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Changes in serum proteins (albumin, immunoglobulins and acute phase proteins) in pulmonary tuberculosis during therapy 治疗期间肺结核患者血清蛋白(白蛋白、免疫球蛋白和急性期蛋白)的变化
Tubercle Pub Date : 1990-09-01 DOI: 10.1016/0041-3879(90)90075-J
C.T. Wong , N. Saha
{"title":"Changes in serum proteins (albumin, immunoglobulins and acute phase proteins) in pulmonary tuberculosis during therapy","authors":"C.T. Wong ,&nbsp;N. Saha","doi":"10.1016/0041-3879(90)90075-J","DOIUrl":"10.1016/0041-3879(90)90075-J","url":null,"abstract":"<div><p>Serum levels of three immunoglobulins (IgG, IgA &amp; IgM), albumin and six acute phase proteins (α1-antitrypsin, haptoglobin, transferrin, α2-macroglobulin, complements C3 &amp; C4) were measured by immunoelectrophoresis in 57 patients with pulmonary tuberculosis when they were first diagnosed, and followed at 1 month, 2 month and 4 month intervals during anti-tuberculosis treatment. These values were compared to those from 41 healthy controls. Significant increases were observed in the initial values of serum IgG, IgM, α1-antitrypsin and haptoglobin, while transferrin and α2-macroglobulin levels were significantly reduced. No changes were observed in the levels of serum albumin, IgA and complement C3. Levels of all measured proteins decreased with treatment. However, at 4 months, IgG and α1-antitrypsin were still significantly elevated when compared to control values, while the level of haptoglobin had decreased to a level significantly lower than that of the control value.</p></div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"71 3","pages":"Pages 193-197"},"PeriodicalIF":0.0,"publicationDate":"1990-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(90)90075-J","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12864858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Tuberculosis of the breast: a rare modern disease 乳腺结核:一种罕见的现代疾病
Tubercle Pub Date : 1990-09-01 DOI: 10.1016/0041-3879(90)90081-I
Ch. Domingo, J. Ruiz, J. Roig, A. Texido, X. Aguilar, J. Morera
{"title":"Tuberculosis of the breast: a rare modern disease","authors":"Ch. Domingo,&nbsp;J. Ruiz,&nbsp;J. Roig,&nbsp;A. Texido,&nbsp;X. Aguilar,&nbsp;J. Morera","doi":"10.1016/0041-3879(90)90081-I","DOIUrl":"10.1016/0041-3879(90)90081-I","url":null,"abstract":"<div><p>A case of mammary tuberculosis is reported. A communication between the axillary glands and the breast emphasises Cooper's theory that the breast becomes secondarily involved by lymphatic extension. Involvement of other organs by acid-fast bacilli could not be demonstrated. A relapse occurred sixteen months after a 6-month course of treatment with rifampicin, isoniazid, ethambutol and pyrazinamide.</p></div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"71 3","pages":"Pages 221-223"},"PeriodicalIF":0.0,"publicationDate":"1990-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(90)90081-I","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13388873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 39
Hepatic tuberculosis; a rare case of bleeding gastric varices 肝结核;胃静脉曲张出血1例
Tubercle Pub Date : 1990-09-01 DOI: 10.1016/0041-3879(90)90082-J
Shyr-Ming Sheen-Chen, Fong-Fu Chou, Dar-In Tai, Hock-Liew Eng
{"title":"Hepatic tuberculosis; a rare case of bleeding gastric varices","authors":"Shyr-Ming Sheen-Chen,&nbsp;Fong-Fu Chou,&nbsp;Dar-In Tai,&nbsp;Hock-Liew Eng","doi":"10.1016/0041-3879(90)90082-J","DOIUrl":"10.1016/0041-3879(90)90082-J","url":null,"abstract":"<div><p>A laparotomy was performed on a 68-year-old female who, in spite of medical treatment, suffered from uncontrolled upper gastrointestinal bleeding due to ruptured gastric varices.</p><p>Histological examination of the liver tissue taken during operation revealed tuberculosis. Hepatic tuberculosis, although rare, should be kept in mind as one of the differential diagnosis when there is unexplained, noncirrhotic bleeding gastric varices.</p></div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"71 3","pages":"Pages 225-227"},"PeriodicalIF":0.0,"publicationDate":"1990-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(90)90082-J","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13388874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Selected list of publications 选定刊物一览表
