United European Gastroenterology Journal最新文献

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Overview of a national endoscopy database: The Trans.IT database and its impact on data registration quality. 国家内窥镜数据库概述:Trans.IT 数据库及其对数据登记质量的影响。
IF 5.8 2区 医学
United European Gastroenterology Journal Pub Date : 2024-09-27 DOI: 10.1002/ueg2.12669
F Theunissen, P C J Ter Borg, R J T Ouwendijk, M J Bruno, P D Siersema
{"title":"Overview of a national endoscopy database: The Trans.IT database and its impact on data registration quality.","authors":"F Theunissen, P C J Ter Borg, R J T Ouwendijk, M J Bruno, P D Siersema","doi":"10.1002/ueg2.12669","DOIUrl":"https://doi.org/10.1002/ueg2.12669","url":null,"abstract":"<p><strong>Background: </strong>The Trans.IT database is a national gastrointestinal (GI) endoscopy database developed in 2012. It automatically collects anonymous data from GI endoscopy procedures in a centralized database. All endoscopists use a structured reporting tool for uniform data collection. In this study, we aim to provide an overview of the database and to evaluate its impact on data registration quality.</p><p><strong>Methods: </strong>We used all ERCPs, colonoscopies and colorectal cancer (CRC)-screening colonoscopies performed between 2016 and 2020. We excluded centers joining after 2016 and patients below age 18. Data registration quality for ERCPs included completeness of data for: intention of ERCP, Schutz score, ASA classification, papillary status (virgin or previous sphincterotomy), cannulation (success or failure to cannulate the desired duct) and procedural success. For colonoscopies: indication, ASA-classification, Boston Bowel Preparation Score (BBPS), cecal intubation, polyp detection rate (PDR). For CRC-screening colonoscopies, ASA-classification, BBPS, cecal intubation, PDR and adenoma detection rate (ADR).</p><p><strong>Results: </strong>A total of 14,156 ERCPs, 150,962 colonoscopies and 37,199 colorectal cancer screening colonoscopies were included in our analysis. For ERCPs, registration of procedural intention, Schutz score, ASA classification, papillary status, cannulation and procedural success improved from 34.9%, 32.7%, 72.6%, 36.5%, 34.6%, 27.2% in 2016, to 86.4%, 84.6%, 97.4%, 86.4%, 82.1%, 84.0%, respectively, in 2020. For non-screening colonoscopies, registration of indication, ASA classification, BBPS, cecal intubation and PDR improved from 40.4%, 60.5%, 47.6%, 69.8% and 32.3% in 2016 to 90.3%, 88.9%, 59.8%, 79.1% and 39.1%, respectively, in 2020. For CRC-cancer screening colonoscopy registration equaled outcome, PDR and ADR changed from 74.7% to 63.6% in 2016 to 66.3% and 53.8% in 2020, respectively.</p><p><strong>Conclusions: </strong>The quality of endoscopy data registration has consistently improved over the years by using the Trans.IT database. This is most likely the result of feedback to performing endoscopists to review performance in real-time online and progressive awareness of quality of data registration.</p>","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy, safety and differential outcomes of immune-chemotherapy with gemcitabine, cisplatin and durvalumab in patients with biliary tract cancers: A multicenter real world cohort. 在胆道癌患者中使用吉西他滨、顺铂和德伐卢单抗进行免疫化疗的疗效、安全性和不同结果:多中心真实世界队列。
IF 5.8 2区 医学
United European Gastroenterology Journal Pub Date : 2024-09-20 DOI: 10.1002/ueg2.12656
Katharina Mitzlaff, Martha M Kirstein, Christian Müller, Marino Venerito, Alexander Olkus, Michael T Dill, Arndt Weinmann, Lorenz Kocheise, Alina Busch, Kornelius Schulze, Gabriel Allo, Dirk-Thomas Waldschmidt, Maryam Barsch, Bertram Bengsch, Michael Quante, Maria A Gonzalez-Carmona, Vera Himmelsbach, Fabian Finkelmeier, Roman Kloeckner, Peter Schirmacher, Jens U Marquardt, Carolin Zimpel
