Updates in Surgery最新文献_第10页

Enhancing bariatric surgery safety for patients refusing blood transfusions: a specialized protocol with comprehensive technical measures. 提高拒绝输血患者的减肥手术安全性：采用综合技术措施的专门方案。

IF 2.4 3区医学

Updates in Surgery Pub Date : 2024-10-01 Epub Date: 2024-06-12 DOI: 10.1007/s13304-024-01912-5

Muhammed Said Dalkılıç, Mehmet Gençtürk, Abdullah Şişik, Hasan Erdem

{"title":"Enhancing bariatric surgery safety for patients refusing blood transfusions: a specialized protocol with comprehensive technical measures.","authors":"Muhammed Said Dalkılıç, Mehmet Gençtürk, Abdullah Şişik, Hasan Erdem","doi":"10.1007/s13304-024-01912-5","DOIUrl":"10.1007/s13304-024-01912-5","url":null,"abstract":"Bariatric surgery has become a leading treatment for obesity, with techniques such as Laparoscopic Sleeve Gastrectomy (LSG) and Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) demonstrating notable success in sustained weight loss and improved quality of life. Technological advancements and improved techniques have enhanced the safety of these procedures. The surgical procedures of Jehovah's Witnesses, who refuse blood transfusions as part of their beliefs, pose unique challenges and have rarely been addressed in the context of bariatric surgery. This report aimed to investigate the safety of bariatric surgery in patients who refuse blood transfusion, with an established protocol to minimize the risk of bleeding. We examined the prospectively collected data of Jehovah's Witness patients who underwent bariatric surgery from 2019 to 2023. The surgeries were conducted following a protocol that included specific measures to prevent bleeding. Data were reviewed for demographics, anthropometrics, comorbidities, preoperative medications, operative time, blood loss, length of hospital stay, hemoglobin level, drainage volume, tranexamic acid use, and postoperative 30-day complications. Eleven Jehovah's Witness patients underwent bariatric surgery, including 10 LSG and 1 LRYGB. A patient with iron deficiency anemia underwent intravenous iron treatment before the surgery. There were no intraoperative complications or major postoperative complications. All patients maintained stable hemodynamics postoperatively. Only one patient encountered nausea-vomiting, classified as a minor complication. One patient experienced a small amount of hemorrhagic drainage, which transitioned to serous after tranexamic acid infusion. Bariatric surgery can be performed safely with established protocols in patients who refuse blood transfusions.","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":"2489-2494"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11541380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between the expression of epithelial-mesenchymal transition (EMT)-related markers and oncologic outcomes of colorectal cancer. 上皮-间质转化（EMT）相关标记物的表达与结直肠癌的肿瘤学预后之间的关系。

IF 2.4 3区医学

Updates in Surgery Pub Date : 2024-10-01 Epub Date: 2024-05-18 DOI: 10.1007/s13304-024-01865-9

Mona Hany Emile, Sameh Hany Emile, Amr Awad El-Karef, Mohamed Awad Ebrahim, Ibrahim Eldosoky Mohammed, Dina Abdallah Ibrahim

{"title":"Association between the expression of epithelial-mesenchymal transition (EMT)-related markers and oncologic outcomes of colorectal cancer.","authors":"Mona Hany Emile, Sameh Hany Emile, Amr Awad El-Karef, Mohamed Awad Ebrahim, Ibrahim Eldosoky Mohammed, Dina Abdallah Ibrahim","doi":"10.1007/s13304-024-01865-9","DOIUrl":"10.1007/s13304-024-01865-9","url":null,"abstract":"Background: Epithelial-mesenchymal transition (EMT) is a key step in the development of colorectal cancer (CRC) that confers metastatic capabilities to cancer cells. The present study aimed to assess the immunohistochemical (IHC) expression and impact of EMT markers, including E-cadherin, Vimentin, β-catenin, and SMAD4, on the oncologic outcomes of CRC.Methods: This was a retrospective review of 118 CRC patients. Tissue slides were retrieved from the slide archive and five tissue microarray construction blocks were constructed. IHC for E-cadherin, Vimentin, β-catenin, and SMAD4 was done. The main outcome was the association between abnormal marker expression and overall survival (OS), and disease-free survival (DFS).Results: Adenocarcinomas accounted for 71.2% of tumors, whereas 25.4% and 3.4% were mucinous and signet ring cell carcinomas. The rates of lymphovascular invasion and perineural invasion were 72.9% and 20.3%, respectively. There was a positive, significant correlation, and association between the four markers. Abnormal expression of E-cadherin was associated with significantly lower OS (p < 0.0001) and similar DFS (p = 0.06). Abnormal Vimentin expression was associated with a significantly higher rate of distant metastasis (p = 0.005) and significantly lower OS and DFS (p < 0.0001). Abnormal expression of β-catenin was associated with significantly lower OS (p < 0.0001) and similar DFS (p = 0.15). Abnormal expression of SMAD4 was associated with significantly lower OS and DFS (p < 0.0001). Abnormal expression of all four markers was associated with a higher disease recurrence, lower OS, and lower DFS.Conclusion: Abnormal expression of each marker was associated with lower OS, whereas abnormal expression of Vimentin and SMAD4 only was associated with lower DFS.","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":"2181-2191"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11541317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transferability of laparoscopic skills acquired from three-dimensional high-definition and ultra-high definition endovision system to two-dimensional high-definition endovision system: an ex-vivo randomized study. 从三维高清和超高清内视镜系统学到的腹腔镜技能能否迁移到二维高清内视镜系统：一项体外随机研究。

