Veterinary Medicine and Science最新文献

{"title":"Heavy Metal Content of Water Hyacinth (Pontederia (Eichhornia) crassipes) and Its Safe Inclusion Levels in Ruminant, Poultry, and Swine Diets: A Critical Review.","authors":"Getachew Assefa, Habtamu Ayalew","doi":"10.1002/vms3.71228","DOIUrl":"10.1002/vms3.71228","url":null,"abstract":"<p><p>Water hyacinth poses significant environmental challenge in many countries. As part of the effort of reducing its negative effect, there is a great interest to use it as animal feed. However, reports of its safe inclusion level are not consistent. Since the heavy metal content of water hyacinth differed with the water quality it grows in, the safe inclusion level recommendation based on single research results can't be reliable to use widely. This study made a review of the heavy metal content of water hyacinth published to 2025 and presented widely applicable safe inclusion level of water hyacinth to ruminant, poultry, and swine based on the 95th percentile value of the heavy metals content report and the maximum tolerable limit of heavy metals reported by NRC (2005). Therefore, based on these values, water hyacinth leaf can be included in ruminants', poultry and swine rations up to 13.5%, 9.19% and 18.4%, respectively, without posing a problem on animals due to the heavy metal intake. Water hyacinth shoot can be included in cattle, sheep and poultry ration up to 17.3%. For swine, it can be included up to 24.4%. The whole plant water hyacinth can safely be used in ruminants and nonruminants' rations up to 6.23% and 6.15%, respectively. These recommendations are safe for 95% of the areas where heavy metal content of water hyacinth reported.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"12 5","pages":"e71228"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13561854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148931298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forensic LC-MS/MS Monitoring of Anticoagulant Rodenticide Poisoning in Cats Over a Half-Decade.","authors":"HyunYoung Chae, Jae-Won Byun, So-Jeong Yim, Bok-Kyung Ku, Tae-Wan Kim, JeongWoo Kang","doi":"10.1002/vms3.71209","DOIUrl":"10.1002/vms3.71209","url":null,"abstract":"<p><strong>Background: </strong>Anticoagulant rodenticides (ARs) are important toxicants in veterinary forensic investigations involving suspected poisoning in cats.</p><p><strong>Objectives: </strong>This study aimed to develop and validate a standardized LC-MS/MS-QTRAP method for the simultaneous identification and quantification of eight ARs in gastric matrices from cats and to assess its applicability to veterinary forensic toxicology.</p><p><strong>Methods: </strong>Automated sample preparation was implemented to reduce inter-analyst variability. Dual confirmation using multiple reaction monitoring (MRM) and enhanced product ion (EPI) spectra was applied to improve identification reliability and minimize false-positive results caused by structurally related compounds. The method was applied to 747 cat forensic toxicology cases submitted between January 2020 and August 2025, in which gastric tissue or gastric contents were available for analysis.</p><p><strong>Results: </strong>ARs were detected in 2.5% of cases (19/747). Coumatetralyl was the most frequently detected AR, followed by flocoumafen and bromadiolone. Flocoumafen was detected despite not being an officially registered active ingredient in Korea, highlighting the need for broad multi-analyte screening.</p><p><strong>Conclusions: </strong>The standardized LC-MS/MS-QTRAP method enabled reliable detection and quantification of ARs in gastric matrices from cats. This approach provides useful forensic evidence of recent AR exposure in suspected poisoning cases and may support improved toxicovigilance for registered and unregistered rodenticides.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"12 5","pages":"e71209"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13561683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148931314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological Characterization of the Lingual Papillae of the Golden Jackal (Canis aureus): A Scanning Electron Microscopy Study.","authors":"Veysel Delibaş","doi":"10.1002/vms3.71231","DOIUrl":"https://doi.org/10.1002/vms3.71231","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to characterise the lingual structures of the Canis aureus using SEM analysis.</p><p><strong>Methods: </strong>This study Tongues of three adult Canis aureus (n = 3) with a mean body weight of 9.77 ± 1.68 kg were examined. Tissue samples collected from various regions of the tongue were fixed using sequential concentrations of acetone, they were analysed using a Sigma 300 Zeiss Gemini FE-SEM.