Tuberculosis最新文献_第4页

“The cytokine profiles of the inflammatory response in chronic granulomatous encephalitis caused by Mycobacterium tuberculosis do not influence the patient's clinical presentation" 由结核分枝杆菌引起的慢性肉芽肿性脑炎炎症反应的细胞因子谱不影响患者的临床表现。

IF 2.9 3区医学

Tuberculosis Pub Date : 2025-12-01 Epub Date: 2025-10-23 DOI: 10.1016/j.tube.2025.102700

Alejandro Rivas-Castro , Itzel Rocío Manzano Espinosa , Diana Villa Sepúlveda , Eduardo Pablo Sánchez Martínez , José Alberto Choreño-Parra , Yaser Sánchez Gama , Ana Sofía Alonso Villaseñor , Fernando Daniel Argueta Muñoz , Erick Gómez Apo , Citlaltepetl Salinas-Lara , Carlos Sánchez-Garibay , Martha Lilia Tena Suck

{"title":"“The cytokine profiles of the inflammatory response in chronic granulomatous encephalitis caused by Mycobacterium tuberculosis do not influence the patient's clinical presentation\"","authors":"Alejandro Rivas-Castro , Itzel Rocío Manzano Espinosa , Diana Villa Sepúlveda , Eduardo Pablo Sánchez Martínez , José Alberto Choreño-Parra , Yaser Sánchez Gama , Ana Sofía Alonso Villaseñor , Fernando Daniel Argueta Muñoz , Erick Gómez Apo , Citlaltepetl Salinas-Lara , Carlos Sánchez-Garibay , Martha Lilia Tena Suck","doi":"10.1016/j.tube.2025.102700","DOIUrl":"10.1016/j.tube.2025.102700","url":null,"abstract":"<div><h3>Introduction</h3><div>Central nervous system tuberculosis (CNS-TB) is the most lethal form of tuberculosis, characterized by severe clinical manifestations and distinctive histopathological changes. Although several cytokines are implicated in the immune response to <em>Mycobacterium tuberculosis</em>, their relationship with disease severity and histological alterations remains unclear. This study aimed to evaluate the associations between cytokine expression, histopathological changes, and clinical features in patients with CNS-TB.</div></div><div><h3>Methods</h3><div>We conducted a retrospective, observational, cross-sectional, descriptive study of 25 biopsies that fulfilled criteria for CNS-TB at the National Institute of Neurology and Neurosurgery “Manuel Velasco Suárez.” Cases were classified according to the Suzaan Marais criteria. Immunohistochemistry was performed to assess IL-1β, IL-4, IL-10, IL-17, IL-23, TNF-α, and IFN-γ expression in meningeal and parenchymal tissues.</div></div><div><h3>Results</h3><div>Strong expression of IL-1β, IL-17, IL-23, and TNF-α was observed in glial cells, vascular endothelial cells, and macrophages, particularly within inflammatory and vascular lesions.</div></div><div><h3>Conclusions</h3><div>Although no direct correlation was found between cytokine expression and clinical severity, the findings support a predominant pro-inflammatory response mediated by IL-1β, IL-17, IL-23, and TNF-α, associated with tissue and vascular damage. The elevated cytokine expression in foam cells suggests a potential role in local immune regulation in CNS-TB.</div></div>","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"155 ","pages":"Article 102700"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145393303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibition of mycobacteria proliferation in macrophages by diaryl ether derivatives of Dehydrozingerone compound and repurposed drugs (Rebamipide, Sofalcone) via NF-κB pathway inhibition Dehydrozingerone化合物二芳基醚衍生物和Rebamipide、Sofalcone通过抑制NF-κB通路抑制巨噬细胞分枝杆菌增殖

IF 2.9 3区医学

Tuberculosis Pub Date : 2025-12-01 Epub Date: 2025-11-21 DOI: 10.1016/j.tube.2025.102706

