Upsala journal of medical sciences最新文献_第9页

Remarkable developments in our performance. 我们的工作有了显著的发展。

IF 3.4 4区医学

Upsala journal of medical sciences Pub Date : 2020-11-01 Epub Date: 2020-10-12 DOI: 10.1080/03009734.2020.1830579

Arne Andersson, Joey Lau Börjesson, Kerstin Westermark

引用次数: 0

Excess deaths from COVID-19 correlate with age and socio-economic status. A database study in the Stockholm region. COVID-19造成的过多死亡与年龄和社会经济地位有关。斯德哥尔摩地区的数据库研究。

IF 3.4 4区医学

Upsala journal of medical sciences Pub Date : 2020-11-01 Epub Date: 2020-10-14 DOI: 10.1080/03009734.2020.1828513

Peter Strang, Per Fürst, Torbjörn Schultz

{"title":"Excess deaths from COVID-19 correlate with age and socio-economic status. A database study in the Stockholm region.","authors":"Peter Strang, Per Fürst, Torbjörn Schultz","doi":"10.1080/03009734.2020.1828513","DOIUrl":"https://doi.org/10.1080/03009734.2020.1828513","url":null,"abstract":"Background: The COVID-19 pandemic has affected the entire health care system, internationally as well as in Sweden. We aimed to study excess deaths (all death causes, but also COVID-19-related deaths) during the COVID-19 pandemic regarding age, socio-economic status, the situation in nursing homes, and place of death for nursing home residents.Design: We performed a descriptive regional registry data study using VAL, the Stockholm Regional Council's central data warehouse, which covers almost all health care use in the county of Stockholm. T tests and chi-square tests were used for comparisons.Results: Compared with 2016-2019, there were excess deaths in March-May 2020 (p < 0.0001), mainly explained by COVID-19, but in April there were also unexplained excess deaths. Individuals dying from COVID-19 were older than patients dying from other causes (p < 0.0001). There were more patient deaths among people residing in less advantaged socio-economic areas (p < 0.0001). Nursing home residents dying from COVID-19 were more often admitted to acute hospitals than residents dying from other causes (p < 0.0001). Also, the proportion of admissions of nursing home residents dying from other causes increased from April to May 2020 (p < 0.0001).Conclusions: Dying from COVID-19 mainly affects the elderly, nursing home residents, and persons from less advantaged socio-economic groups. The pandemic has resulted in an increase in acute admissions of dying nursing home residents to acute hospitals.","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"125 4","pages":"297-304"},"PeriodicalIF":3.4,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/03009734.2020.1828513","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38526391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 48

Electrolyte handling in the isolated perfused rat kidney: demonstration of vasopressin V2-receptor-dependent calcium reabsorption. 电解质处理在离体灌注大鼠肾脏:血管加压素v2受体依赖性钙重吸收的证明。

IF 3.4 4区医学

Upsala journal of medical sciences Pub Date : 2020-11-01 Epub Date: 2020-08-19 DOI: 10.1080/03009734.2020.1804496

Krister Bamberg, Lena William-Olsson, Ulrika Johansson, Anders Arner, Judith Hartleib-Geschwindner, Johan Sällström

{"title":"Electrolyte handling in the isolated perfused rat kidney: demonstration of vasopressin V2-receptor-dependent calcium reabsorption.","authors":"Krister Bamberg, Lena William-Olsson, Ulrika Johansson, Anders Arner, Judith Hartleib-Geschwindner, Johan Sällström","doi":"10.1080/03009734.2020.1804496","DOIUrl":"https://doi.org/10.1080/03009734.2020.1804496","url":null,"abstract":"Abstract Background The most profound effect of vasopressin on the kidney is to increase water reabsorption through V2-receptor (V2R) stimulation, but there are also data suggesting effects on calcium transport. To address this issue, we have established an isolated perfused kidney model with accurate pressure control, to directly study the effects of V2R stimulation on kidney function, isolated from systemic effects. Methods The role of V2R in renal calcium handling was studied in isolated rat kidneys using a new pressure control system that uses a calibration curve to compensate for the internal pressure drop up to the tip of the perfusion cannula. Results Kidneys subjected to V2R stimulation using desmopressin (DDAVP) displayed stable osmolality and calcium reabsorption throughout the experiment, whereas kidneys not administered DDAVP exhibited a simultaneous fall in urine osmolality and calcium reabsorption. Epithelial sodium channel (ENaC) inhibition using amiloride resulted in a marked increase in potassium reabsorption along with decreased sodium reabsorption. Conclusions A stable isolated perfused kidney model with computer-controlled pressure regulation was developed, which retained key physiological functions. The preparation responds to pharmacological inhibition of ENaC channels and activation of V2R. Using the model, the dynamic effects of V2R stimulation on calcium handling and urine osmolality could be visualised. The study thereby provides evidence for a stimulatory role of V2R in renal calcium reabsorption.","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"125 4","pages":"274-280"},"PeriodicalIF":3.4,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/03009734.2020.1804496","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38287710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implementation of a decision aid for recognition and correction of volume alterations (Recova^®) in haemodialysis patients. 血液透析患者识别和纠正体积改变的决策辅助工具(Recova®)的实施。