</p><p><strong>Results: </strong>The results identified four distinct types of papillae in Canis aureus: filiform, conical, fungiform and circumvallate papillae. Filiform papillae featured a triangular main body surrounded by multiple secondary processes, providing a mechanical surface for food prehension and grooming. Conical papillae were observed in two distinct forms at the base of the tongue with pointed or rounded tips facilitating the backward movement of food during swallowing. Fungiform papillae were distributed among the filiform papillae across the lingual surface (except at the base), while circumvallate papillae numbered four in total, each consisting of a rounded main body and a ring-shaped cushion separated by a groove; both types function in gustatory perception. Interestingly, leaf-like papillae, which are found in some other carnivorous species, were not identified in all samples in this study.</p><p><strong>Conclusion: </strong>These SEM findings demonstrate that while the general papillary morphology of Canis aureus aligns with other Canidae species, it exhibits specific differences in the shape and quantity of conical papillae and is characterised by the absence of foliate papillae.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"12 5","pages":"e71231"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149031401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Associated Factors of Gastrointestinal Helminths Infection in Domestic Ruminants in and Around Gondar City, Northwest Ethiopia.","authors":"Wudneh Ayele, Nega Yismaw Alemu, Sefinew Alemu Mekonnen, Moges Maru","doi":"10.1002/vms3.71237","DOIUrl":"10.1002/vms3.71237","url":null,"abstract":"<p><strong>Background: </strong>Gastrointestinal helminth (GIH) infections are major health problems that cause economic losses in Ethiopia; however, information on their prevalence and associated factors in domestic ruminants is limited in and around Gondar city, Northwest Ethiopia.</p><p><strong>Objectives: </strong>To estimate the prevalence, identify GIH based on egg morphology and assess its associated factors in domestic ruminants.</p><p><strong>Methods: </strong>Cross-sectional study was conducted from December 2024 to June 2025. A total of 384 domestic ruminants were sampled using simple random sampling techniques. Faecal samples were collected from each animal and examined using coprological examination techniques.</p><p><strong>Results: </strong>The overall prevalence was 56.5%. Strongyle-type nematodes (most common 37.3%), Strongyloides, Trichuris, Fasciola, Paramphistomum, Moniezia spp. and Nematodirus (least common 1.4%) were identified. Multivariable logistic regression showed significant associations between GIH infection and species, sex, age, study area sites, and management system (P < 0.05). Sheep had 16 times higher odds of infection than goats, and cattle also had increased odds (AOR = 9.74). Females were more likely to be infected than males (AOR = 25.65), and young animals had twice the odds of adults (AOR = 2.01). Extensive and semi-intensive systems had higher infection risks (AOR = 7.31 and 3.21) than intensive systems. Animals in peri-urban kebeles also had a higher infection risk (AOR = 2.46) than those in urban kebeles.</p><p><strong>Conclusions: </strong>Gastrointestinal helminth infections are highly prevalent in the study area, with host and management factors influencing their occurrence. Therefore, the control measures should focus on the potential associated factors, including management system, age, and species of animals.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"12 5","pages":"e71237"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13595309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Deprivation, Cytokine Dysregulation, and the Risk of Cardiac Arrhythmia in Dogs.","authors":"Adithya Sethumadhavan, Arun Hs Kumar","doi":"10.1002/vms3.71212","DOIUrl":"10.1002/vms3.71212","url":null,"abstract":"<p><strong>Background: </strong>Sleep deprivation is increasingly recognised as a potent physiological stressor capable of altering immune function and promoting systemic inflammation. Emerging evidence suggests that these inflammatory changes may contribute to cardiac electrical instability and arrhythmia risk. However, the specific cytokines involved and their mechanistic pathways in canine models remain poorly characterised. This study aimed to (1) identify key cytokines consistently associated with sleep deprivation through a systematic review of the literature, and (2) perform a canine-specific network and Gene Ontology enrichment analysis to characterise their interactions and potential mechanistic links to arrhythmogenesis.