Vaccine最新文献

{"title":"Evaluating cross-protection: Meningococcal vaccines show effectiveness in gonorrhoea prevention – A systematic review and meta-analysis","authors":"I. Szondy ,&nbsp;K. Lőrincz ,&nbsp;A. Walter ,&nbsp;A.A. Mohammed ,&nbsp;P. Hegyi ,&nbsp;N. Kiss ,&nbsp;F.A. Meznerics ,&nbsp;A. Bánvölgyi","doi":"10.1016/j.vaccine.2025.127188","DOIUrl":"10.1016/j.vaccine.2025.127188","url":null,"abstract":"<div><h3>Background</h3><div>Gonorrhoea remains a significant global health concern, with men who have sex with men (MSM) being disproportionately affected. Recent evidence suggests that outer membrane vesicle (OMV) meningococcal vaccines, such as the most widely used 4CMenB vaccine, may provide cross-protection against gonorrhoea.</div></div><div><h3>Objectives</h3><div>We aimed to evaluate the effectiveness of OMV vaccines against gonorrhoea through a systematic review and meta-analysis.</div></div><div><h3>Methods</h3><div>PubMed, Embase, and CENTRAL were searched from inception to 10 July 2024. Original articles were included if they investigated gonorrhoea incidence among recipients of OMV vaccines. Our primary endpoint was the incidence of gonorrhoea among vaccinated and unvaccinated individuals. The risk of bias was assessed using ROBINS-I, and the RoB-2 tools. A random-effects model with a 95 % confidence interval (CI) was applied to estimate pooled effect sizes. The study was registered on PROSPERO, CRD42024530848.</div></div><div><h3>Results</h3><div>We identified 12 eligible studies for qualitative analysis. Six retrospective studies and one prospective study were included in the quantitative analysis, of which six investigated the 4CMenB OMV vaccine. The pooled analysis yielded a vaccine effectiveness (VE) of 38 % [95 % CI:22 %–50 %; I² = 55 %]. Including only the 4CMenB vaccine, VE was 41 % (OR = 0.59; 95 % CI:0.46–0.76; I² = 44 %). Complete vaccination might offer 24 % greater protection compared to partial vaccination (OR = 0.76; 95 % CI:0.31–1.85; I² = 86 %). VE declined in 2–3 years post-vaccination. Four studies were rated as low risk, four as moderate risk, and four as having serious risk of bias. The certainty of the evidence was graded as moderate. The main limitations include the retrospective nature and the high heterogeneity of the included studies.</div></div><div><h3>Conclusions</h3><div>OMV vaccines offer moderate protection against gonorrhoea. 4CMenB OMV vaccine should be prioritised for sexually active individuals over non-OMV alternatives, with emphasis on completing the full vaccination series. Consideration should be given to administering 4CMenB to high-risk MSM groups specifically for gonorrhoea prevention.</div></div>","PeriodicalId":23491,"journal":{"name":"Vaccine","volume":"56 ","pages":"Article 127188"},"PeriodicalIF":4.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143908122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opting for the appropriate methodology for quantification of residual DNA impurities in mRNA vaccines","authors":"Stefan Vieths,&nbsp;Zoe Waibler,&nbsp;Gerald G. Schumann","doi":"10.1016/j.vaccine.2025.127186","DOIUrl":"10.1016/j.vaccine.2025.127186","url":null,"abstract":"","PeriodicalId":23491,"journal":{"name":"Vaccine","volume":"56 ","pages":"Article 127186"},"PeriodicalIF":4.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143908121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morbidity of viral vaccine preventable diseases in the Mexican states bordering the U.S., 2014–2023","authors":"Eriko Padron-Regalado ,&nbsp;Nicole A. Escudero González ,&nbsp;Hilda Nereyda del Carmen Selvera","doi":"10.1016/j.vaccine.2025.127192","DOIUrl":"10.1016/j.vaccine.2025.127192","url":null,"abstract":"<div><div>Mexico and the United States share an international boundary with a considerable extension. The objective of this retrospective study is to assess the morbidity of viral vaccine preventable diseases in the six Mexican states bordering the U.S. from 2014 to 2023. Viral