Tubercle最新文献_第8页

Thiacetazone: in vitro activity against mycobacterium avium and m. tuberculosis 噻乙酮体外抗鸟分枝杆菌和结核分枝杆菌活性研究

Tubercle Pub Date : 1990-12-01 DOI: 10.1016/0041-3879(90)90043-8

L.B. Heifets, Pamela J. Lindholm-Levy, Marcella Flory

引用次数: 20

Drug resistance trends in mycobacterium tuberculosis: Blackburn 1985–1989 结核分枝杆菌耐药趋势:Blackburn 1985-1989

Tubercle Pub Date : 1990-12-01 DOI: 10.1016/0041-3879(90)90042-7

L.P. Ormerod, J.M. Harrison, P.A. Wright

引用次数: 12

Immunotherapy of tuberculosis 结核病的免疫治疗

Tubercle Pub Date : 1990-12-01 DOI: 10.1016/0041-3879(90)90034-6

J.M. Grange

引用次数: 7

Increased prevalence of diabetes mellitus in patients with pulmonary tuberculosis in Tanzania 坦桑尼亚肺结核患者中糖尿病患病率增加

Tubercle Pub Date : 1990-12-01 DOI: 10.1016/0041-3879(90)90040-F

F. Mugusi , A.B.M. Swai , K.G.M.M. Alberti , D.G. McLarty

{"title":"Increased prevalence of diabetes mellitus in patients with pulmonary tuberculosis in Tanzania","authors":"F. Mugusi , A.B.M. Swai , K.G.M.M. Alberti , D.G. McLarty","doi":"10.1016/0041-3879(90)90040-F","DOIUrl":"10.1016/0041-3879(90)90040-F","url":null,"abstract":"<div><p>Glucose tolerance was assessed, according to WHO diagnostic criteria, in 506 consecutive African patients admitted with sputum-positive pulmonary tuberculosis to the tuberculosis wards of Muhimbili Medical Centre, Dar es Salaam. Nine (1.8%) patients were known to have diabetes. Following a 75 g oral glucose tolerance test (OGTT) diabetes was diagnosed in a further 25 (4.9%) patients giving an overall crude diabetes prevalence rate of 6.7%. Impaired glucose tolerance (IGT) was present in 82 (16.2%) subjects. A repeat OGTT was carried out in the 25 patients found to have diabetic values after the first test. Eight (28%) of the 25 patients reverted to normal glucose tolerance after the second test, 6 (24%) to IGT, and 11 (48%) remained with blood glucose values in the diabetic range, giving a crude diabetes prevalence rate of 4%. In a survey of glucose tolerance, using similar methodology, in 693 members of an urban community in Dar es Salaam the prevalence rates of diabetes and IGT were 0.9% and 8.8% respectively. Diabetes was therefore at least four times as common in the tuberculosis patients (p <0.001), and IGT twice as frequent (p <0.0001). This study confirms the relationship between diabetes and tuberculosis. Those caring for patients with tuberculosis should be aware of the increased prevalence of diabetes in their patients, since failure to diagnose the problem may adversely affect prognosis.</p></div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"71 4","pages":"Pages 271-276"},"PeriodicalIF":0.0,"publicationDate":"1990-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(90)90040-F","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13420561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 123

Tubercle Index to volume 71 (1990) 结核病索引至第71卷(1990年)

