Upsala journal of medical sciences最新文献

{"title":"Prevalence and risk factors for age-related cataract in Sweden.","authors":"Amee Patel, Krish Patel","doi":"10.48101/ujms.v126.8349","DOIUrl":"https://doi.org/10.48101/ujms.v126.8349","url":null,"abstract":"","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"126 ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39904730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the Letter to the Editor by Amee Patel.","authors":"Curt Ekström","doi":"10.48101/ujms.v126.8435","DOIUrl":"https://doi.org/10.48101/ujms.v126.8435","url":null,"abstract":"Dear Editor, We have noticed with great pleasure that our article has drawn attention among readers in the United Kingdom. The glaucoma survey in the rural district of Tierp, including 760 subjects 65–74 years of age, was a small study compared with many other population surveys. According to the crosssectional character of the study, it was not possible to assess the effect of previous exposures at baseline. The presence of cataracts was ascertained based on retroillumination with lens opacities evident on slit-lamp examination. A detailed grading of the number of opacities in six stages was also performed. It is unlikely that any type of bias was involved in this part of the study. Nonetheless, as stated in the letter to UJMS, the lack of a standardised lens opacity grading system, like LOCS III, is a likely explanation to the moderate prevalence of cataracts found in the Tierp study. The limited sample size may also account for the lack of association with treated systemic hypertension. We have not discussed ethnicity in the article. However, the importance of exposure to sunlight was mentioned twice. We also discussed the association of myopia with lens opacities. To the best of my knowledge, only one population-based study has previously reported on cataract prevalence in Sweden, namely the Skövde Cataract Study, with the Tierp study being the second [1].","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"126 ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39904731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fertility awareness and intentions among young adults in Greece.","authors":"Ioanna Lardou,&nbsp;Ioannis Chatzipapas,&nbsp;Michail Chouzouris,&nbsp;Panos Xenos,&nbsp;Nikolaos Petrogiannis,&nbsp;Dimitrios Tryfos,&nbsp;Stephanos Chandakas,&nbsp;Themos Grigoriadis,&nbsp;Lina Michala","doi":"10.48101/ujms.v126.8148","DOIUrl":"https://doi.org/10.48101/ujms.v126.8148","url":null,"abstract":"<p><strong>Background: </strong>Greece has a mean age of first motherhood at 31.5 years, higher than the European average age of 29.4. Delaying conception, however, may be an important non-reversible cause of infertility. The aim of this study was to identify possible knowledge deficits regarding fertility in young adults.</p><p><strong>Methods: </strong>This was an online survey of young adults, regarding information on intention to parenthood and knowledge on issues affecting fertility. This study was conducted from February to December 2020, aiming for a representative sample of Greek men and women aged 18 and 26 years. The questionnaire was designed by a multidisciplinary group based on the Cardiff Fertility Knowledge Scale, which contained 22 multiple-choice or Likert-scale questions.</p><p><strong>Results: </strong>We obtained responses from 1875 young adults, whose mean age was 22.1 years. About 91.8% of men and 94.0% of women declared an intention to have children, out of which 44.0% wanted to have two and 29.0% three children. About 52.0 and 50.8% men and women, respectively, aimed to start a family between 31 and 35 years. Residents of rural areas and those with a lower education level more likely aimed to have children before the age of 30. The most prevalent answers for age of ideal parenthood were between 26 and 30 years for a woman and 31-35 years for a man. Smoking, alcohol consumption and sexually transmitted infections were identified as factors affecting both female and male fertility. Half of men and women, respectively, overestimated general success rates of reproductive techniques.