Updates in Surgery最新文献

{"title":"Preoperative hemoglobin to albumin ratio as a prognostic predictor for patients with colorectal cancer surgery.","authors":"Quan Lv, Si-Qi Rao, Zheng Xiang","doi":"10.1007/s13304-025-02061-z","DOIUrl":"10.1007/s13304-025-02061-z","url":null,"abstract":"<p><p>The purpose of this study was to identify whether the preoperative hemoglobin to albumin ratio (HAR) could predict the prognosis of patients who underwent colorectal cancer (CRC) radical resection. This study enrolled 4018 consecutive CRC patients, calculating HAR as the hemoglobin count divided by albumin count. Patients were divided into the high and low HAR groups based on a cut-off value (0.36). Baseline information and short-term outcomes were compared between the two groups. Logistic and Cox regression analyses were conducted to determine whether HAR was an independent risk factor for CRC. A total of 4018 patients were divided into the high HAR group (3295) and the low HAR group (723). It was found that the high HAR group had more females (P < 0.01), less BMI (P = 0.027), less smoking (P < 0.01), less drinking (P < 0.01), less T2DM (P = 0.027), lower albumin (P < 0.01), higher hemoglobin (P < 0.01) and more rectal cancer (P = 0.026). We found that HAR was an independent risk factor for overall complications (P = 0.012, OR = 1.279, 95% CI 1.055-1.550). Moreover, we found that HAR was an independent risk factor for overall survival (OS) (P = 0.012, HR = 1.300, 95% CI 1.059-1.597) and disease-free survival (DFS) (P = 0.030, HR = 1.231, 95% CI 1.021-1.484). We found that the low HAR group had worse OS in stage III (P = 0.012) CRC than the high HAR group. In terms of DFS, the low HAR group also had worse DFS in stage III (P = 0.01) CRC than the high HAR group. HAR was an independent predictive factor for the prognosis of CRC. Therefore, surgeons should pay attention to hemoglobin and albumin values before surgery.</p>","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":"761-769"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early compliance to enhanced recovery protocol as a predictor of complications after liver surgery.","authors":"Cristina Ciulli, Alessandro Fogliati, Andrea Scacchi, Mauro Alessandro Scotti, Michele Aprigliano, Marco Braga, Fabrizio Romano, Mattia Garancini","doi":"10.1007/s13304-025-02148-7","DOIUrl":"10.1007/s13304-025-02148-7","url":null,"abstract":"<p><strong>Background: </strong>Enhanced Recovery Protocol (ERP) has the purpose of minimising postoperative hospitalisation and expediting the restoration of preoperative patient conditions. This study seeks to investigate the correlation between early non-compliance to postoperative items within ERP and complications in liver surgery.</p><p><strong>Methods: </strong>From January 2019 to December 2022 the ERP was proposed to all consecutive patients undergoing liver surgery. Nasogastric tube removal, resuming oral intake and mobilisation and obtaining an adequate glycaemic control were the postoperative items considered as non-compliance indicators. Data were prospectively collected and analysed.</p><p><strong>Results: </strong>192 patients were included, comprising 99(51.6%) hepatocellular carcinoma, 58(30.2%) colorectal metastasis and 24(12.5%) benign/other pathology. A minimally invasive approach was adopted in 57.3% of cases. Postoperative morbidities occurred in 44.8% of patients, while major complications in 13% of patients. Cirrhosis (p < 0.001), minimally invasive approach (p < 0.004), early oral intake (p < 0.019) and early mobilisation (p < 0.019) significantly correlated to morbidity at multivariate analysis. The complication rate escalated from 26.9% in fully compliant patients, to 58% in patients with two non-compliance indicators and to 91.2% in fully non-compliant patients (p < 0.001). The same trend was confirmed for major complications (p < 0.001).</p><p><strong>Conclusions: </strong>Early non-compliance to ERP postoperative items in liver surgery was significantly associated with overall and major morbidity.