Upsala journal of medical sciences最新文献

{"title":"The relationship between NLRP3 rs10159239 and Vaspin rs2236242 gene variants and obstructive sleep apnea.","authors":"Buğra Kerget,&nbsp;Ferhan Kerget,&nbsp;Çiğdem Yüce Kahraman,&nbsp;Alperen Aksakal,&nbsp;Ömer Araz","doi":"10.48101/ujms.v126.7603","DOIUrl":"https://doi.org/10.48101/ujms.v126.7603","url":null,"abstract":"<p><strong>Background: </strong>In obstructive sleep apnea (OSA), recurrent upper airway obstruction and apnea/hypopnea episodes result in endothelial dysfunction, which leads to the release of many proinflammatory cytokines and reactive oxygen species (ROS). ROS induces NLRP3, a protein involved in the synthesis of interleukin (IL)-1 and IL-18; vaspin is a serine protease inhibitor that has an important role in suppressing the activation of NLRP3 inflammasome. In this study, we aimed to investigate the effect of NLRP3 rs10159239 (rs9239) and vaspin rs2236242 (rs6242) single nucleotide polymorphisms (SNPs) on OSA development.</p><p><strong>Methods: </strong>This study included 220 individuals who underwent polysomnography (118 patients with OSA and 102 healthy controls). NLRP3 rs9239 and vaspin rs6242 mutation frequencies were analyzed.</p><p><strong>Results: </strong>The NLRP3 rs9239 SNP genotype analysis revealed no statistically significant differences between the OSA and control groups. In the vaspin gene analysis, the rs6242 AA genotype was significantly more frequent in the OSA group compared with the control group, while the AT genotype was more frequent in controls (<i>P</i> = 0.004, <i>P</i> = 0.02). Comparison of rs6242 allele levels showed that the A allele was significantly more frequent in OSA patients than in controls (<i>P</i> = 0.03). The AA genotype was significantly more frequent in patients with severe OSA than in patients with mild or moderate OSA and the control group (<i>P</i> = 0.001 for all). Serum vaspin levels were significantly lower in carriers of the AA genotype than those with AT and TT genotypes (<i>P</i> = 0.001).</p><p><strong>Conclusion: </strong>The vaspin rs6242 SNP AA genotype increased susceptibility to OSA, while the AT genotype appeared to be protective. The lower plasma vaspin levels in OSA compared with the control group and in patients with the AA genotype suggest that vaspin may be a protective biomarker for OSA.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"126 ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2021-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39276006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are ECG changes in heart-healthy individuals of various ages related to cardiac disease 20 years later?","authors":"Sofia Erelund,&nbsp;Kjell Karp,&nbsp;Urban Wiklund,&nbsp;Rolf Hörnsten,&nbsp;Sandra Arvidsson","doi":"10.48101/ujms.v126.6064","DOIUrl":"https://doi.org/10.48101/ujms.v126.6064","url":null,"abstract":"<p><strong>Background: </strong>This research study aimed at assessing the electrocardiographic (ECG) changes caused by ageing in a cohort of healthy subjects with normal echocardiographic examinations.</p><p><strong>Methods: </strong>A total of 219 healthy individuals (119 males and 100 females) were evaluated for possible arrhythmias with a standard 12-lead resting ECG and 24-h Holter ECG. As the recordings were performed between 1998 and 2000, a 20-year follow-up study was carried out by assessing the local medical records to investigate whether the subjects had experienced any cardiovascular health complications or disease since the baseline assessment.</p><p><strong>Results: </strong>Eighty-three subjects (45 males and 38 females) presented with pathological ECG findings at baseline. The most common finding on analysis of Holter ECG recordings was premature atrial contractions, and the most severe pathological finding was episodes of ventricular tachycardia (eight subjects). Regarding the analysis of the standard 12-lead ECG, the most common finding was left ventricular hypertrophy, and the most severe pathological findings were ST-T changes and prolongation of the QT interval. Despite other cardiac examinations performed on these patients showing normal results, in combination with a strict inclusion criterion, this study showed that 28% of all subjects had pathological resting 12-lead ECGs at rest and 35% had pathological heart rhythms when assessed by 24-h Holter ECG. At follow-up, 21% of females and 43% of males had presented with ECG abnormalities, and 30% of females and 36% of males had cardiovascular disease. There was hypertension in 45% of females and in 58% of males. However, no association was found between the follow-up findings and ECG changes seen at baseline.</p><p><strong>Conclusion: </strong>Although most ECG changes found at baseline could be considered as a normal variation, they may progress to more severe heart complications as the subject ages. The results of this study also validate ECG findings of previous studies and underline that diagnostic criteria should be based on gender and age.