Urology最新文献 - Book学术

GLP-1 Agonist Use Among Men With Localized Prostate Cancer: A Narrative Review and Rationale for Prospective Clinical Trials. GLP-1激动剂在局限性前列腺癌患者中的应用：前瞻性临床试验的叙述回顾和基本原理。

IF 2.1 3区医学

Urology Pub Date : 2025-05-29 DOI: 10.1016/j.urology.2025.04.056

Andrew Fang, Daniel E Frigo, Andrew Hahn, Zayd Razouki, Jessica Hwang, Efstratios Koutroumpakis, Tarek Lawen, Matthew Smith, Jill Hamilton-Reeves, John DiGiovanni, Noel Higgason, Rebekka S Garcia, Brian F Chapin, Curtis Pettaway, Lisly Chery, Patricia Troncoso, Christopher Logothetis, Carrie R Daniel, Peng Wei, Justin R Gregg

引用次数: 0

Letter to the Editor on "Association between Kidney Stones and Subsequent Risk of Upper Tract Urothelial Carcinoma: A Systematic Review and Meta-Analysis". 致编辑的信“肾结石与上尿路上皮癌后续风险之间的关系：系统回顾和荟萃分析”。

IF 2.1 3区医学

Urology Pub Date : 2025-05-28 DOI: 10.1016/j.urology.2025.05.050

Samir Haj Bloukh

引用次数: 0

Topic Mapping to Inform Content to Discuss in Shared Decision-Making for Prostate Cancer. 主题映射为前列腺癌共同决策提供讨论内容。

IF 2.1 3区医学

Urology Pub Date : 2025-05-28 DOI: 10.1016/j.urology.2025.05.053

Nadine A Friedrich, Paul Kokorowski, Michael Luu, Antwon Chaplin, Reva Polineni, Alex Shiang, Dong Shin, Judy Tan, Stephen J Freedland, Brennan Spiegel, Timothy J Daskivich

{"title":"Topic Mapping to Inform Content to Discuss in Shared Decision-Making for Prostate Cancer.","authors":"Nadine A Friedrich, Paul Kokorowski, Michael Luu, Antwon Chaplin, Reva Polineni, Alex Shiang, Dong Shin, Judy Tan, Stephen J Freedland, Brennan Spiegel, Timothy J Daskivich","doi":"10.1016/j.urology.2025.05.053","DOIUrl":"https://doi.org/10.1016/j.urology.2025.05.053","url":null,"abstract":"Objectives: To develop a framework for shared decision-making (SDM) in prostate cancer (PC) by identifying key topics that are covered during consultations. Although SDM is the guidelines-endorsed standard of care, there is no widely accepted standard for what to discuss during SDM. Previous data suggests content discussed during SDM is highly variable.Methods: We transcribed consultations of 50 men with localized PC across multidisciplinary providers. Analysts extracted quotes related to SDM, thematically coded transcripts using an open coding approach, and aggregated consensus themes into broader categories. Frequency of thematic content at a consultation level was calculated.Results: Of 50 consultations, 39(78%) had at least one quote related to SDM. Three major thematic content areas were identified: description of the decision-making process(35/39, 90%), patient preferences and values(31/39, 79%), and physician preferences(30/39, 77%). Description of the decision-making process, not included in current AUA SDM guidelines, included five sub-content areas: (1)general description of SDM, (2)patient role, (3)physician role, (4)decisions order, and (5)decision-making hazards to avoid. These sub-content areas were further subdivided into detailed areas of content discussed. For example, general description of SDM included describing how to make a decision(69%), endorsing the shared nature of decision making(43%), and the difficulty of treatment decisions(23%).Conclusions: Our topic-mapped framework outlines the major thematic content areas covered in PC SDM, which providers can use to guide SDM discussions with patients. Description of the decision-making process-which is critical to ensuring patients understand their active role in SDM-should be included in future iterations of AUA SDM guidelines.","PeriodicalId":23415,"journal":{"name":"Urology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fecal microbiota transplant is associated with resolution of recurrent urinary tract infection. 粪便菌群移植与复发性尿路感染的解决相关。