</p>","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":"697-703"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-expanding metal stent as a bridge to elective surgery versus immediate emergency surgery in left-sided obstructive colorectal cancer: a retrospective comparative study.","authors":"Engeng Chen, Li Chen, Wei Zhang, Wei Zhou","doi":"10.1007/s13304-025-02187-0","DOIUrl":"10.1007/s13304-025-02187-0","url":null,"abstract":"<p><p>Left-sided colorectal obstruction represents a formidable challenge in colorectal cancer management, often necessitating urgent intervention. Although self-expanding metal stents (SEMS) may act as a bridge to more controlled, elective surgery, the question remains whether this strategy confers measurable advantages over immediate emergency surgery (ES). We conducted a single-center, retrospective study comparing outcomes in patients with left-sided colorectal obstruction who underwent either SEMS placement followed by elective resection or direct ES. Between January 2018 and August 2023, 189 eligible patients were included. Perioperative variables, stoma formation, operative blood loss, and survival rates were documented. Kaplan-Meier analyses were performed to assess overall and disease-free survival in both groups. Of the 99 patients allocated to the SEMS group, 98 achieved successful stent deployment and 89 (91%) proceeded to elective surgery without stent-specific complications. Compared with the 100 patients in the ES group, the SEMS cohort exhibited significantly lower intraoperative blood loss (p < 0.001) and an increased rate of minimally invasive surgeries (p < 0.001). While all patients in the ES group underwent colostomy, only 80 in the SEMS group required ileostomy, and an additional 9 underwent primary anastomosis without a diversion. Ileostomy closure was completed more frequently (p = 0.002) and required less operative time (p < 0.001) than colostomy closure, resulting in reduced hospitalization. No significant differences in overall survival (p = 0.091) or disease-free survival (p = 0.22) were observed between the two treatment groups. In selected patients with obstructing left-sided colorectal cancers, SEMS placement as a bridge to elective surgery may reduce operative trauma, facilitate minimally invasive procedures, and lessen the burden of stoma formation, all without compromising long-term oncologic outcomes. Careful patient selection and strict procedural vigilance are fundamental to ensuring the safe adoption of this strategy.</p>","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":"783-790"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic median arcuate ligament release prior to pancreatoduodenectomy.","authors":"Nicholas Ranellone, Asmita Chopra, Amer Zureikat, Alessandro Paniccia","doi":"10.1007/s13304-024-02056-2","DOIUrl":"10.1007/s13304-024-02056-2","url":null,"abstract":"<p><p>Celiac artery stenosis presents significant risks in pancreatoduodenectomy (PD), including elevated incidences of postoperative hepatic ischemia and clinically relevant pancreatic fistulae. Addressing this stenosis preoperatively is crucial to avoid complication. While stenosis predominantly arises from vasculopathy, managed with stenting, median arcuate ligament syndrome (MALS) is an atypical cause characterized by the median arcuate ligament's extrinsic compression of the celiac artery. Pre-PD surgical release of this ligament has demonstrated nearly 90% success rate in resolving ischemic complications. The celiac axis can be decompressed through open or minimally invasive techniques. Robotic-assisted celiac artery decompression is an attractive approach due to superior visualization and enhanced dexterity, which facilitate the complex dissection required at the diaphragmatic hiatus. The patient is a 49-year-old male diagnosed with pancreatic adenocarcinoma, who also exhibited severe celiac axis stenosis on preoperative imaging. Median arcuate ligament release prior to PD was pivotal in preventing hepatic ischemia consequent to the ligation of the gastroduodenal artery during PD and in re-establishing normal arterial flow to the upper gastrointestinal tract, thereby circumventing otherwise preventable complications. The patient underwent an uneventful robotic PD following the median arcuate ligament release. Robotic-assisted median arcuate ligament release prior to pancreatoduodenectomy is a safe and effective technique for decompression of celiac axis stenosis. This procedure facilitates meticulous dissection while minimizing postoperative complications and helps to circumvent otherwise preventable outcomes.</p>","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":"735-738"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Voiding dysfunction after surgery for colorectal deep infiltrating endometriosis: an updated systematic review and meta-analysis.","authors":"Alexandra Madar, Adrien Crestani, Patrick Eraud, Andrew Spiers, Alin Constantin, Fréderic Chiche, Elise Furet, Pierre Collinet, Cyril Touboul, Benjamin Merlot, Horace Roman, Yohann Dabi, Sofiane Bendifallah","doi":"10.1007/s13304-025-02124-1","DOIUrl":"10.1007/s13304-025-02124-1","url":null,"abstract":"<p><p>To define the risk factors of post-operative voiding dysfunction according to the type of surgical procedure performed. A systematic review through PubMed, the Cochrane Library, and Web of Science databases was performed. The Medical Subject Headings terms aimed for English articles about colorectal endometriosis surgery and voiding dysfunction published until December 26, 2022 were used. The primary outcome was the occurrence of post-operative voiding dysfunction. Secondary outcome was the presence of a persistent voiding dysfunction at 1 month. MeSH terms included ''deep endometriosis'', ''surgery'', or ''voiding dysfunction''. Two reviewers (AM, PE) assessed the quality of each article independently. A Study Quality Assessment Tool was used to provide rating of the quality of the included studies. 