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"126 ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2021-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39276004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of extensive bleeding in pigs on laboratory biomarkers.","authors":"Anders Larsson,&nbsp;Gunnar Strandberg,&nbsp;Miklós Lipcsey,&nbsp;Mats Eriksson","doi":"10.48101/ujms.v126.6914","DOIUrl":"https://doi.org/10.48101/ujms.v126.6914","url":null,"abstract":"<p><strong>Background: </strong>During hemorrhage and resuscitation, clinical and laboratory monitoring is useful to guide further management. However, acute changes in the biochemistry due to blood loss and subsequent crystalloid fluid resuscitation have not been fully studied.</p><p><strong>Materials and methods: </strong>Twelve anesthetized, juvenile pigs were used. Atraumatic exsanguination, corresponding to a total blood loss of 40%, was performed through a catheter and completed 2 h after initiation of the experiment. Arterial samples were analyzed by point-of-care testing and venous samples were analyzed. Oxygen delivery was calculated.</p><p><strong>Results: </strong>Shortly after 40% hemorrhage and concomitant fluid supplementation, there were significant reductions in arterial hemoglobin and hematocrit (approximately 25%, respectively). Oxygen delivery was less than half of the baseline value. Lactate in arterial blood was more than doubled after 40% exsanguination. On average, no other clinically significant changes in any of the analytes were observed, but interindividual dispersion was pronounced.</p><p><strong>Conclusions: </strong>Acute exsanguination was associated with decreased hemoglobin and hematocrit levels and increased lactate levels but limited effects on the other biomarkers that were studied. Increased levels of biomarkers in severely bleeding patients could indicate tissue damage and the source should be further investigated.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"126 ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2021-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39587149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Localized IgG4-related disease manifested on the tongue: a case report.","authors":"Helya Hashemi,&nbsp;Andreas Thor,&nbsp;Erik Hellbacher,&nbsp;Marie Carlson,&nbsp;Miklós Gulyás,&nbsp;Lena Blomstrand","doi":"10.48101/ujms.v126.6118","DOIUrl":"https://doi.org/10.48101/ujms.v126.6118","url":null,"abstract":"<p><p>Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory condition that can affect multiple organs. IgG4-RD may show a variety of initial symptoms. In the oral mucosa, lesions present as inflammatory fibrosis with a large number of IgG4-positive plasma cells. Evaluating treatment is a well-known problem in IgG4-RD due to the absence of an established assessment system. There are difficulties in defining the severity of the disease, which is why treatment is primarily based on its clinical manifestations. We present a case report of localized IgG4-RD with ulcerative and proliferative manifestations on the tongue, which clinically mimicked oral squamous cell carcinoma. A tumor-like lesion on the tongue can indicate something else other than the malignant or reactive changes commonly found in the oral mucosa. Multiple differential diagnoses of these atypical oral lesions, including localized IgG4-RD, should be considered.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"126 ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2021-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39276007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poorly controlled ambulatory blood pressure in outpatients with peripheral arterial disease.","authors":"Nina Dahle,&nbsp;Emma Skau,&nbsp;Jerzy Leppert,&nbsp;Johan Ärnlöv,&nbsp;Pär Hedberg","doi":"10.48101/ujms.v126.7609","DOIUrl":"https://doi.org/10.48101/ujms.v126.7609","url":null,"abstract":"<p><strong>Background: </strong>Patients with peripheral arterial disease (PAD) are generally less intensively managed than patients with coronary heart disease (CHD), despite that their risk of complications is believed to be equivalent. Identification of PAD patients at risk of poorly controlled blood pressure (BP) could lead to improved treatment, thus lowering the risk of cardiovascular (CV) complications. We aimed to describe the prevalence of poorly controlled cardiovascular (CV) risk factors, focusing on BP, in outpatients with PAD diagnosed in a vascular ultrasound laboratory.</p><p><strong>Methods: </strong>Consecutive outpatients with carotid and/or lower extremity PAD were included (<i>n =</i> 402) and examined with blood sampling, clinical BP, and 24-h ambulatory BP measurements. A poorly controlled clinical BP was defined as ≥140/90 mmHg, ambulatory BP ≥130/80 mmHg, low-density lipoprotein (LDL)-cholesterol level ≥2.5 mmol/L, and glycated hemoglobin (HbA1c) level >53 mmol/mol in those with diabetes.</p><p><strong>Results: </strong>Most of the patients had poorly controlled clinical (76.6%) and ambulatory BP (51.7%) profiles. Antihypertensive medications were prescribed in 84% of the patients. However, >40% of them used only 0-1 medication, and <25% of them used three or more agents. Clinical BP, a low number of medications, body mass index, and the presence of diabetes independently predicted a poorly controlled ambulatory BP. Nearly one-third of the patients were smokers, and most of the cohort had an LDL-cholesterol level of ≥2.5 mmol/L. An HbA1c level of >53 mmol/mol was present in 55% of diabetic patients.