Tuberculosis最新文献

{"title":"Bioarchaeological and molecular evidence of tuberculosis in human skeletal remains from 18th-19th century orthodox cemeteries in Irkutsk, Eastern Siberia","authors":"Natalia Kharlamova ,&nbsp;Oleg Ogarkov ,&nbsp;Ivan Berdnikov ,&nbsp;Natalia Berdnikova ,&nbsp;Ravil Galeev ,&nbsp;Igor Mokrousov","doi":"10.1016/j.tube.2023.102368","DOIUrl":"https://doi.org/10.1016/j.tube.2023.102368","url":null,"abstract":"<div><p>In this study, we tested the skeletal human remains from the 18th - early 19th century Orthodox cemeteries in Irkutsk, Eastern Siberia, for tuberculosis-associated morphological alterations and <span><em>Mycobacterium tuberculosis</em></span> DNA. The morphologically studied bone collection included 591 individuals of mainly Caucasian origin. The molecular methods (IS<em>6110</em>-PCR and spoligotyping) suggested that at least four individuals (out of 15 TB-suspected, DNA-tested) were positive for the presence of <em>M. tuberculosis</em> DNA. All of them were males (3 maturus, 1 maturus senilis). Two of them date back to the second and third quarters of the 18th century, another to the last quarter of the 18th century, and the last one to the second half of the 19th century. The combined molecular analysis cautiously suggested presence of different strains and at least some of them represented not the currently predominant in Siberia Beijing genotype (<em>M. tuberculosis</em> East-Asian lineage) but strains of European origin. In conclusion, this study presented bioarchaeological and molecular evidence of tuberculosis in human skeletal remains from 18th-19th century Orthodox cemeteries in Irkutsk, Eastern Siberia. The samples are not <em>M. bovis</em> and represent human <em>M. tuberculosis sensu stricto</em><span>. Their precise phylogenetic identity is elusive but evokes the European/Russian origin of at least some isolates.</span></p></div>","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"143 ","pages":"Article 102368"},"PeriodicalIF":3.2,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138438176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The paradoxes of Mycobacterium tuberculosis molecular evolution and consequences for the inference of tuberculosis emergence date","authors":"R. Zein-Eddine ,&nbsp;F. Hak ,&nbsp;A. Le Meur ,&nbsp;C. Genestet ,&nbsp;O. Dumitrescu ,&nbsp;C. Guyeux ,&nbsp;G. Senelle ,&nbsp;C. Sola ,&nbsp;G. Refrégier","doi":"10.1016/j.tube.2023.102378","DOIUrl":"https://doi.org/10.1016/j.tube.2023.102378","url":null,"abstract":"<div><p>The date of <em>Mycobacterium tuberculosis</em> complex emergence has been the subject of long debates. New studies joining archaeological efforts with sequencing methods raise high hopes for solving whether this emergence is closer to 70,000 or to 6000 years before present.</p><p><span>Inferring the date of emergence of this pathogen<span> based on sequence data requires a molecular clock. Several clocks inferred from different types of loci and/or different samples, using both sound reasoning and reliable data, are actually very different, which we refer to as the paradoxes of </span></span><em>M. tuberculosis</em><span> molecular evolution. After having presented these paradoxes, we will remind the limits of the molecular clocks used in the different studies such as the assumption of homogeneous substitution rate. We will then review recent results that shed new light on the characteristics of </span><em>M. tuberculosis</em> molecular evolution: traces of diverse selection pressures, the impact of host dynamics, etc. We provide some ideas on what to do next to get nearer to a reliable dating of <em>Mycobacterium tuberculosis</em> complex emergence. Among them, the collection of additional remains from ancient tuberculosis seems still essential.</p></div>","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"143 ","pages":"Article 102378"},"PeriodicalIF":3.2,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138438177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuberculosis before and after the Black Death (1346–1353 CE) in the Hospital of St John the Evangelist in Cambridge, England","authors":"Jenna M. Dittmar ,&nbsp;Piers D. Mitchell ,&nbsp;Sarah A. Inskip ,&nbsp;Craig Cessford ,&nbsp;John E. Robb","doi":"10.1016/j.tube.2023.102401","DOIUrl":"https://doi.org/10.1016/j.tube.2023.102401","url":null,"abstract":"<div><p>This research explores how the prevalence of tuberculosis (TB) in a medieval hospital was affected by the demographic and social changes that following the Black Death (1346–1353 CE), the initial years of the Second Plague Pandemic. To do this, skeletal remains of individuals buried at the Hospital of St John the Evangelist in Cambridge, England, that could be dated to living before (n = 77) or after (n = 55) the Black Death were assessed for evidence of TB (indicated by destructive lesions of the spine, ribs, large joints, and other recognised criteria). Overall, the odds of females having skeletal lesions caused by TB were over four times higher than males. No significant difference was detected in the prevalence rates in those who lived before and after the Black Death (7.8%, 6/77 before and 11.0%, 6/55 after). However, the odds of females having skeletal evidence of TB were over five times greater after the Black Death than they were before. These findings indicate that women may have been 1) more susceptible to TB, 2) surviving longer post-infection than men, and/or 3) that women with TB were more likely to be admitted to the Hospital especially following the Black Death. It is also possible that impairment due to TB infection may have been a contributing factor for entry into the Hospital for women but not men.