Tubercle Pub Date : 1990-09-01 DOI: 10.1016/0041-3879(90)90084-L
{"title":"Selected list of publications","authors":"","doi":"10.1016/0041-3879(90)90084-L","DOIUrl":"https://doi.org/10.1016/0041-3879(90)90084-L","url":null,"abstract":"","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"71 3","pages":"Pages 231-236"},"PeriodicalIF":0.0,"publicationDate":"1990-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(90)90084-L","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136910622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distribution of liposomes in tuberculous mice 脂质体在结核小鼠体内的分布
Tubercle Pub Date : 1990-09-01 DOI: 10.1016/0041-3879(90)90078-M
L.C. Orozco , M. Forero , M. Wasserman , J.J. Ahumada
{"title":"Distribution of liposomes in tuberculous mice","authors":"L.C. Orozco ,&nbsp;M. Forero ,&nbsp;M. Wasserman ,&nbsp;J.J. Ahumada","doi":"10.1016/0041-3879(90)90078-M","DOIUrl":"10.1016/0041-3879(90)90078-M","url":null,"abstract":"<div><p>The dynamics of the distribution of liposomes for use as drug carriers for the treatment of tuberculosis is studied. While the free radiolabel injected into mice was rapidly excreted by the kidneys, the same label trapped within liposomes was retained for longer periods in the liver, spleen and lung. There were variations in the distribution and retention times of liposomes of different composition.</p><p>When the distribution of liposomes in healthy and tuberculous mice was compared, a greater accumulation in the liver, spleen and lungs of healthy mice was observed, although the retention time in tuberculous mice was longer. These findings merit consideration in the design of therapies based on liposome-entrapped drugs as the dynamics of distribution and retention differ between normal and infected animals.</p></div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"71 3","pages":"Pages 209-214"},"PeriodicalIF":0.0,"publicationDate":"1990-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(90)90078-M","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13388870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Chromosome damage in untreated tuberculosis patients 未经治疗的肺结核患者的染色体损伤
Tubercle Pub Date : 1990-09-01 DOI: 10.1016/0041-3879(90)90070-O
V.V.N. Gopal Rao , E.V. Venkatarama Gupta , I.M. Thomas
{"title":"Chromosome damage in untreated tuberculosis patients","authors":"V.V.N. Gopal Rao ,&nbsp;E.V. Venkatarama Gupta ,&nbsp;I.M. Thomas","doi":"10.1016/0041-3879(90)90070-O","DOIUrl":"10.1016/0041-3879(90)90070-O","url":null,"abstract":"<div><p>The frequency of chromosomal aberrations and sister chromatid exchanges (SCEs) were estimated in the lymphocytes of 95 untreated tuberculosis patients to evaluate the chromosomal damage with reference to bacterial invasion. The frequency of chromosomal aberrations was significantly higher in tuberculosis patients compared to controls (p &lt; 0.001) while the SCE frequency did not show any statistically significant differences. These findings indicate that the basic mechanism of formation of chromosomal aberrations and SCE are different and they suggest that the tubercle bacillus might be capable of inducing chromosome damage.</p></div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"71 3","pages":"Pages 169-172"},"PeriodicalIF":0.0,"publicationDate":"1990-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(90)90070-O","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13389853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Minimal bactericidal and inhibitory concentrations of of loxacin on Mycobacterium fortuitum at pH 7 and 5: therapeutic implications 氧沙星在pH值为7和5时对福氏分枝杆菌的最小杀菌和抑制浓度:治疗意义