IF 2.4 3区医学

Updates in Surgery Pub Date : 2024-10-01 Epub Date: 2024-03-20 DOI: 10.1007/s13304-024-01805-7

Hemanga K Bhattacharjee, Sarvesh Yadav, Ashwani K Mishra, Suhani Suhani, Mohit Joshi, Rajinder Parshad

{"title":"Transferability of laparoscopic skills acquired from three-dimensional high-definition and ultra-high definition endovision system to two-dimensional high-definition endovision system: an ex-vivo randomized study.","authors":"Hemanga K Bhattacharjee, Sarvesh Yadav, Ashwani K Mishra, Suhani Suhani, Mohit Joshi, Rajinder Parshad","doi":"10.1007/s13304-024-01805-7","DOIUrl":"10.1007/s13304-024-01805-7","url":null,"abstract":"Three-dimensional high-definition (3D HD) and ultra-high-definition (4 K HD) endovision systems are rapidly adopted in academic setting. However, transferability of laparoscopic skills acquired from these systems to two-dimensional high-definition (2D HD) endovision system is not known. Forty stereo-enabled surgical residents were randomized into two groups. They performed three standardized surgical tasks, Task 1(Peg transfer), Task 2(Precision touch on uneven surface) and Task 3(Surgical knotting on rubber tube) for 15 repetitions using either 3D HD or 4 K HD. Both groups then performed the same tasks using 2D HD for 5 repetitions. Their performances were evaluated for execution time (speed) and error scores (safety). The residents in 3D HD group performed all three tasks significantly faster than residents in 4 K HD group with comparable error scores. The time taken to complete the tasks on 2D HD were comparable between residents trained in 3D HD and 4 K HD in two out of three tasks (p = 0.027, P = 0.115, p = 0.368 in task 1, 2 and 3 respectively). However, in two out of three tasks, residents trained on 3D HD committed significantly more errors than residents trained on 4 K HD (p < 0.0001, p < 0.001 in task 1 and task 2 respectively). Skill acquired on 4 K HD seems transferable to 2D HD environment. Participants trained in 3D HD made more errors while performing the tasks in 2D HD. It may be prudent to offer additional training on 2D HD to residents trained on 3D HD for safer laparoscopic surgical practice.","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":"2461-2470"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two institutes' experience in laparoendoscopic "rendezvous" technique for patients undergoing laparoscopic cholecystectomy for stones in the gallbladder and bile duct: a prospective randomized comparative clinical trial. 两家医疗机构为胆囊和胆管结石患者实施腹腔镜胆囊切除术的 "交会 "技术经验：一项前瞻性随机比较临床试验。

IF 2.4 3区医学

Updates in Surgery Pub Date : 2024-10-01 Epub Date: 2024-09-25 DOI: 10.1007/s13304-024-01973-6

Mohamed Farid, Azza Baz, Alaaedin Ramadan, Mohamed Elhorbity, Ashraf Amer, Ahmed Arafa

