Upsala journal of medical sciences最新文献

{"title":"Assessing the relationship between systemic immune-inflammation index and mortality in patients with hypertrophic cardiomyopathy.","authors":"Ziqiong Wang,&nbsp;Haiyan Ruan,&nbsp;Liying Li,&nbsp;Xin Wei,&nbsp;Ye Zhu,&nbsp;Jiafu Wei,&nbsp;Xiaoping Chen,&nbsp;Sen He","doi":"10.48101/ujms.v126.8124","DOIUrl":"https://doi.org/10.48101/ujms.v126.8124","url":null,"abstract":"<p><strong>Background: </strong>This study investigates the predictive value of the systemic immune-inflammation index (SII), which was calculated as platelet × neutrophil/lymphocyte ratio, for all-cause mortality in patients with hypertrophic cardiomyopathy (HCM).</p><p><strong>Methods: </strong>A total of 360 HCM patients were enrolled. They were divided into three groups based on the tertiles of baseline SII. The association between SII and all-cause mortality was analyzed.</p><p><strong>Results: </strong>There were 53 HCM patients who died during a mean follow-up time of 4.8 years (min: 6 days and max: 10.8 years), and the mortality rate was 3.0 per 100 person years. The cumulative mortality rate was significantly different among the three tertiles of SII (<i>P</i> = 0.004), and the mortality rate in tertile 3 was much higher than that in the first two tertiles. In reference to tertile 1, the fully adjusted hazard ratios of all-cause mortality were 1.02 for the tertile 2 (95% confidence interval [CI]: 0.45-2.31, <i>P</i> = 0.966) and 2.31 for tertile 3 (95% CI: 1.10-4.87, <i>P</i> = 0.027). No significant interactions between SII and other variables were observed during subgroup analysis. The discriminative power was better for mid-term outcome than that for short-term or long-term outcomes. Sensitivity analyses including patients with normal platelet and white blood cell count have revealed similar results.</p><p><strong>Conclusion: </strong>SII was a significant risk factor for all-cause mortality in HCM patients. However, the discriminative power was poor to moderate. It could be used in combination with other risk factors in mortality risk stratification in HCM.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2021-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39897978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy in detecting major depressive episodes in older adults using the Swedish versions of the GDS-15 and PHQ-9.","authors":"Johnny Pellas,&nbsp;Mattias Damberg","doi":"10.48101/ujms.v126.7848","DOIUrl":"https://doi.org/10.48101/ujms.v126.7848","url":null,"abstract":"<p><strong>Objectives: </strong>The purpose of this study was to evaluate the diagnostic accuracy at different cut-off values for the Swedish versions of the 15-item Geriatric Depression Scale (GDS-15) and Patient Health Questionnaire (PHQ-9) compared with a structured clinical psychiatric interview in older adults.</p><p><strong>Methods: </strong>Community-dwelling participants (<i>N</i> = 113) aged 65 years or older completed the Swedish versions of the GDS-15 and PHQ-9 and were then interviewed using the Mini International Neuropsychiatric Interview (MINI) to establish the presence or absence of current major depressive episodes (MDEs). Areas under the curve (AUC) were calculated for each scale, as well as the sensitivity, specificity, and Youden's index for different cut-off values.</p><p><strong>Results: </strong>Seventeen participants met the criteria for MDEs. The AUC was 0.97 for the GDS-15 and 0.95 for the PHQ-9. A cut-off of ≥6 on the GDS-15 yielded a sensitivity of 94%, a specificity of 88%, and a Youden's index of 0.82. A cut-off of ≥5 on the PHQ-9 yielded a sensitivity of 100%, a specificity of 81%, and a Youden's index of 0.81. The proposed cut-off of ≥10 on the PHQ-9 produced excellent specificity of 95% but a lower sensitivity of 71%.</p><p><strong>Conclusions: </strong>This study indicates that the Swedish versions of the GDS-15 and PHQ-9 have comparable accuracy as screening instruments for older adults with MDEs. However, the proposed cut-off of 10 on the PHQ-9 might be too high when applied to older individuals in Sweden, and further investigations in larger samples in different healthcare settings are warranted.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39604843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated gaseous luminal nitric oxide and circulating IL-8 as features of <i>Helicobacter pylori</i>-induced gastric inflammation.","authors":"Hiwa K Saaed,&nbsp;Lisa Chiggiato,&nbsp;Dominic-Luc Webb,&nbsp;Ann-Sofie Rehnberg,&nbsp;Carlos A Rubio,&nbsp;Ragnar Befrits,&nbsp;Per M Hellström","doi":"10.48101/ujms.v126.8116","DOIUrl":"https://doi.org/10.48101/ujms.v126.8116","url":null,"abstract":"<p><strong>Background: </strong>Gastric nitric oxide (NO) production in response to <i>Helicobacter pylori</i> via inducible nitric oxide synthase (iNOS) is suggested as a biomarker of inflammation and cytotoxicity. The aim of this study was to investigate relationships between gastric [NO], immunological biomarkers and histopathology.