</p><p><strong>Conclusion: </strong>The knowledge of fertility, particularly with regards to assisted reproductive techniques' success rates, may be overestimated as more young adults plan for having children after the age of 30.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"126 ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39904732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The profile of the COvid-19 VACcination register SAFEty study in Sweden (CoVacSafe-SE).","authors":"Rickard Ljung,&nbsp;Anders Sundström,&nbsp;Maria Grünewald,&nbsp;Charlotte Backman,&nbsp;Nils Feltelius,&nbsp;Rolf Gedeborg,&nbsp;Björn Zethelius","doi":"10.48101/ujms.v126.8136","DOIUrl":"https://doi.org/10.48101/ujms.v126.8136","url":null,"abstract":"<p><strong>Background: </strong>The coronavirus disease 2019 (COVID-19) vaccines have been rapidly implemented in national vaccination programs world-wide after accelerated approval processes. The large population exposure achieved in very short time requires systematic monitoring of safety. The Swedish Medical Products Agency has launched a project platform for epidemiological surveillance to detect and characterise suspected adverse effects of COVID-19 vaccines in Sweden.</p><p><strong>Methods: </strong>The platform includes all individuals 12 years or older in Sweden in 2021 and will be updated annually. Data, including vaccine and COVID-19 disease data, socioeconomic and demographic data, comorbidity, prescribed medicines and healthcare utilisation outcomes, are obtained from several national registers in collaboration with other Swedish Government agencies. Data from 2015 to 2019 are used as a historical comparison cohort unexposed to both the COVID-19 pandemic and to the COVID-19 vaccines.</p><p><strong>Results: </strong>The primary study cohort includes 8,305,978 adults 18 years and older permanently residing in Sweden on 31 December 2020. The historical control cohort includes 8,679,641 subjects. By 31 July 2021, around 50% of those 18 years and older and two-thirds of those 50 years and older were vaccinated with at least one dose, 90% of those 70 years or older had two doses.</p><p><strong>Conclusions: </strong>The nationwide register-based study cohort created by the Swedish Medical Products Agency with regular updates of individual level linkage of COVID-19 vaccination exposure data to other health data registers will facilitate both safety signal detection and evaluation and other pharmacoepidemiological studies.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"126 ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2021-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39897977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the relationship between systemic immune-inflammation index and mortality in patients with hypertrophic cardiomyopathy.","authors":"Ziqiong Wang,&nbsp;Haiyan Ruan,&nbsp;Liying Li,&nbsp;Xin Wei,&nbsp;Ye Zhu,&nbsp;Jiafu Wei,&nbsp;Xiaoping Chen,&nbsp;Sen He","doi":"10.48101/ujms.v126.8124","DOIUrl":"https://doi.org/10.48101/ujms.v126.8124","url":null,"abstract":"<p><strong>Background: </strong>This study investigates the predictive value of the systemic immune-inflammation index (SII), which was calculated as platelet × neutrophil/lymphocyte ratio, for all-cause mortality in patients with hypertrophic cardiomyopathy (HCM).</p><p><strong>Methods: </strong>A total of 360 HCM patients were enrolled. They were divided into three groups based on the tertiles of baseline SII. The association between SII and all-cause mortality was analyzed.</p><p><strong>Results: </strong>There were 53 HCM patients who died during a mean follow-up time of 4.8 years (min: 6 days and max: 10.8 years), and the mortality rate was 3.0 per 100 person years. The cumulative mortality rate was significantly different among the three tertiles of SII (<i>P</i> = 0.004), and the mortality rate in tertile 3 was much higher than that in the first two tertiles. In reference to tertile 1, the fully adjusted hazard ratios of all-cause mortality were 1.02 for the tertile 2 (95% confidence interval [CI]: 0.45-2.31, <i>P</i> = 0.966) and 2.31 for tertile 3 (95% CI: 1.10-4.87, <i>P</i> = 0.027). No significant interactions between SII and other variables were observed during subgroup analysis. The discriminative power was better for mid-term outcome than that for short-term or long-term outcomes. Sensitivity analyses including patients with normal platelet and white blood cell count have revealed similar results.