Upsala journal of medical sciences最新文献

{"title":"Can diffusion tensor imaging (DTI) outperform standard magnetic resonance imaging (MRI) investigations in post-COVID-19 autoimmune encephalitis?","authors":"Francesco Latini,&nbsp;Markus Fahlström,&nbsp;David Fällmar,&nbsp;Niklas Marklund,&nbsp;Janet L Cunningham,&nbsp;Amalia Feresiadou","doi":"10.48101/ujms.v127.8562","DOIUrl":"https://doi.org/10.48101/ujms.v127.8562","url":null,"abstract":"<p><strong>Background: </strong>Neurological and psychiatric manifestations related to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection are widely recognised. Standard magnetic resonance imaging (MRI) investigations are normal in 40-80% of symptomatic patients, eventually delaying appropriate treatment when MRI is unrevealing any structural changes. The aim of this study is to investigate white matter abnormalities during an early stage of post-COVID-19 (coronavirus disease 2019) encephalitis while conventional MRI was normal.</p><p><strong>Methods: </strong>A patient with post-COVID-19 autoimmune encephalitis was investigated by serial MRIs and diffusion tensor imaging (DTI). Ten healthy control individuals (HC) were utilised as a control group for the DTI analysis. Major projection, commissural and association white matter pathways were reconstructed, and multiple diffusion parameters were analysed and then compared to the HC average using a z-test for serial examinations.</p><p><strong>Results: </strong>Eleven days after the onset of neurological symptoms, DTI revealed early white matter changes, compared with HC, when standard MRI was normal. On day 68, DTI showed multiple white matter lesions compared with HC, visible at this time also by the MRI images, indicating inflammatory changes in different association and projection white matter pathways.</p><p><strong>Conclusion: </strong>We confirm a limitation in the sensitivity of conventional MRI at the acute setting of post-COVID-19 autoimmune encephalitis. A complementary DTI investigation could be a valuable diagnostic tool in early therapeutic decisions concerning COVID-19-related neurological symptoms.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2022-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40043358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of paroxysmal atrial fibrillation in 994 patients with a cerebrovascular event by intermittent 21-day ECG-monitoring and 7-day continuous Holter-recording.","authors":"Johanna Pennlert,&nbsp;Mårten Rosenqvist,&nbsp;Milos Kesek","doi":"10.48101/ujms.v127.8318","DOIUrl":"https://doi.org/10.48101/ujms.v127.8318","url":null,"abstract":"Background The detection of paroxysmal atrial fibrillation (AF) is of importance in stroke care. The method used is continuous electrocardiogram (ECG)-monitoring or multiple short ECG-recordings during an extended period. Their relative efficiency is a matter of discussion. In a retrospective cohort study on 994 patients with an ischemic stroke or transient ischemic attack (TIA), we have compared continuous 7-day monitoring to intermittent recording 60 sec three times daily with a handheld device during 3 weeks. We related the result to subsequent occurrence of AF as detected in 12-lead ECG recordings. Methods The patients were identified in the local database of cardiovascular investigations. Their clinical profile and vital status during the follow-up were obtained from the Swedish Stroke Register and the Swedish general population registry. For comparison, we used an age- and sex-matched population with no known cerebrovascular event and a population with a cerebrovascular event that was not screened. Results AF was detected in 7.1% by continuous screening and in 5.1% by intermittent screening (P = 0.3). During follow-up of 32 months, AF in 12-lead ECG was found in 7.0%. In the subgroup with positive screening, 46.3% had AF compared with 6.7% in the subgroup with negative screening (P < 0.0001). Conclusions The two screening approaches had a similar yield of arrhythmia, in spite of the group with intermittent monitoring having a more favorable clinical profile. A positive screening was highly predictive of AF in ECG during the follow-up.","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40043357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of lipid-lowering treatment intensity and