</p><p><strong>Materials and methods: </strong>Esophagogastroduodenoscopy was done in 96 dyspepsia patients. Luminal [NO] was measured by chemiluminescence. Biopsies were taken from gastric antrum and corpus for culture and histopathology. <i>H. pylori</i> IgG was detected by immunoblot assay. Biobanked plasma from 76 dyspepsia patients (11 <i>H. pylori</i> positives) was analyzed for 39 cytokines by multiplexed ELISA.</p><p><strong>Results: </strong><i>H. pylori</i>-positive patients had higher [NO] (336 ± 26 ppb, mean ± 95% CI, <i>n</i> = 77) than <i>H. pylori</i>-negative patients (128 ± 47 ppb, <i>n</i> = 19) (<i>P</i> < 0.0001). Histopathological changes were found in 99% of <i>H. pylori</i>-positive and 37% of <i>H. pylori</i>-negative patients. Histopathological concordance was 78-100% between corpus and antrum. Correlations were found between gastric [NO] and severity of acute, but not chronic, inflammation. Plasma IL-8 (increased in <i>H. pylori</i> positives) had greatest difference between positive and negative groups, with eotaxin, MIP-1β, MCP-4, VEGF-A, and VEGF-C also higher (<i>P</i> < 0.004 to <i>P</i> < 0.032). Diagnostic odds ratios using 75% cut-off concentration were 7.53 for IL-8, 1.15 for CRP, and 2.88 for gastric NO.</p><p><strong>Conclusions: </strong>Of the parameters tested, increased gastric [NO] and circulating IL-8 align most consistently and selectively in <i>H. pylori</i>-infected patients. Severity of mucosal inflammatory changes is proportional to luminal [NO], which might be tied to IL-8 production. It is proposed that IL-8 be further investigated as a blood biomarker of treatment outcomes.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2021-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39604842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between BMI and 90-day mortality in patients with and without diabetes seeking care at the emergency department.","authors":"Per Wändell,&nbsp;Axel C Carlsson,&nbsp;Anders Larsson,&nbsp;Olle Melander,&nbsp;Torgny Wessman,&nbsp;Johan Ärnlöv,&nbsp;Toralph Ruge","doi":"10.48101/ujms.v126.7590","DOIUrl":"https://doi.org/10.48101/ujms.v126.7590","url":null,"abstract":"<p><strong>Background: </strong>The impact of body mass index (BMI) on mortality varies with age and disease states. The aim of this research study was to analyse the associations between BMI categories and short- and long-term mortality in patients with or without diabetes seeking care at the emergency department (ED) with acute dyspnoea.</p><p><strong>Population and methods: </strong>Patients aged ≥18 years at ED during daytime on weekdays from March 2013 to July 2018 were included. Participants were triaged according to the Medical Emergency Triage and Treatment System-Adult score (METTS-A), and blood samples were collected. Totally, 1,710 patients were enrolled, with missing values in 113, leaving 1,597 patients, 291 with diabetes and 1,306 without diabetes. The association between BMI and short-term (90-day) and long-term (mean follow-up time 2.1 years) mortality was estimated by Cox regression with normal BMI (18.5-24.9) as referent category, with adjustment for age, sex, METTS-A scoring, glomerular filtration rate, smoking habits and cardiovascular comorbidity in a fully adjusted model. The Bonferroni correction was also used.</p><p><strong>Results: </strong>Regarding long-term mortality, patients with diabetes and BMI category ≥30 kg/m² had a fully adjusted Hazard Ratio (HR) of 0.40 (95% confidence interval [CI]: 0.23-0.69), significant after the Bonferroni correction. Amongst patients without diabetes, those with underweight had an increased risk but only of borderline significance, whilst risks in those with overweight or obesity did not differ from reference.Regarding short-term mortality, risks did not differ from reference amongst patients with or without diabetes.</p><p><strong>Conclusions: </strong>We found divergent long-term mortality risks in patients with and without diabetes, with lower risk in obese patients (BMI ≥ 30 kg/m²) with diabetes, but no increased risk for patients without diabetes and overweight (BMI: 25-29.9 kg/m²) and obesity.