{"title":"Efficacy, safety and differential outcomes of immune-chemotherapy with gemcitabine, cisplatin and durvalumab in patients with biliary tract cancers: A multicenter real world cohort.","authors":"Katharina Mitzlaff, Martha M Kirstein, Christian Müller, Marino Venerito, Alexander Olkus, Michael T Dill, Arndt Weinmann, Lorenz Kocheise, Alina Busch, Kornelius Schulze, Gabriel Allo, Dirk-Thomas Waldschmidt, Maryam Barsch, Bertram Bengsch, Michael Quante, Maria A Gonzalez-Carmona, Vera Himmelsbach, Fabian Finkelmeier, Roman Kloeckner, Peter Schirmacher, Jens U Marquardt, Carolin Zimpel","doi":"10.1002/ueg2.12656","DOIUrl":"https://doi.org/10.1002/ueg2.12656","url":null,"abstract":"<p><strong>Background: </strong>Combined Immuno-chemotherapy consisting of gemcitabine, cisplatin and the programmed death-ligand one inhibitor durvalumab (GCD) is the new standard of care for patients with biliary tract cancers (BTC) based on positive results of the TOPAZ-1 study.</p><p><strong>Objective: </strong>We here evaluated the efficacy and safety of GCD for BTC in a German multicenter real-world patient cohort.</p><p><strong>Methods: </strong>Patients with BTC treated with GCD from 9 German centers were included. Clinicopathological baseline parameters, overall survival (OS), response rate and adverse events (AEs) were retrospectively analyzed. The prognostic impact was determined by Kaplan-Meier analyses and Cox regression models.</p><p><strong>Results: </strong>A total of 165 patients treated with GCD between 2021 and 2024 were included in the study. Median OS and median progression-free survival were 14 months (95% CI 10.3-17.7) and 8 months (95% CI 6.8-9.2), respectively. The best overall response rate was 28.5% and disease control rate was 65.5%. While extrahepatic and intrahepatic BTC showed similar outcomes, mOS was significantly shorter in patients with gall bladder cancer (GB-CA) with 9 months (95% CI 5.5-12.4; p = 0.02). In univariate analyses age ≥70 years, Eastern Cooperative Oncology Group (ECOG) performance status (PS) ≥1, status post cholecystectomy, GB-CA and high baseline CRP values were significantly associated with OS. ECOG PS ≥ 1 and GB-CA remained independent prognostic factors for OS in multivariable cox regression analysis. AEs have been reported in 130 patients (78.8%), including 149 grade 3-4 AEs (25.5%). One patient died of severe infectious pneumonia. Immune-related (ir)AEs occurred in 17 patients (10.3%), including 9 grade 3-4 irAEs (2.2%), which led to treatment interruption in 4 patients.</p><p><strong>Conclusions: </strong>Immuno-chemotherapy in patients with BTC was feasible, effective and safe in a real-life scenario. Our results were comparable to the phase 3 clinical trial results (TOPAZ-1). Reduced efficacy was noted in patients with GB-CA and/or a reduced performance status that warrants further investigation.</p>","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guideline for the assessment and management of gastrointestinal symptoms following colorectal surgery-A UEG/ESCP/EAES/ESPCG/ESPEN/ESNM/ESSO collaboration. Part II-Good practice guidance | sequelae to benign diseases. 结直肠手术后胃肠道症状的评估和管理指南--UEG/ESCP/EAES/ESPCG/ESPEN/ESNM/ESSO 合作项目。第二部分--良性疾病后遗症的良好实践指南。
IF 6 2区 医学
United European Gastroenterology Journal Pub Date : 2024-09-14 DOI: 10.1002/ueg2.12659
Anke H C Gielen,