</p></div>","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"143 ","pages":"Article 102401"},"PeriodicalIF":3.2,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1472979223000999/pdfft?md5=94c39e25fa5f23a9e51241dca99a430d&pid=1-s2.0-S1472979223000999-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138437677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upper Paleolithic tuberculosis: A probable case illustrated by paleoimaging methods (Azilian site of Les Iboussières, France)","authors":"Hélène Coqueugniot ,&nbsp;György Pálfi ,&nbsp;Bernard Gély ,&nbsp;Olivier Dutour","doi":"10.1016/j.tube.2023.102373","DOIUrl":"https://doi.org/10.1016/j.tube.2023.102373","url":null,"abstract":"<div><p><span><span>The aim of this paper is to present the results of μCT-scan and 3D imaging<span> analyses of two skeletal lesions observed on human remains of one of the last European hunter-gatherers from the late Paleolithic (Azilian period): a </span></span>sacroiliac osteoarthritis<span><span> and a femoral lesion suggestive of a soft tissue abscess imprint. These two skeletal elements (fused left </span>sacrum and coxal bone, and right femur) displayed </span></span>osteometric criteria indicating that they belonged to the same individual. These two associated lesions are consistent with a low-grade osteoarticular infection, and suggest a diagnosis of pelvic tuberculosis with a cold abscess of the thigh. If molecular confirmation is obtained, this case would be the first evidence of tuberculosis among Upper Palaeolithic populations.</p></div>","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"143 ","pages":"Article 102373"},"PeriodicalIF":3.2,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138437820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitive lipid biomarker detection for tuberculosis in late Neanderthal skeletons from Subalyuk Cave, Hungary","authors":"Oona Y-C. Lee ,&nbsp;Houdini H.T. Wu ,&nbsp;Gurdyal S. Besra ,&nbsp;David E. Minnikin ,&nbsp;Heidi Y. Jaeger ,&nbsp;Frank Maixner ,&nbsp;Albert Zink ,&nbsp;Mihály Gasparik ,&nbsp;Ildikó Pap ,&nbsp;Zsolt Bereczki ,&nbsp;György Pálfi","doi":"10.1016/j.tube.2023.102420","DOIUrl":"https://doi.org/10.1016/j.tube.2023.102420","url":null,"abstract":"<div><p>Skeletal remains of two Neanderthal individuals, a 25-35 year-old woman and a 3-4 year-old child, were discovered in a Subalyuk Cave in North-Eastern Hungary. Radiocarbon dating of the female and child remains revealed an age of 39,732–39,076 and 36,117–35,387 cal BP, respectively. Paleopathological studies of these Neanderthal remains revealed probable evidence of skeletal mycobacterial infection, including in the sacrum of the adult specimen and the endocranial surface of the child's skull. Application of PCR amplification to the juvenile cranium and a vertebra gave a positive result (IS6110) for tuberculosis, backed up by spoligotyping. Lipid biomarker analyses of the same two specimens revealed definitive signals for C₃₂ mycoserosates, a very characteristic component of the <em>Mycobacterium tuberculosis</em> complex (MTBC). A vertebra from the adult provided weak evidence for mycocerosate biomarkers. The correlation of probable skeletal lesions with characteristic amplified DNA fragments and a proven lipid biomarker points to the presence of tuberculosis in these Neanderthals. In particular, the closely similar biomarker profiles, for two distinct juvenile cranial and vertebral bones, strengthen this diagnosis.</p></div>","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"143 ","pages":"Article 102420"},"PeriodicalIF":3.2,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S147297922300118X/pdfft?md5=84b743b0d0c0b8238c124bf7c72d644f&pid=1-s2.0-S147297922300118X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138437917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards the reconstruction of a global TB history using a new pipeline “TB-Annotator\"","authors":"Gaetan Senelle ,&nbsp;Muhammed Rabiu Sahal ,&nbsp;Kevin La ,&nbsp;Typhaine Billard-Pomares ,&nbsp;Julie Marin ,&nbsp;Faiza Mougari ,&nbsp;Antoine Bridier-Nahmias ,&nbsp;Etienne Carbonnelle ,&nbsp;Emmanuelle Cambau ,&nbsp;Guislaine Refrégier ,&nbsp;Christophe Guyeux ,&nbsp;Christophe Sola","doi":"10.1016/j.tube.2023.102376","DOIUrl":"https://doi.org/10.1016/j.tube.2023.102376","url":null,"abstract":"<div><p><em>Mycobacterium tuberculosis</em><span> complex (MTBC) has a population structure consisting of 9 human and animal lineages<span>. The genomic diversity within these lineages is a pathogenesis factor that affects virulence, transmissibility, host response, and antibiotic resistance. Hence it is important to develop improved information systems for tracking and understanding the spreading and evolution of genomes. We present results obtained thanks to a new informatics platform for computational biology of MTBC, that uses a convenience sample from