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2021-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39520883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assembly of tetraspanins, galectin-3, and distinct N-glycans defines the solubilization signature of seminal prostasomes from normozoospermic and oligozoospermic men.","authors":"Tamara Janković,&nbsp;Jelena Danilović Luković,&nbsp;Irena Miler,&nbsp;Ninoslav Mitić,&nbsp;Ljiljana Hajduković,&nbsp;Miroslava Janković","doi":"10.48101/ujms.v126.7673","DOIUrl":"https://doi.org/10.48101/ujms.v126.7673","url":null,"abstract":"<p><strong>Background: </strong>Prostasomes, extracellular vesicles (EVs) abundantly present in seminal plasma, express distinct tetraspanins (TS) and galectin-3 (gal-3), which are supposed to shape their surface by an assembly of different molecular complexes. In this study, detergent-sensitivity patterns of membrane-associated prostasomal proteins were determined aiming at the solubilization signature as an intrinsic multimolecular marker and a new parameter suitable as a reference for the comparison of EVs populations in health and disease.</p><p><strong>Methods: </strong>Prostasomes were disrupted by Triton X-100 and analyzed by gel filtration under conditions that maintained complete solubilization. Redistribution of TS (CD63, CD9, and CD81), gal-3, gamma-glutamyltransferase (GGT), and distinct N-glycans was monitored using solid-phase lectin-binding assays, transmission electron microscopy, electrophoresis, and lectin blot.</p><p><strong>Results: </strong>Comparative data on prostasomes under normal physiology and conditions of low sperm count revealed similarity regarding the redistribution of distinct N-glycans and GGT, all presumed to be mainly part of the vesicle coat. In contrast to this, a greater difference was found in the redistribution of integral membrane proteins, exemplified by TS and gal-3. Accordingly, they were grouped into two molecular patterns mainly consisting of overlapped CD9/gal-3/wheat germ agglutinin-reactive glycoproteins and CD63/GGT/concanavalin A-reactive glycoproteins.</p><p><strong>Conclusions: </strong>Solubilization signature can be considered as an all-inclusive distinction factor regarding the surface properties of a particular vesicle since it reflects the status of the parent cell and the extracellular environment, both of which contribute to the composition of spatial membrane arrangements.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2021-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39430340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality in Eosinophilic Esophagitis - a nationwide, population-based matched cohort study from 2005 to 2017.","authors":"Lovisa Röjler,&nbsp;John J Garber,&nbsp;Bjorn Roelstraete,&nbsp;Marjorie M Walker,&nbsp;Jonas F Ludvigsson","doi":"10.48101/ujms.v126.7688","DOIUrl":"https://doi.org/10.48101/ujms.v126.7688","url":null,"abstract":"<p><strong>Background: </strong>There is a lack of knowledge about mortality in eosinophilic esophagitis (EoE). Therefore, this study aimed to examine the mortality in EoE.</p><p><strong>Methods: </strong>A nationwide, population-based matched cohort study was conducted of all EoE patients in Sweden diagnosed between July 2005 and December 2017. Individuals with EoE (<i>n</i> = 1,625) were identified through prospectively recorded histopathology codes from all gastrointestinal pathology reports in Sweden, representing 28 pathology departments (the ESPRESSO study). Each individual with EoE was then matched with up to five reference individuals from the general population (<i>n</i> = 8,003) for age, sex, year of birth, and place of residence. We used the Cox proportional hazard modeling to estimate the adjusted hazard ratio (aHR) and 95% confidence interval (95% CI) while adjusting for other potential confounders. In sensitivity analyses, mortality in EoE patients was compared with mortality in their siblings.</p><p><strong>Results: </strong>Through December 2017, 34 deaths were confirmed in EoE patients (4.60 per 1,000 person-years) compared with 165 in reference individuals (4.57 per 1,000 person-years). This rate corresponds to an aHR of 0.97 (95% CI = 0.67-1.40). HRs were similar in males (aHR = 1.00 [0.66-1.51]) and females (aHR = 0.92 [0.38-2.18]). We observed no increased risk in mortality due to esophageal or other gastrointestinal cancers in patients with EoE (aHR = 1.02 [0.51-2.02]).Mortality was similar in EoE patients and their siblings (aHR = 0.91 [0.44-1.85]).</p><p><strong>Conclusion: </strong>In this nationwide, population-based matched cohort study in Sweden, there was no increased risk of death in patients with EoE compared with their siblings and the general population.