{"title":"Two institutes' experience in laparoendoscopic \"rendezvous\" technique for patients undergoing laparoscopic cholecystectomy for stones in the gallbladder and bile duct: a prospective randomized comparative clinical trial.","authors":"Mohamed Farid, Azza Baz, Alaaedin Ramadan, Mohamed Elhorbity, Ashraf Amer, Ahmed Arafa","doi":"10.1007/s13304-024-01973-6","DOIUrl":"10.1007/s13304-024-01973-6","url":null,"abstract":"There is still disagreement on the best treatment option for cholecystocholedocholithiasis. Although there are some benefits to the single-step procedure, the \"laparoendoscopic rendezvous\" (LERV) technique that include a lower risk of post-ERCP pancreatitis and a shorter hospital stay, the standard technique is still the two-step approach for clearing the common bile duct (CBD) using ERCP and then performing a laparoscopic cholecystectomy. The purpose of this study was to assess the effectiveness and safety of the LERV technique vs. the standard two-step approach. Four hundred thirty-six patients with symptomatized concomitant stones at both the gall bladder (GB) and the (CBD), at two gastroenterology centers in Zagazig city, Egypt, from January 2010 till April 2022, were analyzed. Patients were randomly divided into two equally groups. The overall length of hospital stay was the primary outcome, and the success of CBD clearance and morbidity, particularly post-ERCP pancreatitis, were the secondary endpoints. The LERV group experienced a significantly shorter hospital stay (median 2(2-8) days compared to 4.5 (4-11) days for the two-stage approach (p < 0.001)). The two groups did not differ in terms of CBD clearing success. Also, there was no significant difference in the number of patients with post-ERCP pancreatitis between the LERV group [14 patients (6.4%)] and the two-stage approach [26 patients (11.9%)] with p value = 0.703. For patients with cholecystocholedocholithiasis, the optimal treatment must be determined by the knowledge and resources that are accessible locally. Our data further supported the idea that treating patients with cholecystocholedocholithiasis in one stage is a safe and successful strategy.","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":"2237-2245"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11541338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Convined clinical prognostic model in colorectal cancer. Convined 大肠癌临床预后模型。

IF 2.4 3区医学

Updates in Surgery Pub Date : 2024-10-01 Epub Date: 2024-01-18 DOI: 10.1007/s13304-023-01690-6

Gallarín Salamanca Isabel María, Espín Jaime María Teresa, Molina Fernández Manuel, Moran Penco Jose Miguel

{"title":"Convined clinical prognostic model in colorectal cancer.","authors":"Gallarín Salamanca Isabel María, Espín Jaime María Teresa, Molina Fernández Manuel, Moran Penco Jose Miguel","doi":"10.1007/s13304-023-01690-6","DOIUrl":"10.1007/s13304-023-01690-6","url":null,"abstract":"Current staging systems in patients with colorectal cancer (CRC) utilize relatively few patient characteristics in comparison to the breadth of information available. The objective of our study is to analyze the heterogeneous set of variables that may influence mortality and recurrence independently in patients with CCR, and prepare a predictive model of survival and recurrence. Data from 288 patients who had undergone scheduled surgery for stage I-III cancer of the colon and upper rectum were used to construct Cox models for DFS and overall CSS at five years. We have jointly examined clinical variables, serological markers and histological variables with the aim of identifying new prognostic factors. Internal and external validation was carried out on each of the nomograms obtained. Perineural invasion; high platelet-lymphocyte ratio (PLR) and the pN stage were the variables that emerged as an independent risk factor of recurrence. The variables related independently to overall CSS were the presence of blood in stools, high PLR and nodal involvement. We have created a predictive model of recurrence and mortality at 5 years with data that is easily available (clinical, analytical and histological variables) which can help personalize the treatment and follow-up of patients with CRC. We also conducted an adequate internal and external validation.","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":"2173-2179"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescence-guided laparoscopic lymph node biopsy for lymphoma: the FLABILY study. 荧光引导下淋巴瘤腹腔镜淋巴结活检：FLABILY 研究。

IF 2.4 3区医学

Updates in Surgery Pub Date : 2024-10-01 Epub Date: 2024-06-14 DOI: 10.1007/s13304-024-01909-0

Marco Casaccia, Giovanni Alemanno, Paolo Prosperi, Graziano Ceccarelli, Stefano Olmi, Alberto Oldani, Mauro Santarelli, Roberta Tutino, Franco De Cian