IF 2.1 3区医学

Urology Pub Date : 2025-05-28 DOI: 10.1016/j.urology.2025.05.052

Stacy H Jeong, Sandip P Vasavada, Bret Lashner, Glenn T Werneburg

{"title":"Fecal microbiota transplant is associated with resolution of recurrent urinary tract infection.","authors":"Stacy H Jeong, Sandip P Vasavada, Bret Lashner, Glenn T Werneburg","doi":"10.1016/j.urology.2025.05.052","DOIUrl":"https://doi.org/10.1016/j.urology.2025.05.052","url":null,"abstract":"Objective: To investigate the association of fecal microbiota transplant (FMT) therapy, an effective treatment for recurrent C. difficile colitis, with resolution of recurrent UTI (rUTI).Methods: A prospectively accrued database of patients who underwent FMT for recurrent Clostridoides difficile colitis was retrospectively reviewed for individuals with rUTI in the two years prior to FMT. Recurrent UTI status (defined as two UTI episodes in six months or three UTI episodes in one year) and UTI frequency in the two years prior to the FMT were compared to those in the two year follow up period after FMT using the two-tailed Wilcoxin matched pairs signed rank test. A p-value <0.05 was considered statistically significant.Results: Of 11 patients who had rUTI in the two years preceding FMT, no patient had rUTI over the follow up period following FMT (p=0.001). The average number of UTIs in the two years prior to FMT was 3.7 (range 2-6), and the average number of UTIs in the follow up period was 0.27 (range 0-1) (p=0.001). The Kaplan-Meier estimate, the median time to UTI recurrence, was 19.6 months (95% CI: 15.2 - 23.9). There was no marked difference in antibiotic susceptibility profiles before and after FMT.Conclusions: FMT was associated with resolution of rUTI and reduction in UTI frequency in this cohort. The results of this study support the hypothesis that modulation of the gut microbiome may reduce rUTI risk, and support a clinical trial to further assess the safety and efficacy of FMT for rUTI.","PeriodicalId":23415,"journal":{"name":"Urology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor on "Deep Learning Algorithms to Predict Differential Renal Function <40% in Unilateral Hydronephrosis Based on Key Parameters of Urinary Tract Ultrasound". 关于“基于尿路超声关键参数预测单侧肾积水差异肾功能<40%的深度学习算法”的致编辑信。

IF 2.1 3区医学

Urology Pub Date : 2025-05-28 DOI: 10.1016/j.urology.2025.05.044

Yuekun Fang, Shengyi Chen, Bin Cheng

引用次数: 0

Self-Efficacy in Managing Female Sexual Dysfunction in Interstitial Cystitis. 自我效能感在处理间质性膀胱炎女性性功能障碍中的作用。

IF 2.1 3区医学

Urology Pub Date : 2025-05-27 DOI: 10.1016/j.urology.2025.05.010

Susanna Sutherland, A Grace Kelly, Elizabeth G Walsh, Roger R Dmochowski, Rochell Burton, Lindsey C McKernan

{"title":"Self-Efficacy in Managing Female Sexual Dysfunction in Interstitial Cystitis.","authors":"Susanna Sutherland, A Grace Kelly, Elizabeth G Walsh, Roger R Dmochowski, Rochell Burton, Lindsey C McKernan","doi":"10.1016/j.urology.2025.05.010","DOIUrl":"https://doi.org/10.1016/j.urology.2025.05.010","url":null,"abstract":"Objective: To examine relations between clinical features and female sexual dysfunction in a sample of women with Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS), with a focus on sexual self-efficacy, or confidence in ability to manage symptoms. Female sexual dysfunction (FSD) is prevalent in IC/BPS. Several areas of sexual functioning are impacted, including experiences of pain during and after sex which is significantly disruptive to quality of life. Despite evidence that emotional health and FSD relate, less is known about how to address FSD in IC/BPS.Methods: Sixty-eight female participants [m = 43.89 (SD =13.15) years] with IC/BPS reported demographics, diagnostic symptoms of IC/BPS, pain, mood, sexual self-efficacy, and sexual function. Regression explored the relation of urologic symptoms, pain and emotional distress to FSD, and the additional predictive utility of sexual self-efficacy when assessing this relationship.Results: While pelvic and mood symptoms effectively predicted FSD, the addition of sexual self-efficacy to the model produced significant model improvement, such that greater self-efficacy was associated with better sexual functioning, and variance in FSD was no longer predicted by pain or depression.Conclusions: Results emphasize the influential role that confidence in ability to manage symptoms plays in FSD, beyond known influences such as mood or symptom severity. Complementing existing treatment with education or intervention including skills-building to increase patient confidence in ability to manage sexual pain may improve sexual function in IC/BPS. A model of intervention appropriate for physician implementation in the clinical setting is discussed, and potential self-management strategies are reviewed.","PeriodicalId":23415,"journal":{"name":"Urology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to Letter to the Editor from Drs. Yuan, Li and Hu on "Urges to Drink Predict Urine Output Volume in Patients with Kidney Stones". 给编辑的回信。袁、李、胡关于“敦促饮酒预测肾结石患者尿量”的研究。

IF 2.1 3区医学

Urology Pub Date : 2025-05-27 DOI: 10.1016/j.urology.2025.05.054

David E Conroy, Yingjia Liu, Necole M Streeper

引用次数: 0

Safety of Partial and Radical Nephrectomy for Complex Locally Advanced Renal Cell Carcinoma After Neo-Adjuvant Immune Checkpoint Inhibition - Analysis from a Phase 1b Trial (Durvalumab +/- Tremelimumab). 新辅助免疫检查点抑制后，部分和根治性肾切除术治疗复杂的局部晚期肾细胞癌的安全性-来自1b期试验（Durvalumab +/- Tremelimumab）的分析

IF 2.1 3区医学

Urology Pub Date : 2025-05-27 DOI: 10.1016/j.urology.2025.05.023

Jason M Scovell, Brian I Rini, Venkatesh Krishnamurthi, Jihad Kaouk, Christopher J Weight, Moshe C Ornstein, Georges Pascal-Haber, Mohamed Eltemamy, Shilpa Gupta, Steven C Campbell, Joseph Zabell