</p><p><strong>Conclusion: </strong>SII was a significant risk factor for all-cause mortality in HCM patients. However, the discriminative power was poor to moderate. It could be used in combination with other risk factors in mortality risk stratification in HCM.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"126 ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2021-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39897978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy in detecting major depressive episodes in older adults using the Swedish versions of the GDS-15 and PHQ-9.","authors":"Johnny Pellas,&nbsp;Mattias Damberg","doi":"10.48101/ujms.v126.7848","DOIUrl":"https://doi.org/10.48101/ujms.v126.7848","url":null,"abstract":"<p><strong>Objectives: </strong>The purpose of this study was to evaluate the diagnostic accuracy at different cut-off values for the Swedish versions of the 15-item Geriatric Depression Scale (GDS-15) and Patient Health Questionnaire (PHQ-9) compared with a structured clinical psychiatric interview in older adults.</p><p><strong>Methods: </strong>Community-dwelling participants (<i>N</i> = 113) aged 65 years or older completed the Swedish versions of the GDS-15 and PHQ-9 and were then interviewed using the Mini International Neuropsychiatric Interview (MINI) to establish the presence or absence of current major depressive episodes (MDEs). Areas under the curve (AUC) were calculated for each scale, as well as the sensitivity, specificity, and Youden's index for different cut-off values.</p><p><strong>Results: </strong>Seventeen participants met the criteria for MDEs. The AUC was 0.97 for the GDS-15 and 0.95 for the PHQ-9. A cut-off of ≥6 on the GDS-15 yielded a sensitivity of 94%, a specificity of 88%, and a Youden's index of 0.82. A cut-off of ≥5 on the PHQ-9 yielded a sensitivity of 100%, a specificity of 81%, and a Youden's index of 0.81. The proposed cut-off of ≥10 on the PHQ-9 produced excellent specificity of 95% but a lower sensitivity of 71%.</p><p><strong>Conclusions: </strong>This study indicates that the Swedish versions of the GDS-15 and PHQ-9 have comparable accuracy as screening instruments for older adults with MDEs. However, the proposed cut-off of 10 on the PHQ-9 might be too high when applied to older individuals in Sweden, and further investigations in larger samples in different healthcare settings are warranted.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"126 ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39604843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated gaseous luminal nitric oxide and circulating IL-8 as features of <i>Helicobacter pylori</i>-induced gastric inflammation.","authors":"Hiwa K Saaed,&nbsp;Lisa Chiggiato,&nbsp;Dominic-Luc Webb,&nbsp;Ann-Sofie Rehnberg,&nbsp;Carlos A Rubio,&nbsp;Ragnar Befrits,&nbsp;Per M Hellström","doi":"10.48101/ujms.v126.8116","DOIUrl":"https://doi.org/10.48101/ujms.v126.8116","url":null,"abstract":"<p><strong>Background: </strong>Gastric nitric oxide (NO) production in response to <i>Helicobacter pylori</i> via inducible nitric oxide synthase (iNOS) is suggested as a biomarker of inflammation and cytotoxicity. The aim of this study was to investigate relationships between gastric [NO], immunological biomarkers and histopathology.</p><p><strong>Materials and methods: </strong>Esophagogastroduodenoscopy was done in 96 dyspepsia patients. Luminal [NO] was measured by chemiluminescence. Biopsies were taken from gastric antrum and corpus for culture and histopathology. <i>H. pylori</i> IgG was detected by immunoblot assay. Biobanked plasma from 76 dyspepsia patients (11 <i>H. pylori</i> positives) was analyzed for 39 cytokines by multiplexed ELISA.