United European Gastroenterology Journal最新文献

{"title":"Microlithiasis-Induced Acute Papillitis Triggers Acute Pancreatitis: Where Do We Go From Here?","authors":"Rolf B Schwarz, Robert C Verdonk, Marc G Besselink","doi":"10.1002/ueg2.70211","DOIUrl":"10.1002/ueg2.70211","url":null,"abstract":"","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":"14 3","pages":"e70211"},"PeriodicalIF":6.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher Colonic Tissue Drug Concentrations of Subcutaneous Compared to Intravenous Administration of Infliximab Therapy in Patients With Inflammatory Bowel Disease.","authors":"X Roblin, S Nancey, K Papamichael, F Mechi, J Ouvrier-Buffet, A L Charlois, A S Peaucelle, L Bastide, A A Berger, M Barrau, A S Cheifetz, G Duru, S Paul","doi":"10.1002/ueg2.70207","DOIUrl":"10.1002/ueg2.70207","url":null,"abstract":"<p><strong>Background: </strong>Intestinal tissue levels of infliximab (IFX) in patients with inflammatory bowel disease (IBD) treated with subcutaneous (SC) therapy have not been previously assessed.</p><p><strong>Objective: </strong>To compare serum and colonic tissue IFX concentrations in IBD patients receiving SC versus intravenous (IV) IFX.</p><p><strong>Methods: </strong>This observational cross-sectional study included IBD patients on stable SC or IV IFX maintenance therapy undergoing routine follow-up colonoscopy. Clinical activity required elevated CDAI or Mayo score plus ≥ 1 biomarker (fecal calprotectin > 250 μg/g or CRP > 5 mg/L). Blood samples and two colonic biopsies were collected for serum and tissue IFX measurements.</p><p><strong>Results: </strong>Thirty-five patients were included. Serum and tissue IFX concentrations were significantly higher in the SC versus IV group (22 μg/mL vs. 9 μg/mL, p < 0.001; 25 μg/g vs. 10 μg/g, p = 0.002). Serum and colonic tissue IFX levels were positively correlated in both cohorts (IV: r = 0.42; p = 0.014; SC: r = 0.43; p = 0.001). Colonic tissue IFX concentrations were higher in patients with mild-moderate endoscopic activity than in those without active disease (p < 0.001). Serum and colonic tissue IFX levels both predicted sustained clinical remission, with optimal thresholds of 14.5 μg/mL (p = 0.015) and 17 μg/g (p < 0.005), respectively. Colonic tissue IFX showed higher predictive accuracy (AUROC 0.82, p = 0.01) than serum (AUROC 0.76, p = 0.045).</p><p><strong>Conclusions: </strong>SC IFX achieved significantly higher serum and colonic tissue concentrations than IV IFX. Colonic tissue IFX levels demonstrated superior clinical relevance and may support future tissue-based therapeutic drug monitoring strategies in IBD.</p>","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":"14 3","pages":"e70207"},"PeriodicalIF":6.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Recommendation to Reality: The Follow-Up Gap in Coeliac Disease.","authors":"Juha Taavela","doi":"10.1002/ueg2.70208","DOIUrl":"10.1002/ueg2.70208","url":null,"abstract":"","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":"14 3","pages":"e70208"},"PeriodicalIF":6.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147504915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IPMN Management, Time to Move Beyond Surgical Thresholds.","authors":"Gabriele Capurso, Stefano Crippa","doi":"10.1002/ueg2.70217","DOIUrl":"https://doi.org/10.1002/ueg2.70217","url":null,"abstract":"","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":"14 3","pages":"e70217"},"PeriodicalIF":6.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13089681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147718077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Bone Disease in Coeliac Disease: Protecting Bone, Resources, or Both?","authors":"Francesco Tovoli, Alessandro Granito, Guido Zavatta","doi":"10.1002/ueg2.70213","DOIUrl":"10.1002/ueg2.70213","url":null,"abstract":"","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":"14 3","pages":"e70213"},"PeriodicalIF":6.