IF 3.4 4区医学

Upsala journal of medical sciences Pub Date : 2020-11-01 Epub Date: 2020-08-27 DOI: 10.1080/03009734.2020.1804495

Jenny Stenberg, Magnus Lindberg, Hans Furuland

{"title":"Implementation of a decision aid for recognition and correction of volume alterations (Recova®) in haemodialysis patients.","authors":"Jenny Stenberg, Magnus Lindberg, Hans Furuland","doi":"10.1080/03009734.2020.1804495","DOIUrl":"https://doi.org/10.1080/03009734.2020.1804495","url":null,"abstract":"Background: Fluid overload is associated with mortality in haemodialysis patients, and 30% of patients remain fluid-overloaded after dialysis. The aim of this study was to evaluate if implementation of Recova®, a decision aid combining clinical assessment with bioimpedance spectroscopy, facilitates individualization of target weight determination and thereby contributes to improved fluid status in maintenance haemodialysis patients.Methods: The impact of the implementation was measured as the proportion of participants at an adequate target weight at the end of the study, assessed as change in symptoms, hydration status, and N-terminal pro-brain natriuretic peptide (NT-proBNP). Nurses were instructed to use Recova every 2 weeks, and the process of the intervention was measured as frequencies of fluid status assessments, bioimpedance measurements, and target weight adjustments.Results: Forty-nine patients at two haemodialysis units were enrolled. In participants with fluid overload (n = 10), both overhydration and fluid overload symptom score decreased. In fluid-depleted participants (n = 20), target weight adjustment frequency and the estimated target weight increased. The post-dialytic negative overhydration was reduced, but NT-proBNP increased.Conclusions: Implementation of Recova in haemodialysis care increased the monthly frequencies of bioimpedance measurements and target weight adjustments, and it contributed to symptom reduction.Trial registration: The Uppsala County Council Registry of Clinical Trials: FoU 2019-0001-15.","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"125 4","pages":"281-292"},"PeriodicalIF":3.4,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/03009734.2020.1804495","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38315503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Work at inpatient care units is associated with an increased risk of SARS-CoV-2 infection; a cross-sectional study of 8679 healthcare workers in Sweden. 住院护理部门的工作与SARS-CoV-2感染风险增加有关;对瑞典8679名医护人员的横断面研究。

IF 3.4 4区医学

Upsala journal of medical sciences Pub Date : 2020-11-01 Epub Date: 2020-07-20 DOI: 10.1080/03009734.2020.1793039

Anna-Karin Lidström, Fredrik Sund, Bo Albinsson, Johan Lindbäck, Gabriel Westman

{"title":"Work at inpatient care units is associated with an increased risk of SARS-CoV-2 infection; a cross-sectional study of 8679 healthcare workers in Sweden.","authors":"Anna-Karin Lidström, Fredrik Sund, Bo Albinsson, Johan Lindbäck, Gabriel Westman","doi":"10.1080/03009734.2020.1793039","DOIUrl":"https://doi.org/10.1080/03009734.2020.1793039","url":null,"abstract":"Background: During the Covid-19 pandemic, the protection of healthcare workers has been in focus throughout the world, but the availability and quality of personal protective equipment has at times and in some settings been suboptimal.Materials and methods: A total of 8679 healthcare workers and healthcare support staff in the county of Uppsala, north of Stockholm, were included in this cross-sectional study. All subjects were analysed for IgG anti-SARS-CoV-2, and predictors for positive serostatus were analysed in a logistic regression model including demographic parameters and self-reported employment characteristics.Results: Overall, 577 (6.6%) were classified as seropositive, with no statistically significant differences between healthcare workers and support staff. Among healthcare workers, age (OR 0.987 per year, 95% CI 0.980-0.995), time to sampling (OR 1.019 per day, 95% CI 1.004-1.035), and employment at an outpatient care unit (OR 0.620, 95% CI 0.487-0.788) were statistically significantly associated with risk of infection. Covid-19 specific units were not at particular risk, compared to other units with comparable characteristics and staff demography.Conclusion: Our findings indicate that SARS-CoV-2 transmission is related to inpatient healthcare work, and illustrate the need for a high standard of basic hygiene routines in all inpatient care settings.","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"125 4","pages":"305-310"},"PeriodicalIF":3.4,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/03009734.2020.1793039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38176015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Distinctive alteration in the expression of autophagy genes in Drosophila models of amyloidopathy and tauopathy. 淀粉样变性和牛头病果蝇模型中自噬基因表达的显著改变。