</p><p><strong>Results: </strong><i>H. pylori</i>-positive patients had higher [NO] (336 ± 26 ppb, mean ± 95% CI, <i>n</i> = 77) than <i>H. pylori</i>-negative patients (128 ± 47 ppb, <i>n</i> = 19) (<i>P</i> < 0.0001). Histopathological changes were found in 99% of <i>H. pylori</i>-positive and 37% of <i>H. pylori</i>-negative patients. Histopathological concordance was 78-100% between corpus and antrum. Correlations were found between gastric [NO] and severity of acute, but not chronic, inflammation. Plasma IL-8 (increased in <i>H. pylori</i> positives) had greatest difference between positive and negative groups, with eotaxin, MIP-1β, MCP-4, VEGF-A, and VEGF-C also higher (<i>P</i> < 0.004 to <i>P</i> < 0.032). Diagnostic odds ratios using 75% cut-off concentration were 7.53 for IL-8, 1.15 for CRP, and 2.88 for gastric NO.</p><p><strong>Conclusions: </strong>Of the parameters tested, increased gastric [NO] and circulating IL-8 align most consistently and selectively in <i>H. pylori</i>-infected patients. Severity of mucosal inflammatory changes is proportional to luminal [NO], which might be tied to IL-8 production. It is proposed that IL-8 be further investigated as a blood biomarker of treatment outcomes.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"126 ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2021-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39604842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between BMI and 90-day mortality in patients with and without diabetes seeking care at the emergency department.","authors":"Per Wändell,&nbsp;Axel C Carlsson,&nbsp;Anders Larsson,&nbsp;Olle Melander,&nbsp;Torgny Wessman,&nbsp;Johan Ärnlöv,&nbsp;Toralph Ruge","doi":"10.48101/ujms.v126.7590","DOIUrl":"https://doi.org/10.48101/ujms.v126.7590","url":null,"abstract":"<p><strong>Background: </strong>The impact of body mass index (BMI) on mortality varies with age and disease states. The aim of this research study was to analyse the associations between BMI categories and short- and long-term mortality in patients with or without diabetes seeking care at the emergency department (ED) with acute dyspnoea.</p><p><strong>Population and methods: </strong>Patients aged ≥18 years at ED during daytime on weekdays from March 2013 to July 2018 were included. Participants were triaged according to the Medical Emergency Triage and Treatment System-Adult score (METTS-A), and blood samples were collected. Totally, 1,710 patients were enrolled, with missing values in 113, leaving 1,597 patients, 291 with diabetes and 1,306 without diabetes. The association between BMI and short-term (90-day) and long-term (mean follow-up time 2.1 years) mortality was estimated by Cox regression with normal BMI (18.5-24.9) as referent category, with adjustment for age, sex, METTS-A scoring, glomerular filtration rate, smoking habits and cardiovascular comorbidity in a fully adjusted model. The Bonferroni correction was also used.</p><p><strong>Results: </strong>Regarding long-term mortality, patients with diabetes and BMI category ≥30 kg/m² had a fully adjusted Hazard Ratio (HR) of 0.40 (95% confidence interval [CI]: 0.23-0.69), significant after the Bonferroni correction. Amongst patients without diabetes, those with underweight had an increased risk but only of borderline significance, whilst risks in those with overweight or obesity did not differ from reference.Regarding short-term mortality, risks did not differ from reference amongst patients with or without diabetes.</p><p><strong>Conclusions: </strong>We found divergent long-term mortality risks in patients with and without diabetes, with lower risk in obese patients (BMI ≥ 30 kg/m²) with diabetes, but no increased risk for patients without diabetes and overweight (BMI: 25-29.9 kg/m²) and obesity.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"126 ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2021-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39520883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assembly of tetraspanins, galectin-3, and distinct N-glycans defines the solubilization signature of seminal prostasomes from normozoospermic and oligozoospermic men.","authors":"Tamara Janković,&nbsp;Jelena Danilović Luković,&nbsp;Irena Miler,&nbsp;Ninoslav Mitić,&nbsp;Ljiljana Hajduković,&nbsp;Miroslava Janković","doi":"10.48101/ujms.v126.7673","DOIUrl":"https://doi.org/10.48101/ujms.v126.7673","url":null,"abstract":"<p><strong>Background: </strong>Prostasomes, extracellular vesicles (EVs) abundantly present in seminal plasma, express distinct tetraspanins (TS) and galectin-3 (gal-3), which are supposed to shape their surface by an assembly of different molecular complexes. In this study, detergent-sensitivity patterns of membrane-associated prostasomal proteins were determined aiming at the solubilization signature as an intrinsic multimolecular marker and a new parameter suitable as a reference for the comparison of EVs populations in health and disease.