Urolithiasis最新文献_第8页

Unveiling urinary microbiota dysbiosis in urolithiasis: beyond gut microbiome. 揭示尿石症的泌尿微生物群失调：超越肠道微生物群。

IF 2 2区医学

Urolithiasis Pub Date : 2025-06-23 DOI: 10.1007/s00240-025-01795-0

Yuxuan Song, Jingyi Chen, Ning Chen, Tao Xu

引用次数: 0

Comparison of two different tract dilatation techniques in percutaneous nephrolithotomy: Amplatz versus balloon. 两种不同的肾道扩张技术在经皮肾镜取石术中的比较：安铂与球囊。

IF 2 2区医学

Urolithiasis Pub Date : 2025-06-21 DOI: 10.1007/s00240-025-01800-6

Güven Erbay, Ahmet Şanlı

{"title":"Comparison of two different tract dilatation techniques in percutaneous nephrolithotomy: Amplatz versus balloon.","authors":"Güven Erbay, Ahmet Şanlı","doi":"10.1007/s00240-025-01800-6","DOIUrl":"10.1007/s00240-025-01800-6","url":null,"abstract":"The aim of this study was to compare the efficacy and safety of the Amplatz dilation (AD) and balloon dilation (BD) techniques for tract dilation during percutaneous nephrolithotomy (PCNL). We retrospectively reviewed medical records of clinical data from 345 patients who underwent PCNL at the Urology Clinic of Karaman Training and Research Hospital from February 2021 to January 2025. AD was used in 119 patients and BD was used in 171 patients. Hemoglobin decrease, blood transfusion rate, glomerular filtration rate (GFR) decrease, total operation time, hospital stay, fluoroscopy time, nephrostomy removal time, success rate and complications were compared between the two groups. Similar baseline characteristics were observed in the two groups. Compared to the BD group, the operation time (40 m vs. 54 m, p = 0.002), fluoroscopy time (150 s vs. 265 s, p < 0.001) and hospital stay (4 day vs. 5 day, p = 0.009) were significantly higher in the AD group. Hemoglobin decrease (1.8 g/dl vs. 1.0 g/dl, p: 0.012) and blood transfusion rate (15.1% vs. 8.7%, p:0.036) were observed higher in the AD group than in the BD group. Additionally success rate rate was higher for BD group than Amplatz group (90.35% vs. 84.62%, p:0.015). The complication rates based on Clavien classification such as urine leakage, renal function alteration and renal pelvic perforation were similar in two groups with no significant difference. Only bleeding and blood transfusion requirement were observed to be statistically significantly higher in the AD group (14.2% vs. 8.7%, p:0.042). BD appears to be a faster, more effective, safer and superior dilatation technique than AD, whereas BD was significantly more expensive than AD. Further confirmatory research is necessary to confirm and validate these findings.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"123"},"PeriodicalIF":2.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Symptomatic urinary stone disease in Kazakhstan: hospitalization trends from the national electronic healthcare system (2014-2021). 哈萨克斯坦的症状性尿路结石病：来自国家电子医疗系统的住院趋势（2014-2021年）

IF 2 2区医学

Urolithiasis Pub Date : 2025-06-21 DOI: 10.1007/s00240-025-01788-z

Makhmud Suleiman, Yesbolat Sakko, Aidana Mustafa, Chingiz Baimenov, Ulanbek Zhanbyrbekuly, Abduzhappar Gaipov

