strong>Escherichia coli were isolated from the prostate secretions of men of reproductive age (20-45 years) with chronic bacterial prostatitis using a generally accepted bacteriological method, the type was determined using MALDI-TOF mass spectrometry, virulence genes were PCR and sequencing.</p><p><strong>Results: </strong>The genomes of the studied strains contain genes encoding groups of virulence factors: adhesins, toxins, capsule antigens, siderophores, invasins, and anti-immunity of the macroorganism. Itwas shown that the genes of adhesins, siderophores, and immune system counteraction factors prevailed in E. coli.</p><p><strong>Conclusion: </strong>Further studies of E. coli strains using genome-wide sequencing and proteomics technologies are needed. The accumulation of the obtained data will make it possible to use virulence genes as diagnostic markers in patients with chronic prostatitis, indicating the presence of infection.</p>","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 4","pages":"22-27"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148971343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Limitations in the Interpretation of Kidney Function Markers During Testosterone Replacement Therapy].","authors":"L Polishchuk D, V Amosova M, A Amosov N, M Kulieva Z, K Guguchkina S, V Amosov A, V Fadeev V, L Demidko Yu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Changes in kidney function parameters in men receiving testosterone replacement therapy (TRT) may influence the clinical assessment of treatment safety. However, the physiological meaning of these changes remains uncertain. In most cases, kidney function during TRT is evaluated using surrogate laboratory markers rather than glomerular filtration rate (GFR) measured with exogenous filtration markers. This creates a risk of misinterpretation, as the observed changes may reflect not only true alterations in glomerular filtration, but also therapy-related effects and patient phenotype-related characteristics. Existing studies do not allow a reliable distinction to be made between true changes in filtration function, changes in the characteristics of the marker used, or a combination of both, since most of them rely on surrogate indicators without comparison with measured GFR. Therefore, the question of what changes in kidney function parameters during TRT actually mean, and how they should be interpreted, remains unresolved.</p>","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 3","pages":"149-155"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Retrograde intrarenal surgery: analysis of costs and correspondence between the clinical-statistical group tariff and actual expenses in a federal medical institution in St. Petersburg].","authors":"K Gadzhiev N, D Petrov A, S Burlykin V, A Shkarupa A, A Gorgotsky I, S Gorelov D, V Semenyakin I, N Akopyan G, A Malkhasyan V, G Martov A","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>RIRS is one of the main treatment options for urolithiasis. However, its high resource utilization and increasing number of procedures raise concerns regarding the sufficiency of reimbursement within the obligatory medical insurance (OMI) system. From 2022 to 2025, OMI tariffs for RIRS have shown steady growth, driven by the transition of the procedure to higher-reimbursed disease-related group (DRG groups). Nevertheless, despite the increase in tariffs, the issue of their adequacy for covering the costs of high-complexity interventions persists.</p><p><strong>Aim: </strong>To analyze the sufficiency of the DRG tariff to compensate for the actual costs of performing RIRS of varying complexity levels in a federal medical institution in St. Petersburg.</p><p><strong>Materials and methods: </strong>A cost analysis of 157 RIRS cases performed in 2024 at the N.I. Pirogov High Medical Technologies Clinic, St. Petersburg State University, was conducted. Costs were categorized as direct and indirect. The actual expenses were compared with the disease-related group (DRG) tariff.</p><p><strong>Results: </strong>The average costs per treated RIRS case ranged from 139,000 to 180,000 rubles, depending on the complexity category. Direct costs accounted for 88-91% of the total expenditures. The DRG tariff (147,000 rubles) covered only the expenses for low-complexity (Category I) procedures. In more complex cases, the actual costs exceeded the tariff by 11.5-22.4%. As a result, for 83% of patients treated with RIRS at the clinic, the established tariffs were insufficient to reimburse the actual expenses, leading to a deficit of 3.01 million rubles.</p><p><strong>Conclusion: </strong>In order to increase the economic sustainability of clinics operating under the DRG-based payment system, the possibility of introducing new reimbursement mechanisms is being considered. In particular, it is proposed to use differentiated values of the coefficient of complexity of patient treatment in the provision of RIRS procedures, depending on the appropriate category of complexity. For regional medical organizations with their own payment system (Moscow and St. Petersburg), it is recommended to provide tariffs that cover costs for all categories of RIRS complexity.