adherence on cardiovascular outcomes in patients with a recent myocardial infarction: a Swedish register-based study.","authors":"Maria K Svensson,&nbsp;Francesc Sorio Vilela,&nbsp;Margrét Leósdóttir,&nbsp;Jonas Banefelt,&nbsp;Maria Lindh,&nbsp;Alexander Rieem Dun,&nbsp;Anna Norhammar,&nbsp;Guillermo Villa","doi":"10.48101/ujms.v127.8296","DOIUrl":"https://doi.org/10.48101/ujms.v127.8296","url":null,"abstract":"<p><strong>Background: </strong>Oral lipid-lowering treatment (LLT) is the standard of care for patients with cardiovascular disease (CVD). However, insufficient treatment intensity and poor adherence can lead to suboptimal treatment benefit, rendering patients at increased risk of CVD.</p><p><strong>Aims: </strong>The objective of this study was to evaluate trends in LLT intensity and adherence in Sweden over time, and their association with major adverse cardiovascular events (MACE) after recent myocardial infarction (MI), and also to assess the impact of transition from secondary to primary care on intensity and adherence.</p><p><strong>Methods and results: </strong>This retrospective observational cohort study used data from Swedish nationwide patient registers and included patients on LLT after an MI in the years 2010-2016 (<i>n</i> = 50,298; mean age, 68 years; 69% men). LLT intensity was evaluated over time (overall, for 2010-2013 and for 2014-2016) as the proportion of patients prescribed low-, moderate-, and high-intensity LLT. Adherence was assessed as the proportion of days covered. A combined measure of intensity and adherence was also considered. Differences in treatment patterns and MACE were assessed. Initiation of high-intensity LLT increased over the two time periods studied (2010-2013, 32%; 2014-2016, 91%). Adherence varied by LLT intensity and was highest in patients receiving high-intensity LLT (>80%), especially during the first time period. Little change in treatment intensity or the combined measure of intensity and adherence was observed after transition to primary care. There was a significant association between the combined measure of intensity and adherence and MACE reduction (hazard ratio [95% confidence interval] per 10% increase in the combined measure: 0.84 [0.82-0.86]; <i>P</i> < 0.01).</p><p><strong>Conclusion: </strong>The proportion of post-MI patients with high LLT intensity and adherence has increased in recent years, with little change after transfer from specialist to primary care. The combination of LLT intensity and adherence is important for preventing future cardiovascular events.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2022-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40042913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of exercise echocardiography in patients with wild-type transthyretin amyloidosis","authors":"C. Aguilera Agudo, V. Moñivas Palomero, E. González López, S. Mingo Santos","doi":"10.48101/ujms.v127.8410","DOIUrl":"https://doi.org/10.48101/ujms.v127.8410","url":null,"abstract":"Background Wild-type transthyretin amyloidosis is a systemic disease with predominantly cardiac symptoms. The aim of this study was to assess the short-term prognosis of these patients through contractile reserve measured by stress echocardiography, given the usefulness that this parameter has demonstrated in other populations. We considered major events as death from any cause and hospitalization for heart failure. Material and methods We conducted a study with a 1-year follow-up in 11 patients who were proposed to undergo a stress echocardiogram, with the follow-up as usual according to their doctor. We excluded pacemaker wearers, patients with permanent atrial fibrillation, those incapable of exertion at low loads, and those with poor acoustic windows. Results We found that contractile reserve estimated by right ventricular free wall longitudinal strain is correlated with a lower rate of death (all of them cardiovascular deaths) and hospitalizations for heart failure. Conclusions Contractile reserve assessed by right ventricular free wall longitudinal strain is a predictor of major events in patients with wild-type transthyretin cardiac amyloidosis.","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47575302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The retirement of Editor-in-Chief Arne Andersson, Upsala Journal of