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39430339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LncRNA DRAIC regulates cell proliferation and migration by affecting the miR-34a-5p/ITGA6 signal axis in Hirschsprung's disease.","authors":"Chuancheng Sun,&nbsp;Bing Xu,&nbsp;Liang Wang,&nbsp;Yilin Su","doi":"10.48101/ujms.v126.7895","DOIUrl":"https://doi.org/10.48101/ujms.v126.7895","url":null,"abstract":"<p><strong>Background: </strong>Hirschsprung's disease (HSCR) is a common defect in newborns, and studies have revealed that long non-coding RNA (lncRNA) is involved in the progression of HSCR. This research study aims to investigate the mechanism of downregulated RNA in cancer (DRAIC) on cell proliferation and migration in HSCR.</p><p><strong>Methods: </strong>Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to detect the expression of DRAIC in HSCR bowel stenosis tissues and normal colon tissues. Cell-counting kit-8 (CCK-8) and Transwell assays were employed to explore whether cellular functions change after overexpression or knockdown of the DRAIC in SH-SY5Y cells and human 293T cells. Protein expression levels were determined by Western blot analysis. RNA pull-down and dual-luciferase reporter assays were used to confirm the competitive relationship of DRAIC and integrin subunit alpha 6 (ITGA6) through their association with miR-34a-5p.</p><p><strong>Results: </strong>The lncRNA DRAIC was significantly increased in colon tissue from HSCR patients. The overexpression of DRAIC inhibited SH-SY5Y cell and human 293T cell proliferation and migration. Knockdown of DRAIC, however, promoted cell proliferation and migration. The RNA pull-down and dual-luciferase reporter assays have proven the competitive relationship between DRAIC and ITGA6 through their association with miR-34a-5p. Further rescue experiments have confirmed that DRAIC regulates cell proliferation and migration by affecting the miR-34a-5p/ITGA6 signal axis in HSCR.</p><p><strong>Conclusion: </strong>DRAIC promoted cell proliferation and migration by regulating the miR-34a-5p/ITGA6 signal axis in HSCR.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2021-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39378311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum concentrations of Thymidine kinase 1 measured using a novel antibody-based assay in patients with Hodgkin Lymphoma.","authors":"Johan Mattsson Ulfstedt,&nbsp;Per Venge,&nbsp;Sofia Holmgren,&nbsp;Gunilla Enblad,&nbsp;Staffan Eriksson,&nbsp;Daniel Molin","doi":"10.48101/ujms.v126.6119","DOIUrl":"https://doi.org/10.48101/ujms.v126.6119","url":null,"abstract":"<p><strong>Background: </strong>Thymidine kinase 1 (TK1) is an intracellular protein associated with DNA synthesis, expressed during the G1 phase and remained elevated through the M phase, with a potential as a biomarker for cell proliferation. In this study, we explore the possible use of TK1 in Hodgkin lymphoma (HL).</p><p><strong>Methods: </strong>Serum concentrations of TK1 (S-TK1) were measured in 46 newly diagnosed HL patients using prospectively collected biobanked serum samples. The samples were analyzed using a novel antibody-based TK1 immunosorbent assay (ELISA).</p><p><strong>Results: </strong>The concentrations of S-TK1 were elevated in HL patients compared with healthy controls (median 0.32 μg/L vs. 0.24 μg/L, <i>P</i> = 0.003). A further increase in S-TK1 was observed during the treatment. The S-TK1 concentrations were higher in patients with advanced stage disease, low B-Hb, elevated P-LD and in those with B-symptoms. A high ESR correlated with low S-TK1.</p><p><strong>Conclusions: </strong>The study results suggest that S-TK1, measured using a novel antibody-based assay, has the potential to be a biomarker in HL. However, while S-TK1 levels are elevated at baseline compared with healthy controls, a limited number of patients and comparatively short follow-up time render reliable conclusions difficult.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2021-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39378310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the diagnosis of eosinophilic esophagitis based on histopathology reports in Sweden.","authors":"Lovisa Röjler,&nbsp;Ida Glimberg,&nbsp;Marjorie M Walker,&nbsp;John J Garber,&nbsp;Jonas F Ludvigsson","doi":"10.48101/ujms.v126.7687","DOIUrl":"https://doi.org/10.48101/ujms.v126.7687","url":null,"abstract":"<p><strong>Background: </strong>Eosinophilic esophagitis (EoE) is a relatively new diagnosis, where until recently a specific international classification of disease code was missing. One way to identify patients with EoE is to use histopathology codes. We validated the clinicopathological EoE diagnosis based on histopathology reports and patient charts to establish these data sources as the basis for a nationwide EoE patient cohort.