vaccine preventable diseases are a major health concern because they can cause serious illness and death. From the analysis of 9 nationally notifiable viral vaccine preventable diseases, only varicella and mumps had a significant higher incidence than the national average. A higher incidence of varicella was also observed in the U.S. border states for the years of the study. A deeper analysis revealed that varicella is seasonal in the Mexican border states and its incidence is steadily declining throughout the years of study. For mumps, the higher incidence in the border states can be attributed to outbreaks in the years 2018 and 2019. Of importance, we observed an increasing morbidity of the viral vaccine preventable diseases after the emergence of COVID-19 in 2020. These data indicate that the incidence of certain infectious diseases is historically higher in the border states than the national average, and that continuous surveillance is crucial, especially after the COVID-19 pandemic.</div></div>","PeriodicalId":23491,"journal":{"name":"Vaccine","volume":"56 ","pages":"Article 127192"},"PeriodicalIF":4.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143908123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunogenicity evaluation of respiratory syncytial virus prefusogenic-F based virus-like-particles consisting of G and M proteins in mice","authors":"Ahmedali S. Mandviwala ,&nbsp;Archana Kulkarni Munje ,&nbsp;Anke L.W. Huckriede ,&nbsp;Vidya A. Arankalle ,&nbsp;Harshad P. Patil","doi":"10.1016/j.vaccine.2025.127203","DOIUrl":"10.1016/j.vaccine.2025.127203","url":null,"abstract":"<div><div>Human respiratory syncytial virus (hRSV) is a major cause of severe respiratory disease in infants and young children worldwide. Studies have shown that fusion-inactive prefusogenic fusion protein (F), a partially cleaved F protein made by inserting mutations in the furin cleavage site II of the fusion protein sequence, is equally immunogenic as the prefusion F and provides higher protection than postfusion structures of the F protein. Here we have developed respiratory syncytial virus (RSV) virus-like-particles (RSV-VLPs) containing baculovirus-produced prefusogenic-F, RSV glycoprotein and matrix proteins and studied their protective efficacy in BALB/c mice. Morphology and successful assembly of VLPs were confirmed by electron microscopy and western blot. Mice immunized with the VLPs developed higher levels of serum IgG and neutralizing antibodies as compared to mice immunized with inactivated RSV. The VLPs induced higher levels of IFN-γ and IL-4, enhanced T cell responses and prevented lung pathology after RSV challenge. Overall, our results indicate that RSV-VLPs containing prefusogenic F, glycoprotein and matrix proteins are a potential vaccine candidate against RSV.</div></div>","PeriodicalId":23491,"journal":{"name":"Vaccine","volume":"56 ","pages":"Article 127203"},"PeriodicalIF":4.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143908124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioural and social drivers of vaccination among child and adult migrants in Morocco: A qualitative interview study","authors":"Oumnia Bouaddi ,&nbsp;Mohamed Khalis ,&nbsp;Moudrike Abdellatifi ,&nbsp;Farah Seedat ,&nbsp;Anna Deal ,&nbsp;Wafa Chemao-Elfihri ,&nbsp;Bouchra Assarag ,&nbsp;Hassan Chrifi ,&nbsp;Nelly Chavassieux ,&nbsp;Ibrahim M. Sorie Turay ,&nbsp;Cédric Kané Gohi ,&nbsp;Tarik Oufkir ,&nbsp;Ana Requena-Méndez ,&nbsp;Sally Hargreaves ,&nbsp;Stella Evangelidou ,&nbsp;On behalf of the MENA Migrant Health Working Group","doi":"10.1016/j.vaccine.2025.127166","DOIUrl":"10.1016/j.vaccine.2025.127166","url":null,"abstract":"<div><h3>Background</h3><div>The World Health Organization's Immunization Agenda 2030 calls for ensuring universal access to vaccination across the life course for all groups including migrants. The aim of this study is to explore factors driving uptake of vaccination among migrants in Morocco.