氧沙星在pH值为7和5时对福氏分枝杆菌的最小杀菌和抑制浓度:治疗意义

Tubercle Pub Date : 1990-09-01 DOI:10.1016/0041-3879(90)90077-L

W. Wai Yew , S. Yuk Lin Kwan , W. Keung Ma , K. Sang Lui

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引用次数: 1

摘要

用氟喹诺酮类药物氧氟沙星成功地治疗了胸骨切开伤口的偶发分枝杆菌感染。我们在体外研究了该抗生素在中性pH(7)和酸性pH(5)条件下对生物体的MBCs和mic，发现后者条件下这些值显着升高。这为在体内环境下治疗这些感染提供了提示。

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Minimal bactericidal and inhibitory concentrations of of loxacin on Mycobacterium fortuitum at pH 7 and 5: therapeutic implications

Mycobacterium fortuitum infections of sternotomy wounds have been successfully treated with ofloxacin, a fluoroquinolone. We studied the MBCs and MICs in vitro of this antibiotic on the organism under neutral pH (7) and acidic pH (5) and found marked escalation of these values under the latter condition. This provides hints on the therapy of these infections under in vivo settings.

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Tubercle

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