public/private SRAs, designated as </span></span><em>TB-Annotator</em><span><span>. Version 1 was a first interactive graphic-based web tool based on 15,901 representative genomes. Version 2, still interactive, is a more sophisticated database, developed using the Snakemake Workflow Management System (WMS) that allows an unsupervised global and scalable analysis of the content of the USA National Center for Biotechnology Information Short Read Archives database. This platform analyzes nucleotide variants, the presence/absence of genes, known regions of difference and detect new deletions, the insertion sites of mobile genetic elements, and allows </span>phylogenetic trees to be built, imported in a graphical interface and interactively analyzed between the data and the tree. The objective of </span><em>TB-Annotator</em> is triple: detect recent epidemiological links, reconstruct distant phylogeographical histories as well as perform more complex phenotypic/genotypic Genome-Wide Association Studies (GWAS). In this paper, we compare the various taxonomic SNPs-based labels and hierarchies previously described in recent reference papers for L1, and present a comparative analysis that allows identification of <em>alias</em> and thus provides the basis of a future unifying naming scheme for L1 sublineages. We present a global phylogenetic tree built with RAxML-NG, and one on L2; at the time of writing, we characterized about 200 sublineages, with many new ones; a detail tree for Modern L2 and a hierarchical scheme allowing to facilitate L2 lineage assignment are also presented.</p></div>","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"143 ","pages":"Article 102376"},"PeriodicalIF":3.2,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138438164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in mortality by tuberculosis in non-industrialized Coimbra (Portugal): Trends between 1861 and 1914","authors":"Ana Luisa Santos ,&nbsp;Bruno M. Magalhães ,&nbsp;Cinzia Roggio","doi":"10.1016/j.tube.2023.102394","DOIUrl":"https://doi.org/10.1016/j.tube.2023.102394","url":null,"abstract":"<div><p>Considering that before antibiotics and vaccination the course of tuberculosis depended mostly on the patient's immune response, this study tested the hypothesis that the mortality profile remained similar during the transition from the 19th to 20th century.</p><p>The biographical data of the individuals buried in the Coimbra Municipal Cemetery of Conchada were analysed, and the records of those who were born in the city and had tuberculosis registered as the cause of death were analysed using SPSS.</p><p><span>The years of death were grouped: 1861–1870 (n = 124, 22.5%), 1871–1880 (n = 234, 42.4%), and 1910–1914 (5 years, n = 194, 35.1%). Mortality by tuberculosis has increased over the years. A total of 552 individuals, 242 females (43.8%) and 310 males (56.2%) died of tuberculosis (p &lt; 0.05). The mean age at death (min = 11 days, max = 86 years) decreased over time, respectively 51.8, 53.1, and 35.8 years-old for individuals &gt;20. Deaths by pulmonary tuberculosis<span> (n = 38, 1861–1870; n = 115, 1910–1914) and meningeal tuberculosis (n = 0, 1861–1870; n = 48, 1910–1914) increased over time, whereas </span></span>scrofula<span> decreased (n = 23, 1861–1870; n = 3, 1910–1914). Only a 12 years-old male (0.2%) died of bone tuberculosis. Infant (0-3 years-old) mortality occurred mainly (50.5%,48/95) between July and October.</span></p><p>The hypothesis tested was not confirmed. Death by tuberculosis has increased, which may be a consequence of population growth, deterioration of the living conditions, and/or changes in bacterial virulence and/or in the host immune system.</p></div>","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"143 ","pages":"Article 102394"},"PeriodicalIF":3.2,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138438172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paleopathology and evolution of tuberculosis editorial","authors":"György Pálfi,&nbsp;Olivier Dutour,&nbsp;Tamás Hajdu,&nbsp;Christophe Sola,&nbsp;Albert Zink","doi":"10.1016/j.tube.2023.102428","DOIUrl":"https://doi.org/10.1016/j.tube.2023.102428","url":null,"abstract":"","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"143 ","pages":"Article 102428"},"PeriodicalIF":3.2,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138437781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front Matter 1 - Full Title Page [Supplement Issue]","authors":"","doi":"10.1016/S1472-9792(23)00139-7","DOIUrl":"https://doi.org/10.1016/S1472-9792(23)00139-7","url":null,"abstract":"","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"143 ","pages":"Article 102441"},"PeriodicalIF":3.2,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138437918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outside Front Cover - Journal name, Cover image, Volume issue details, ISSN, Cover Date, Elsevier Logo and Society Logo if required","authors":"","doi":"10.1016/S1472-9792(23)00137-3","DOIUrl":"https://doi.org/10.1016/S1472-9792(23)00137-3","url":null,"abstract":"","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"143 ","pages":"Article 102439"},"PeriodicalIF":3.2,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138437698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}