{"title":"Symptomatic urinary stone disease in Kazakhstan: hospitalization trends from the national electronic healthcare system (2014-2021).","authors":"Makhmud Suleiman, Yesbolat Sakko, Aidana Mustafa, Chingiz Baimenov, Ulanbek Zhanbyrbekuly, Abduzhappar Gaipov","doi":"10.1007/s00240-025-01788-z","DOIUrl":"10.1007/s00240-025-01788-z","url":null,"abstract":"This study aims to investigate the prevalence and trends of USD in Kazakhstan using retrospective data from the Unified National Electronic Health System (UNEHS), spanning from 2014 to 2021. Urinary stone disease (USD), a prevalent urological condition globally, is characterized by the formation of stones in any part of the urinary tract, including the kidneys, ureters, bladder, or urethra. A total of 162,538 hospitalization records from 132,915 patients diagnosed with urolithiasis were analyzed. The study reveals an overall hospitalization prevalence of 1.31 per 1,000 individuals, with the highest rates observed in the southern regions, including Turkestan and Almaty, which align with the geographical characteristics of the \"stone belt.\" Demographic data show a predominance of hospitalizations among individuals aged 50 and above, with a near-equal gender distribution, reflecting a global trend of increasing USD prevalence in women. The urban-rural disparity in hospitalization rates highlights a higher burden in urban areas, potentially due to lifestyle and healthcare access factors. Surgical interventions, particularly ureteral and kidney surgeries, were most frequently performed in urban hospitals. Despite significant healthcare improvements, the study underscores the need for more detailed epidemiological data on USD in Kazakhstan, emphasizing regional, environmental, and socioeconomic factors. The findings provide critical insights for public health strategies and resource allocation aimed at addressing the growing burden of USD in Kazakhstan.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"121"},"PeriodicalIF":2.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reevaluating the management of residual fragments after percutaneous nephrolithotomy. 经皮肾镜取石术后残余碎片处理的再评价。

IF 2 2区医学

Urolithiasis Pub Date : 2025-06-21 DOI: 10.1007/s00240-025-01801-5

Fu-Xiang Lin, Jun-Jun Wu, Zhan-Ping Xu

引用次数: 0

Decoding coffee's chlorogenic acid: genetic-network pharmacology insights on kidney stones. 解读咖啡中的绿原酸：肾结石的遗传网络药理学见解。

IF 2 2区医学

Urolithiasis Pub Date : 2025-06-21 DOI: 10.1007/s00240-025-01776-3

Xin Hou, Han Meng, Demei Ying, Ruiqi Tian, Xuli Guo, Bo Li, Yuzhi Chen

{"title":"Decoding coffee's chlorogenic acid: genetic-network pharmacology insights on kidney stones.","authors":"Xin Hou, Han Meng, Demei Ying, Ruiqi Tian, Xuli Guo, Bo Li, Yuzhi Chen","doi":"10.1007/s00240-025-01776-3","DOIUrl":"10.1007/s00240-025-01776-3","url":null,"abstract":"Chlorogenic acid, a principal bioactive component of coffee, has been proposed to reduce the risk of urinary tract stones, though its underlying mechanisms remain unclear. This study integrated Mendelian randomization and network pharmacology approaches to investigate its potential therapeutic role. A two-step Mendelian randomization analysis was conducted using genome-wide association data from the UK Biobank (coffee intake) and Finngen (upper urinary tract stones), focusing on European populations. Instrumental variables were rigorously selected to ensure valid causal inference. Coffee intake was significantly associated with a reduced risk of urinary tract stones, independent of caffeine levels, and this association remained robust across multiple analytical models. Mediation analysis identified 35 serum proteins potentially involved in this relationship. To explore the molecular mechanisms, two major caffeoylquinic acid isomers in coffee were examined through network pharmacology. ANP32A and its interacting protein APEX1 emerged as key targets, both implicated in oxidative stress and inflammation pathways relevant to stone pathogenesis. These findings suggest that chlorogenic acid may exert protective effects against urinary tract stones by modulating specific proteins and biological pathways, offering insight into potential preventive strategies.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"124"},"PeriodicalIF":2.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CDKN1A attenuates ferroptosis in renal tubular epithelial cells and alleviates calcium oxalate crystal deposition under hyperoxaluric conditions. CDKN1A减轻高血氧条件下肾小管上皮细胞的铁下垂，减轻草酸钙晶体沉积。