Safiya Mehraj , Shazia Ali , Chetan Kumar , Asif Ali , Zahoor Ahmad

{"title":"Inhibition of mycobacteria proliferation in macrophages by diaryl ether derivatives of Dehydrozingerone compound and repurposed drugs (Rebamipide, Sofalcone) via NF-κB pathway inhibition","authors":"Safiya Mehraj , Shazia Ali , Chetan Kumar , Asif Ali , Zahoor Ahmad","doi":"10.1016/j.tube.2025.102706","DOIUrl":"10.1016/j.tube.2025.102706","url":null,"abstract":"<div><h3>Background</h3><div>Chronic inflammation fuels tissue damage and morbidity in numerous diseases, including Tuberculosis, underscoring the vital need for Host-Directed Therapies to safely modulate the exaggerated host response. We investigated the immunomodulatory potential of Sofalcone and Rebamipide alongside a novel Diaryl Ether derivative of Dehydrozingerone DHZ (6), hypothesizing that they exert therapeutic effects by targeting the central inflammatory driver, the NF-κB pathway.</div></div><div><h3>Methods</h3><div>We evaluated the safety and efficacy of the compounds in THP-1 macrophages infected with <em>M. smegmatis.</em> Mechanistic studies utilized Western blotting, immunofluorescence, and ELISA to track NF-κB activation. MMP activity was assessed by gelatin zymography, and ROS production was quantified using the DCFH-DA assay.</div></div><div><h3>Results</h3><div>All compounds exhibited low cytotoxicity and significantly reduced intracellular bacterial survival. Agents potently and consistently inhibited the NF-κB cascade, evidenced by ≈ 83 % suppression of upstream P-IKKα/IKKβ and up to ≈89 % reduction in p65 phosphorylation. This molecular blockade prevented p65 nuclear translocation and resulted in a downstream functional benefit: near total abolition of MMP-2/9 activity and ≈71 % mitigation of ROS production.</div></div><div><h3>Conclusion</h3><div>Our results unequivocally validate NF-κB inhibition by DHZ (6), Sofalcone, and Rebamipide as a powerful strategy for HDT. These compounds are promising adjunct therapies to suppress host inflammation and limit tissue damage.</div></div>","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"155 ","pages":"Article 102706"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of tuberculosis infection dynamics using Caputo fractional-order models with diagnosis and treatment interventions 用Caputo分数阶模型分析结核感染动态与诊断和治疗干预。

IF 2.9 3区医学

Tuberculosis Pub Date : 2025-12-01 Epub Date: 2025-09-27 DOI: 10.1016/j.tube.2025.102694

Oluwafemi Ezekiel Abiodun , Morufu Oyedunsi Olayiwola

{"title":"Analysis of tuberculosis infection dynamics using Caputo fractional-order models with diagnosis and treatment interventions","authors":"Oluwafemi Ezekiel Abiodun , Morufu Oyedunsi Olayiwola","doi":"10.1016/j.tube.2025.102694","DOIUrl":"10.1016/j.tube.2025.102694","url":null,"abstract":"<div><div>This paper develops and analyzes a Caputo fractional-order mathematical model for tuberculosis (TB) transmission that incorporates testing, therapy, isolation, and treatment interventions. The model divides the population into five compartments—susceptible, exposed, infectious, isolated, and recovered—and its qualitative properties, including positivity, boundedness, existence, and uniqueness of solutions, are established. The basic reproduction number R<sub>0</sub> is derived, and sensitivity analysis identifies transmission, progression, testing, and treatment rates as critical drivers of TB dynamics. Using the Laplace–Adomian decomposition method (LADM), numerical simulations are performed to assess the impact of fractional-order derivatives on disease spread and control. The results show that increasing the order of the fractional derivative enhances the accuracy of the model and reveals memory effects in TB dynamics. Moreover, early diagnosis, therapy, and isolation significantly reduce infection levels and improve recovery outcomes. These findings highlight the advantages of fractional-order models over classical approaches and provide valuable insights for designing effective TB control strategies.</div></div>","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"155 ","pages":"Article 102694"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to Editor: manuscript entitled “Utility of pleural fluid-derived extracellular vesicles as a source of Mycobacterium tuberculosis antigens MPT51 and MPT64 for pleural TB diagnosis: a proof-of-concept study” by Jindal et al. published in Tuberculosis150 (2025) 102578 致编辑的信：由Jindal等人撰写的题为“胸膜液来源的细胞外囊泡作为结核分枝杆菌抗原MPT51和MPT64用于胸膜结核诊断的效用：一项概念验证研究”的手稿，发表在结核菌150(2025)102578上。

IF 2.9 3区医学

Tuberculosis Pub Date : 2025-12-01 Epub Date: 2025-10-14 DOI: 10.1016/j.tube.2025.102695