Medical Sciences 2006–2022: an amazing journey under Arne’s stewardship","authors":"G. Wikström, Michael Welsh","doi":"10.48101/ujms.v127.8630","DOIUrl":"https://doi.org/10.48101/ujms.v127.8630","url":null,"abstract":"","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2022-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46675335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of rapid antigen test prototype for detection of SARS-CoV-2 in saliva samples","authors":"Agnija Kivrane, Viktorija Igumnova, Elza Elizabete Liepina, D. Skrastina, A. Leončiks, Zanna Rudevica, Svjatoslavs Kistkins, A. Reinis, Anna Zilde, A. Kazaks, R. Ranka","doi":"10.48101/ujms.v127.8207","DOIUrl":"https://doi.org/10.48101/ujms.v127.8207","url":null,"abstract":"Background The development of easy-to-perform diagnostic methods is highly important for detecting current coronavirus disease (COVID-19). This pilot study aimed at developing a lateral flow assay (LFA)-based test prototype to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus in saliva samples. Methods Mice were immunized using the recombinant receptor-binding domain (rRBD) of SARS-CoV-2 virus spike protein. The combinations of the obtained mouse anti-receptor-binding domain (RBD) polyclonal antibodies (PAbs) and several commercial antibodies directed against the SARS-CoV-2 spike protein were used for enzyme-linked immunosorbent assay (ELISA) to select antibody pairs for LFA. The antibody pairs were tested in a LFA format using saliva samples from individuals with early SARS-CoV-2 infection (n = 9). The diagnostic performance of the developed LFA was evaluated using saliva samples from hospitalized COVID-19 patients (n = 111); the median time from the onset of symptoms to sample collection was 10 days (0–24 days, interquartile range (IQR): 7–13). The reverse transcription-polymerase chain reaction (rRT-PCR) was used as a reference method. Results Based on ELISA and preliminary LFA results, a combination of mouse anti-RBD PAbs (capture antibody) and rabbit anti-spike PAbs (detection antibody) was chosen for clinical analysis of sample. When compared with rRT-PCR results, LFA exhibited 26.5% sensitivity, 58.1% specificity, 50.0% positive prediction value (PPV), 33.3% negative prediction value (NPV), and 38.7% diagnostic accuracy. However, there was a reasonable improvement in assay specificity (85.7%) and PPV (91.7%) when samples were stratified based on the sampling time. Conclusion The developed LFA assay demonstrated a potential of SARS-CoV-2 detection in saliva samples. Further technical assay improvements should be made to enhance diagnostic performance followed by a validation study in a larger cohort of both asymptomatic and symptomatic patients in the early stage of infection.","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2022-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48660686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated data extraction of electronic medical records: Validity of data mining to construct research databases for eligibility in gastroenterological clinical trials.","authors":"Nora Joseph,&nbsp;Ida Lindblad,&nbsp;Sara Zaker,&nbsp;Sharareh Elfversson,&nbsp;Maria Albinzon,&nbsp;Øyvind Ødegård,&nbsp;Li Hantler,&nbsp;Per M Hellström","doi":"10.48101/ujms.v127.8260","DOIUrl":"https://doi.org/10.48101/ujms.v127.8260","url":null,"abstract":"<p><strong>Background: </strong>Electronic medical records (EMRs) are adopted for storing patient-related healthcare information. Using data mining techniques, it is possible to make use of and derive benefit from this massive amount of data effectively. We aimed to evaluate validity of data extracted by the Customized eXtraction Program (CXP).</p><p><strong>Methods: </strong>The CXP extracts and structures data in rapid standardised processes. The CXP was programmed to extract TNFα-native active ulcerative colitis (UC) patients from EMRs using defined International Classification of Disease-10 (ICD-10) codes. Extracted data were read in parallel with manual assessment of the EMR to compare with CXP-extracted data.</p><p><strong>Results: </strong>From the complete EMR set, 2,802 patients with code K51 (UC) were extracted. Then, CXP extracted 332 patients according to inclusion and exclusion criteria. Of these, 97.5% were correctly identified, resulting in a final set of 320 cases eligible for the study. When comparing CXP-extracted data against manually assessed EMRs, the recovery rate was 95.6-101.1% over the years with 96.1% weighted average sensitivity.