</div></div><div><h3>Methods</h3><div>We conducted a multi-site exploratory qualitative study using semi-structured interviews with adult migrants and health professionals in Morocco. We did a hybrid thematic analysis guided by the WHO's Behavioural and Social Drivers of Vaccination (BeSD) uptake framework.</div></div><div><h3>Results</h3><div>We interviewed 23 migrant participants (15/23 female, mean age 30.0 years ±2.0, average time of stay in Morocco 4.72 years ±8.79) and 8 primary care professionals. We found that although migrant children and adults were entitled to free vaccinations, various individual, social, and practical issues influenced their motivation and uptake. For childhood vaccination, caregivers showed high confidence in vaccine benefits and safety, but faced administrative difficulties, limited information, orientation, and language barriers. For adult vaccination, mistrust and scepticism toward specific vaccines, such as the COVID-19 vaccine, persisted, mainly due to misinformation. Except for the tetanus vaccine for pregnant women and the COVID-19 vaccine, migrant adults were rarely offered adult or catch-up vaccinations, often due to the absence of health worker recommendations and non-verification of vaccine history. Migrants emphasized the need for improved communication with health professionals and addressing language barriers and called for increased sensitization to reduce vaccine scepticism and hesitancy, better information on service locations, particularly through community-based organizations and outreach efforts for hard-to-reach migrants.</div></div><div><h3>Conclusions</h3><div>Despite entitlement to vaccination services, vaccination uptake among migrants in Morocco may be influenced by various individual, social, and practical factors. Tailored and targeted interventions are urgently needed, including efforts to prioritize improving communication with health professionals, removing language barriers, and developing appropriate delivery and communication strategies for these communities.</div></div>","PeriodicalId":23491,"journal":{"name":"Vaccine","volume":"56 ","pages":"Article 127166"},"PeriodicalIF":4.5,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surveillance of adverse events following immunisation with meningococcal B vaccine (4CMenB), South Australia, 2018–2022","authors":"Kate Wheldrake ,&nbsp;Jana Sisnowski ,&nbsp;Michele AHoure ,&nbsp;Nicholas Anagnostou ,&nbsp;Sara Almond ,&nbsp;Louise Flood","doi":"10.1016/j.vaccine.2025.127158","DOIUrl":"10.1016/j.vaccine.2025.127158","url":null,"abstract":"<div><div>South Australia (SA)’s ongoing statewide Meningococcal B Vaccination Program (the Program) provides 4CMenB (Bexsero) to children aged six weeks to 12 months, and young people aged 15 to 17 years.</div><div>This retrospective study aimed to evaluate the safety profile of 4CMenB, using routinely collected data on adverse events following immunisation (AEFI). The study population was all participants in the Program, as well as those who received 4CMenB through the National Immunisation Program (NIP), from the Program's commencement on 1 October 2018 to 30 June 2022. Information about AEFIs was collated and classified according to the Australian Product Information (PI) for 4CMenB and the internal Meningococcal B Immunisation Program Vaccine Safety Plan (the Safety Plan).</div><div>The total number of 4CMenB vaccines distributed (and not subsequently discarded) during the study period for both the Program and the NIP was 437,462 vaccines. A total of 306 AEFI notifications were received during the study period, equating to a reporting rate of 69.9 notifications per 100,000 doses. Most reported AEFI were known, common, non-serious adverse events (85 % of reports), followed by serious AEFI (13 %) and suspected unexpected serious adverse reactions (SUSAR) (2 %). The most frequently reported non-serious AEFI clinical features were rash (14 %), injection site reaction (14 %), nausea/vomiting/diarrhoea (11 %) and fever (11 %). Of the serious AEFI, the most frequently reported were hypotonic-hyporesponsive events (HHE) (<em>n</em> = 12; 30 %), various problems requiring inpatient hospital admission (<em>n</em> = 10; 25 %), and high fever greater than 40 °C (<em>n</em> = 6; 15 %). There were five episodes of anaphylaxis or anaphylactoid reaction, four episodes of seizure and two episodes of febrile convulsion. No specific new safety signal was ascertained from review of serious AEFI and SUSAR. A high proportion (83 %) of children under two years with reported AEFI were administered prophylactic acetaminophen.