Tuberculosis最新文献

{"title":"Upper Paleolithic tuberculosis: A probable case illustrated by paleoimaging methods (Azilian site of Les Iboussières, France)","authors":"Hélène Coqueugniot ,&nbsp;György Pálfi ,&nbsp;Bernard Gély ,&nbsp;Olivier Dutour","doi":"10.1016/j.tube.2023.102373","DOIUrl":"https://doi.org/10.1016/j.tube.2023.102373","url":null,"abstract":"<div><p><span><span>The aim of this paper is to present the results of μCT-scan and 3D imaging<span> analyses of two skeletal lesions observed on human remains of one of the last European hunter-gatherers from the late Paleolithic (Azilian period): a </span></span>sacroiliac osteoarthritis<span><span> and a femoral lesion suggestive of a soft tissue abscess imprint. These two skeletal elements (fused left </span>sacrum and coxal bone, and right femur) displayed </span></span>osteometric criteria indicating that they belonged to the same individual. These two associated lesions are consistent with a low-grade osteoarticular infection, and suggest a diagnosis of pelvic tuberculosis with a cold abscess of the thigh. If molecular confirmation is obtained, this case would be the first evidence of tuberculosis among Upper Palaeolithic populations.</p></div>","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138437820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitive lipid biomarker detection for tuberculosis in late Neanderthal skeletons from Subalyuk Cave, Hungary","authors":"Oona Y-C. Lee ,&nbsp;Houdini H.T. Wu ,&nbsp;Gurdyal S. Besra ,&nbsp;David E. Minnikin ,&nbsp;Heidi Y. Jaeger ,&nbsp;Frank Maixner ,&nbsp;Albert Zink ,&nbsp;Mihály Gasparik ,&nbsp;Ildikó Pap ,&nbsp;Zsolt Bereczki ,&nbsp;György Pálfi","doi":"10.1016/j.tube.2023.102420","DOIUrl":"https://doi.org/10.1016/j.tube.2023.102420","url":null,"abstract":"<div><p>Skeletal remains of two Neanderthal individuals, a 25-35 year-old woman and a 3-4 year-old child, were discovered in a Subalyuk Cave in North-Eastern Hungary. Radiocarbon dating of the female and child remains revealed an age of 39,732–39,076 and 36,117–35,387 cal BP, respectively. Paleopathological studies of these Neanderthal remains revealed probable evidence of skeletal mycobacterial infection, including in the sacrum of the adult specimen and the endocranial surface of the child's skull. Application of PCR amplification to the juvenile cranium and a vertebra gave a positive result (IS6110) for tuberculosis, backed up by spoligotyping. Lipid biomarker analyses of the same two specimens revealed definitive signals for C₃₂ mycoserosates, a very characteristic component of the <em>Mycobacterium tuberculosis</em> complex (MTBC). A vertebra from the adult provided weak evidence for mycocerosate biomarkers. The correlation of probable skeletal lesions with characteristic amplified DNA fragments and a proven lipid biomarker points to the presence of tuberculosis in these Neanderthals. In particular, the closely similar biomarker profiles, for two distinct juvenile cranial and vertebral bones, strengthen this diagnosis.</p></div>","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S147297922300118X/pdfft?md5=84b743b0d0c0b8238c124bf7c72d644f&pid=1-s2.0-S147297922300118X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138437917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards the reconstruction of a global TB history using a new pipeline “TB-Annotator\"","authors":"Gaetan Senelle ,&nbsp;Muhammed Rabiu Sahal ,&nbsp;Kevin La ,&nbsp;Typhaine Billard-Pomares ,&nbsp;Julie Marin ,&nbsp;Faiza Mougari ,&nbsp;Antoine Bridier-Nahmias ,&nbsp;Etienne Carbonnelle ,&nbsp;Emmanuelle Cambau ,&nbsp;Guislaine Refrégier ,&nbsp;Christophe Guyeux ,&nbsp;Christophe Sola","doi":"10.1016/j.tube.2023.102376","DOIUrl":"https://doi.org/10.1016/j.tube.2023.102376","url":null,"abstract":"<div><p><em>Mycobacterium tuberculosis</em><span> complex (MTBC) has a population structure consisting of 9 human and animal lineages<span>. The genomic diversity within these lineages is a pathogenesis factor that affects virulence, transmissibility, host response, and antibiotic resistance. Hence it is important to develop improved information systems for tracking and understanding the spreading and evolution of genomes. We present results obtained thanks to a new informatics platform for computational biology of MTBC, that uses a convenience sample from public/private SRAs, designated as </span></span><em>TB-Annotator</em><span><span>. Version 1 was a first interactive graphic-based web tool based on 15,901 representative