{"title":"Safety of Partial and Radical Nephrectomy for Complex Locally Advanced Renal Cell Carcinoma After Neo-Adjuvant Immune Checkpoint Inhibition - Analysis from a Phase 1b Trial (Durvalumab +/- Tremelimumab).","authors":"Jason M Scovell, Brian I Rini, Venkatesh Krishnamurthi, Jihad Kaouk, Christopher J Weight, Moshe C Ornstein, Georges Pascal-Haber, Mohamed Eltemamy, Shilpa Gupta, Steven C Campbell, Joseph Zabell","doi":"10.1016/j.urology.2025.05.023","DOIUrl":"https://doi.org/10.1016/j.urology.2025.05.023","url":null,"abstract":"Objective: To determine the surgical safety after neo-adjuvant durvalumab +/- tremelimumab for patients with locally advanced renal rell carcinoma (RCC) METHODS: An open-label phase 1b trial of neoadjuvant durvalumab +/- tremelimumab in locally advanced RCC was performed at two sites between 2016-2020 (NCT02762006). Inclusion criteria included clinical stage T2b-4 and/or N1, M0 disease, ECOG 0-1, and adequate organ function. A total of four cohorts were evaluated. In the neoadjuvant setting, cohort 1 received durvalumab (D) x 1, and cohorts 2, 2a, and 3 received D + Tremelimumab (T) x 1 dose. Cohorts 1-2a also received adjuvant therapy. Pre- and post-surgical patient characteristics were evaluated and descriptive statistics are presented.Results: Twenty-five patients underwent neo-adjuvant therapy prior to radical/partial nephrectomy and twenty-three received adjuvant therapy after surgery. Tumors were surgically complex with the most common RENAL score being 11xh and renal vein thrombus present in 6 patients. Median estimated blood loss was 400cc with 3 patients requiring postoperative transfusion (4 units total). No intraoperative complications occurred. There was note of intraoperative adhesions near the kidney in 4 cases (16%). Three patients required re-admission and 5 Clavien-Dindo complications occurred within 30 days of surgery (2-3b).Conclusions: Surgery for locally advanced renal cell carcinoma is safe for patients after neoadjuvant durvalumab +/- tremelimumab.","PeriodicalId":23415,"journal":{"name":"Urology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analyzing the Patterns of Industry Payments in Urology: A Benchmark Comparison with Other Surgical Specialties. 分析泌尿外科的行业支付模式：与其他外科专业的基准比较。

IF 2.1 3区医学

Urology Pub Date : 2025-05-27 DOI: 10.1016/j.urology.2025.05.043

Daniel Salevitz, Madison Ransdell, Chung-Yon Lin, Gwen Grimsby

{"title":"Analyzing the Patterns of Industry Payments in Urology: A Benchmark Comparison with Other Surgical Specialties.","authors":"Daniel Salevitz, Madison Ransdell, Chung-Yon Lin, Gwen Grimsby","doi":"10.1016/j.urology.2025.05.043","DOIUrl":"https://doi.org/10.1016/j.urology.2025.05.043","url":null,"abstract":"Objective: To examine differences in industry payments across multiple surgical specialties, and to examine differences in payments to pediatric urologists (PU) with other urologic subspecialists (UO).Methods: The 2022 Open Payments dataset was downloaded from the Center for Medicare and Medicaid website. Industry payments were collected for urologists, otolaryngologists (ENT), orthopedic (Ortho), and plastic (Plastics) surgeons for comparison. Descriptive statistics with Kruskal-Wallis and chi-square tests were performed to evaluate payment distributions across these specialties, and between PU and OU.Results: In 2022, industry payments were reported to 9,686 urologists. Ortho received the highest number and dollar amount of payments with 315,664 payments valuing nearly $600 million. Urologists received 207,961 payments at $33.5 million, Plastics with 58,446 at $93 million, and ENT with 70,006 payments and $13.7 million. The specialties had statistically significantly different distribution of payments in total number and amount of money paid (p<0.0001). PU received 906 payments and $162,826, versus OU with 207,055 payments valuing $33.4 million, and the distribution of these payments was also significantly different (p<0.0001).Conclusions: The distribution of payments differed significantly across the surgical subspecialties examined. There was also a staggering difference in industry payments between pediatric urologists and other urologists, which highlights a disparity in interactions between medical device and pharmaceutical companies even within the specialty of Urology.","PeriodicalId":23415,"journal":{"name":"Urology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial Comment on Exploring the Clinical Landscape of Priapism related to Intracavernosal Injection Therapy: Patient Characteristics, Management Patterns, and Erectile Dysfunction Outcomes. 探讨阴茎勃起与海绵体内注射治疗相关的临床情况：患者特征、管理模式和勃起功能障碍结局。

IF 2.1 3区医学

Urology Pub Date : 2025-05-27 DOI: 10.1016/j.urology.2025.05.046

Brittany Berk, Petar Bajic

引用次数: 0