</div><div>Our findings from prolonged, population-based analysis of AEFI complement the existing safety data on the 4CMenB vaccine and may be used to inform the implementation of 4CMenB vaccination programs at scale in other jurisdictions.</div></div>","PeriodicalId":23491,"journal":{"name":"Vaccine","volume":"56 ","pages":"Article 127158"},"PeriodicalIF":4.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the COVID-19 pandemic on influenza knowledge, attitudes, and vaccination practices in at-risk groups in the Kyrgyz Republic: A comparative study","authors":"Rakhat Akmatova ,&nbsp;Dinara Otorbaeva ,&nbsp;Malembe S. Ebama","doi":"10.1016/j.vaccine.2025.127159","DOIUrl":"10.1016/j.vaccine.2025.127159","url":null,"abstract":"<div><h3>Instruction</h3><div>Influenza remains a global health concern, causing significant annual morbidity and mortality. Vaccination is the most effective preventive measure; however, global vaccine coverage remains insufficient to establish herd immunity. In Kyrgyzstan, despite a national immunization program, influenza vaccine uptake among the risk groups has fluctuated between 11 % to 50 %. Understanding shifts in vaccination intentions before and during the COVID-19 pandemic is critical for refining public health strategies and institutional approach for improving vaccination coverage.</div></div><div><h3>Methods</h3><div>This cross-sectional study assessed influenza-related knowledge, attitudes, and practices (KAP) among risk groups (pregnant women, adults with chronic diseases, healthcare workers) in Kyrgyzstan before and during the pandemic (<em>N</em> = 7200). Data were analyzed using EPI Info, with descriptive statistics and logistic regression models to identify associations between socio-demographic/KAP factors and vaccination intentions/recommendations.</div></div><div><h3>Results</h3><div>Pre-pandemic, lower education (OR = 2.2; 95 %CI 1.4–3.2) and employment (OR = 1.4; 95 %CI 1.0–1.8) predicted higher vaccination intent among pregnant women; these associations waned during the pandemic, though women without comorbidities maintained stronger intent. Among adults with chronic diseases, divorced individuals (OR = 2.74; 95 %CI 1.12–6.6) in pre-pandemic and those distrusting vaccine protective effect (OR = 7.74; 95 %CI 4.2–14.1) showed heightened willingness for vaccination in the pandemic time. Healthcare workers with &gt;5 years' experience and those treating children (OR = 2.39; 95 %CI 1.24–4.6) were more likely to recommend vaccines during the pandemic, reversing pre-pandemic trends. Prioritization of the target groups also shifted: older adults and comorbid patients gained emphasis during the pandemic, whereas children and medical staff were prioritized earlier.</div></div><div><h3>Conclusion</h3><div>The COVID-19 pandemic reshaped influenza vaccine uptake dynamics, altering socio-demographic predictors and KAP patterns. Addressing vaccine hesitancy, misinformation, and structural barriers through tailored education and proactive healthcare engagement is vital. These findings underscore the need for adaptable, context-sensitive vaccination strategies and robust public health interventions to sustain immunization progress in evolving epidemiological landscapes.</div></div>","PeriodicalId":23491,"journal":{"name":"Vaccine","volume":"56 ","pages":"Article 127159"},"PeriodicalIF":4.