{"title":"Tuberculosis in patients with various HLA phenotypes","authors":"A.G. Khomenko, V.I. Litvinov, V.P. Chukanova, L.E. Pospelov","doi":"10.1016/0041-3879(90)90074-I","DOIUrl":"10.1016/0041-3879(90)90074-I","url":null,"abstract":"<div><p>Tuberculosis patients and healthy subjects from six ethnic groups of the Soviet Union were HLA-A, -B, -C, and DR typed. The frequencies of the HLA-A, -B and -C antigens differed amongst the ethnic groups. With all groups, however, patients with tuberculosis showed a significantly increased frequency of HLA-DR2 and a reduced frequency of HLADR3 type. Unfavourable dynamics of tuberculosis was significantly associated with an increased incidence of B15 and DR2 and a reduced incidence of B27 and DR3. Family studies revealed that the inheritance of susceptibility to tuberculosis (from parent to offspring) is associated with the inheritance of certain HLA haplotypes. Tuberculosis patients bearing the DR2 antigen had increased levels of IgG antibodies to PPD and the frequency of B7 and, more particularly, DR2 was higher in anergic patients.</p></div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"71 3","pages":"Pages 187-192"},"PeriodicalIF":0.0,"publicationDate":"1990-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(90)90074-I","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13389857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
TuberclePub Date : 1990-09-01Epub Date: 2004-04-15DOI: 10.1016/0041-3879(90)90081-I
Ch. Domingo, J. Ruiz, J. Roig, A. Texido, X. Aguilar, J. Morera
{"title":"Tuberculosis of the breast: a rare modern disease","authors":"Ch. Domingo, J. Ruiz, J. Roig, A. Texido, X. Aguilar, J. Morera","doi":"10.1016/0041-3879(90)90081-I","DOIUrl":"10.1016/0041-3879(90)90081-I","url":null,"abstract":"<div><p>A case of mammary tuberculosis is reported. A communication between the axillary glands and the breast emphasises Cooper's theory that the breast becomes secondarily involved by lymphatic extension. Involvement of other organs by acid-fast bacilli could not be demonstrated. A relapse occurred sixteen months after a 6-month course of treatment with rifampicin, isoniazid, ethambutol and pyrazinamide.</p></div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"71 3","pages":"Pages 221-223"},"PeriodicalIF":0.0,"publicationDate":"1990-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(90)90081-I","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13388873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
TuberclePub Date : 1990-09-01Epub Date: 2004-04-15DOI: 10.1016/0041-3879(90)90084-L
{"title":"Selected list of publications","authors":"","doi":"10.1016/0041-3879(90)90084-L","DOIUrl":"https://doi.org/10.1016/0041-3879(90)90084-L","url":null,"abstract":"","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"71 3","pages":"Pages 231-236"},"PeriodicalIF":0.0,"publicationDate":"1990-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(90)90084-L","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136910622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
TuberclePub Date : 1990-09-01Epub Date: 2004-04-15DOI: 10.1016/0041-3879(90)90082-J
Shyr-Ming Sheen-Chen, Fong-Fu Chou, Dar-In Tai, Hock-Liew Eng
{"title":"Hepatic tuberculosis; a rare case of bleeding gastric varices","authors":"Shyr-Ming Sheen-Chen, Fong-Fu Chou, Dar-In Tai, Hock-Liew Eng","doi":"10.1016/0041-3879(90)90082-J","DOIUrl":"10.1016/0041-3879(90)90082-J","url":null,"abstract":"<div><p>A laparotomy was performed on a 68-year-old female who, in spite of medical treatment, suffered from uncontrolled upper gastrointestinal bleeding due to ruptured gastric varices.</p><p>Histological examination of the liver tissue taken during operation revealed tuberculosis. Hepatic tuberculosis, although rare, should be kept in mind as one of the differential diagnosis when there is unexplained, noncirrhotic bleeding gastric varices.</p></div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"71 3","pages":"Pages 225-227"},"PeriodicalIF":0.0,"publicationDate":"1990-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(90)90082-J","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13388874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
TuberclePub Date : 1990-09-01Epub Date: 2004-04-15DOI: 10.1016/0041-3879(90)90078-M
L.C. Orozco , M. Forero , M. Wasserman , J.J. Ahumada
{"title":"Distribution of liposomes in tuberculous mice","authors":"L.C. Orozco , M. Forero , M. Wasserman , J.J. Ahumada","doi":"10.1016/0041-3879(90)90078-M","DOIUrl":"10.1016/0041-3879(90)90078-M","url":null,"abstract":"<div><p>The dynamics of the distribution of liposomes for use as drug carriers for the treatment of tuberculosis is studied. While the free radiolabel injected into mice was rapidly excreted by the kidneys, the same label trapped within liposomes was retained for longer periods in the liver, spleen and lung. There were variations in the distribution and retention times of liposomes of different composition.</p><p>When the distribution of liposomes in healthy and tuberculous mice was compared, a greater accumulation in the liver, spleen and lungs of healthy mice was observed, although the retention time in tuberculous mice was longer. These findings merit consideration in the design of therapies based on liposome-entrapped drugs as the dynamics of distribution and retention differ between normal and infected animals.</p></div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"71 3","pages":"Pages 209-214"},"PeriodicalIF":0.0,"publicationDate":"1990-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(90)90078-M","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13388870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