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13045754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Changing Landscape of Chronic Pancreatitis Research Trajectories Over Two Decades: A Global Meta-Analysis Using MeSH Terms.","authors":"Ling-Ying Jiang, Chao Wu, Kıvanç Görgülü, Yan-Wei Lv, Hana Algül, Chao Han, Liang-Hao Hu","doi":"10.1002/ueg2.70200","DOIUrl":"10.1002/ueg2.70200","url":null,"abstract":"<p><strong>Objectives: </strong>Significant progress has been made in research on chronic pancreatitis (CP). It is essential to analyze recent trends in this field to guide future clinical investigations.</p><p><strong>Methods: </strong>Publications related to CP research from 2000 to 2023 were retrieved from PubMed. An analysis was conducted on Medical Subject Headings (MeSH) terms, publication dates, and affiliations. For MeSH terms with a frequency greater than 30 times, co-occurrence analysis was performed to demonstrate the overall trend of CP research. For those that occurred more than 200 times, heat maps, 3D surface maps, and Ribbon Charts were created to illustrate the trend of changes every 2 years.</p><p><strong>Results: </strong>A total of 14,260 publications with 6775 MeSH terms from 2000 to 2023 were retrieved, and six clusters were obtained from the co-occurrence analysis. From 2000 to 2023, 35 MeSH terms with decreasing trends and 7 MeSH terms with increasing trends (MH-I) were selected to create a heat map. 7 MH-I were \"signal transduction,\" \"inflammation,\" \"quality of life,\" \"diabetes mellitus, type 2,\" \"exocrine pancreatic insufficiency,\" \"islets of Langerhans transplantation,\" and \"transplantation, autologous.\"</p><p><strong>Conclusion: </strong>The 21^st century has witnessed CP research being propelled by both basic science and clinical research. Pathogenesis research focuses on signal transduction, while clinical research mainly focuses on the CP patients' quality of life, including pain, endocrine and exocrine function of the pancreas, among which pancreatic islet autograft transplantation is currently a hot topic. Emerging research topics such as stem cells and gut microbiota offer novel approaches for CP therapy.</p>","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":"14 3","pages":"e70200"},"PeriodicalIF":6.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147532912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Joint Global Epidemiology of Pancreatic Cancer and Pancreatitis: Co-Occurrence Patterns, Shared Risk Factors, and Projections to 2040.","authors":"Laiang Yao, Cuiyue Wang, Fansheng Meng, Shuai Shao, Xiangming Xu","doi":"10.1002/ueg2.70209","DOIUrl":"10.1002/ueg2.70209","url":null,"abstract":"<p><strong>Background: </strong>Pancreatic cancer and pancreatitis cause substantial mortality and morbidity, yet their joint global burden, epidemiology and determinants are rarely assessed together. We quantified their joint incidence burden, identified co-occurrence patterns, and examined shared risk exposures across countries.</p><p><strong>Methods: </strong>Incidence rates for both diseases among adults aged ≥ 25 years across 204 countries and territories were obtained from the Global Burden of Disease (GBD) 2021 study. Temporal trends were assessed through estimated annual percent changes (EAPC). Country-level co-occurrence clusters were identified using Gaussian mixture modeling. Random forest models with Shapley additive explanations were used to investigate associated risk exposures. Non-seasonal time-series models were used to forecast incidence to 2040.</p><p><strong>Results: </strong>High-income countries predominantly clustered as dual-high for both conditions and showed modest to rapidly increasing incidence, whereas most sub-Saharan African countries were dual-low and largely stable. Many middle-SDI (Sociodemographic index) settings remained low but increased moderately over time. Smoking, alcohol use, high body-mass index, and diets high in red and processed meat were shared risk factors, with higher exposure levels in high-SDI regions. Projections indicate that pancreatic cancer incidence will continue to rise globally through 2040, driven mainly by high- and high-middle SDI regions, while pancreatitis incidence will remain comparatively stable.