{"title":"Guideline for the assessment and management of gastrointestinal symptoms following colorectal surgery-A UEG/ESCP/EAES/ESPCG/ESPEN/ESNM/ESSO collaboration. Part II-Good practice guidance | sequelae to benign diseases.","authors":"Anke H C Gielen,","doi":"10.1002/ueg2.12659","DOIUrl":"https://doi.org/10.1002/ueg2.12659","url":null,"abstract":"","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":null,"pages":null},"PeriodicalIF":6.0,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142250445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fecal urgency and incontinence in inflammatory bowel disease perceived by physician and patient: Results from the Swiss fecal urgency survey. 医生和患者对炎症性肠病患者排便急迫和失禁的看法:瑞士粪便紧迫感调查结果。
IF 5.8 2区 医学
United European Gastroenterology Journal Pub Date : 2024-09-08 DOI: 10.1002/ueg2.12657
Nadia Wespi, Stephan Vavricka, Stephan Brand, Patrick Aepli, Emanuel Burri, Benjamin Misselwitz, Frank Seibold, Petr Hruz, Laurent Peyrin-Biroulet, Alain Schoepfer, Luc Biedermann, Christiane Sokollik, Gerhard Rogler, Thomas Greuter
{"title":"Fecal urgency and incontinence in inflammatory bowel disease perceived by physician and patient: Results from the Swiss fecal urgency survey.","authors":"Nadia Wespi, Stephan Vavricka, Stephan Brand, Patrick Aepli, Emanuel Burri, Benjamin Misselwitz, Frank Seibold, Petr Hruz, Laurent Peyrin-Biroulet, Alain Schoepfer, Luc Biedermann, Christiane Sokollik, Gerhard Rogler, Thomas Greuter","doi":"10.1002/ueg2.12657","DOIUrl":"https://doi.org/10.1002/ueg2.12657","url":null,"abstract":"<p><strong>Introduction: </strong>Although increasingly appreciated, little is known about the prevalence of fecal urgency, fecal incontinence and differences between patients' and physicians' perception in inflammatory bowel disease (IBD).</p><p><strong>Methods: </strong>We performed an online patient and physician survey to evaluate the assessment, prevalence and impact of fecal urgency and incontinence in IBD.</p><p><strong>Results: </strong>A total of 593 patients (44.0% ulcerative colitis (UC), 53.5% Crohn's disease (CD), 2.2% indeterminate colitis, 2 not specified) completed the survey (65.8% females, mean age 47.1 years). Fecal urgency was often reported (UC: 98.5%, CD: 96.2%) and was prevalent even during remission (UC: 65.9%, CD: 68.5%). Fecal urgency considerably impacted daily activities (visual analog scale [VAS] 5, IQR 3-8). Yet, 22.8% of patients have never discussed fecal urgency with their physicians. Fecal incontinence was experienced by 44.7% of patients and 7.9% on a weekly basis. Diapers/pads were required at least once a month in 20.4% of patients. However, 29.7% of patients never talked with their physician about fecal incontinence. UC was an independent predictor for the presence of moderate-severe fecal urgency (OR 1.65, 95% CI 1.13-2.41) and fecal incontinence (OR 1.77, 95% CI 1.22-2.59). All physicians claimed to regularly inquire about fecal urgency and incontinence. However, the impact of these symptoms on daily activities was overestimated compared with the patient feedback (median VAS 8 vs. 5, p = 0.0113, and 9 vs. 5, p = 0.0187).</p><p><strong>Conclusions: </strong>Fecal urgency and incontinence are burdensome symptoms in IBD, with a similar prevalence in UC and CD. A mismatch was found between the physician and patient perception. These symptoms should be addressed during outpatient visits.</p>","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142155004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organic versus functional dichotomy in gastroenterology: Are we ready to move the needle? 胃肠病学中的器质性与功能性二分法:我们准备好了吗?