</p>","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 3","pages":"139-148"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Pilot study of bovhyaluronidase azoximer in patients with acquired proximal seminal tract obstruction].","authors":"I Gamidov S, Yu Popova A, V Shatylko T","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Acquired proximal seminal tract obstruction may develop as a result of infectious-inflammatory, post-traumatic, or iatrogenic lesions of the epididymis and proximal segments of the vas deferens. In bilateral disease, it leads to obstructive azoospermia. Surgical sperm retrieval and microsurgical reconstruction remain the principal approaches to infertility management; however, conservative treatment targeting the inflammatory and fibrotic component of obstruction is of practical interest.</p><p><strong>Aim: </strong>To carry out a pilot assessment of the potential effect of different dosage forms of bovhyaluronidase azoximer on semen parameters in patients with acquired proximal seminal tract obstruction.</p><p><strong>Material and methods: </strong>A total of 80 men with obstructive azoospermia caused by proximal seminal tract obstruction and associated infertility were examined. The patients were divided into two groups of 40 patients each. In the first group, bovhyaluronidase azoximer was administered as rectal suppositories at a dose of 3000 IU; in the second group, it was administered as a lyophilizate for intramuscular injection at a dose of 3000 IU. Follow-up examination and semen analysis were performed once, 95-105 days after the start of therapy. Statistical analysis was primarily descriptive; the proportions of patients with spermatozoa detected in the ejaculate were compared using Fishers exact test.</p><p><strong>Results: </strong>Spermatozoa appeared in the ejaculate in 10 of 80 patients (12.5%). The median sperm concentration was 0.85 million/mL, the median total sperm count was 1.65 million, and the median total motile sperm count was 0.1815 million. In the suppository group, spermatozoa appeared in 6 of 40 patients (15.0%); in the intramuscular injection group, spermatozoa were detected in 4 of 40 patients (10.0%). The between-group difference was not statistically significant (p=0.737).</p><p><strong>Discussion: </strong>The number of spermatozoa obtained was insufficient for natural conception; however, in selected cases it could be of practical value for cryopreservation and subsequent use in intracytoplasmic sperm injection programs. These results should be considered preliminary because of the pilot design, absence of a control group, and limited number of patients with a positive response.</p><p><strong>Conclusion: </strong>The obtained data suggest that bovhyaluronidase azoximer may be considered a potentially pathogenetically substantiated component of complex therapy in patients with proximal seminal tract obstruction. Further studies of appropriate methodological quality are required to clarify the clinical significance of these findings.</p>","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 3","pages":"52-59"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Rethinking the known technique of heterotopic continent uroderivation and searching for optimal ways to improve functional results].","authors":"A Perepechay V, I Senin S, N Vasilyev O","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The increasing number of performed cystectomies (CE) has significantly heightened the demand for effective urinary diversion methods. The declining use of continent cutaneous urinary diversion (CCUD) leads to an impoverishment of the modern reconstructive urology arsenal and a reduced quality of life for post-cystectomy patients when orthotopic neocystoplasty is not feasible.</p><p><strong>Aim: </strong>To conduct a comparative analysis of the clinical and functional outcomes of the classic and modified Kock pouch continent cutaneous urinary diversion.</p><p><strong>Materials and methods: </strong>The results of a consecutive series of 56 patients were analyzed. The patients underwent: open CE with classic Kock CCUD (13 patients, 23.2%), open CE with modified Kock CCUD (27 patients, 48.2%), and laparoscopic CE with modified Kock CCUD (16 patients, 28.6%).</p><p><strong>Results: </strong>The incidence of resecting a prolapsed valve nipple decreased by 6.2 times with the modified technique. Valve revision was required in 30.8% of patients after the classic procedure compared to 7.0% after the modified procedure, resulting in a 4.4-fold reduction in revision frequency. Reservoir calculi formation was 1.4 times lower in the modified surgery group. Difficult catheterization decreased by 23.9% (a 4.5-fold reduction) in the modified group. Continence rates were 76.9% and 93.1% in the compared groups, respectively, showing a 16.2% improvement (a 1.2-fold increase) with the modified Kock reservoir. The advantages of surgical approaches (open vs. laparoscopic) and diversion modification (modified vs. classic Kock procedure) become apparent only when considering long-term postoperative outcomes ( more or equal 90 days).</p><p><strong>Conclusion: </strong>Despite the waning popularity of the traditional heterotopic Kock continent urinary diversion, which undoubtedly depletes the arsenal of modern reconstructive urology, its modified version represents a promising tool in the hands of a contemporary urologist.</p>","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 3","pages":"24-31"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Efficacy and safety of the drug based on bovine testicular polypeptides in the treatment of male infertility: results of a multicenter observational study].","authors":"S Rogozin D, V Prokopyev Ya, V Moskvichev D, V FanievM, Z Khamalyan A, Yu Nikiforov D, A Staroselskaya M, Yu Lazarev I, N Zel A, A Koval N","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>providing objective data on the shortterm and longterm efficacy and safety of the drug based on bovine testicular polypeptides in realworld clinical practice.