{"title":"Fluorescence-guided laparoscopic lymph node biopsy for lymphoma: the FLABILY study.","authors":"Marco Casaccia, Giovanni Alemanno, Paolo Prosperi, Graziano Ceccarelli, Stefano Olmi, Alberto Oldani, Mauro Santarelli, Roberta Tutino, Franco De Cian","doi":"10.1007/s13304-024-01909-0","DOIUrl":"10.1007/s13304-024-01909-0","url":null,"abstract":"To date, no reports have indicated laparoscopic lymph node biopsies using Indocyanine green (ICG) in cases of lymphoproliferative disease. Preliminary data of patients undergoing fluorescence-guided laparoscopic lymph node biopsy (FGLLB) using ICG was retrospectively analysed from the multicentre registry FLABILY study. Between June 2022 and February 2024, 50 patients underwent FGLLB. The surgical biopsy aimed to re-stage lymphoproliferative disease for 25 patients and to establish a diagnosis in 25 patients. The median duration of the procedure was 65 ± 26.5 min. All the procedures were performed laparoscopically. One surgical conversion occurred due to bleeding. Median length of hospitalization was 1 ± 1.7 days. Two unrelated complications occurred in the immediate postoperative course. ICG was administrated preoperatively by means of an inguinal, perilesional, or intravenous injection according to the anatomical sites of the biopsy. Fluorescence was obtained in 43/50 (86%) of patients. A significant difference was highlighted in the appearance of fluorescence in sub-mesocolic lymph nodes compared to supra-mesocolic and mesenteric lymph nodes (41/49 (83.6%) vs. 13/22 (59%), p = 0,012). In 98% of cases, FGLLB provided the information necessary for the correct diagnosis. Fluorescence with ICG offers a simple and safe method for detecting pathological lymph nodes. FGLLB in suspected intra-abdominal lymphoma can largely benefit from this new opportunity which, to date, has not yet been tested. Further studies with a larger case series are needed to confirm its efficacy.","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":"2449-2454"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11541296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyroid cartilage needle vs. endotracheal tube electrodes in EBSLN monitoring during thyroidectomy. 甲状腺软骨针与气管插管电极在甲状腺切除术期间的 EBSLN 监测中的对比。

IF 2.4 3区医学

Updates in Surgery Pub Date : 2024-10-01 Epub Date: 2024-09-05 DOI: 10.1007/s13304-024-01982-5

Can Uc, Yigit Turk, Murat Ozdemir, Gokhan Icoz, Ozer Makay

{"title":"Thyroid cartilage needle vs. endotracheal tube electrodes in EBSLN monitoring during thyroidectomy.","authors":"Can Uc, Yigit Turk, Murat Ozdemir, Gokhan Icoz, Ozer Makay","doi":"10.1007/s13304-024-01982-5","DOIUrl":"10.1007/s13304-024-01982-5","url":null,"abstract":"During thyroidectomy, both needle electrodes (NE) and endotracheal tube electrodes (ETE) can be used. Incomplete contact of the endotracheal tube electrode with the vocal cords, endotracheal tube electrode may hinder an optimal outcome and even result in an inability to obtain an electromyography wave while neuromonitoring the external branch of the superior laryngeal nerve (EBSLN). There is no study that compares NE and ETE for EBSLN monitoring. Therefore, this study compares NE and ETE recordings during EBSLN monitoring. Twenty-six consecutive patients undergoing total thyroidectomy were included in this study. Intraoperative neuromonitoring was performed simultaneously with both NEs and ETEs. Pre-resection (V1, R1, and S1) and post-resection (V2, R2, and S2) amplitudes and latencies were recorded for both types of electrodes. The Mann-Whitney U test was used for statistical analysis. Twenty-one women and five men were included, and 52 nerves at risk were evaluated. The mean amplitudes for right S1 (314 vs. 168 µV, p = 0.009) and right S2 (428 vs. 161 µV, p: 0.001) and for left S1 (346 vs. 229 µV, p: 0.017) and left S2 (413 vs. 229 µV, p: 0.009) were statistically higher for the NE group. All amplitudes obtained using NEs, except on the left for V1, R1, V2, and R2, were statistically higher than those obtained using ETEs. There was no loss of signal or vocal cord palsy in the patients. There were no needle-related complications. EBSLN monitoring using NE is a safe alternative to ETE. With NE, higher amplitudes were obtained. Level of evidence: Level 3.","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":"2337-2342"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Achieving fascial closure with preoperative botulinum toxin injections in abdominal wall reconstruction: outcomes from a high-volume center. 在腹壁重建术中通过术前注射肉毒素实现筋膜闭合：一个高产量中心的成果。

IF 2.4 3区医学

Updates in Surgery Pub Date : 2024-10-01 Epub Date: 2024-03-20 DOI: 10.1007/s13304-024-01802-w

Lucas Fair, Steven G Leeds, Syed Harris Bokhari, Simon Esteva, Tanner Mathews, Gerald O Ogola, Marc A Ward, Bola Aladegbami