</p><p><strong>Conclusion: </strong>Utilisation of the CXP software can be considered as an effective way to extract relevant EMR data without significant errors. Hence, by extracting from EMRs, CXP accurately identifies patients and has the capacity to facilitate research studies and clinical trials by finding patients with the requested code as well as funnel down itemised individuals according to specified inclusion and exclusion criteria. Beyond this, medical procedures and laboratory data can rapidly be retrieved from the EMRs to create tailored databases of extracted material for immediate use in clinical trials.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2022-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39930750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Desmosomes in squamous cell carcinomas.","authors":"Vitorino Modesto Dos Santos,&nbsp;Lister Arruda Modesto Dos Santos,&nbsp;Taciana Arruda Modesto Sugai","doi":"10.48101/ujms.v127.8250","DOIUrl":"https://doi.org/10.48101/ujms.v127.8250","url":null,"abstract":"Dear Editor The differential diagnosis of adenocarcinomas and squamous cell cancer may present a challenging task in diagnostic pathology. We appreciated the informative study by Galindo et al. recently published in the Upsala Journal of Medical Science evaluating the expression of three desmosomal proteins in nonsmall cell lung cancer (1). Desmosomes are structures of the plasma membrane participating in intercellular adhesion; and proteins of the plakophilin (PKP) family, like desmoplakin and plakoglobin, play a functional role in the desmosome plaques, with PKP1 as a major component (1). Another desmosomal protein, desmoglein 3 (DSG3), can act as tumor suppressor and is downregulated in stages of invasion and metastasis. In addition, the study included several established markers for NSCLC differentiation (CK5/6, p40, p63, CK7, TTF1, and Napsin A) as well as the novel marker keratin 15 (KRT15) (1). Protein staining related to the desmosome plaque has been utilized to establish the diagnosis of squamous cell carcinoma (SCC), as the example of pulmonary and head and neck regions. Gene sequences corresponding to the desmosome plaque-related proteins PKP1, DSG3, and KRT15 are differentially expressed in primary pulmonary adenocarcinoma and SCC (1). The established and novel markers were evaluated to distinguish pulmonary SCCs (n = 41) from adenocarcinomas (n = 44) in small lung biopsies. Their respective specificities for correctly diagnosed SCC were 97.4%, 94.6%, and 100% (g). Using CK5/6, p63, and PKP1 correctly determined SCC in 97.6% of cases. Moreover, PKP1 and DSG3 expression showed association with the patient outcome (1). In addition to desmosome proteins, other tools have been used for diagnosis, clinical management, and prognostication of either suspicious or confirmed cases of SCC (1–5). PERP (apoptosis effector of p53 related to PMP22) can stabilize desmosomes and suppress the SCC development, and the local control of SCC becomes inefficient if it is absent (2). Holmes et al. analyzed the 2-year cumulative incidence of local recurrence in 44 patients with SCC and described 44.4% recurrence for the PERP-negative and 16.4% for the PERP-positive group. The authors highlighted that PERP loss at SCC surgical margins is a predictor of relapses (2). Overexpression of kallikrein 7 (KLK7) in oral SCC can promote degradation of desmosomes, favoring local tumor invasion and metastases to the lymph nodes (3). Kumar et al. studied KLK7 expression in 30 patients with oral SCCs compared to normal controls. KLK7 was differentially expressed in all tumors varying with the histopathological grades and clinical stages. KLK7 expression increased from SCC low to high grade and from clinical stages 1–4, and this enhanced activity promoted over-desquamation and was related to poor prognosis (3). The authors emphasized the potential role of KLK7 as a useful diagnostic marker for oral SCC to monitor response to therapy, or as a candidate target for the treatme","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2022-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39904733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocan as a potential marker in diagnosis and predicting disease severity in COVID-19 patients: a promising biomarker for patients with false-negative RT-PCR.","authors":"Esra Laloglu,&nbsp;Handan Alay","doi":"10.48101/ujms.v127.8211","DOIUrl":"https://doi.org/10.48101/ujms.v127.8211","url":null,"abstract":"<p><strong>Background: </strong>Endothelial-specific molecule 1 (endocan) has emerged as an inflammatory biomarker in recent years. The purpose of this study was to investigate the diagnostic value of serum endocan levels in the prediction of COVID-19 disease among patients with a false-negative reverse transcription polymerase change reaction (RT-PCR) test, and also to determine its correlation with the clinical severity of the disease.</p><p><strong>Methods: </strong>Thirty patients with positive RT-PCR results and 30 with false-negative RT-PCR results, both with suspected COVID-19 in terms of clinical, radiological, and laboratory findings, were included in the study. Thirty healthy controls were also enrolled.</p><p><strong>Results: </strong>Serum endocan levels were estimated to be 821.8 ± 99.3 pg/mL in COVID-19 RT-PCR (+) patients, 803.9 ± 97.0 pg/mL in RT-PCR false (-) patients with suspected COVID-19, and 382.9 ± 37.5 pg/mL in the control group. No significant difference was observed between RT-PCR (+) and RT-PCR false (-) patients (<i>P</i> = 0.68). However, serum endocan levels differed significantly between patient groups and control group (<i>P</i> < 0.05). With a cut-off value of 444.2 pg/mL serum endocan levels differentiated COVID-19 cases from healthy individuals with 92% sensitivity and 80% specificity. Moreover, a significant positive correlation was observed between serum endocan levels and clinical severity (<i>P</i> < 0.01, <i>r</i> = 0.94).</p><p><strong>Conclusions: </strong>There is a need for different laboratory markers capable of assisting diagnosis and showing COVID-19 infection in suspected COVID-19 RT-PCR false-negative patients. Endocan levels can be used as an assistant blood test for identifying COVID-19 patients with false-negative RT-PCR tests and in determining the clinical severity of the disease.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"12 ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39904729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Violence and sexual risk taking reported by young people at Swedish youth clinics.","authors":"Sofia Hammarström,&nbsp;Siw Alehagen,&nbsp;Helena Kilander","doi":"10.48101/ujms.v127.7823","DOIUrl":"https://doi.org/10.48101/ujms.v127.7823","url":null,"abstract":"<p><strong>Background: </strong>Early identification of sexual risk taking and exposure to violence is fundamental when seeking to strengthen young people's health. The purpose of this study was to study factors associated with sexual risk taking and ill health, as well as to study gender differences, and the associations amongst exposure to multiple forms of violence, sexual risk taking and ill health.</p><p><strong>Methods: </strong>This was a cross-sectional study based on data from 3,205 young people answering a questionnaire belonging to the Sexual health Identification Tool (SEXIT 2.0), during consultations at 12 youth clinics in Sweden. The analyses are based on descriptive statistics and nominal multiple regression analysis.</p><p><strong>Results: </strong>Male, transgender and non-binary youths reported significantly more events of sexual risk taking and ill health compared to women. Those who reported sexual initiation before the age of 15 (OR 2.87, CI 1.81-4.56), three or more sexual partners in the past 12 months (OR 2.68, CI 1.70-4.22) and to have ever experienced an unintended pregnancy (OR 2.29, CI 1.32-3.97) were more than twice as likely to report exposure to physical, emotional and sexual violence. Transgender, non-binary youths and women were more exposed to multiple violence (OR 3.68, 13.50) compared to men.</p><p><strong>Conclusions: </strong>Transgender and non-binary youths are exposed to significantly more violence compared to women and men. Experiences of sexual risk taking and ill health demonstrated strong associations with exposure to multiple violence.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39601330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}