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of vaccine education intervention on vaccine uptake and vaccine knowledge among older adults: A systematic review with meta-analysis","authors":"Yee Tang Chan ,&nbsp;Sek Ying Chair ,&nbsp;Rui Tong Gao ,&nbsp;Ming Him Ng ,&nbsp;Vivian Wing Yan Lee","doi":"10.1016/j.vaccine.2025.127182","DOIUrl":"10.1016/j.vaccine.2025.127182","url":null,"abstract":"<div><div>Educational intervention is one approach for providing vaccine knowledge and encouraging vaccine uptake. However, up till now, no systematic review reporting the effectiveness of vaccine educational intervention on vaccine uptake and/or knowledge enhancement for disease preventeable by the vaccine of interest, compared to conventional/standard or no intervention, for older adults aged 60 or above was found.</div><div>Six databases, including PubMed, OVID, CINAHL, Web of Science, the Cochrane Library, and the British Nursing Index, were searched. Vaccine educational interventions in this study were interventions that encourage vaccine uptake and/or provide knowledge enhancement on diseases prevented by the vaccine. Conventional/standard or no intervention refers to vaccine educational intervention that existed prior to the commencement of the intervention or no vaccine educational intervention was performed at all. All included studies were randomized control trials. The appraisal was performed with the Cochrane Risk of Bias Tool Version 1 (RoB 1). Meta-analysis was performed with RevMan Web. Ten studies were included in the meta-analysis, with a sample size of 419,523. This review demonstrated that vaccine educational intervention improves vaccine uptake (Relative Risk: 1.19, <em>p</em> = 0.008, 95 % confidence interval: 1.05–1.35). Furthermore, interactive vaccine educational intervention had a statistically significant effect on improving vaccine uptake among older adults (Relative Risk = 1.33, 95 % confidence interval: 1.08–1.62, <em>p</em> = 0.006). Neither continuous nor conducted once only intervention were found to have statistically significant improvement in vaccine uptake in the subgroup analysis. Vaccine educational interventions were found to have statistically significant effects on vaccine knowledge enhancement (Mean Difference: 0.42, 95 % confidence interval: 0.11–0.74, <em>p</em> = 0.008). The findings demonstrate that educational interventions significantly encourage vaccine uptake and knowledge enhancement in older adults. However, the limited amount of included literature and the high heterogeneity observed may limit the generalizability of the findings of this study. Further RCTs are recommended to bring more assertive results.</div></div>","PeriodicalId":23491,"journal":{"name":"Vaccine","volume":"56 ","pages":"Article 127182"},"PeriodicalIF":4.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serotype specific pneumococcal vaccine effectiveness in children with sickle cell disease: A two-decade analysis","authors":"Ziyu Zhang ,&nbsp;Melike Yildirim ,&nbsp;Pinar Keskinocak ,&nbsp;Yazdani Basha Shaik Dasthagirisaheb ,&nbsp;Sarah Hinderstein ,&nbsp;Khang Tran ,&nbsp;Molly Crockett ,&nbsp;Meagan Burns ,&nbsp;Hillary Johnson ,&nbsp;Marija Popstefanija ,&nbsp;Lawrence C. Madoff ,&nbsp;Stephen I. Pelton ,&nbsp;Inci Yildirim","doi":"10.1016/j.vaccine.2025.127193","DOIUrl":"10.1016/j.vaccine.2025.127193","url":null,"abstract":"<div><h3>Objectives</h3><div>Sickle cell disease (SCD) is the most common genetic hematologic disease globally and children with SCD are at increased risk for pneumococcal disease.</div></div><div><h3>Methods</h3><div>We utilized data from population-based enhanced surveillance for invasive pneumococcal disease (IPD) in children &lt;18 years of age in Massachusetts from 2002 to 2020. We calculated incidence rates (IR) among children with SCD using bootstrapping resampling and incidence rate ratios (IRR) for pre- and post-PCV13 periods. Vaccine effectiveness (VE) was calculated as 100*(1-IRR), and PCV13 vaccine failure probability was predicted using a random forest model.