22 studies were included in the final analysis. Rectal shaving was associated with less voiding dysfunction than segmental resection (OR 0.33; 95%CI [0.20: 0.54]; I² = 0%; p < 10^-3). No difference was found between rectal shaving and discoid excision (OR 0.44; 95%CI [0.07: 2.84]; I² = 55%; p = 0.39), nor between discoid excision and segmental resection (OR 0.44; 95%CI [0.18: 1.09]; I² = 49%; p = 0.08). Conservative surgery (i.e., shaving and discoid) was associated with less voiding dysfunction than radical surgery (i.e., segmental resection) (OR 0.37; 95%CI [0.25: 0.55]; I² = 0%; p < 10^-3). Regarding persistent voiding dysfunction, rectal shaving and discoid excision were less associated with voiding dysfunction than segmental resection (respectively, OR 0.30; 95%CI [0.14: 0.66]; I² = 0%; p = 0.003 and OR 0.13; 95%CI [0.03: 0.57]; I² = 0%; p = 0.007). Conservative bowel procedures are associated with lower rates of persistent post-operative voiding dysfunction and should be considered first when possible.Trial registration: Our meta-analysis was registered under the PROSPERO number: CRD42023395356.</p>","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":"739-748"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143371213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of metastasectomy on survival in patients with oligometastatic stage 4a lung cancer: a retrospective analysis.","authors":"Ahmet Ulusan, Bekir Elma, Hilal Zehra Kumbasar Danaci, Maruf Sanli, Ahmet Feridun Isik","doi":"10.1007/s13304-025-02120-5","DOIUrl":"10.1007/s13304-025-02120-5","url":null,"abstract":"<p><p>The aim of our study is to evaluate the impact of metastasectomy on survival in patients with oligometastatic stage 4 lung cancer. Fifty-nine oligometastatic lung cancer cases operated on in our clinic between January 2015 and January 2024 were retrospectively examined. Demographic characteristics, metastasis type, metastasis locations, treatments applied, location of the primary tumor, histological type of the tumor, and metastasectomy status of the patients included in the study were evaluated. All patients underwent surgery for primary lung cancer. Generally, the mass in the lung was excised first. The metastasis was then removed. When brain surgery became a priority in some brain metastases, the metastasis was first removed and then the lesion in the lung was completely removed. In patients with oligometastasis, the tumor was either completely removed surgically or a complete cure was achieved with radiotherapy. All patients were stage 4a patients with metastases. The median age of the patients was 61 (36-76) years. 31 (52.6%) of the patients were aged 60 and over. 96.6% (n:57) of the patients were male and 3.4% (n:2) were female. Histopathological diagnosis was 35.6% squamous cell carcinoma (SCC) and 42.4% adeno cancer. 61.0% of the patients had brain metastases and 23.7% had adrenal metastases. The hospital stay of the patients was 14.0 ± 9.9 days. Disease-free survival time was 18.3 ± 24.4 months and overall survival time was 13.6 ± 11.5 months. While 32.2% (n:19) of the patients were alive, 67.8% (n:40) died. The survival rate was statistically significantly higher in patients who underwent metastasectomy compared to those who did not undergo metastasectomy (p = 0.027). The risk factors were found to be significantly associated with survival in the logistic regression analysis included metastasectomy (OR: 3.942, p = 0.030), diagnosis (SCC) (OR: 9,000, p = 0.042), recurrence (OR: 5.248, p = 0.012), adjuvant RT (OR: 0.298, p = 0.045), and neoadjuvant therapy (OR: 4.154, p = 0.040). In stage 4a lung cancer patients with oligometastasis, curative treatment of metastasis (metastasectomy) has a positive effect on survival. The low rate of radiotherapy and chemotherapy treatments given after metastasectomy will protect patients from the side effects of these treatments.