IF 5.8 2区 医学
United European Gastroenterology Journal Pub Date : 2024-09-01 Epub Date: 2024-05-17 DOI: 10.1002/ueg2.12588
Daniel Keszthelyi
{"title":"Organic versus functional dichotomy in gastroenterology: Are we ready to move the needle?","authors":"Daniel Keszthelyi","doi":"10.1002/ueg2.12588","DOIUrl":"10.1002/ueg2.12588","url":null,"abstract":"","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11497647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between pancreatic adenocarcinoma risk and concentration of organochlorine pesticides in adipose tissue and urine: A targeted-screening analysis case-control study (PESTIPAC). 胰腺癌风险与脂肪组织和尿液中有机氯农药浓度之间的关系:一项有针对性的筛查分析病例对照研究(PESTIPAC)。
IF 5.8 2区 医学
United European Gastroenterology Journal Pub Date : 2024-09-01 Epub Date: 2024-08-08 DOI: 10.1002/ueg2.12602
Mathias Brugel, Sidonie Callon, Claire Carlier, Koceila Lamine Amroun, Damien Botsen, Reza Kianmanesh, Marine Perrier, Tullio Piardi, Yohann Renard, Rami Rhaiem, Souleiman El Balkhi, Olivier Bouché
{"title":"Association between pancreatic adenocarcinoma risk and concentration of organochlorine pesticides in adipose tissue and urine: A targeted-screening analysis case-control study (PESTIPAC).","authors":"Mathias Brugel, Sidonie Callon, Claire Carlier, Koceila Lamine Amroun, Damien Botsen, Reza Kianmanesh, Marine Perrier, Tullio Piardi, Yohann Renard, Rami Rhaiem, Souleiman El Balkhi, Olivier Bouché","doi":"10.1002/ueg2.12602","DOIUrl":"10.1002/ueg2.12602","url":null,"abstract":"<p><strong>Background: </strong>Knowledge about environmental pancreatic adenocarcinoma (PA) risk factors, including pesticide exposure, remains limited. Organochlorine (OC) accumulates in adipose tissue and can help reflect long-term exposure.</p><p><strong>Patients and methods: </strong>Age and body mass index (BMI) of patients with PA were matched with those undergoing a surgery for a benign disease on age and BMI (1:1). Targeted analyses screened 345 pesticides and metabolites, including 29 OC, in adipose tissue and urine samples. The primary aim was to investigate the association between organochlorine concentrations in visceral fat or urine, and PA. Adjusted conditional logistic regressions were carried out accounting for multiple testing.</p><p><strong>Results: </strong>Trans-nonachlor (odds ratio [OR] = 1.325, 95% confidence interval [CI] [1.108-1.586]), cis-nonachlor (OR = 15.433, 95% CI [2.733-87.136]), Mirex (OR = 2.853, 95% CI [1.213-6.713]) and 4,4 DDE (OR = 1.019, 95% CI [1.005-1.034]) in fat and a greater number of positive samples (OR = 1.758 95% CI [1.11-2.997]) were significantly associated with higher odds of PA. In contrast, as awaited, urine samples did not yield any statistically significant associations for all tested pesticides.</p><p><strong>Conclusion: </strong>Some OCs were associated with higher odds of PA. The underlying mechanisms of pancreatic aggression need to be investigated to refine these findings.</p><p><strong>Trial registration: </strong>Clinicaltrials.gov NCT04429490.</p>","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11497671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anticipating pancreatic cancer diagnosis through early computerised tomography findings: An ongoing holy quest. 通过早期计算机断层扫描结果预测胰腺癌诊断:持续不断的神圣探索。
IF 5.8 2区 医学
United European Gastroenterology Journal Pub Date : 2024-09-01 Epub Date: 2024-07-05 DOI: 10.1002/ueg2.12575
J L Van Laethem, M A Bali
{"title":"Anticipating pancreatic cancer diagnosis through early computerised tomography findings: An ongoing holy quest.","authors":"J L Van Laethem, M A Bali","doi":"10.1002/ueg2.12575","DOIUrl":"10.1002/ueg2.12575","url":null,"abstract":"","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11497711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vedolizumab and new-onset spondyloarthritis: Debunking the myth. 维多单抗与新发脊柱关节炎:揭开神话的面纱。
IF 5.8 2区 医学
United European Gastroenterology Journal Pub Date : 2024-09-01 Epub Date: 2024-07-11 DOI: 10.1002/ueg2.12624
Joana Roseira, Irene Marafini, Nurulamin M Noor