IF 2 2区医学

Urolithiasis Pub Date : 2025-06-19 DOI: 10.1007/s00240-025-01793-2

Chujiang He, Zijie Xu, Chaoliang Xu, Minglei Sha, Yi Shao

{"title":"CDKN1A attenuates ferroptosis in renal tubular epithelial cells and alleviates calcium oxalate crystal deposition under hyperoxaluric conditions.","authors":"Chujiang He, Zijie Xu, Chaoliang Xu, Minglei Sha, Yi Shao","doi":"10.1007/s00240-025-01793-2","DOIUrl":"https://doi.org/10.1007/s00240-025-01793-2","url":null,"abstract":"Hyperoxaluria is a recognized risk factor for calcium oxalate nephrolithiasis, often contributing to tubular injury and crystal deposition. This study aimed to investigate the involvement of ferroptosis in hyperoxaluria-induced renal damage and identify key regulatory genes with therapeutic relevance. In vivo and in vitro hyperoxaluria models were established, and ferroptosis-related differentially expressed genes (FRDEGs) were screened via GEO and FerrDb databases. Functional enrichment analyses were conducted using GO and KEGG. CDKN1A was identified as a hub gene through PPI network analysis and subsequently validated in both in vivo and in vitro hyperoxaluria models via RT-qPCR and Western blotting. Concurrently, activation of ferroptosis was observed under hyperoxaluric conditions in both models, as indicated by changes in key ferroptosis markers. In HK-2 cells, CDKN1A expression decreased upon Erastin exposure, and its knockdown enhanced ferroptosis sensitivity, confirming its potential suppressive role. Additionally, analysis of the human dataset GSE73680 revealed a significant upregulation of CDKN1A expression in Randall's plaques from calcium oxalate stone patients and enrichment of ferroptosis-related pathways, consistent with findings from the mouse dataset, supporting its relevance in crystal-associated pathology. Furthermore, candidate compounds potentially activating CDKN1A were predicted based on GTEx-derived expression profiles. These findings suggest that ferroptosis contributes to hyperoxaluria-associated renal epithelial injury and crystal deposition. CDKN1A may exert a protective role by modulating ferroptosis, providing mechanistic insight into oxalate-induced kidney injury and offering a basis for developing strategies to mitigate the risk of calcium oxalate stone formation.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"119"},"PeriodicalIF":2.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation of a machine learning-based prediction model for urinary calculi recurrence. 基于机器学习的尿路结石复发预测模型的开发与验证。

IF 2 2区医学

Urolithiasis Pub Date : 2025-06-19 DOI: 10.1007/s00240-025-01792-3

Jiangkun Guo, Jinhang Zhang, Jinxiao Zhang, Changbao Xu, Xikun Wang, Changwei Liu

引用次数: 0

Infundibulopelvic angle assessment: non-contrast computed tomography vs. traditional methods. 骨盆骨盆角评估：非对比计算机断层扫描与传统方法。

IF 2 2区医学

Urolithiasis Pub Date : 2025-06-17 DOI: 10.1007/s00240-025-01789-y

Xiangqin Gao, Pengxin Wang, Hai-Ling Ding, Jinjin Shan, Si-Jun Wang

{"title":"Infundibulopelvic angle assessment: non-contrast computed tomography vs. traditional methods.","authors":"Xiangqin Gao, Pengxin Wang, Hai-Ling Ding, Jinjin Shan, Si-Jun Wang","doi":"10.1007/s00240-025-01789-y","DOIUrl":"https://doi.org/10.1007/s00240-025-01789-y","url":null,"abstract":"This study aimed to assess the efficacy of a novel methodology for quantifying the infundibulopelvic angle using non-contrast computed tomography with conventional techniques involving intravenous urography or retrograde pyelography. We retrospectively analyzed 35 patients who underwent 64 simultaneous kidney multirow computed tomography scans and intravenous urography or retrograde pyelography. The infundibulopelvic angle values were measured for each patient. A paired t-test was conducted to compare the infundibulopelvic angle measurement values derived from the computed tomography scans with those obtained through intravenous urography or retrograde pyelography. The mean age of the cohort was 48.86 ± 16.21 years, with 26 males and 9 females. The mean infundibulopelvic angle measured via computed tomography was 41.58 ± 16.15°, compared with 42.02 ± 16.96° using traditional methods. The paired t-test results did not indicate a statistically significant difference between the values obtained using the two measurement methods (p > 0.05). Thus, the infundibulopelvic angle measurements derived from non-contrast computed tomography scans were found to be comparable to those obtained using traditional contrast-based imaging techniques. This new methodology offers clinical simplicity, obviates the need for intravenous contrast agents, mitigates financial expenditures, and potentially shortens the duration of hospitalization for patients.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"117"},"PeriodicalIF":2.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal trends and projections of urolithiasis in China and globally from 1990 to 2030: insights from the global burden of disease study 2021. 1990 - 2030年中国和全球尿石症的时间趋势和预测：来自2021年全球疾病负担研究的见解

