Tubercle最新文献_第6页

Susceptibility of captive wildfowl to avian tuberculosis: the importance of genetic and environmental factors 圈养野禽对禽结核的易感性:遗传和环境因素的重要性

Tubercle Pub Date : 1991-06-01 DOI: 10.1016/0041-3879(91)90036-R

R.L. Cromie , M.J. Brown , D.J. Price , J.L. Stanford

引用次数: 30

Efficacy of intermittent pyrazinamide in experimental murine tuberculosis 间歇性吡嗪酰胺治疗实验性小鼠肺结核的疗效

Tubercle Pub Date : 1991-06-01 DOI: 10.1016/0041-3879(91)90037-S

J.M. Dickinson, D.A. Mitchison

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引用次数: 9

Selected list of publications 选定刊物一览表

Tubercle Pub Date : 1991-06-01 DOI: 10.1016/0041-3879(91)90045-T

引用次数: 0

Reply from Dr Campbell 坎贝尔博士的答复

Tubercle Pub Date : 1991-03-01 DOI: 10.1016/0041-3879(91)90029-R

Ian Campbell

引用次数: 0

The Koch phenomenon and delayed hypersensitivity: 1891–1991 科赫现象与迟发性超敏反应:1891-1991

Tubercle Pub Date : 1991-03-01 DOI: 10.1016/0041-3879(91)90018-N

G.H. Bothamley, J.M. Grange

引用次数: 33

Tuberculosis in Saudi Arabia: Initial and secondary drug resistance among indigenous and non-indigenous populations 沙特阿拉伯的结核病:土著和非土著人口的初始和继发耐药性

Tubercle Pub Date : 1991-03-01 DOI: 10.1016/0041-3879(91)90024-M

Razina Zaman

引用次数: 25

Cytokines and the Koch phenomenon 细胞因子和科赫现象

Tubercle Pub Date : 1991-03-01 DOI: 10.1016/0041-3879(91)90019-O

G.A.W. Rook, R. Al Attiyah

引用次数: 97

Activities of pefloxacin and ofloxacin against mycobacteria: in vitro and mouse experiments 培氟沙星和氧氟沙星抗分枝杆菌活性的体外及小鼠实验

Tubercle Pub Date : 1991-03-01 DOI: 10.1016/0041-3879(91)90025-N

C. Truffot-Pernot, B. Ji, J. Grosset

{"title":"Activities of pefloxacin and ofloxacin against mycobacteria: in vitro and mouse experiments","authors":"C. Truffot-Pernot, B. Ji, J. Grosset","doi":"10.1016/0041-3879(91)90025-N","DOIUrl":"10.1016/0041-3879(91)90025-N","url":null,"abstract":"<div>The minimal inhibitory concentrations for 90% of strains (MIC90) of ofloxacin against Mycobacterium tuberculosis and Mycobacterium xenopi was 2 mg/I. This was three dilutions lower than that of pefloxacin and was well within the range of drug concentrations achievable in man. The antituberculosis activities of both quinolones were independent of resistance of the strains to other antimycobacteriaI agents. Mycobacterium avium-intracellulare was resistant to both compounds with MIC90s greater than 16 mg/l. The maximum serum levels (Cmax) of both compounds increased proportionally with increasing dose size. The terminal elimination half-life (<math><mtext>T</mtext><msub><mi></mi><mn><mtext>1</mtext><mtext>2</mtext></mn></msub></math>) of pefloxacin was longer than that of ofloxacin, but the <math><mtext>T</mtext><msub><mi></mi><mn><mtext>1</mtext><mtext>2</mtext></mn></msub></math> of both compounds in mice were much shorter than in man. The area under the concentration curve (AUC) of pefloxacin was double than that of ofloxacin. In the mouse, pefloxacin at doses up to 150 mg/kg daily was inactive against M. tuberculosis infection: in terms of survival rate the minimal effective dose of ofloxacin against M. tuberculosis infection was 150 mg/kg daily when given by gavage or by incorporation into the mouse diet at a concentration of 0.1 %, but in terms of cfu counts, ofloxacin 150 mg/kg daily only displayed a moderate degree of activity similar to ethambutol 100 mg/kg daily. The therapeutic effects of ofloxacin against M. tuberculosis infection were dose-related: 300 mg/kg daily by gavage or 0.4% in mouse diet displayed much better therapeutic effects than lower dosages. Since the AUC in mice treated with ofloxacin 150 mg/kg daily is close to that in man treated with a clinically tolerated dose—600 mg daily—such a dosage may be only moderately effective against human tuberculosis.</div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"72 1","pages":"Pages 57-64"},"PeriodicalIF":0.0,"publicationDate":"1991-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(91)90025-N","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13069931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 64

Selected list of publications 选定刊物一览表

Tubercle Pub Date : 1991-03-01 DOI: 10.1016/0041-3879(91)90032-N

引用次数: 0

The global tuberculosis situation and the new control strategy of the World Health Organization 全球结核病形势与世界卫生组织新的控制战略

Tubercle Pub Date : 1991-03-01 DOI: 10.1016/0041-3879(91)90017-M

Arata Kochi

引用次数: 285