</p><p><strong>Conclusion: </strong>Poorly controlled clinical and ambulatory systolic BP profiles were common. In addition, suboptimal control of other important CV risk factors was detected. The findings of this study highlight the need for better preventive efforts against CV risk factors in outpatients with PAD.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"126 ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2021-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38918103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Staphylococcus aureus</i> bacteremia and cardiac implantable electronic devices in a county hospital setting: a population-based retrospective cohort study.","authors":"Sara Pichtchoulin,&nbsp;Ingrid Selmeryd,&nbsp;Elisabeth Freyhult,&nbsp;Pär Hedberg,&nbsp;Jonas Selmeryd","doi":"10.48101/ujms.v126.5653","DOIUrl":"https://doi.org/10.48101/ujms.v126.5653","url":null,"abstract":"<p><strong>Background: </strong>Due to a high incidence of cardiac implantable electronic device-associated infective endocarditis (CIED-IE) in cases of <i>Staphylococcus aureus</i> bacteremia (SAB) and high mortality with conservative management, guidelines advocate device removal in all subjects with SAB. We aimed to investigate the clinical course of SAB in patients with a CIED (SAB+CIED) in a Swedish county hospital setting and relate it to guideline recommendations.</p><p><strong>Methods: </strong>All CIED carriers with SAB, excluding clinical pocket infections, in the County of Västmanland during 2010-2017 were reviewed retrospectively.</p><p><strong>Results: </strong>There were 61 cases of SAB+CIED during the study period, and CIED-IE was diagnosed in 13/61 (21%) cases. In-hospital death occurred in 19/61 (31%) cases, 34/61 (56%) cases were discharged with CIED device retained, and 8/61 (13%) cases were discharged after device removal. Subjects dying during hospitalization were elderly and diseased. No events was seen if the CIED was removed. Among four discharged cases with conservatively managed CIED-IE one relapse occured. Among 30 cases discharged with retained CIED and no evidence of IE, 22/30 (73%) cases had an uneventful follow-up, whereas adverse events secondary to overlooked CIED-IE were likely in 1/30 (3%) cases and could not be definitely excluded in additionally 4/30 (13%) cases.</p><p><strong>Conclusions: </strong>During the study period, management became more active and prognosis improved. The heterogeneity within the population of SAB+CIED suggests that a management strategy based on an individual risk/benefit analysis could be an alternative to mandatory device removal.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"126 ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2021-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25525071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High risk of cardiovascular side effects after treatment of Hodgkin's lymphoma - is there a need for intervention in long-term survivors?","authors":"Anne Andersson,&nbsp;Gunilla Enblad,&nbsp;Martin Erlanson,&nbsp;Ann-Sofie Johansson,&nbsp;Daniel Molin,&nbsp;Björn Tavelin,&nbsp;Ulf Näslund,&nbsp;Beatrice Melin","doi":"10.48101/ujms.v126.6117","DOIUrl":"https://doi.org/10.48101/ujms.v126.6117","url":null,"abstract":"<p><strong>Background: </strong>Hodgkin lymphoma (HL) patients have a good prognosis after adequate treatment. Previous treatment with mantle field irradiation has been accompanied by an increased long-term risk of cardiovascular disease (CVD). This study identified co-morbidity factors for the development of cardiovascular side effects and initiated an intervention study aimed to decrease morbidity and mortality of CVD in HL survivors.</p><p><strong>Design: </strong>Hodgkin lymphoma patients aged ≤45 years diagnosed between 1965 and 1995 were invited to participate. In total, 453 patients completed a questionnaire that addressed co-morbidity factors and clinical symptoms. Of these, 319 accepted to participate in a structured clinical visit. The statistical analyses compared individuals with CVD with those with no CVD.</p><p><strong>Results: </strong>Cardiovascular disease was reported by 27.9%. Radiotherapy (odds ratio [OR]: 3.27), hypertension and hypercholesterolemia were shown to be independent risk factors for the development of CVD. The OR for CVD and valve disease in patients who received radiotherapy towards mediastinum was 4.48 and 6.07, respectively. At clinical visits, 42% of the patients were referred for further investigation and 24% of these had a cardiac ultrasound performed due to previously unknown heart murmurs.</p><p><strong>Conclusion: </strong>Radiotherapy towards mediastinum was an independent risk factor for CVD as well as hypercholesterolemia and hypertension. A reasonable approach as intervention for this cohort of patients is regular monitoring of hypertension and hypercholesterolemia and referral to adequate investigation when cardiac symptoms appear. Broad knowledge about the side effects from radiotherapy in the medical community and well-structured information regarding late side effects to the patients are all reasonable approaches as late effects can occur even 40 years after cancer treatment.