Promod K. Mehta

引用次数: 0

Minimal immune cell subset differences in a cohort of close contacts of tuberculosis index cases 结核病指数病例密切接触者队列中最小免疫细胞亚群差异

IF 2.9 3区医学

Tuberculosis Pub Date : 2025-12-01 Epub Date: 2025-11-15 DOI: 10.1016/j.tube.2025.102707

Sudhasini Panda , Catherine Cheng , Naomi Hillery , Donald G. Catanzaro , Nelly Ciobanu , Valeriu Crudu , Timothy Rodwell , Antonino Catanzaro , Julie G. Burel , Bjoern Peters , Cecilia S. Lindestam Arlehamn

{"title":"Minimal immune cell subset differences in a cohort of close contacts of tuberculosis index cases","authors":"Sudhasini Panda , Catherine Cheng , Naomi Hillery , Donald G. Catanzaro , Nelly Ciobanu , Valeriu Crudu , Timothy Rodwell , Antonino Catanzaro , Julie G. Burel , Bjoern Peters , Cecilia S. Lindestam Arlehamn","doi":"10.1016/j.tube.2025.102707","DOIUrl":"10.1016/j.tube.2025.102707","url":null,"abstract":"<div><div>Understanding the perturbations in immune response across the spectrum of TB infection is still unclear. Here, we followed close contacts of pulmonary TB patients with serial QFT testing at 0, 3, 6, and 12 months, and stratified them into six subgroups: QFT-increasing (low/high), QFT-converters (QFT-to QFT+), QFT + stable, and QFT-individuals. Despite these distinct QFT trajectories, we observed <strong>minimal differences in immune cell frequencies, activation profiles, and T-helper subset distributions among QFT subgroups,</strong> suggesting limited immunological stratification based on QFT dynamics. Ex vivo immune phenotyping, including CD4, CD8, NKT cell frequencies, memory T-cell subsets, and activated T-cells (HLA-DR<sup>+</sup>CD38<sup>+</sup>), failed to distinguish between QFT subgroups, suggesting blood-based immune profiling may not capture subtle immunological transitions among different QFT subgroups. Active TB (ATB) patients showed marked immune alterations, with elevated antigen-specific CD4 T-cells, activated T cells, intermediate monocytes, NK cells at-diagnosis, which declined following treatment, indicating immune recovery. This suggest, while ex vivo immune profiling effectively distinguishes ATB from non-diseased states, it lacks the sensitivity to resolve QFT-based subgroups. Findings suggest either immune similarity among close contacts regardless of QFT status or limits of blood-based profiling in detecting early changes, underscoring the difficulty of distinguishing QFT subgroups with conventional ex vivo approaches.</div></div>","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"155 ","pages":"Article 102707"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145550934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ESAT-6 of Mycobacterium tuberculosis downregulates cofilin1, leads to filamentous actin enrichment and reduces the phagosome acidification in infected macrophages, which are partially reversed by a single methionine mutation 结核分枝杆菌的ESAT-6下调cofilin1，导致丝状肌动蛋白富集并减少感染巨噬细胞的吞噬体酸化，这一过程可通过单个蛋氨酸突变部分逆转

IF 2.9 3区医学

Tuberculosis Pub Date : 2025-12-01 Epub Date: 2025-08-28 DOI: 10.1016/j.tube.2025.102680

