Urology最新文献

{"title":"Recovery of Social Continence and Sexual Function in Men With High-risk Prostate Cancer After Radical Prostatectomy: Results From a Statewide Collaborative","authors":"Daniel Triner ,&nbsp;Kyle Johnson ,&nbsp;Sabir Meah ,&nbsp;Stephanie Daignault-Newton ,&nbsp;Neil Vaishampayan ,&nbsp;Apoorv Dhir ,&nbsp;Corinne Labardee ,&nbsp;Stephanie Ferrante ,&nbsp;Kevin B. Ginsburg ,&nbsp;Brian R. Lane ,&nbsp;Arvin K. George ,&nbsp;Alice Semerjian ,&nbsp;Michigan Urological Surgery Improvement Collaborative","doi":"10.1016/j.urology.2024.06.018","DOIUrl":"10.1016/j.urology.2024.06.018","url":null,"abstract":"<div><h3>Objectives</h3><div>To examine post-operative urinary<span><span> and sexual functional outcomes for men with high-risk prostate cancer<span> (HRPCa) who underwent radical prostatectomy (RP) within the Michigan </span></span>Urological Surgery Improvement Collaborative (MUSIC).</span></div></div><div><h3>Methods</h3><div>We identified patients who underwent RP for HRPCa in MUSIC between 2014 and 2023. HRPCa was defined according to American Urological Association criteria. Patients completed Expanded Prostate Cancer Index Composite (EPIC-26) pre-RP and 3-, 6-, 12-, and 24-months postoperatively. Primary outcomes included social continence<span>, defined as 0-1 pads used daily; and recovery of sexual function, defined as the ability to achieve erections firm enough for intercourse. Multivariable and bivariate analyses were performed to identify factors associated with recovery of social continence and sexual function.</span></div></div><div><h3>Results</h3><div>Around 1323 patients were included in the post-RP urinary continence analysis and 422 men in the sexual function analysis. Fifty-eight percent and 86% of patients achieved social continence at 3- and 12-months post-RP, respectively. Continence recovery was associated with higher baseline EPIC-26 urinary continence scores (OR 1.10, per 5 points, 95% CI 1.06-1.15, <em>P</em> &lt;.001), and negatively associated with increasing age (OR 0.78 per 5-year increase, 95% CI 0.71-0.85 <em>P</em><span> &lt;.001). Fifteen percent of patients had recovery of sexual function at 12-month post-RP. On bivariate analysis, recovery of sexual function was associated with nerve-sparing at time of RP, lower pre-operative PSA, and not receiving post-RP ADT/RT.</span></div></div><div><h3>Conclusion</h3><div>RP for HRPCa has acceptable rates of postoperative social continence. However, post-RP recovery of sexual function remains a challenge. This information has important implications for pre-operative counseling and post-operative follow-up for patients with HRPCa.</div></div>","PeriodicalId":23415,"journal":{"name":"Urology","volume":"193 ","pages":"Pages 125-132"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bladder Embryonal Rhabdomyosarcoma Presenting in the Perinatal Period: Report of Two Consecutive Cases","authors":"Catalina Sánchez B. ,&nbsp;Mandy Rickard ,&nbsp;Avram Denburg ,&nbsp;Adree Khondker ,&nbsp;Furqan Shaikh ,&nbsp;Rodrigo Romao ,&nbsp;Michael E. Chua ,&nbsp;Joana Dos Santos ,&nbsp;Armando J. Lorenzo","doi":"10.1016/j.urology.2024.06.070","DOIUrl":"10.1016/j.urology.2024.06.070","url":null,"abstract":"<div><div>Bladder embryonal rhabdomyosarcomas (ERMS) are malignant soft tissue tumors that rarely present in the perinatal period. Herein, we report 2 cases that were diagnosed in the newborn period (one with concomitant posterior urethral valves [PUV]), managed with chemotherapy and surgical resection to minimize the need for radiation.</div></div>","PeriodicalId":23415,"journal":{"name":"Urology","volume":"193 ","pages":"Pages e85-e88"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Contralateral Disease in Men With Unilateral Lesions on Multiparametric Magnetic Resonance Imaging","authors":"Vyom Sawhney,&nbsp;Richard Huang,&nbsp;William C. Huang,&nbsp;Herbert Lepor,&nbsp;Samir S. Taneja,&nbsp;James Wysock","doi":"10.1016/j.urology.2024.07.009","DOIUrl":"10.1016/j.urology.2024.07.009","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate predictors of contralateral clinically significant prostate cancer (csPCa) in men with biopsy-proven unilateral lesions on magnetic resonance imaging (MRI).