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"126 ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2021-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38821751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observations by a statistical watchdog.","authors":"Adam Taube","doi":"10.48101/ujms.v126.5665","DOIUrl":"10.48101/ujms.v126.5665","url":null,"abstract":"<p><p>During more than five decades, the author has kept a critical eye on how statistical methods are (mis-)used in medical research. Some areas are presented where serious statistical mistakes are prevalent. Two investigations with erroneous conclusions are described in detail. Situations where outside authorities have tried to mute medical researchers are also commented upon. The authors own efforts to improve the use of statistical methods and the current situation with easily accessible statistical program packages are described. Finally, the importance of continued 'statistical cleansing' is stressed.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"126 ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2021-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25389997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of spironolactone on extrasystoles and heart rate variability in haemodialysis patients: a randomised crossover trial.","authors":"Michael Eklund,&nbsp;Olof Hellberg,&nbsp;Hans Furuland,&nbsp;Yang Cao,&nbsp;Erik Nilsson","doi":"10.48101/ujms.v126.5660","DOIUrl":"https://doi.org/10.48101/ujms.v126.5660","url":null,"abstract":"<p><strong>Background: </strong>Spironolactone treatment reduces mortality in haemodialysis (HD) patients. The objective of this study was to evaluate if spironolactone affects cardiac electric activity in this population.</p><p><strong>Methods: </strong>Participants were randomised to start with spironolactone 50 mg daily or observation (12 weeks) with subsequent washout (6 weeks) and crossover to the other intervention (12 weeks). Long-term electrocardiograms were recorded and assessed with blinding to treatment. The primary outcome was premature ventricular complexes (PVC), and secondary outcomes were atrial premature contractions (APC) and heart rate variability (HRV).</p><p><strong>Results: </strong>Thirty participants were recruited, and data for 16 participants were included in the analysis. Treatment was associated with an increase in PVCs by 9.7 [95% confidence interval (CI): 1.5 to 18] h^-1. HRV time-domain variables increased during treatment, the standard deviation of all beat-to-beat intervals by 18 (95% CI: 3.3 to 32) milliseconds (ms) and the standard deviation of the averages of beat-to-beat intervals in all 5-min segments of the entire recording by 16 (95% CI: 1.5 to 30) ms. There were no significant differences in other variables.</p><p><strong>Conclusion: </strong>Spironolactone treatment increases PVCs in HD, indicating a possible proarrhythmic effect. However, improved cardiac autonomic function, as indicated by an increased HRV, may contribute to the survival benefit from spironolactone treatment in HD patients.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"126 ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2021-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25389998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors for age-related cataract in Sweden.","authors":"Magnus Hugosson, Curt Ekström","doi":"10.1080/03009734.2020.1802375","DOIUrl":"10.1080/03009734.2020.1802375","url":null,"abstract":"<p><strong>Background: </strong>Cataract is a major cause of visual impairment worldwide. There is a paucity of prevalence studies from Sweden. Therefore, we report the prevalence of cataract and its risk factors in a population-based study of older adults in Sweden.</p><p><strong>Methods: </strong>The Tierp Glaucoma Survey was conducted in the municipality of Tierp, Sweden, including 760 subjects aged 65-74 years. The presence of cataract was determined based on retroillumination, with lens opacities evident on slit-lamp examination. To assess risk factors for cataract, odds ratios (ORs) were calculated, adjusted for age and gender.</p><p><strong>Results: </strong>A total of 234 individuals were found to have cataract, 12 of whom had undergone cataract surgery. The prevalence adjusted for nonparticipation was 31.5% (95% confidence interval [CI] 29.4-33.6), 35.2% (95% CI 28.7-41.8) in females and 26.2% (95% CI 19.8-32.6) in males. Cataract was associated with age ≥70 years (OR 1.93; 95% CI 1.41-2.64), female gender (OR 1.54; 95% CI 1.12-2.11), and myopia (OR 2.3; 95% CI 1.16-3.56), while pseudoexfoliation, smoking, diabetes, hypertension, and ischaemic heart disease were not.</p><p><strong>Conclusion: </strong>Nearly one-third of the sample were estimated to have lens opacities, or had undergone cataract surgery, making cataract a frequent disorder of older age. The study provided further evidence that increasing age, female gender, and myopia are associated with cataract.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":"125 4","pages":"311-315"},"PeriodicalIF":1.5,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38231524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}