P.P. Mahesh , R.J. Retnakumar , K.C. Sivakumar , Sathish Mundayoor

{"title":"ESAT-6 of Mycobacterium tuberculosis downregulates cofilin1, leads to filamentous actin enrichment and reduces the phagosome acidification in infected macrophages, which are partially reversed by a single methionine mutation","authors":"P.P. Mahesh , R.J. Retnakumar , K.C. Sivakumar , Sathish Mundayoor","doi":"10.1016/j.tube.2025.102680","DOIUrl":"10.1016/j.tube.2025.102680","url":null,"abstract":"<div><div><em>Mycobacterium tuberculosis</em> (<em>M. tuberculosis</em>) persists within macrophages by evading phagosome maturation. In this study, we considered the role of actin dynamics in this process. Macrophages infected with virulent <em>M. tuberculosis</em> showed high F-actin/G-actin ratio, accompanied by reduced expression of the actin-depolymerizing protein cofilin1 and increased levels of its inactive phosphorylated form. Overexpression of a constitutively active cofilin1 variant reduced F-actin accumulation and enhanced phagosome acidification. Similar effects were observed with sorafenib, a PI3K-dependent activator of cofilin1, which decreased F-actin levels and promoted phagosome acidification in infected macrophages. Ectopic expression of the mycobacterial virulence factor ESAT-6 in macrophages led to cofilin1 downregulation. ESAT-6 also increased F-actin, altered cell morphology and impaired phagosome acidification in infections with avirulent <em>M. tuberculosis</em> strain. As cofilin1 is positively regulated by reactive oxygen species (ROS), we examined the role of methionine in ESAT-6-mediated ROS suppression. Mutation of methionine 93 in ESAT-6 increased intracellular ROS, enhanced phagosome acidification, and decreased F-actin levels. These findings reveal that <em>M. tuberculosis</em> impairs phagosome acidification by modulating host actin dynamics at least partially through ESAT-6–mediated suppression of cofilin1 and ROS. Enhancing cofilin1 activity may represent a potential therapeutic strategy to restore phagosome function and improve bacterial clearance, more specifically during the initial establishment of infection.</div></div>","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"155 ","pages":"Article 102680"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the role of PezAT and MbcTA toxin-antitoxin systems in the pathophysiology of Mycobacterium tuberculosis 了解PezAT和MbcTA毒素-抗毒素系统在结核分枝杆菌病理生理中的作用

IF 2.9 3区医学

Tuberculosis Pub Date : 2025-12-01 Epub Date: 2025-10-23 DOI: 10.1016/j.tube.2025.102703

Manisha Singh , Deepika Chaudhary , Arun Sharma, Sonu Kumar Gupta, Imran Ahmad, Yashwant Kumar, Ramandeep Singh

{"title":"Understanding the role of PezAT and MbcTA toxin-antitoxin systems in the pathophysiology of Mycobacterium tuberculosis","authors":"Manisha Singh , Deepika Chaudhary , Arun Sharma, Sonu Kumar Gupta, Imran Ahmad, Yashwant Kumar, Ramandeep Singh","doi":"10.1016/j.tube.2025.102703","DOIUrl":"10.1016/j.tube.2025.102703","url":null,"abstract":"<div><div>Toxin antitoxin (TA) systems are bicistronic genetic elements encoding for a stable toxin and its cognate labile antitoxin. The genome of <em>Mycobacterium tuberculosis</em> (<em>M. tuberculosis</em>) encodes a large repertoire of TA systems and these are highly conserved in members of the <em>M. tuberculosis</em> complex. In the present study, we have characterised PezAT and MbcTA TA systems from <em>M. tuberculosis.</em> We show that the transcript levels of toxins and antitoxins belonging to PezAT and MbcTA were increased in <em>M. tuberculosis</em> exposed to oxidative stress, nitrosative stress and rifampicin. We also show that the relative levels of precursors for the peptidoglycan biosynthesis were increased in the PezT overexpression strain of <em>M. smegmatis</em> relative to uninduced cultures. Here, we have used temperature-sensitive mycobacteriophages to generate Δ<em>pezAT</em> and Δ<em>mbcT</em> mutant strains of <em>M. tuberculosis</em>. We demonstrate that the deletion of <em>pezAT</em> reduced the growth of <em>M. tuberculosi</em>s upon exposure to detergent stress or rifampicin. However, the deletion of <em>mbcT</em> does not affect <em>M. tuberculosis</em> growth in various stress conditions. We also report that both PezAT and MbcT are dispensable for <em>M. tuberculosis</em> growth in macrophages and guinea pigs. Overall, these findings suggest that functional redundancy exists between TA systems.</div></div>","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"155 ","pages":"Article 102703"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145525596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

M. bovis FadR mutant exhibits an altered colony morphotype and increased virulence 牛分枝杆菌FadR突变体表现出改变的菌落形态和增加的毒力

IF 2.9 3区医学

Tuberculosis Pub Date : 2025-12-01 Epub Date: 2025-09-06 DOI: 10.1016/j.tube.2025.102689

Vandana Singh , Mohd Mustkim Ansari , Debashis Dutta , R.S. Rajmani , Amit Singh , Bhupendra N. Singh