genomes. Version 2, still interactive, is a more sophisticated database, developed using the Snakemake Workflow Management System (WMS) that allows an unsupervised global and scalable analysis of the content of the USA National Center for Biotechnology Information Short Read Archives database. This platform analyzes nucleotide variants, the presence/absence of genes, known regions of difference and detect new deletions, the insertion sites of mobile genetic elements, and allows </span>phylogenetic trees to be built, imported in a graphical interface and interactively analyzed between the data and the tree. The objective of </span><em>TB-Annotator</em> is triple: detect recent epidemiological links, reconstruct distant phylogeographical histories as well as perform more complex phenotypic/genotypic Genome-Wide Association Studies (GWAS). In this paper, we compare the various taxonomic SNPs-based labels and hierarchies previously described in recent reference papers for L1, and present a comparative analysis that allows identification of <em>alias</em> and thus provides the basis of a future unifying naming scheme for L1 sublineages. We present a global phylogenetic tree built with RAxML-NG, and one on L2; at the time of writing, we characterized about 200 sublineages, with many new ones; a detail tree for Modern L2 and a hierarchical scheme allowing to facilitate L2 lineage assignment are also presented.</p></div>","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138438164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in mortality by tuberculosis in non-industrialized Coimbra (Portugal): Trends between 1861 and 1914","authors":"Ana Luisa Santos ,&nbsp;Bruno M. Magalhães ,&nbsp;Cinzia Roggio","doi":"10.1016/j.tube.2023.102394","DOIUrl":"https://doi.org/10.1016/j.tube.2023.102394","url":null,"abstract":"<div><p>Considering that before antibiotics and vaccination the course of tuberculosis depended mostly on the patient's immune response, this study tested the hypothesis that the mortality profile remained similar during the transition from the 19th to 20th century.</p><p>The biographical data of the individuals buried in the Coimbra Municipal Cemetery of Conchada were analysed, and the records of those who were born in the city and had tuberculosis registered as the cause of death were analysed using SPSS.</p><p><span>The years of death were grouped: 1861–1870 (n = 124, 22.5%), 1871–1880 (n = 234, 42.4%), and 1910–1914 (5 years, n = 194, 35.1%). Mortality by tuberculosis has increased over the years. A total of 552 individuals, 242 females (43.8%) and 310 males (56.2%) died of tuberculosis (p &lt; 0.05). The mean age at death (min = 11 days, max = 86 years) decreased over time, respectively 51.8, 53.1, and 35.8 years-old for individuals &gt;20. Deaths by pulmonary tuberculosis<span> (n = 38, 1861–1870; n = 115, 1910–1914) and meningeal tuberculosis (n = 0, 1861–1870; n = 48, 1910–1914) increased over time, whereas </span></span>scrofula<span> decreased (n = 23, 1861–1870; n = 3, 1910–1914). Only a 12 years-old male (0.2%) died of bone tuberculosis. Infant (0-3 years-old) mortality occurred mainly (50.5%,48/95) between July and October.</span></p><p>The hypothesis tested was not confirmed. Death by tuberculosis has increased, which may be a consequence of population growth, deterioration of the living conditions, and/or changes in bacterial virulence and/or in the host immune system.</p></div>","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138438172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paleopathology and evolution of tuberculosis editorial","authors":"György Pálfi,&nbsp;Olivier Dutour,&nbsp;Tamás Hajdu,&nbsp;Christophe Sola,&nbsp;Albert Zink","doi":"10.1016/j.tube.2023.102428","DOIUrl":"https://doi.org/10.1016/j.tube.2023.102428","url":null,"abstract":"","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138437781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front Matter 1 - Full Title Page [Supplement Issue]","authors":"","doi":"10.1016/S1472-9792(23)00139-7","DOIUrl":"https://doi.org/10.1016/S1472-9792(23)00139-7","url":null,"abstract":"","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138437918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outside Front Cover - Journal name, Cover image, Volume issue details, ISSN, Cover Date, Elsevier Logo and Society Logo if required","authors":"","doi":"10.1016/S1472-9792(23)00137-3","DOIUrl":"https://doi.org/10.1016/S1472-9792(23)00137-3","url":null,"abstract":"","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138437698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"More