</p><p><strong>Conclusion: </strong>Co-occurrence of pancreatic cancer and pancreatitis follows a strong sociodemographic gradient that parallels the distribution of modifiable risk exposures. Integrated strategies combining targeted surveillance with lifestyle and metabolic risk reduction are needed to mitigate the growing joint burden of pancreatic diseases.</p>","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":"14 3","pages":"e70209"},"PeriodicalIF":6.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13066764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147532872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Reducing Post-Endoscopy Upper Gastrointestinal Cancer-Less Is More?","authors":"Yuichi Mori, Tony C Tham","doi":"10.1002/ueg2.70218","DOIUrl":"10.1002/ueg2.70218","url":null,"abstract":"","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":"14 3","pages":"e70218"},"PeriodicalIF":6.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13091542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147718064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"For Intermediate-Size Sessile Serrated Lesions, Durable Clearance Should Remain the Decisive Endpoint.","authors":"Chengqian Ye, Guosheng Lin, Qingjie Wu, Zhaochu Wang","doi":"10.1002/ueg2.70219","DOIUrl":"10.1002/ueg2.70219","url":null,"abstract":"","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":"14 3","pages":"e70219"},"PeriodicalIF":6.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Endoscopic Ultrasound and Multidisciplinary Team Evaluation on the Management of Pancreatic Cystic Lesions.","authors":"Mohamad Dbouk, Osama Altayar, Mark J Hoegger, Juan Reyes Genere, Arvind Rengarajan, Vincent M Mellnick, Anup S Shetty, Linda Chu, Atif Zaheer, Ghazal Zandieh, Vladimir Kushnir, Gabriel Lang, Michael Goggins, William Hawkins, Adeel Khan, William Burns, Kelly Lafaro, Kian-Huat Lim, Katrina Pederson, Elham Afghani, Koushik Das","doi":"10.1002/ueg2.70212","DOIUrl":"https://doi.org/10.1002/ueg2.70212","url":null,"abstract":"<p><strong>Background: </strong>Retrospective evaluations of multidisciplinary team (MDT) review of pancreatic cystic lesions (PCL) demonstrate improved PCL management. Endoscopic ultrasound (EUS) evaluates PCL for worrisome features; however, its influence on MDT is unclear and may be attenuated by anchoring/confirmation bias. We aimed to evaluate the impact of EUS and the overall performance of MDT evaluation of PCL.</p><p><strong>Methods: </strong>Four mock MDT sessions at two institutions were presented imaging from 40 consecutive PCL cases (20 \"high-risk\" with advanced neoplasia, 20 \"low-risk\" with pathologic low-grade dysplasia or ≥ 3 years of non-progression on surveillance), with and without upfront EUS/FNA (cytology, CEA, Amylase), in a randomized, crossover design. Group 1 adjudicated without EUS, Group 2 adjudicated with EUS, and Group 3 adjudicated with EUS after initially adjudicating without it.</p><p><strong>Results: </strong>The cohort included branch-duct (n = 20), mixed type (n = 6), and main duct (n = 4) IPMN, MCN (n = 5), and non-mucinous PCL (n = 5). Group 2 (EUS) correctly identified mucinous PCL with 97% sensitivity and 70% specificity, significantly higher than Group 1 (No EUS) (Sensitivity 91%, Specificity 20%; p = 0.04). Group 3 (Unblinded to EUS) performed significantly worse in mucinous PCL identification compared with Group 2, indicating cognitive bias (Sensitivity 97%, Specificity 10% (p = 0.0003)). Group 2 correctly identified high-risk PCL that required surgical intervention with 85% sensitivity and 85% specificity, significantly higher than Group 1 (Sensitivity 60%, Specificity 75%; p = 0.0016) and Group 3 (Sensitivity 73%, Specificity 80%, p = 0.0485).</p><p><strong>Conclusion: </strong>While susceptible to cognitive bias, EUS significantly improves MDT assessment of PCL. MDT establishes a high bar for iterative additions of biomarkers to PCL analysis.</p>","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":"14 3","pages":"e70212"},"PeriodicalIF":6.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13103870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}