</p><p><strong>Methods: </strong>Prostasomes were disrupted by Triton X-100 and analyzed by gel filtration under conditions that maintained complete solubilization. Redistribution of TS (CD63, CD9, and CD81), gal-3, gamma-glutamyltransferase (GGT), and distinct N-glycans was monitored using solid-phase lectin-binding assays, transmission electron microscopy, electrophoresis, and lectin blot.</p><p><strong>Results: </strong>Comparative data on prostasomes under normal physiology and conditions of low sperm count revealed similarity regarding the redistribution of distinct N-glycans and GGT, all presumed to be mainly part of the vesicle coat. In contrast to this, a greater difference was found in the redistribution of integral membrane proteins, exemplified by TS and gal-3. Accordingly, they were grouped into two molecular patterns mainly consisting of overlapped CD9/gal-3/wheat germ agglutinin-reactive glycoproteins and CD63/GGT/concanavalin A-reactive glycoproteins.</p><p><strong>Conclusions: </strong>Solubilization signature can be considered as an all-inclusive distinction factor regarding the surface properties of a particular vesicle since it reflects the status of the parent cell and the extracellular environment, both of which contribute to the composition of spatial membrane arrangements.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"126 ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2021-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39430340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality in Eosinophilic Esophagitis - a nationwide, population-based matched cohort study from 2005 to 2017.","authors":"Lovisa Röjler,&nbsp;John J Garber,&nbsp;Bjorn Roelstraete,&nbsp;Marjorie M Walker,&nbsp;Jonas F Ludvigsson","doi":"10.48101/ujms.v126.7688","DOIUrl":"https://doi.org/10.48101/ujms.v126.7688","url":null,"abstract":"<p><strong>Background: </strong>There is a lack of knowledge about mortality in eosinophilic esophagitis (EoE). Therefore, this study aimed to examine the mortality in EoE.</p><p><strong>Methods: </strong>A nationwide, population-based matched cohort study was conducted of all EoE patients in Sweden diagnosed between July 2005 and December 2017. Individuals with EoE (<i>n</i> = 1,625) were identified through prospectively recorded histopathology codes from all gastrointestinal pathology reports in Sweden, representing 28 pathology departments (the ESPRESSO study). Each individual with EoE was then matched with up to five reference individuals from the general population (<i>n</i> = 8,003) for age, sex, year of birth, and place of residence. We used the Cox proportional hazard modeling to estimate the adjusted hazard ratio (aHR) and 95% confidence interval (95% CI) while adjusting for other potential confounders. In sensitivity analyses, mortality in EoE patients was compared with mortality in their siblings.</p><p><strong>Results: </strong>Through December 2017, 34 deaths were confirmed in EoE patients (4.60 per 1,000 person-years) compared with 165 in reference individuals (4.57 per 1,000 person-years). This rate corresponds to an aHR of 0.97 (95% CI = 0.67-1.40). HRs were similar in males (aHR = 1.00 [0.66-1.51]) and females (aHR = 0.92 [0.38-2.18]). We observed no increased risk in mortality due to esophageal or other gastrointestinal cancers in patients with EoE (aHR = 1.02 [0.51-2.02]).Mortality was similar in EoE patients and their siblings (aHR = 0.91 [0.44-1.85]).</p><p><strong>Conclusion: </strong>In this nationwide, population-based matched cohort study in Sweden, there was no increased risk of death in patients with EoE compared with their siblings and the general population.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"126 ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39430339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}