Tubercle Pub Date : 1990-12-01 DOI: 10.1016/0041-3879(90)90049-E

引用次数: 0

Selected list of publications 选定刊物一览表

Tubercle Pub Date : 1990-12-01 DOI: 10.1016/0041-3879(90)90048-D

引用次数: 0

Tuberculostatic activity of henna (Lawsonia inermis Linn.) 指甲花的抗结核活性

Tubercle Pub Date : 1990-12-01 DOI: 10.1016/0041-3879(90)90044-9

V.K. Sharma

引用次数: 86

Adrenocortical function in patients with pulmonary tuberculosis 肺结核患者的肾上腺皮质功能

Tubercle Pub Date : 1990-12-01 DOI: 10.1016/0041-3879(90)90041-6

G. Raghupati Sarma, Chandra Immanuel, Geetha Ramachandran, P.V. Krishnamurthy, V. Kumaraswami, R. Prabhakar

{"title":"Adrenocortical function in patients with pulmonary tuberculosis","authors":"G. Raghupati Sarma, Chandra Immanuel, Geetha Ramachandran, P.V. Krishnamurthy, V. Kumaraswami, R. Prabhakar","doi":"10.1016/0041-3879(90)90041-6","DOIUrl":"10.1016/0041-3879(90)90041-6","url":null,"abstract":"<div><p>Adrenocortical function was studied in patients with pulmonary tuberculosis and the findings compared with those in healthy subjects. Plasma cortisol levels in newly diagnosed patients were appreciably higher than in the healthy subjects (P< 0.001). A normal (positive) response to ACTH (tetracosactrin) stimulation was observed in 35 (97%) of 36 healthy subjects, 15 (56%) of 27 newly diagnosed patients with tuberculosis and 5 (42%) of 12 chronic cases (i.e. those who had had the disease for more than 3 years); the difference between the healthy subjects and the two groups of tuberculosis patients was highly significant (P<0.001). Dexamethasone caused an appreciable decrease in the plasma cortisol levels of tuberculosis patients. Considering the diurnal variation of cortisol secretion, there was a steady decline in the cortisol levels between 08:00 and 20:00 in the healthy subjects (P=0.02); in the tuberculosis patients, however, there was a decrease upto 16:00 followed by a significant increase (P=0.05), and the mean value at 20:00 was similar to that at 08:00.</p></div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"71 4","pages":"Pages 277-282"},"PeriodicalIF":0.0,"publicationDate":"1990-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(90)90041-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13420562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

Volume 71 contents 第71卷目录

Tubercle Pub Date : 1990-12-01 DOI: 10.1016/0041-3879(90)90050-I

引用次数: 0

Improved immunotherapy for pulmonary tuberculosis with Mycobacterium vaccae 母牛分枝杆菌感染肺结核的改进免疫疗法

Tubercle Pub Date : 1990-12-01 DOI: 10.1016/0041-3879(90)90038-A

G.M. Bahr , M.A. Shaaban , M. Gabriel , B. Al-Shimali , Z. Siddiqui , T.D. Chugh , F.M. Denath , A. Shahin , K. Behbehani , L. Chedid , G.A.W. Rook , J.L. Stanford

{"title":"Improved immunotherapy for pulmonary tuberculosis with Mycobacterium vaccae","authors":"G.M. Bahr , M.A. Shaaban , M. Gabriel , B. Al-Shimali , Z. Siddiqui , T.D. Chugh , F.M. Denath , A. Shahin , K. Behbehani , L. Chedid , G.A.W. Rook , J.L. Stanford","doi":"10.1016/0041-3879(90)90038-A","DOIUrl":"10.1016/0041-3879(90)90038-A","url":null,"abstract":"<div><p>We previously demonstrated that a single intradermal injection of 10<sup>9</sup> irradiation-killed <em>M. vaccae</em>, given 1 month after starting chemotherapy, caused significant changes in responses to mycobacterial antigens. Amongst 38 patients with pulmonary tuberculosis, 29% had lymphocytes responding to common mycobacterial antigens after the injection, compared with only 11 % of 49 similar patients after an injection of saline (p < 0.03).</p><p>To increase the proportion of responders to these antigens, six modifications of the potentially immunotherapeutic injection, randomized with injections of saline, have been assessed by biochemical, clinical, haematological, immunological and radiological criteria.</p><p>Subsequent lymphocyte proliferation to mycobacterial antigens enabled the modifications to be ranked in order of efficacy. Tuberculin plus murabutide plus 10<sup>9</sup> irradiated <em>M. vaccae</em> (36% of 25), an autoclaved preparation of 10<sup>9</sup><em>M. vaccae</em> (45% of 22), and 2 x 10<sup>9</sup> irradiated <em>M. vaccae</em> (75% of 12) were the most effective. Antibody responses in several IgG subclasses to mycobacteria, but not streptococci, were also significantly increased by the most effective modifications over the 8 weeks following injection.</p><p>Detailed radiological study showed that use of the autoclaved bacilli was followed by a delay in clearing of consolidation, but by better closing of cavities than was found in the control group, suggesting enhanced, or altered, immunological activity around the lesions.</p></div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"71 4","pages":"Pages 259-266"},"PeriodicalIF":0.0,"publicationDate":"1990-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(90)90038-A","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13420559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 47