{"title":"Vedolizumab and new-onset spondyloarthritis: Debunking the myth.","authors":"Joana Roseira, Irene Marafini, Nurulamin M Noor","doi":"10.1002/ueg2.12624","DOIUrl":"10.1002/ueg2.12624","url":null,"abstract":"","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11497691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peroral endoscopic myotomy for hypercontractile (Jackhammer) esophagus: A retrospective multicenter series with long-term follow-up. 口周内镜下肌切开术治疗过度收缩食管(Jackhammer):长期随访的多中心回顾性系列研究。
IF 5.8 2区 医学
United European Gastroenterology Journal Pub Date : 2024-09-01 Epub Date: 2024-06-14 DOI: 10.1002/ueg2.12586
David Albers, Mana Witt, John E Pandolfino, Thomas Rösch, Guido Schachschal, Torsten Beyna, Horst Neuhaus, Christian Gerges, Jennis Kandler, Hans-Dieter Allescher, Jan Martinek, Alessandro Repici, Alanna Ebigbo, Helmut Messmann, Brigitte Schumacher, Yuki B Werner
{"title":"Peroral endoscopic myotomy for hypercontractile (Jackhammer) esophagus: A retrospective multicenter series with long-term follow-up.","authors":"David Albers, Mana Witt, John E Pandolfino, Thomas Rösch, Guido Schachschal, Torsten Beyna, Horst Neuhaus, Christian Gerges, Jennis Kandler, Hans-Dieter Allescher, Jan Martinek, Alessandro Repici, Alanna Ebigbo, Helmut Messmann, Brigitte Schumacher, Yuki B Werner","doi":"10.1002/ueg2.12586","DOIUrl":"10.1002/ueg2.12586","url":null,"abstract":"<p><strong>Introduction: </strong>Long-term outcome data are limited for non-achalasia esophageal motility disorders treated by peroral endoscopy myotomy (POEM) as a separate group. We investigated a subset of symptomatic patients with hypercontractile esophagus (Jackhammer esophagus).</p><p><strong>Methods: </strong>Forty two patients (mean age 60.9 years; 57% female, mean Eckardt score 6.2 ± 2.1) treated by primary peroral myotomy for symptomatic Jackhammer esophagus 2012-2018 in seven European centers were retrospectively analyzed; myotomy included the lower esophageal sphincter but did not extend more than 1 cm into the cardia in contrast to POEM for achalasia. Manometry data were re-reviewed by an independent expert. The main outcome was the failure rate defined by retreatment or an Eckardt score >3 after at least two years following POEM.</p><p><strong>Results: </strong>Despite 100% technical success (mean intervention time 107 ± 48.9 min, mean myotomy length 16.2 ± 3.7 cm), the 2-year success rate was 64.3% in the entire group. In a subgroup analysis, POEM failure rates were significantly different between Jackhammer-patients without (n = 22), and with esophagogastric junction outflow obstruction (EGJOO, n = 20) (13.6% % vs. 60%, p = 0.003) at a follow-up of 46.5 ± 19.0 months. Adverse events occurred in nine cases (21.4%). 14 (33.3%) patients were retreated, two with surgical fundoplication due to reflux. Including retreatments, an improvement in symptom severity was found in 33 (78.6%) at the end of follow-up (Eckardt score ≤3, mean Eckardt change 4.34, p < 0.001). EGJOO (p = 0.01) and frequency of hypercontractile swallows (p = 0.02) were predictors of POEM failure. The development of a pseudodiverticulum was observed in four cases within the subgroup of EGJOO.</p><p><strong>Conclusions: </strong>Patients with symptomatic Jackhammer without EGJOO benefit from POEM in long-term follow-up. Treatment of Jackhammer with EGJOO, however, remains challenging and probably requires full sphincter myotomy and future studies which should address the pathogenesis of this variant and alternative strategies.</p>","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11497736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Young GI angle: UEG research fellowship-Benefits of going abroad. Young GI angle:UEG 研究奖学金--出国的好处。
IF 5.8 2区 医学
United European Gastroenterology Journal Pub Date : 2024-09-01 Epub Date: 2024-08-29 DOI: 10.1002/ueg2.12654
Antonio Molinaro, Lucas Wauters
{"title":"Young GI angle: UEG research fellowship-Benefits of going abroad.","authors":"Antonio Molinaro, Lucas Wauters","doi":"10.1002/ueg2.12654","DOIUrl":"10.1002/ueg2.12654","url":null,"abstract":"","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11497723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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