</p><p><strong>Methods: </strong>A structured search of PubMed and Google Scholar identified 25 articles, of which 24 unique records were screened and seven met all inclusion criteria. From these studies, seven cytokines (IL-6, IL-17A, TNF, IL-1, IL-21, IFN-γ, and CRP) were consistently associated with sleep deprivation and were subjected to canine-specific protein-protein interaction analysis using the STRING database. Network topology and enriched biological processes were evaluated to identify mechanistic pathways connected to cardiac electrophysiology.</p><p><strong>Results: </strong>Network analysis revealed several highly interconnected signalling nodes, including IL-10, IL-1β, JAK1, JAK2, IL-6, STAT3, TNF, IFN-γ, IL-2, and IL-4. Enrichment analysis indicated activation of processes such as chemokine production, positive regulation of osteoclast differentiation, JAK-STAT signalling, membrane protein ectodomain proteolysis, and regulation of vitamin D metabolism. Integration of primary and secondary networks revealed three major clusters cantered on interleukin signalling, TNF-driven pathways, and CRP-associated acute-phase responses. Collectively, these pathways converge on cytokine-mediated mechanisms known to influence myocardial conduction and increase arrhythmia susceptibility.</p><p><strong>Conclusions: </strong>These findings indicate that sleep deprivation activates coordinated inflammatory networks that may predispose dogs to arrhythmias through multiple interconnected biological pathways. Therapeutic strategies addressing both inflammation and electrical instability may be required to fully manage arrhythmia risk in sleep-deprived canine patients.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"12 5","pages":"e71212"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Effects of Matricaria chamomilla Extract in an Immunosuppressed Mouse Model of Cryptosporidiosis.","authors":"Kousha Kiani, Mohammad Hashemnia, Farid Rezaei, Hadi Cheraghi","doi":"10.1002/vms3.71148","DOIUrl":"10.1002/vms3.71148","url":null,"abstract":"<p><strong>Background: </strong>Cryptosporidiosis, caused by Cryptosporidium parvum, is an opportunistic protozoan infection that can lead to severe intestinal pathology in immunocompromised hosts. Despite extensive research, current chemotherapeutic options, such as nitazoxanide and paromomycin, remain suboptimal, underscoring the need for safe and effective alternatives. Chamomile (Matricaria chamomilla L.), known for its antioxidant, anti-inflammatory, and antiparasitic activities, has recently attracted attention as a potential phytotherapeutic agent.</p><p><strong>Methods: </strong>This experimental study evaluated the therapeutic efficacy of a hydroalcoholic chamomile extract in immunosuppressed Swiss albino mice infected experimentally with C. parvum. Animals were divided into five groups: normal control, chamomile control, infected untreated, infected treated with paromomycin (100 mg/kg/day) and infected treated with chamomile extract (100 mg/kg/day). Oocyst shedding, intestinal histopathology and oxidative stress biomarkers were assessed at Days 0 (7 days post-infection), and 3, 7 and 11 post-treatment.</p><p><strong>Results: </strong>Chamomile treatment significantly reduced oocyst shedding compared with the untreated infected group (p < 0.05) and improved intestinal tissue architecture by attenuating villous atrophy, epithelial desquamation and inflammatory cell infiltration. Biochemical assays revealed that chamomile markedly increased TAC and GPx activity while reducing MDA levels. Although paromomycin showed a more rapid reduction in oocyst output, chamomile induced a gradual but sustained improvement with pronounced antioxidant and anti-inflammatory effects.</p><p><strong>Conclusion: </strong>Hydroalcoholic extract of M. chamomilla was associated with reduced oocyst shedding, improved intestinal histopathology, and enhanced antioxidant status in immunosuppressed mice infected with C. parvum, supporting its potential as an adjunctive phytotherapeutic approach that warrants further mechanistic, pharmacological and long-term investigation.