</div></div><div><h3>Methods</h3><div>We retrospectively identified men with no prior diagnosis of PCa with unilateral biopsy-confirmed csPCa within PI-RADS 2-5 lesions within our institutional biopsy database. Multivariate logistic regression was used to identify clinical predictors of contralateral disease.</div></div><div><h3>Results</h3><div>Four hundred ninety men met study inclusion criteria, of which 385 men (78.6%) had no contralateral csPCa and 105 men (21.4%) had contralateral csPCa (Fig. 1).</div><div>Prior negative biopsy (OR 0.34 [0.14, 0.75], <em>P</em> = .012), prostate-specific antigen density (OR 18.8 [2.77, 249], <em>P</em> = .017), and tumor location in the transverse plane (“Posterior”: OR 1.93 [1.02, 3.87], <em>P</em> = .048; “Throughout Transverse Plane”: OR 6.56 [2.26, 19.6], <em>P</em> &lt; .001) were significantly associated with contralateral csPCa in multivariate logistic regression models. However, there appear to be no attributes within the MRI-targeted tumor that reliably predict contralateral csPCa (Table 2).</div></div><div><h3>Conclusion</h3><div>Approximately 20% of men with unilateral MRI findings and csPCa on targeted biopsy were found to have contralateral csPCa on systematic biopsy (SB). Prior negative biopsy was associated with a decreased odds of contralateral csPCa. Prostate-specific antigen density and tumor in the posterior aspect of or throughout the transverse plane were associated with increased odds of contralateral csPCA. Consideration of these clinical factors may afford an opportunity to only use SB in cases in which the odds of contralateral csPCa are high.</div></div>","PeriodicalId":23415,"journal":{"name":"Urology","volume":"193 ","pages":"Pages 147-152"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initial Antimicrobial Testing of a Novel Reusable Intermittent Urinary Catheter System and Catheter Reprocessing Device","authors":"Alyssa A. La Bella ,&nbsp;Alex Molesan ,&nbsp;Daniel A. Wollin ,&nbsp;Souvik Paul ,&nbsp;Ana L. Flores-Mireles","doi":"10.1016/j.urology.2024.07.015","DOIUrl":"10.1016/j.urology.2024.07.015","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy of the Aurie System, a preclinical prototype allowing for standardized intermittent catheter (IC) reuse of novel reusable no-touch ICs. Individuals with neurogenic bladder often require single-use ICs to urinate, but urinary tract infection (UTI) is a common cause of morbidity for IC users. Safer no-touch catheters are not easily affordable, and the Aurie System attempts to provide no-touch catheters at a fraction of the price by allowing for standardized and safe IC reuse.</div></div><div><h3>Methods</h3><div>Standard ICs were inoculated with <em>Escherichia coli</em> and <em>Pseudomonas aeruginosa</em> and incubated for 48 hours to assess microbial burden and biofilm formation (the latter using infrared fluorescence imaging). This procedure was repeated with Aurie ICs, focusing on evaluating catheter microbial burden after inoculation and reprocessing with the prototype washer-disinfector. This was repeated with up to 100 cycles to evaluate repetitive use.</div></div><div><h3>Results</h3><div>Standard ICs showed bacterial attachment and biofilm development peaking at 24 hours of incubation. The Aurie catheters produced a similar outcome but, after reprocessing, microbial burden was reduced below the level of detection. Repeat cycles showed pathogen clearance to similar levels. One catheter reached 100 cycles and there was no viable pathogen load after reprocessing.