than one millennium (2nd-16th century CE) of the White Plague in the Carpathian Basin – New cases, expanding knowledge","authors":"Krisztián Kiss ,&nbsp;Marianna Bálint ,&nbsp;Anett Gémes ,&nbsp;Antónia Marcsik ,&nbsp;Áron Dávid ,&nbsp;Sándor Évinger ,&nbsp;Péter Gróf ,&nbsp;Dániel Gróh ,&nbsp;Katalin Éva Gyenesei ,&nbsp;István János ,&nbsp;Barbara Kolozsi ,&nbsp;Loránd Olivér Kovács ,&nbsp;Orsolya Mateovics-László ,&nbsp;Csilla Líbor ,&nbsp;Mónika Merczi ,&nbsp;Erika Molnár ,&nbsp;Csilla Emese Németh ,&nbsp;György Pálfi ,&nbsp;Ágota Perémi ,&nbsp;Zsófia Rácz ,&nbsp;Tamás Szeniczey","doi":"10.1016/j.tube.2023.102387","DOIUrl":"https://doi.org/10.1016/j.tube.2023.102387","url":null,"abstract":"<div><p>The causative agent of tuberculosis is still a widespread pathogen, which caused the death of ca. 1.6 million people globally in 2021. The paleopathological study of human remains revealed the antiquity of the disease and its continuous presence throughout the history of humankind. The Carpathian Basin has always been a biocultural melting pot, since it has seen several migrations over the centuries, and served as a location of admixture and interaction for numerous populations of different cultures. Thus, this geographical territory is ideal for the examination of the coevolutionary processes of hosts and their pathogens. We aimed to reveal the spatial and temporal distribution of tuberculosis cases excavated inside the borders of Hungary between the 2nd and 16th centuries CE. We established a comprehensive database by collecting 114 already published cases and introducing 39 new cases. The involved cases include those that have been confirmed by different molecular methods, as well as possible infections that were identified based on the presence of macromorphological and radiological alterations. The progress of future molecular and paleopathological studies can be facilitated by our dataset, as it presents spatial and temporal information concerning the spread of the disease in the Carpathian Basin, as well as the biological profile and detailed paleopathological description of lesions illustrated by photo- and radiographs.</p></div>","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138437780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oldest evidence of tuberculosis in the Mediterranean islands: From the mainland to Cyprus","authors":"Françoise Le Mort ,&nbsp;Joseph Oussama Baker ,&nbsp;Bérénice Chamel ,&nbsp;Hélène Coqueugniot ,&nbsp;Olivier Dutour","doi":"10.1016/j.tube.2023.102388","DOIUrl":"https://doi.org/10.1016/j.tube.2023.102388","url":null,"abstract":"<div><p>Recent studies combining macroscopical observations and microCT analysis strongly suggested the diagnosis of tuberculosis for a child from the site of Khirokitia (Cyprus, 7th - early 6th millennium cal. BC), whose age at death is between 5 and 7 years. Many single primary burials were discovered at the site where the dead (MNI = 243) are buried in the same way, whatever their age. Nevertheless, the burial of this child presents a unique feature on the site (a male <span><em>Ovis</em></span> trophy marking the limit of the burial pit), probably indicating specific attention for this young deceased. This case is the oldest known in the Mediterranean islands and presents a particular interest from a paleoepidemiological point of view. Indeed, considering, on the one hand, the settlement pattern of the island of Cyprus by migrants from the Near East, and on the other hand, the presence of human tuberculosis in the Near East as early as about 10,500 years BP, it is very likely that the prehistoric migrants brought the disease from mainland to Cyprus.</p></div>","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138437916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In gratitude for the collaborative partnership with David E. Minnikin","authors":"Orsolya Anna Váradi ,&nbsp;Antónia Marcsik ,&nbsp;Muriel Masson ,&nbsp;Erika Molnár ,&nbsp;Ildikó Pap ,&nbsp;Olga Spekker ,&nbsp;András Szekeres ,&nbsp;György Pálfi","doi":"10.1016/j.tube.2023.102364","DOIUrl":"https://doi.org/10.1016/j.tube.2023.102364","url":null,"abstract":"","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1472979223000628/pdfft?md5=0fea52d0473409670db79bb57d6144ad&pid=1-s2.0-S1472979223000628-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138438143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}