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"12 5","pages":"e71148"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13581436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148983554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survey of Rift Valley Fever Virus Antibodies and Risk Factors in Small Ruminants in Maiduguri, Borno State, Nigeria: A Cross-Sectional Serological Study.","authors":"Sani Mohammed, Abdulrahman Mohammed, Adamu Saleh Saidu, Muhammad Mamman Gashua, Shuaibu Gidado Adamu, Ibrahim Malami Yusuf, Daniel Jigbin, Abdulyekeen O Tijani, Hassan Ismail Musa","doi":"10.1002/vms3.71009","DOIUrl":"10.1002/vms3.71009","url":null,"abstract":"<p><strong>Background: </strong>Rift Valley fever (RVF) is a zoonotic viral disease transmitted through mosquito bites commonly reported in low- to medium-income countries such as Nigeria. It impacts livestock productivity and trade, causing abortions and high rates of mortality, particularly among young animals.</p><p><strong>Objectives: </strong>A cross-sectional study was aimed to determine the presence of RVF virus antibodies (anti-RVFV IgG antibodies) and to identify related risk factors in small ruminants within Maiduguri Metropolis, Borno State, Nigeria.</p><p><strong>Methods: </strong>Ninety-six blood samples were collected; information on species, age and sex of the animals was recorded; history of flooding was assessed based on farmer report and observation. The study used a commercial ELISA kit (competitive, multispecies) to identify the presence of RVF virus antibodies, in accordance with the manufacturer's guidelines.</p><p><strong>Results: </strong>This study established an overall seroprevalence of RVFV antibodies of 47.9% (95% confidence interval [CI]: 37.9-57.9) in small ruminants. The prevalence rate for sheep was higher (52.1%) compared to goats (43.8%). Females (68.6%), young animals (51.2%) and places flooded (68.3%) showed a higher seroprevalence. The findings indicate that age (OR: 2.4; 95% CI: 1.1-5.2), sex (OR:2.8; 95% CI: 1.2-6.2) and proximity to flood-prone areas (OR: 2.1; 95% CI: 1.0-4.3) were significant (p ≤ 0.05) risk factors for the RVF virus.</p><p><strong>Conclusion: </strong>The studies indicate previous exposure and potential epidemiological role of small ruminants in RVF virus transmission in Maiduguri Metropolis. It is recommended that regular monitoring and effective surveillance be carried out; mosquito vector populations be regulated during flooding or rainy seasons and the public be informed about the disease's impact on humans, livestock and the economy.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"12 5","pages":"e71009"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13542572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dihydrotestosterone Promotes Hetian Sheep Dermal Papilla Cell Proliferation by Inhibiting the TGF-β/Smad Signalling Pathway.","authors":"Qinqin Wang, Xuan Liu, Zhiya Feng, Jianping Zhang, Chunyang Li, Ruijun Shi, Shuwei Li","doi":"10.1002/vms3.71118","DOIUrl":"10.1002/vms3.71118","url":null,"abstract":"<p><p>Hair follicles, as key accessory organs in mammalian skin, are precisely regulated for growth and development influenced by genetic factors, hormones, and the local microenvironment. This study investigated the effect of dihydrotestosterone (DHT) on the proliferation of dermal papilla cells (DPCs) from Xinjiang Hetian sheep and its regulatory relationship with the TGF-β/Smad signalling pathway. DPCs were isolated from the back skin tissue of newborn Hetian sheep by collagenase II digestion, and their characteristics were identified by primary culture, passage, and double immunofluorescence staining with α-SMA and CD133 labelling. CCK-8 and EdU assays were used to evaluate the effect of varying DHT concentrations (0, 1, 10, 100, and 1000 nM) on DPC proliferation. The results showed that with the increased DHT concentration, cell proliferation also increased, and the highest rate was observed at 1000 nM. Furthermore, qPCR analysis revealed that 1000 nM DHT significantly upregulated Smad6 gene expression (p < 0.05), while it inhibited the expression of TGF-β1, TGF-βRII, and Smad5 (p < 0.05). These findings suggest that high DHT concentrations may promote DPC proliferation by inhibiting the TGF-β/Smad signalling pathway. This suggests a critical role of this pathway in regulating hair follicle development and hormone-dependent hair growth, providing evidence for the molecular mechanism of androgen action on dermal papilla cell function.