</p><p><strong>Materials and methods: </strong>A prospective, multicenter, noninterventional observational study enrolled 668 patients with impaired spermatogenesis (oligoasthenozoospermia) and diagnosed male infertility. The patients received Testivell 5 mg once a week for 10 weeks. During the subsequent three visits at 3month intervals and the follow-up period of up to 9 months, the parameters listed below were analyzed: semen analysis parameters, DNA fragmentation index, and clinical outcomes (pregnancy achievement and live birth).</p><p><strong>Results: </strong>Treatment with Testivell demonstrated improvements in semen parameters in all study populations and subpopulations: sperm concentration increased from 21 [7; 46] to 34 [12; 62] mln/mL (p<0,001); the number of progressively motile sperm cells rose from 12.6 [2.3; 41.3] to 31.2 [6.6; 74.7] mln (p<0,001); and the proportion of morphologically normal sperm increased from 2 [1; 3] to 3 [1; 4]% (p<0,001). In patients with initially elevated DNA fragmentation, the index decreased from 27 [21; 37] to 11 [2; 17.5]% (p<0,001). 184 participants who completed the therapy course underwent a full followup cycle with monitoring of conceptions and births. A total of 85 pregnancies were recorded, corresponding to a clinical efficacy rate of 48,9% [37.7%; 52.4%]. Data on 70 pregnancy outcomes were collected, and in all cases, the pregnancies resulted in the birth of a healthy live infant. Testivell demonstrated good tolerability when used in combination with other drugs. No clinically significant adverse reactions were observed.</p><p><strong>Conclusion: </strong>Real-orld clinical practice has provided evidence of both shortterm efficacy (regarding basic ejaculate parameters and DNA fragmentation) and longterm efficacy (as reflected by pregnancy and live birth rates in couples), along with the safety of a course of therapy using a testicular polypeptidebased drug. Testivell is suitable for use in the management of idiopathic infertility, as an adjunctive therapy in cases with established causes of infertility, and as part of preparation for assisted reproductive technologies (ART) for couples when male infertility is associated with spermatogenesis disorders (oligoasthenozoospermia).</p>","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 3","pages":"60-70"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Functional and oncological outcomes of robot-assisted and laparoscopic partial nephrectomy].","authors":"G Ivanov A, B Zingerenko M, V Pervushin V, A Timaev K, M Ekhoyan M","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Laparoscopic partial nephrectomy (LPN) and robot-assisted partial nephrectomy (RAPN) are widely used organ-sparing treatment methods for T1 renal cell carcinoma (RCC). Numerous international meta-analyses on this topic have shown that RAPN provides perioperative outcomes comparable to those of LPN, while offering additional advantages such as significantly lower blood loss and a shorter warm ischemia time. However, no superiority of either technique over the other has yet been demonstrated with regard to oncological outcomes and preservation of renal function.</p><p><strong>Aim: </strong>To compare functional and oncological outcomes of laparoscopic and robot-assisted partial nephrectomy for RCC at A.S. Loginov Moscow Clinical Scientific Center with data from international studies.</p><p><strong>Materials and methods: </strong>A search of current literature on outcomes of RAPN and LPN was performed using PubMed. The most relevant publications were analyzed and served as the basis for this study. In addition, we retrospectively analyzed the surgical outcomes of 277 patients who underwent surgery for RCC using the Da Vinci robotic surgical system (n=175, group 1) or a laparoscopic technique (n=102, group 2) at A.S. Loginov Moscow Clinical Scientific Center between 2019 and 2024. Functional and oncological outcomes were collected and compared between the two groups.</p><p><strong>Results: </strong>The postoperative decline in creatinine clearance was significantly greater in patients in group 2. Positive surgical margins and recurrence of RCC were also significantly more common in group 2.</p><p><strong>Conclusion: </strong>The use of a robotic system for partial nephrectomy is an alternative to the laparoscopic technique, providing reliable functional and oncological outcomes. This is supported both by studies from a number of international centers and by the results obtained at A.S. Loginov Moscow Clinical Scientific Center.</p>","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 3","pages":"19-23"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Optimization of surgical treatment selection for male stress urinary incontinence].","authors":"M Asadulaev M, O Korolev D, E Enikeev M, M Rapoport L","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Male stress urinary incontinence (SUI) following prostate surgery significantly impairs quality of life. The main surgical treatment options for SUI are male sling (MS) implantation and artificial urinary sphincter (AUS) implantation. The optimal choice of procedure depends on the severity of incontinence. The 24-hour pad test and pad count do not reliably reflect the functional status of the external urethral sphincter (EUS). The Male Stress Incontinence Grading Scale (MSIGS) has been proposed to improve patient stratification.