TuberclePub Date : 1990-09-01Epub Date: 2004-04-15DOI: 10.1016/0041-3879(90)90070-O
V.V.N. Gopal Rao , E.V. Venkatarama Gupta , I.M. Thomas
{"title":"Chromosome damage in untreated tuberculosis patients","authors":"V.V.N. Gopal Rao , E.V. Venkatarama Gupta , I.M. Thomas","doi":"10.1016/0041-3879(90)90070-O","DOIUrl":"10.1016/0041-3879(90)90070-O","url":null,"abstract":"<div><p>The frequency of chromosomal aberrations and sister chromatid exchanges (SCEs) were estimated in the lymphocytes of 95 untreated tuberculosis patients to evaluate the chromosomal damage with reference to bacterial invasion. The frequency of chromosomal aberrations was significantly higher in tuberculosis patients compared to controls (p < 0.001) while the SCE frequency did not show any statistically significant differences. These findings indicate that the basic mechanism of formation of chromosomal aberrations and SCE are different and they suggest that the tubercle bacillus might be capable of inducing chromosome damage.</p></div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"71 3","pages":"Pages 169-172"},"PeriodicalIF":0.0,"publicationDate":"1990-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(90)90070-O","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13389853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
TuberclePub Date : 1990-09-01Epub Date: 2004-04-15DOI: 10.1016/0041-3879(90)90077-L
W. Wai Yew , S. Yuk Lin Kwan , W. Keung Ma , K. Sang Lui
{"title":"Minimal bactericidal and inhibitory concentrations of of loxacin on Mycobacterium fortuitum at pH 7 and 5: therapeutic implications","authors":"W. Wai Yew , S. Yuk Lin Kwan , W. Keung Ma , K. Sang Lui","doi":"10.1016/0041-3879(90)90077-L","DOIUrl":"10.1016/0041-3879(90)90077-L","url":null,"abstract":"<div><p><em>Mycobacterium fortuitum</em> infections of sternotomy wounds have been successfully treated with ofloxacin, a fluoroquinolone. We studied the MBCs and MICs <em>in vitro</em> of this antibiotic on the organism under neutral pH (7) and acidic pH (5) and found marked escalation of these values under the latter condition. This provides hints on the therapy of these infections under <em>in vivo</em> settings.</p></div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"71 3","pages":"Pages 205-208"},"PeriodicalIF":0.0,"publicationDate":"1990-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(90)90077-L","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13388869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
TuberclePub Date : 1990-09-01Epub Date: 2004-04-15DOI: 10.1016/0041-3879(90)90083-K
S.H. Annobil , A. Al-Hilfi , T. Kazi
{"title":"Primary tuberculosis of the penis in an infant","authors":"S.H. Annobil , A. Al-Hilfi , T. Kazi","doi":"10.1016/0041-3879(90)90083-K","DOIUrl":"10.1016/0041-3879(90)90083-K","url":null,"abstract":"<div><p>Primary tuberculosis of the penis with associated bilateral inguinal lymph node enlargement and a discharging sinus is described. Its rarity is emphasized and its likely mode of transmission is also highlighted so that it can be looked for in areas where infantile circumcision is practised, particularly in developing countries.</p></div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"71 3","pages":"Pages 229-230"},"PeriodicalIF":0.0,"publicationDate":"1990-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(90)90083-K","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13388875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
TuberclePub Date : 1990-09-01Epub Date: 2004-04-15DOI: 10.1016/0041-3879(90)90072-G
M.R. Sedaghatian, I.A.K. Shana'a
{"title":"Evaluation of BCG at birth in the United Arab Emirates","authors":"M.R. Sedaghatian, I.A.K. Shana'a","doi":"10.1016/0041-3879(90)90072-G","DOIUrl":"10.1016/0041-3879(90)90072-G","url":null,"abstract":"<div><p>A total of 387 healthy full term infants who received BCG vaccination at birth were evaluated by the tuberculin PPD test at 6–8 weeks post vaccination. A total of 92% of these infants had visible BCG scars at that time. All infants were tested with PPD but only 264 returned for the test to be read. The tuberculin test was negative in 37 (14%) and of less than 5 mm induration in another 60 (23%) of the infants.</p><p>The same pattern was observed in different nationalities. Of 11 infants with no BCG scar after vaccination, 3 had positive PPD reactions of more than 5 mm induration. There was a significant correlation between the size of the BCG scar and induration of tuberculin test P < 0.001. The complications of the vaccination were minimal. We have observed 3 sterile abscesses at the site of BCG vaccination which resolved spontaneously. We think the available vaccine is safe and potent, and that the rate of BCG scar formation and of tuberculin conversion is higher than in most studies.</p></div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"71 3","pages":"Pages 177-180"},"PeriodicalIF":0.0,"publicationDate":"1990-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(90)90072-G","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13389855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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