</p>","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":"937-945"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of the comprehensive complication index in the prediction of tumor-related death in transplanted patients with hepatocellular carcinoma.","authors":"Quirino Lai, Fabio Melandro, Alessandro Vitale, Davide Ghinolfi, Laurent Coubeau, Riccardo Pravisani, Greg Nowak, Federico Mocchegiani, Marco Vivarelli, Massimo Rossi, Bo-Göran Ericzon, Umberto Baccarani, Paolo De Simone, Umberto Cillo, Jan Lerut","doi":"10.1007/s13304-025-02101-8","DOIUrl":"10.1007/s13304-025-02101-8","url":null,"abstract":"<p><p>Liver transplantation (LT) is the primary treatment for selected patients with hepatocellular carcinoma (HCC). However, HCC-related mortality post-LT remains a significant concern, with up to 10% of cases reported in international series. Identifying risk factors for adverse clinical outcomes is essential. We hypothesized that post-LT HCC-related mortality rates are higher in patients with a high (≥ 42) Comprehensive Complication Index (CCI) calculated at discharge. This study aims to compare post-LT HCC-related mortality rates between two groups of patients with high versus low CCI following LT for HCC. This study included data from seven collaborative European centers. A cohort of 1121 HCC patients transplanted between 2005 and 2019, surviving more than six months post-LT, was analyzed retrospectively. Patients were divided into two groups based on the CCI at discharge: Low-CCI Group (n = 942, 84.0%) and High-CCI Group (n = 179, 16.0%). An inverse probability of treatment weighting (IPTW) approach was applied for analysis. In the post-IPTW cohort, four multivariable logistic regression models with mixed effects identified independent risk factors for HCC-related death, overall death, recurrence, and early recurrence. A CCI score of ≥ 42 emerged as an independent risk factor across all models. Specifically, CCI ≥ 42 was associated with increased odds of HCC-related death (OR = 3.35; P < 0.0001), overall death (OR = 2.63; P < 0.0001), overall recurrence (OR = 2.09; P = 0.001), and early recurrence (OR = 1.88; P = 0.02). A CCI score at discharge should be considered a critical factor for recurrence and HCC-related mortality risk. Incorporating CCI into standard post-LT predictive models may enhance prognostic accuracy for adverse HCC outcomes.</p>","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":"705-715"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical application of the KangDuo-Surgical Robot-01 in distal gastrectomy for gastric cancer.","authors":"Zeshen Wang, Pengcheng Sun, Yuming Ju, Shiyang Jin, Qiancheng Wang, Yuzhe Wei, Guanyu Zhu, Kuan Wang","doi":"10.1007/s13304-025-02108-1","DOIUrl":"10.1007/s13304-025-02108-1","url":null,"abstract":"<p><p>This study aimed to explore the safety, feasibility, and efficacy of using KangDuo-Surgical Robot-01 (KD-SR-01) for distal gastrectomy in patients with gastric cancer. We prospectively enrolled patients undergoing KD-SR-01 assisted distal gastrectomy at our center from September 2023 to December 2023. Data on baseline characteristics, perioperative details, and short-term follow-up were collected prospectively. Descriptive statistical analysis was performed. This study included 15 patients with a median age of 60 years (range: 44-74) and a median body mass index of 24.7 [interquartile range (IQR): 19.8-27.0]. None of the patients required conversion to laparotomy or open surgery during lymphadenectomy. Ten patients underwent D2+ lymphadenectomy, four had D2, and one had D1+. Eleven patients had robotic-assisted BII anastomosis, one had robotic-assisted BI anastomosis, and three had laparoscopic BII anastomosis. All patients had negative surgical margins. The median operative time was 210.0 min (IQR: 200.0-225.0), with a median anastomosis time of 32.0 min (IQR: 21.5-54.5) for robotic-assisted BII anastomosis and 20 min for BI anastomosis. The median estimated blood loss was 30 ml (range: 30-50), and the median postoperative hospital stay was 7.0 days (IQR: 7.0-8.0). Four patients (26.7%) experienced Clavien-Dindo grade II postoperative complications, including two cases of hypoalbuminemia, one case of pneumonia, and one case of moderate anemia, with no device-related complications. Short-term follow-up indicated normal postoperative recovery with no radiographic evidence of recurrence. The KD-SR-01 is safe, feasible, and effective for distal gastrectomy and robotic-assisted gastrointestinal reconstruction.