</p><p><strong>Objective: </strong>To evaluate the effectiveness of preoperative assessment of SUI severity based on a combination of MSIGS and the 24-hour pad test in guiding surgical decision-making in men with post-prostatectomy SUI.</p><p><strong>Materials and methods: </strong>From 2016 to 2022, SUI severity in our clinic was determined using only the 24-hour pad test. From 2022 to 2025, the MSIGS was incorporated into preoperative evaluation. Patients with urine loss less or equal 200 g/day and MSIGS less or equal 2 underwent sling implantation, whereas those with urine loss >200 g/day and MSIGS more or equal 3 received AUS implantation.</p><p><strong>Results: </strong>Between 2016 and 2025, a total of 39 patients underwent surgery: 13 with slings and 26 with AUS. A history of pelvic radiotherapy (RT) was present in 15.4% (2/13) of sling patients and 30.8% (8/26) of AUS patients. After the introduction of combined assessment (pad test + MSIGS), the proportion of AUS implantations increased from 27% (n=3) to 82% (n=23) (OR=12.27; 95% CI 2.53-50.45; p=0.002). Furthermore, sling efficacy improved from 25% to 80% when patient selection was based on the combined approach (OR=12.00; 95% CI 0.67-165.6; p=0.103). Importantly, the higher rate of AUS implantation was not associated with reduced efficacy (p>0.05).</p><p><strong>Conclusion: </strong>The choice of surgical treatment for SUI depends on incontinence severity and prior RT. Male sling implantation is effective in mild cases but its efficacy is markedly reduced in severe SUI and in patients with prior RT. The AUS remains the gold standard for severe SUI. The combination of MSIGS and the 24-hour pad test improves diagnostic accuracy and optimises implant selection, which is particularly valuable in patients with moderate SUI.</p>","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 3","pages":"14-18"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Features of the bladder cytokine status in combined experimental models of vitamin D deficiency and chronic bacterial cystitis].","authors":"I Bratchikov O, A Koryagin E","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Cytokine-mediated mechanisms play a substantial role in the pathogenesis of chronic bacterial cystitis. However, the design of the vast majority of previous studies has not taken into account the systemic nutritional and metabolic status of the subjects, which may independently affect cytokine metabolism and the parameters under investigation, irrespective of infection. Vitamin D has well-documented immunomodulatory and anti-inflammatory properties, and its deficiency is reliably associated with an increased risk of both the first episode of urinary tract infection (UTI) and recurrent UTIs. Nevertheless, the effect of vitamin D status on cytokine metabolism in the bladder during UTIs remains largely unexplored.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To investigate the features of bladder cytokine status in experimental models of vitamin D deficiency and chronic bacterial cystitis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;The study was carried out in 20 sexually mature female albino rats. Following experimental induction of vitamin D deficiency, the animals were divided into two groups: a control group without vitamin D deficiency (n=10) and a main group with vitamin D deficiency (n=10). A model of recurrent chronic bacterial cystitis was subsequently induced in both groups. Cytokine status was assessed at both stages of the experiment by measuring tissue concentrations of secretory immunoglobulin A (sIgA), interleukin-8 (IL-8), and interleukin-10 (IL-10) in bladder homogenates using a solid-phase chromogenic enzyme-linked immunosorbent assay (sandwich ELISA). Statistical analysis was performed using Microsoft Excel spreadsheets and Statistica V10 (StatSoft Inc., USA) and SPSS Statistics V17 (USA) software packages.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The mean baseline tissue concentration of sIgA in the intact bladder of animals with vitamin D deficiency was significantly 1.4-fold lower than in the control group (p&lt;0.001), whereas baseline IL-8 and IL-10 concentrations did not differ significantly between the groups (p&gt;0.05). In the chronic bacterial cystitis model, the mean induced tissue concentrations of sIgA, IL-8, and IL-10 in the bladder of animals with vitamin D deficiency were significantly lower than in the control group by 2.5-fold, 1.7-fold, and 2.8-fold, respectively (p&lt;0.001).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion: &lt;/strong&gt;Vitamin D deficiency in the experimental model of chronic bacterial cystitis was associated with a substantial and significant reduction in local anti-infectious immunity and bladder immune reactivity. This was manifested by the development of a decompensated hypoergic infectious-inflammatory process in the bladder, which may represent one of the mechanisms underlying the increased risk of UTIs and their recurrence reported in the literature in the setting of vitamin D deficiency.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Vitamin D deficiency may independently suppress local anti-infectious immunity and immune","PeriodicalId":23546,"journal":{"name":"Urologiia","volume":" 3","pages":"44-51"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}