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"12 5","pages":"e71118"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149031359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjunctive Therapy With a Perna canaliculus and Euphausia superba Extract (EAB-277^TM) for Clinical Signs of Tracheal Collapse in Dogs: A Prospective, Randomized and Placebo-Controlled Exploratory Trial.","authors":"Wasutorn Yangwanitset, Somkiat Huaijantug, Mookmanee Taechikantaphat, Melanie Hezzell, Walasinee Sakcamduang","doi":"10.1002/vms3.71159","DOIUrl":"10.1002/vms3.71159","url":null,"abstract":"<p><strong>Background: </strong>Tracheal collapse is a common canine respiratory disease characterized by dorsoventral cartilage flattening, airway lumen narrowing and subsequent mucosal inflammation.</p><p><strong>Objectives: </strong>To investigate the efficacy of EAB-277, a marine lipid extract combining Perna canaliculus (30 mg) and Euphausia superba (20 mg) as an adjunctive therapy in the management of tracheal collapse in dogs.</p><p><strong>Methods: </strong>Forty-one dogs with confirmed tracheal collapse were randomly assigned to receive standard conventional medications plus either EAB-277 (n = 21) or a placebo (n = 20). The EAB-277 treatment protocol included a loading dose for the initial 14 days. Clinical signs and quality of life were assessed together with fluoroscopy, radiography, haematology and serum biochemistry on Days 0, 14, 28 and 56.</p><p><strong>Results: </strong>Dogs receiving EAB-277 showed a significant improvement in exercise tolerance by Day 14. Concurrently, fluoroscopic analysis demonstrated significant reductions in the percentage change in tracheal luminal diameter across the cervical, thoracic inlet and intrathoracic regions by Day 14. Both groups showed significant improvements in cough scores throughout the study, with no statistical difference between the groups.</p><p><strong>Conclusions: </strong>Although conventional medical therapy effectively manages the clinical signs of tracheal collapse, particularly cough, this study demonstrates that EAB-277 provides additional benefits by significantly improving exercise tolerance and reducing dynamic tracheal collapse at the cervical, thoracic inlet and intra-thoracic regions, which might have the potential to enhance airway health.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"12 5","pages":"e71159"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13475633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palliative Debulking of an Aortic Body Tumour With Right Atrial Invasion in a Dog Under Partial Cardiopulmonary Bypass.","authors":"Shuji Suzuki, Sachiyo Tanaka, Nobuo Kanno, Takuya Yogo, Yasuji Harada, Masaki Michishita, Yasushi Hara","doi":"10.1002/vms3.71244","DOIUrl":"10.1002/vms3.71244","url":null,"abstract":"<p><strong>Background: </strong>Aortic body tumours are uncommon heart-base neoplasms in dogs, and intracardiac extension causing clinically significant right atrial obstruction is rarely described.</p><p><strong>Case presentation: </strong>A 7-year-1-month-old, 15.2-kg, castrated male French Bulldog was evaluated for 2 weeks of lethargy, hyporexia, exercise intolerance, abdominal distension, and polydipsia. Transthoracic echocardiography revealed severe right-sided cardiac enlargement and a heterogeneous right atrial intracavitary mass (3.2 × 3.1 cm) suspected to arise from the heart base, with tricuspid regurgitation (maximal velocity 4.03 m/s). Abdominal ultrasonography showed hepatic venous congestion and marked ascites; fluid was a modified transudate. Medical therapy failed to resolve ascites, and surgical debulking was performed on Day 7 under partial cardiopulmonary bypass. The mass was firmly adherent to the atrial septal aspect and could not be completely excised. Postoperatively, ascites and clinical signs resolved, right-sided cardiac enlargement decreased, and tricuspid regurgitation was no longer detectable; the dog was discharged on Day 14. A recurrent right atrial mass was documented on Day 360 without recurrence of right-sided heart failure. The dog died on Day 390 from pancreatitis-associated biliary obstruction and multiple organ failure. Necropsy confirmed an aortic body tumour with intracardiac extension into the right atrium and pulmonary metastasis with tumour emboli.</p><p><strong>Conclusion: </strong>Partial cardiopulmonary bypass-assisted palliative debulking may temporarily relieve life-limiting intracardiac obstruction in carefully selected dogs; however, this approach is high-risk and non-curative, and its contribution to long-term survival remains uncertain because postoperative toceranib therapy and the natural behaviour of the tumour may also have influenced the clinical course.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"12 5","pages":"e71244"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149031366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}