{"title":"Achieving fascial closure with preoperative botulinum toxin injections in abdominal wall reconstruction: outcomes from a high-volume center.","authors":"Lucas Fair, Steven G Leeds, Syed Harris Bokhari, Simon Esteva, Tanner Mathews, Gerald O Ogola, Marc A Ward, Bola Aladegbami","doi":"10.1007/s13304-024-01802-w","DOIUrl":"10.1007/s13304-024-01802-w","url":null,"abstract":"Preoperative injection of Botulinum Toxin A (Botox) has been described as an adjunctive therapy to facilitate fascial closure of large hernia defects in abdominal wall reconstruction (AWR). The purpose of this study was to evaluate the impact of Botox injections on fascial closure and overall outcomes to further validate its role in AWR. A prospectively maintained database was retrospectively reviewed to identify all patients undergoing AWR at our institution between January 2014 and March 2022. Patients who did and did not receive preoperative Botox injections were analyzed and compared. A total of 426 patients were included (Botox 76, NBotox 350). The Botox group had significantly larger hernia defects (90 cm2 vs 9 cm2, p < 0.01) and a higher rate of component separations performed (60.5% vs 14.4%, p < 0.01). Despite this large difference in hernia defect size, primary fascial closure rates were similar between the groups (p = 0.49). Notably, the Botox group had higher rates of surgical-site infections (SSIs)/surgical-site occurrences (SSOs) (p < 0.01). Following propensity score matching to control for multiple patient factors including age, sex, diabetes, chronic obstructive pulmonary disease (COPD), and hernia size, the Botox group still had a higher rate of component separations (50% vs 26.3%, p = 0.03) and higher incidence of SSIs/SSOs (39.5% vs 13.5%, p = 0.01). Multimodal therapy with Botox injections and component separations can help achieve fascial closure of large defects during AWR. However, adding these combined therapies may increase the occurrence of postoperative SSIs/SSOs.","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":"2421-2428"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conditional survival nomogram for patients with colon mucinous adenocarcinoma to predict prognosis: a dynamic survival analysis. 结肠粘液腺癌患者预测预后的条件生存提名图：动态生存分析。

IF 2.4 3区医学

Updates in Surgery Pub Date : 2024-10-01 Epub Date: 2024-05-10 DOI: 10.1007/s13304-024-01869-5

Huajun Cai, Ye Wang, Shoufeng Li, Zhen Pan, Tianbao Xu, Yunjin Wang, Yiyi Zhang, Jinfu Zhuang, Xing Liu, Guoxian Guan

{"title":"Conditional survival nomogram for patients with colon mucinous adenocarcinoma to predict prognosis: a dynamic survival analysis.","authors":"Huajun Cai, Ye Wang, Shoufeng Li, Zhen Pan, Tianbao Xu, Yunjin Wang, Yiyi Zhang, Jinfu Zhuang, Xing Liu, Guoxian Guan","doi":"10.1007/s13304-024-01869-5","DOIUrl":"10.1007/s13304-024-01869-5","url":null,"abstract":"The aim was to assess conditional survival for colon mucinous adenocarcinoma (MAC) patients, and to construct nomograms to predict conditional survival probability. Survival analysis was done using conditional survival, which was defined as the probability of surviving additional y years for patients who have survived for x years. The mathematical definition was express as: CS (y|x) = S (x + y)/S (x). Cox regression analyses were used to identify prognostic factors. A nomogram is constructed to predict conditional disease-free survival (DFS) and overall survival (OS) probability according to years that already survive. A total of 179 colon MAC patients were included. The 5-year DFS was 67% after surgery, and the 5-year survival probability of patients, who already survived 1, 2, 3, and 4 years were 75%, 87%, 95%, and 98%, respectively. The 5-year OS was 73% after surgery and increased to 76%, 82%, 88%, and 92% at 1, 2, 3, and 4 years, respectively. Subgroup analyses demonstrated the superiority of conditional survival was more pronounced in advanced stages than in stage I. And pT stage, pN stage, and lymphovascular invasion were significantly associated with DFS and OS. Conditional survival nomograms were constructed to predict the 5-year conditional DFS and OS probability given survival for 1, 2, 3, 4 years after surgery. Conditional survival can provide dynamic survival probability according to years that already survive, especially for patients with advanced stages. Taking into account the years already survived accounted for, novel nomograms contributed to effectively predicting conditional survival.","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":"2163-2171"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140899711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Intraperitoneal prophylactic drain after pancreaticoduodenectomy: an Italian survey. 更正：胰十二指肠切除术后腹膜内预防性引流：意大利调查。

IF 2.4 3区医学

Updates in Surgery Pub Date : 2024-10-01 DOI: 10.1007/s13304-024-01967-4

Claudio Ricci, Nicolò Pecorelli, Alessandro Esposito, Giovanni Capretti, Stefano Partelli, Giovanni Butturini, Ugo Boggi, Alessandro Cucchetti, Alessandro Zerbi, Roberto Salvia, Massimo Falconi

引用次数: 0