</div></div><div><h3>Results</h3><div>Children with SCD had higher IR during both pre−/post-PCV13 periods compared with otherwise healthy children 240.0/100,000 versus 4.6/100,000 in pre-PCV13 period (2002–2009); 172.7/100,000 versus 1.9/100,000 in post-PCV13 period (2011−2020), respectively. After widespread use of PCV7 for a decade, a modest reduction of 28.1 % (95% CI 25.9–37.2%) in the incidence of overall IPD during the post-PCV13 period was observed in children with SCD, whereas a more substantial 59.5% (96% CI 57.8–61.4%) reduction was observed in otherwise healthy children. There was a 60.8% (95% CI 55.2%-NA) reduction in the incidence of VST13 IPD in children with SCD and an 83.0% (95% CI 80.67–85.63%) reduction in children without underlying health condition. Overall, 61.1% of the remaining IPD among children with SCD were due to non-PCV13 serotypes (8, 10A, 15A,15B, 22F, 23B), many of which are included in expanded valency vaccines.</div></div><div><h3>Conclusion</h3><div>Children with SCD continue to have higher rates of IPD compared with otherwise healthy children despite vaccination. Majority of the remaining disease is due to serotypes not included in vaccine formulations that have been used for the last two decades. Our study highlights the potential value of expanded valency vaccines and importance of risk-based vaccination strategies tailored for this vulnerable population.</div></div>","PeriodicalId":23491,"journal":{"name":"Vaccine","volume":"56 ","pages":"Article 127193"},"PeriodicalIF":4.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Risk Behaviour among 14,614 Human Papillomavirus Vaccinated and Unvaccinated Danish Young Women","authors":"Maria Holst Algren ,&nbsp;Amalie Timmermann ,&nbsp;Palle Valentiner-Branth ,&nbsp;Lau Caspar Thygesen ,&nbsp;Janne Schurmann Tolstrup","doi":"10.1016/j.vaccine.2025.127202","DOIUrl":"10.1016/j.vaccine.2025.127202","url":null,"abstract":"<div><h3>Background</h3><div>Human papillomavirus (HPV) is a common sexually transmitted infection. Risky behaviours such as non-condom use, smoking, and binge drinking tend to cluster within the same individuals, increasing their propensity to become infected with HPV. This study aimed to compare risk behaviours, including non-condom use, smoking, and frequent binge drinking, among HPV-vaccinated and unvaccinated young women in Denmark.</div></div><div><h3>Methods</h3><div>Survey data from 14,614 young women aged 15–23 years from the Danish National Youth Study 2019 was used to analyze non-condom use, smoking, and frequent binge drinking. Data on HPV vaccination status was extracted from the Danish Vaccination Register. Associations were assessed using multilevel logistic regression.</div></div><div><h3>Results</h3><div>In unadjusted analyses, the odds of non-condom use were higher among vaccinated women compared to unvaccinated women (OR: 1.30, 95% CI: 1.09–1.55). Associations were weaker and not statistically significant after adjustment for age. After adjusting for other demographic and socioeconomic factors, smoking, and binge drinking, the odds of non-condom use were 21% higher (95% CI: 1‐44%) among vaccinated women than among unvaccinated women. When excluding women in steady relationships using hormonal contraceptives, the association was attenuated and no longer statistically significant. HPV vaccination status was not associated with smoking or binge drinking.</div></div><div><h3>Conclusions</h3><div>This study showed no clear association between being HPV vaccinated and risk behaviour including, smoking and binge drinking among young women. Non-condom use was more prevalent among the HPV-vaccinated women, but the results suggest that age, relationship status and hormonal contraceptive use may explain a considerable part of the association.</div></div>","PeriodicalId":23491,"journal":{"name":"Vaccine","volume":"56 ","pages":"Article 127202"},"PeriodicalIF":4.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}