</p>","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":"859-866"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective ileostomy creation after anterior resection of the rectum (PICARR): a decision-making exploring international survey.","authors":"Andrea Balla, Federica Saraceno, Marika Rullo, Salvador Morales-Conde, Eduardo M Targarona Soler, Salomone Di Saverio, Mario Guerrieri, Pasquale Lepiane, Nicola Di Lorenzo, Michel Adamina, Isaias Alarcón, Alberto Arezzo, Jesus Bollo Rodriguez, Luigi Boni, Sebastiano Biondo, Francesco Maria Carrano, Manish Chand, John T Jenkins, Justin Davies, Salvadora Delgado Rivilla, Paolo Delrio, Ugo Elmore, Eloy Espin-Basany, Alessandro Fichera, Blas Flor Lorente, Nader Francis, Marcos Gómez Ruiz, Dieter Hahnloser, Eugenio Licardie, Carmen Martinez, Monica Ortenzi, Yves Panis, Carlos Pastor Idoate, Alessandro M Paganini, Miguel Pera, Roberto Perinotti, Daniel A Popowich, Timothy Rockall, Riccardo Rosati, Alberto Sartori, Daniele Scoglio, Mostafa Shalaby, Vicente Simó Fernández, Neil J Smart, Antonino Spinelli, Patricia Sylla, Pieter J Tanis, Javier Valdes Hernandez, Steven D Wexner, Pierpaolo Sileri","doi":"10.1007/s13304-025-02111-6","DOIUrl":"10.1007/s13304-025-02111-6","url":null,"abstract":"<p><p>In our previous survey of experts, surgeon's decision-making process (DMP) about protective ileostomy (PI) creation after anterior resection was investigated. Based on our previous data, a multiple choice questionnaire has been developed. The aim is to perform a quantitative analysis of the results obtained from an international survey and to describe the clinical practice worldwide. Ten questions were related to participants' demographics and, 20 questions (of which 17 Likert scale questions) investigated the DMP regarding PI creation. To evaluate the tendency of the answers in the Likert-type questions, the mean of the answers obtained was compared with the mean point of the Likert scale. The survey was completed by 1019 physicians. Neoadjuvant chemoradiotherapy and distance of the anastomosis from the anal verge ≤ 10 cm were each considered alone sufficient to justify creation of a PI, with statistically significant differences in comparison to the mean point of the scales in (p =  < 0.0001 in both cases). Total Mesorectal Excision alone was not considered a factor sufficient to create a PI (p = 0.416). Most of the participants agree to define their approach to create a PI \"tailored\" to patients' risk factors (p =  < 0.0001) and \"influenced by my experience\" in case of patients with low/moderate risk of anastomotic leakage (p =  < 0.0001). This study provides useful insights on the worldwide clinical practice regarding creation of PI following anterior resection. Given the lack of standardization and evidence-based guidelines, this analysis may be helpful to assist surgeons' practice.</p>","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":"805-823"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic predictors of postoperative recurrence in node-negative intrahepatic cholangiocarcinoma.","authors":"Bo Zhang, Xiang-Yu Wang, Lu-Yu Yang, Xiao-Tian Shen, Ying Zhu, Wen-Wei Zhu, Jie Fan, Lu Lu, Jin-Hong Chen","doi":"10.1007/s13304-025-02189-y","DOIUrl":"10.1007/s13304-025-02189-y","url":null,"abstract":"<p><p>Recent studies have revealed the prognostic value of genetic alterations in intrahepatic cholangiocarcinoma (ICC). However, the influence of individual mutations on postoperative recurrence has not been comprehensively evaluated, especially for lymph node-negative cases. A total of 589 localized ICCs with clinically or pathologically negative lymph node (cN0M0 or pN0M0) from 3 independent cohorts were included. The impact of clinicopathological and mutational parameters on recurrence-free survival (RFS) and post-recurrence survival (PRS) was analyzed using the Cox proportional hazards model. The effect of prognostic mutations on RFS and PRS was estimated by Kaplan-Meier analysis. Extremes of survivorship analysis was used to reveal distinct genomic profiles between cases with very early recurrence (VER) and long-term no recurrence (LNR). Among the recurrent mutations, only TP53 and KRAS showed significant association with RFS in both of the two screening cohorts. In the validation cohort, TP53 and KRAS mutations were both independent predictors for shorter RFS. Compared with wild-type patients, TP53 and KRAS mutations were more frequently observed in VER group than in LNR group, and were more enriched in patients with intrahepatic and extra-hepatic recurrence (IER). Furthermore, TP53 mutation was significantly associated with worse survival and lower probability of repeated hepatectomy in patients suffered from recurrence. TP53 and KRAS mutations were important genetic predictors that correlated with earlier and more aggressive recurrence in node-negative ICC patients after surgery. Effective peri-operative therapies for these high-risk tumor biology are needed to improve the clinical outcome for related patients.</p>","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":"675-684"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}