IF 3.4 4区医学

Upsala journal of medical sciences Pub Date : 2020-11-01 Epub Date: 2020-07-11 DOI: 10.1080/03009734.2020.1785063

Mehrnaz Haghi, Raheleh Masoudi, Seyed Morteza Najibi

{"title":"Distinctive alteration in the expression of autophagy genes in Drosophila models of amyloidopathy and tauopathy.","authors":"Mehrnaz Haghi, Raheleh Masoudi, Seyed Morteza Najibi","doi":"10.1080/03009734.2020.1785063","DOIUrl":"https://doi.org/10.1080/03009734.2020.1785063","url":null,"abstract":"Background: Alzheimer's disease (AD) is one the most common types of dementia. Plaques of amyloid beta and neurofibrillary tangles of tau are two major hallmarks of AD. Metabolism of these two proteins, in part, depends on autophagy pathways. Autophagy dysfunction and protein aggregation in AD may be involved in a vicious circle. The aim of this study was to investigate whether tau or amyloid beta 42 (Aβ42) could affect expression of autophagy genes, and whether they exert their effects in the same way or not.Methods: Expression levels of some autophagy genes, Hook, Atg6, Atg8, and Cathepsin D, were measured using quantitative PCR in transgenic Drosophila melanogaster expressing either Aβ42 or Tau R406W.Results: We found that Hook mRNA levels were downregulated in Aβ42-expressing flies both 5 and 25 days old, while they were increased in 25-day-old flies expressing Tau R406W. Both Atg6 and Atg8 were upregulated at day 5 and then downregulated in 25-day-old flies expressing either Aβ42 or Tau R406W. Cathepsin D expression levels were significantly increased in 5-day-old flies expressing Tau R406W, while there was no significant change in the expression levels of this gene in 5-day-old flies expressing Aβ42. Expression levels of Cathepsin D were significantly decreased in 25-day-old transgenic flies expressing Tau R406W or Aβ42.Conclusion: We conclude that both Aβ42 and Tau R406W may affect autophagy through dysregulation of autophagy genes. Interestingly, it seems that these pathological proteins exert their toxic effects on autophagy through different pathways and independently.","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"125 4","pages":"265-273"},"PeriodicalIF":3.4,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/03009734.2020.1785063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38152681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Complete response with combined BRAF and MEK inhibition in BRAF mutated advanced low-grade serous ovarian carcinoma. BRAF和MEK联合抑制对BRAF突变的晚期低度浆液性卵巢癌的完全应答。

IF 3.4 4区医学

Upsala journal of medical sciences Pub Date : 2020-11-01 Epub Date: 2020-10-10 DOI: 10.1080/03009734.2020.1826612

Bengt Tholander, Anthoula Koliadi, Johan Botling, Hanna Dahlstrand, Anne Von Heideman, Håkan Ahlström, Kjell Öberg, Gustav J Ullenhag

引用次数: 7

Natural language processing and machine learning to enable automatic extraction and classification of patients' smoking status from electronic medical records. 通过自然语言处理和机器学习，可以从电子病历中自动提取和分类患者的吸烟状况。

IF 3.4 4区医学

Upsala journal of medical sciences Pub Date : 2020-11-01 Epub Date: 2020-07-22 DOI: 10.1080/03009734.2020.1792010