Tubercle Pub Date : 1990-09-01 DOI: 10.1016/0041-3879(90)90077-L
W. Wai Yew , S. Yuk Lin Kwan , W. Keung Ma , K. Sang Lui
{"title":"Minimal bactericidal and inhibitory concentrations of of loxacin on Mycobacterium fortuitum at pH 7 and 5: therapeutic implications","authors":"W. Wai Yew ,&nbsp;S. Yuk Lin Kwan ,&nbsp;W. Keung Ma ,&nbsp;K. Sang Lui","doi":"10.1016/0041-3879(90)90077-L","DOIUrl":"10.1016/0041-3879(90)90077-L","url":null,"abstract":"<div><p><em>Mycobacterium fortuitum</em> infections of sternotomy wounds have been successfully treated with ofloxacin, a fluoroquinolone. We studied the MBCs and MICs <em>in vitro</em> of this antibiotic on the organism under neutral pH (7) and acidic pH (5) and found marked escalation of these values under the latter condition. This provides hints on the therapy of these infections under <em>in vivo</em> settings.</p></div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"71 3","pages":"Pages 205-208"},"PeriodicalIF":0.0,"publicationDate":"1990-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(90)90077-L","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13388869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Cardiac tamponade due to tuberculous mediastinal lymphadenitis 结核性纵隔淋巴结炎引起的心包填塞
Tubercle Pub Date : 1990-09-01 DOI: 10.1016/0041-3879(90)90080-R
C. Paredes, F. Del Campo, C. Zamarron
{"title":"Cardiac tamponade due to tuberculous mediastinal lymphadenitis","authors":"C. Paredes,&nbsp;F. Del Campo,&nbsp;C. Zamarron","doi":"10.1016/0041-3879(90)90080-R","DOIUrl":"10.1016/0041-3879(90)90080-R","url":null,"abstract":"<div><p>Pneumopericardium is rare in tuberculous mediastinal lymphadenitis. Much rarer is the association of pneumopericardium with cardiac tamponade. The case is reported of a 29-year-old patient in whom tuberculous mediastinal lymphadenitis resulted in a fatal tension pneumopericardium.</p></div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"71 3","pages":"Pages 219-220"},"PeriodicalIF":0.0,"publicationDate":"1990-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(90)90080-R","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13388872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Primary tuberculosis of the penis in an infant 婴儿阴茎的原发性结核
Tubercle Pub Date : 1990-09-01 DOI: 10.1016/0041-3879(90)90083-K
S.H. Annobil , A. Al-Hilfi , T. Kazi
{"title":"Primary tuberculosis of the penis in an infant","authors":"S.H. Annobil ,&nbsp;A. Al-Hilfi ,&nbsp;T. Kazi","doi":"10.1016/0041-3879(90)90083-K","DOIUrl":"10.1016/0041-3879(90)90083-K","url":null,"abstract":"<div><p>Primary tuberculosis of the penis with associated bilateral inguinal lymph node enlargement and a discharging sinus is described. Its rarity is emphasized and its likely mode of transmission is also highlighted so that it can be looked for in areas where infantile circumcision is practised, particularly in developing countries.</p></div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"71 3","pages":"Pages 229-230"},"PeriodicalIF":0.0,"publicationDate":"1990-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(90)90083-K","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13388875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Tubercle 1978–1990 结节1978 - 1990。
Tubercle Pub Date : 1990-09-01 DOI: 10.1016/0041-3879(90)90068-J
J.M. Grange
{"title":"Tubercle 1978–1990","authors":"J.M. Grange","doi":"10.1016/0041-3879(90)90068-J","DOIUrl":"10.1016/0041-3879(90)90068-J","url":null,"abstract":"","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"71 3","pages":"Pages 157-159"},"PeriodicalIF":0.0,"publicationDate":"1990-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(90)90068-J","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13389851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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