{"title":"M. bovis FadR mutant exhibits an altered colony morphotype and increased virulence","authors":"Vandana Singh , Mohd Mustkim Ansari , Debashis Dutta , R.S. Rajmani , Amit Singh , Bhupendra N. Singh","doi":"10.1016/j.tube.2025.102689","DOIUrl":"10.1016/j.tube.2025.102689","url":null,"abstract":"<div><div>FadR, a GntR family transcriptional regulator, is known to maintain fatty acid homeostasis in prokaryotes. In this study, a <em>fadR</em> deletion mutant was generated in <em>Mycobacterium bovis</em>, which exhibited distinct morphological changes, along with enhanced permeability and increased antibiotic susceptibility. Interrupted cell-wall homeostasis often leads to such collateral phenotype. To gain insight into the lipid profile, we conducted lipidomics analysis, which revealed that the levels of DAT and PAT were higher in the mutant, while keto-mycolate methyl esters were lower. Further, key proteins responsible for altered phenotypes and lipid profiles were identified using a comparative proteomics approach between <em>M. bovis</em> and the Δ<em>fadR</em> mutant. In addition to lipid metabolism, several intermediary metabolic and stress response proteins predicted to have roles in the growth, survival, and pathogenicity of mycobacteria were also altered in the mutant. Notably, deletion of <em>fadR</em> led to hypervirulence in the animal model. Taken together, this study establishes a crucial role of FadR in the survival of mycobacteria by regulating lipid metabolism, providing insights into its potential as a target for therapeutic strategies against slow-growing mycobacteria.</div></div>","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"155 ","pages":"Article 102689"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145046233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating selection at intermediate scales within genes provides robust identification of genes under positive selection in M. tuberculosis clinical isolates 在中间尺度评估基因内的选择为结核分枝杆菌临床分离株的阳性选择提供了强有力的基因鉴定。

IF 2.9 3区医学

Tuberculosis Pub Date : 2025-12-01 Epub Date: 2025-09-11 DOI: 10.1016/j.tube.2025.102690

Thomas R. Ioerger, Anthony Shatby

{"title":"Evaluating selection at intermediate scales within genes provides robust identification of genes under positive selection in M. tuberculosis clinical isolates","authors":"Thomas R. Ioerger, Anthony Shatby","doi":"10.1016/j.tube.2025.102690","DOIUrl":"10.1016/j.tube.2025.102690","url":null,"abstract":"<div><div>Multiple studies have reported genes in the <em>M. tuberculosis</em> (Mtb) genome that are under diversifying selection, based on genetic variants among Mtb clinical isolates. These might reflect adaptions to selection pressures associated with modern clinical treatment of TB. Many, but not all, of these genes under selection are related to drug resistance. Most of these studies have evaluated selection at the gene-level. However, positive selection can be evaluated on different scales, including individual sites (codons) and local regions within an ORF. In this paper, we use GenomegaMap, a Bayesian method for calculating selection, to evaluate selection of genes in the Mtb genome at all three levels. We present evidence that the intermediate analysis (windows of codons) yields the most credible list of candidate genes under selection (excluding PPE and PE_PGRS genes, which are predicted less reliably due to frequent sequencing errors). A further advantage of this approach is that it identifies specific regions within proteins that are under selective pressure, which is useful for structural and functional interpretation. In an analysis of two separate collections of Mtb clinical isolates (from Moldova; and a globally-representative set), we observed 53 and 173 significant genes under selection, with 36 % overlap. The lists of genes under selection include many drug-resistance genes, as well as other genes that have previously been reported to be under selection (<em>resR, phoR</em>). The specific regions under selection identified within drug-resistance genes are shown to correspond to protein structural features known to be involved in resistance, supporting accuracy of the method. Positive selection in several ESX-1-related genes was also observed, suggesting adaptation to immune pressure.</div></div>","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"155 ","pages":"Article 102690"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Constructive appraisal of Zhong et al.’s study on Mycobacterium tuberculosis dormant antigens and PB2-DIMQ vaccine: Opportunities for translational strengthening 对Zhong等人结核分枝杆菌休眠抗原和PB2-DIMQ疫苗研究的建设性评价：加强翻译的机会。

IF 2.9 3区医学

Tuberculosis Pub Date : 2025-12-01 Epub Date: 2025-11-19 DOI: 10.1016/j.tube.2025.102708

Parth Aphale , Shashank Dokania , Himanshu Shekhar

引用次数: 0