Andrea Caccamisi, Leif Jørgensen, Hercules Dalianis, Mats Rosenlund

{"title":"Natural language processing and machine learning to enable automatic extraction and classification of patients' smoking status from electronic medical records.","authors":"Andrea Caccamisi, Leif Jørgensen, Hercules Dalianis, Mats Rosenlund","doi":"10.1080/03009734.2020.1792010","DOIUrl":"https://doi.org/10.1080/03009734.2020.1792010","url":null,"abstract":"Background: The electronic medical record (EMR) offers unique possibilities for clinical research, but some important patient attributes are not readily available due to its unstructured properties. We applied text mining using machine learning to enable automatic classification of unstructured information on smoking status from Swedish EMR data.Methods: Data on patients' smoking status from EMRs were used to develop 32 different predictive models that were trained using Weka, changing sentence frequency, classifier type, tokenization, and attribute selection in a database of 85,000 classified sentences. The models were evaluated using F-score and accuracy based on out-of-sample test data including 8500 sentences. The error weight matrix was used to select the best model, assigning a weight to each type of misclassification and applying it to the model confusion matrices. The best performing model was then compared to a rule-based method.Results: The best performing model was based on the Support Vector Machine (SVM) Sequential Minimal Optimization (SMO) classifier using a combination of unigrams and bigrams as tokens. Sentence frequency and attributes selection did not improve model performance. SMO achieved 98.14% accuracy and 0.981 F-score versus 79.32% and 0.756 for the rule-based model.Conclusion: A model using machine-learning algorithms to automatically classify patients' smoking status was successfully developed. Such algorithms may enable automatic assessment of smoking status and other unstructured data directly from EMRs without manual classification of complete case notes.","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"125 4","pages":"316-324"},"PeriodicalIF":3.4,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/03009734.2020.1792010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38178735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Correlation analysis of coagulation dysfunction and liver damage in patients with novel coronavirus pneumonia: a single-center, retrospective, observational study. 新型冠状病毒肺炎患者凝血功能障碍与肝损害的相关性分析:单中心、回顾性、观察性研究

IF 3.4 4区医学

Upsala journal of medical sciences Pub Date : 2020-11-01 Epub Date: 2020-09-29 DOI: 10.1080/03009734.2020.1822960

Sai Chen, Hanting Liu, Tie Li, Rong Huang, Rong Gui, Junhua Zhang

{"title":"Correlation analysis of coagulation dysfunction and liver damage in patients with novel coronavirus pneumonia: a single-center, retrospective, observational study.","authors":"Sai Chen, Hanting Liu, Tie Li, Rong Huang, Rong Gui, Junhua Zhang","doi":"10.1080/03009734.2020.1822960","DOIUrl":"https://doi.org/10.1080/03009734.2020.1822960","url":null,"abstract":"Background: The novel coronavirus disease 2019 (COVID-19) is currently breaking out worldwide. COVID-19 patients may have different degrees of coagulopathy, but the mechanism is not yet clear. We aimed to analyse the relationship between coagulation dysfunction and liver damage in patients with COVID-19.Methods: A retrospective analysis of 74 patients with COVID-19 admitted to the First People's Hospital of Yueyang from 1 January to 30 March 2020 was carried out. According to the coagulation function, 27 cases entered the coagulopathy group and 47 cases entered the control group. A case control study was conducted to analyse the correlation between the occurrence of coagulation dysfunction and liver damage in COVID-19 patients.Results: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST), markers of liver damage, were positively correlated with coagulopathy (p = 0.039, OR 2.960, 95% CI 1.055-8.304; and p = 0.028, OR 3.352, 95% CI 1.137-9.187). Alkaline phosphatase (ALP), γ-glutamyl transpeptidase (γ-GT), and total bilirubin (TBIL) were not statistically correlated with coagulopathy. According to the diagnosis and treatment plan, the included cases were classified into mild, moderate, severe, and critical. The results showed that the occurrence of coagulation dysfunction had no statistical correlation with the severity of COVID-19.Conclusion: Coagulation dysfunction in patients with COVID-19 is closely related to liver damage. A longer course of the disease may cause a vicious circle of coagulopathy and liver damage. Clinicians need to closely monitor coagulation and liver function tests and to give prophylactic or supportive therapy when needed.","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"125 4","pages":"293-296"},"PeriodicalIF":3.4,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/03009734.2020.1822960","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38431715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Oxygen sensing; a stunningly elegant molecular machinery highjacked in cancer. 氧气传感;一个在癌症中被劫持的极其优雅的分子机器。

IF 3.4 4区医学

Upsala journal of medical sciences Pub Date : 2020-08-01 Epub Date: 2020-06-24 DOI: 10.1080/03009734.2020.1769231

Lena Claesson-Welsh

引用次数: 6