</div></div><div><h3>Conclusion</h3><div>Intermittent urinary catheters, when cleaned inappropriately, can harbor viable bacteria and biofilm. The Aurie System, when used to disinfect novel reusable ICs within a prototype reprocessing device, can reduce microbial burden below level of detection even after 100 cycles. This suggests the Aurie System may be a feasible technology for safe IC reuse.</div></div>","PeriodicalId":23415,"journal":{"name":"Urology","volume":"193 ","pages":"Pages 8-15"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Editorial Comment on “A Single Injection of Platelet-rich Plasma Injection for the Treatment of Stress Urinary Incontinence in Females: A Randomized Placebo-controlled Trial”","authors":"Leah Ashton ,&nbsp;Hannah Nakatsuka ,&nbsp;Colin M. Johnson ,&nbsp;Kimberly Kenne ,&nbsp;Karl J. Kreder ,&nbsp;Ryan Kruse ,&nbsp;Linder Wendt ,&nbsp;Elizabeth B. Takacs ,&nbsp;Annah J. Vollstedt","doi":"10.1016/j.urology.2024.07.030","DOIUrl":"10.1016/j.urology.2024.07.030","url":null,"abstract":"","PeriodicalId":23415,"journal":{"name":"Urology","volume":"193 ","pages":"Page 70"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141767438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment on “The Current Application and Future Potential of Artificial Intelligence in Renal Cancer”","authors":"Betty Wang,&nbsp;Nicholas Heller,&nbsp;Christopher J. Weight","doi":"10.1016/j.urology.2024.08.021","DOIUrl":"10.1016/j.urology.2024.08.021","url":null,"abstract":"","PeriodicalId":23415,"journal":{"name":"Urology","volume":"193 ","pages":"Pages 164-165"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142005360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluoroscopic and CT Cystography Following Robotic Suprapubic Prostatectomy","authors":"Jordan Kassab ,&nbsp;Megan Ngai ,&nbsp;Parth Joshi ,&nbsp;Eric J. Moskowitz","doi":"10.1016/j.urology.2024.08.039","DOIUrl":"10.1016/j.urology.2024.08.039","url":null,"abstract":"","PeriodicalId":23415,"journal":{"name":"Urology","volume":"193 ","pages":"Pages e80-e81"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor on “Long-term Outcomes of Augmentation Cystoplasty in Genitourinary Tuberculosis in Adults: A 12-Year Follow-up Experience at a Tertiary Care Center”","authors":"Giovanni Drocchi ,&nbsp;Guglielmo Mantica ,&nbsp;Carlo Terrone ,&nbsp;André Van der Merwe","doi":"10.1016/j.urology.2024.08.044","DOIUrl":"10.1016/j.urology.2024.08.044","url":null,"abstract":"","PeriodicalId":23415,"journal":{"name":"Urology","volume":"193 ","pages":"Page 249"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment on “Racial/Ethnic and Socioeconomic Disparities and Self-reported Work Productivity in Urinary Incontinence Females Using the National Institute of Diabetes and Digestive and Kidney Diseases Data”","authors":"Oluwarotimi S. Nettey","doi":"10.1016/j.urology.2024.08.035","DOIUrl":"10.1016/j.urology.2024.08.035","url":null,"abstract":"","PeriodicalId":23415,"journal":{"name":"Urology","volume":"193 ","pages":"Page 62"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation not Causation: Looking Back at the History of VUR","authors":"Tenny Zhang,&nbsp;Jeremy Wiygul","doi":"10.1016/j.urology.2024.06.002","DOIUrl":"10.1016/j.urology.2024.06.002","url":null,"abstract":"<div><div><span><span>Vesicoureteral reflux (VUR) is a medical condition where urine flows retrograde from the </span>bladder<span> superiorly, and has traditionally been considered a risk factor for kidney damage in children. However, over the past decade and a half, several </span></span>randomized controlled trials have shown the risk of kidney damage in the presence of VUR is low, and any treatment for VUR does not change that risk. Here, we review the history of VUR as a pathologic condition, how the interpretation of that history led to possibly overestimating the danger, and how current findings should be seen in the context of that history.</div></div>","PeriodicalId":23415,"journal":{"name":"Urology","volume":"193 ","pages":"Pages 231-236"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}