IF 2 2区医学

Urolithiasis Pub Date : 2025-06-17 DOI: 10.1007/s00240-025-01790-5

Jian Wu

{"title":"Temporal trends and projections of urolithiasis in China and globally from 1990 to 2030: insights from the global burden of disease study 2021.","authors":"Jian Wu","doi":"10.1007/s00240-025-01790-5","DOIUrl":"https://doi.org/10.1007/s00240-025-01790-5","url":null,"abstract":"Urolithiasis is a prevalent urological condition that poses a significant public health challenge worldwide. This study investigates the impact of urolithiasis in China and globally between 1990 and 2021, with projections through 2030. Data on incidence and disability-adjusted life years (DALYs), along with age-standardized rates (ASR), were obtained from the Global Burden of Disease (GBD) 2021. Temporal trends were assessed by utilizing the Estimated Annual Percentage Change (EAPC) and Joinpoint regression analysis. Decomposition analyses were performed to assess the contributions of population growth, aging, and epidemiological changes. Future age-standardized incidence rates (ASIR) were forecast using the Auto-Regressive Integrated Moving Average (ARIMA) model. In 2021, the global number of urolithiasis cases reached 73.12 million, with China accounting for over 18 million. The condition primarily affects males and individuals aged 50-59 years. In both China and globally, the ASR of incidence and DALYs showed a downward trend from 1990 to 2021, with a more pronounced decline in China. However, the total number of incident cases continued to rise. Decomposition analysis revealed that population aging was a major contributor to the increase in cases in China, while global increases were largely driven by population growth. Projections from the ARIMA model indicate a slight further decrease in ASIRs by 2030 for both China and globally. These findings highlight the need for future efforts to focus on optimizing healthcare resources and strengthening primary prevention strategies to mitigate the public health impact of urolithiasis.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"118"},"PeriodicalIF":2.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global research trends in minimally invasive treatments for kidney stones: A bibliometric analysis (2015-2024). 肾结石微创治疗的全球研究趋势：文献计量分析（2015-2024）。

IF 2 2区医学

Urolithiasis Pub Date : 2025-06-16 DOI: 10.1007/s00240-025-01785-2

Tunahan Ates, Ibrahim Halil Sukur, Fesih Ok, Mehmet Gurkan Arikan, Nebil Akdogan

{"title":"Global research trends in minimally invasive treatments for kidney stones: A bibliometric analysis (2015-2024).","authors":"Tunahan Ates, Ibrahim Halil Sukur, Fesih Ok, Mehmet Gurkan Arikan, Nebil Akdogan","doi":"10.1007/s00240-025-01785-2","DOIUrl":"https://doi.org/10.1007/s00240-025-01785-2","url":null,"abstract":"The prevalence of kidney stone disease has been increasing globally, resulting in a rise in minimally invasive treatment methods. Percutaneous nephrolithotomy (PCNL), retrograde intrarenal surgery (RIRS), extracorporeal shock wave lithotripsy (SWL), and endoscopic combined intrarenal surgery (ECIRS) have become standard procedures. This study aims to evaluate global publication trends in this field over the last decade. A bibliometric analysis was conducted using the Web of Science Core Collection database. A total of 3,693 articles published between 2015 and 2024 were analyzed. VOSviewer and Bibliometrix R package were used for data visualization, which included co-authorship networks, keyword co-occurrence analysis, and thematic evolution mapping. However, this analysis did not differentiate between various author roles, which may have influenced the perceived scientific impact of certain researchers, potentially favoring those with strong political or organizational affiliations. China, Turkey, and the USA were the top contributors to publications, with the USA ranking first in total citations. The number of studies has significantly increased over the past decade, indicating a growing trend. The most studied procedures were PCNL and related techniques, followed by RIRS, which has become more popular due to advancements in laser technology and flexible ureteroscopy. Thematic analysis identified trends in postoperative outcomes, complication management, and predictive models for treatment success. Thematic evolution mapping showed a decline in SWL studies, but an increase in interest in ECIRS and multimodal approaches. Minimally invasive kidney stone treatments have advanced significantly, with PCNL remaining the gold standard for large stones and RIRS emerging as a competitive alternative. Future research should focus on optimizing surgical outcomes, integrating AI-based decision support systems, and expanding international collaborations to enhance patient care.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"116"},"PeriodicalIF":2.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0