</p><p><strong>Methods: </strong>Through the Epidemiology Strengthened by histoPathology Reports in Sweden (ESPRESSO) study, we randomly selected 165 patients from five Swedish health care regions with a histopathologic diagnosis of EoE. Patients were assigned a histopathology diagnosis of EoE if they had ≥15 eosinophils per high-power field or, in the absence of eosinophil quantification, the pathologist interpreted the biopsy as consistent with EoE. Patient charts were scrutinized to see if the other diagnostic criteria were fulfilled. Of the 131 received patient charts, 111 (85%) had sufficient information to be included in the study.</p><p><strong>Results: </strong>Of the 111 validated patients, 99 had EoE, corresponding to a positive predictive value of 89% (95% confidence interval = 82-94%). Dysphagia was the most common symptom (<i>n</i> = 78, 70%), followed by food impaction (<i>n</i> = 64, 58%) and feeding difficulties (<i>n</i> = 37, 33%). Twelve patients had coexisting asthma (11%) and 16 allergic rhinitis (14%). Seventeen patients underwent esophageal dilatation (15%), of which seven had more than one dilatation. Ninety-seven (87%) patients had a proton-pump inhibitor treatment ≤2 years before or after the diagnosis. Forty-two patients (38%) had been prescribed inhalation steroids and 64 (58%) had undergone esophageal radiology.</p><p><strong>Conclusion: </strong>Histopathology reports from the ESPRESSO cohort with esophageal eosinophilic inflammation are suggestive of EoE.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2021-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39378309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of nutritional state on the fatty acid composition of circulating lipid fractions: implications for their use as biomarkers of dietary fat intake.","authors":"Sion A Parry,&nbsp;Fredrik Rosqvist,&nbsp;Sarah Peters,&nbsp;Rebecca K Young,&nbsp;Thomas Cornfield,&nbsp;Pamela Dyson,&nbsp;Leanne Hodson","doi":"10.48101/ujms.v126.7649","DOIUrl":"https://doi.org/10.48101/ujms.v126.7649","url":null,"abstract":"<p><strong>Background: </strong>The fatty acid (FA) composition of blood can be used as an objective biomarker of dietary FA intake. It remains unclear how the nutritional state influences the FA composition of plasma lipid fractions, and thus their usefulness as biomarkers in a non-fasted state.</p><p><strong>Objectives: </strong>To investigate the associations between palmitate, oleate and linoleate in plasma lipid fractions and self-reported dietary FA intake, and assess the influence of meal consumption on the relative abundance of these FA in plasma lipid fractions (i.e. triglyceride [TG], phospholipids [PLs] and cholesterol esters [CEs]).</p><p><strong>Design: </strong>Analysis was performed in plasma samples collected from 49 (34 males and 15 females) participants aged 26-57 years with a body mass index (BMI) between 21.6 and 34.2 kg/m², all of whom had participated in multiple study visits, thus a pooled cohort of 98 data sets was available for analysis. A subset (<i>n</i> = 25) had undergone nutritional interventions and was therefore used to investigate the relationship between the FA composition of plasma lipid fractions and dietary fat intake.</p><p><strong>Results: </strong>Significant (<i>P</i> < 0.05) positive associations were observed between dietary polyunsaturated fat and linoleate abundance in plasma CE. When investigating the influence of meal consumption on postprandial FA composition, we found plasma TG palmitate significantly (<i>P</i> < 0.05) decreased across the postprandial period, whereas oleate and linoleate increased. A similar pattern was observed in plasma PL, whereas linoleate abundance decreased in the plasma CE.</p><p><strong>Conclusion: </strong>Our data demonstrate that the FA composition of plasma CE may be the lipid fraction to utilise as an objective biomarker when investigating recent (i.e. previous weeks-months) dietary FA intakes. In addition, we show that the consumption of a high-fat meal influences the FA composition of plasma TG, PL and CE over the course of the postprandial period, and therefore, suggest that fasting blood samples should be utilised when using FA composition as a biomarker of dietary FA intake.</p>","PeriodicalId":23458,"journal":{"name":"Upsala journal of medical sciences","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39378312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}