Disorders of the gut-brain interaction among European people with obesity: Prevalence and burden of compatible symptoms.

IF 5.8 2区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

United European Gastroenterology Journal Pub Date : 2025-04-07 DOI:10.1002/ueg2.12700

Chloé Melchior, Jóhann P Hreinsson, Jan Tack, Jutta Keller, Qasim Aziz, Olafur S Palsson, Shrikant I Bangdiwala, Ami D Sperber, Magnus Simrén, Jean-Marc Sabaté

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引用次数: 0

Abstract

Introduction: The prevalence of disorders of the gut-brain interaction (DGBI) among people with obesity in the general population is unknown. Our aim was to assess the prevalence of DGBI among obese subjects in the general population in comparison with normal or overweight subjects, as well as exploring factors associated with DGBI in obesity in Europe.

Methods: We included subjects who completed the internet-based survey of the Rome Foundation Global Epidemiology study in 11 European countries. Obesity was defined as a BMI>30 kg/m² and participants were divided into three classes: 1: BMI 30 to <35 kg/m², 2: BMI 35 to <40 kg/m², and 3: BMI 40 kg/m² or higher. The prevalence of symptoms compatible with DGBI was reported and compared between obese and normal or overweight (BMI between 18.5 and <30 kg/m²) participants. Factors potentially associated with DGBI and obesity including demographics, psychological distress (PHQ-4), non-GI somatic symptoms (PHQ-12), quality of life (PROMIS-10), healthcare access, medication and food consumption were assessed.

Results: We included 20,117 participants in our analysis. The prevalence of obesity was 17.8% (95% CI 17.3, 18.4), with 12.6%, 3.7% and 1.6% in obesity classes 1, 2 and 3, respectively. The prevalence of any DGBI was 44.2% in the obese group versus 39.6% in the normal or overweight group (OR = 1.20 (1.12, 1.30)), with all DGBI being more prevalent in the obese versus normal or overweight group, with the exception for functional constipation where the opposite pattern was seen. Female sex, higher level of psychological distress and more severe non-GI somatic symptoms were seen in the group with DGBI associated with obesity.

Conclusions: Symptoms compatible with DGBI are common among European people with obesity in the general population and are linked with certain demographic and disease-related factors. This should be acknowledged in the management of patients with obesity.

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欧洲肥胖人群肠脑相互作用障碍：患病率和相容症状负担

简介：肠脑相互作用障碍（DGBI）在肥胖人群中的患病率尚不清楚。我们的目的是评估与正常或超重人群相比，肥胖人群中DGBI的患病率，并探索欧洲肥胖人群中DGBI的相关因素。方法：我们纳入了在11个欧洲国家完成罗马基金会全球流行病学研究网络调查的受试者。肥胖被定义为BMI超过30 kg/m2，参与者被分为三类：1:BMI 30至2,2:BMI 35至2,3:BMI 40 kg/m2或更高。报告了与DGBI相容的症状的患病率，并比较了肥胖和正常或超重（BMI在18.5和2之间）参与者。评估可能与DGBI和肥胖相关的因素，包括人口统计学、心理困扰（PHQ-4）、非gi躯体症状（PHQ-12）、生活质量（promise -10）、医疗保健获取、药物和食物消费。结果：我们在分析中纳入了20117名参与者。肥胖患病率为17.8% (95% CI 17.3, 18.4)，其中肥胖1、2和3级分别为12.6%、3.7%和1.6%。肥胖组DGBI患病率为44.2%，而正常或超重组为39.6% (or = 1.20(1.12, 1.30))，所有DGBI在肥胖组比正常或超重组更普遍，但功能性便秘除外，其模式相反。在与肥胖相关的DGBI组中，女性、更高程度的心理困扰和更严重的非胃肠道躯体症状。结论：与DGBI相容的症状在欧洲普通人群中的肥胖人群中很常见，并且与某些人口统计学和疾病相关因素有关。在肥胖患者的管理中应认识到这一点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

United European Gastroenterology Journal GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

10.50

自引率

13.30%

发文量

147

期刊介绍： United European Gastroenterology Journal (UEG Journal) is the official Journal of the United European Gastroenterology (UEG), a professional non-profit organisation combining all the leading European societies concerned with digestive disease. UEG’s member societies represent over 22,000 specialists working across medicine, surgery, paediatrics, GI oncology and endoscopy, which makes UEG a unique platform for collaboration and the exchange of knowledge.