Turkish Journal of Pharmaceutical Sciences最新文献

A Novel Controlled Release Implant of Insulin Based on Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Polymer Prepared by Extrusion. 基于挤出法制备聚（3-羟基丁酸酯-co-3-羟基戊酸酯）聚合物的新型胰岛素控释植入物

IF 1.8

Turkish Journal of Pharmaceutical Sciences Pub Date : 2024-11-21 DOI: 10.4274/tjps.galenos.2023.10663

Fatemeh Dadgar Pakdel, Javad Dadgar Pakdel, Ali Najmeddin, Afshin Peirovi, Mohammad Hossein Nicknam, Farid Abedin Dorkoosh

{"title":"A Novel Controlled Release Implant of Insulin Based on Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Polymer Prepared by Extrusion.","authors":"Fatemeh Dadgar Pakdel, Javad Dadgar Pakdel, Ali Najmeddin, Afshin Peirovi, Mohammad Hossein Nicknam, Farid Abedin Dorkoosh","doi":"10.4274/tjps.galenos.2023.10663","DOIUrl":"10.4274/tjps.galenos.2023.10663","url":null,"abstract":"Objectives: The aim of this study was to develop a biodegradable implant with a slow release of insulin to minimize the amount of repeated drug injections in patients.Developing and designing implants with controlled release of active protein has always been a challenge. To optimize and control the release of insulin in this project, the drug complexing mechanism was used by dextran sulfate sodium (DS) and Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) polymer.Materials and methods: The efficacy of drug binding was evaluated under different molecular ratios of DS, and then a thermogravimetric analysis test was done to check the stability of the drug complex in extrusion. In the final stage, rod-shaped implants of complexed insulin were prepared by an extrusion process, and the drug release was evaluated within 32 days. The drug release kinetics were evaluated using mathematical models.Results: The results showed an increase in insulin binding efficiency percent, up to a ratio of 2.6. The drug release from the implant containing complex insulin was completely controlled. The drug release followed a zero-order release model. Interestingly, the complex form of the drug showed a temperature resistance of 160 °C for ten minutes.Conclusion: In this study, for the first time, a controlled release implant of insulin has been developed based on a PHBV polymer. In this method, the extrusion process has been used, which provides the possibility of preparing implants on an industrial scale in the future. Also, their development appears to be a promising treatment for diabetic patients and leads to the elimination of frequent drug injections and then more adherence of the patients to the continuation of the treatment process.","PeriodicalId":23378,"journal":{"name":"Turkish Journal of Pharmaceutical Sciences","volume":" ","pages":"483-488"},"PeriodicalIF":1.8,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48709722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of Enterocin Production from Probiotic Enterococcus faecium Using Taguchi Experimental Design. 田口实验设计优化益生菌粪肠球菌产肠毒素的研究

IF 1.8

Turkish Journal of Pharmaceutical Sciences Pub Date : 2024-07-12 DOI: 10.4274/tjps.galenos.2023.83451

Dina Manny, Amr El-Waseif, Eslam Abd El-Wahed

{"title":"Optimization of Enterocin Production from Probiotic Enterococcus faecium Using Taguchi Experimental Design.","authors":"Dina Manny, Amr El-Waseif, Eslam Abd El-Wahed","doi":"10.4274/tjps.galenos.2023.83451","DOIUrl":"10.4274/tjps.galenos.2023.83451","url":null,"abstract":"Objectives: Enterocin is a significant broad-spectrum peptide antibiotic produced by Enterococcus faecium (E. faecium). Enterocin production by E. faecium was investigated using the Taguchi experimental design. The Taguchi models were used to save the time and effort required for optimizing the different conditions affecting its production. They were applied to optimize the conditions for enterocin production using the least number of experiments and the least number of required materials.Materials and methods: Seven factors i.e., pH, temperature, time of incubation, aeration rate, inoculum size, carbohydrate concentration, and bile salt concentrations, each at three levels were selected and an orthogonal array layout of L273 was performed.Results: The experimental results indicated that the best incubation conditions were; 48 hours incubation on a nutrient medium at pH 6.5, temperature at 25 °C, aeration rate at 0 round per minute, inoculum size 20 mL, and bile salt concentration. It was 5%, and the carbon concentration was 2.0%. All these factors combined led to the best enterocin production by E. faecium.Conclusion: This optimization of enterocin production by the Taguchi experimental models emphasized some important results regarding the interaction of the different driving factors leading to the best enterocin production in one experiment.","PeriodicalId":23378,"journal":{"name":"Turkish Journal of Pharmaceutical Sciences","volume":"1 1","pages":"192-198"},"PeriodicalIF":1.8,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41613629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of a Synthetic PEI-based Polymeric Vector for ING4 Gene Delivery to MCF-7 Breast Cancer Cells 评估基于 PEI 的合成聚合物载体向 MCF-7 乳腺癌细胞传递 ING4 基因的效果

IF 1.7

Turkish Journal of Pharmaceutical Sciences Pub Date : 2023-12-25 DOI: 10.4274/tjps.galenos.2023.72430

Uğur Karagöz, Remant Bahadur Kc, Elif İşel, A. G. Kantarci, Hasan Uludag

引用次数: 0

Evaluation of Anticancer and Antioxidant Activities of Coffee Stem Parasite Extract (Scurrula Ferruginea (Roxb. Ex Jack) Danser) and in Silico Studies of its Isolate 咖啡茎寄生虫提取物（Scurrula Ferruginea (Roxb. Ex Jack) Danser）的抗癌和抗氧化活性评估及其分离物的硅学研究

IF 1.7

Turkish Journal of Pharmaceutical Sciences Pub Date : 2023-12-25 DOI: 10.4274/tjps.galenos.2023.26243

Destria Roza, Gianna Fadhilah, Eka Indriani, Yuli Asih Wiliranti, T. Juwitaningsih

引用次数: 0

Development of Cyclosporine A Nanosuspension using Experimental Design by Response Surface Methodology: In Vitro Evaluations 响应面法实验设计制备环孢素A纳米混悬液:体外评价

Turkish Journal of Pharmaceutical Sciences Pub Date : 2023-11-14 DOI: 10.4274/tjps.galenos.2023.68054

Sıla Gülbağ Pınar, Nevin Çelebi

引用次数: 0

Formulation and Evaluation of Triamcinolone Acetonide-loaded Oral Disintegrated Film with Different Polymers via Solvent Casting Method 不同聚合物载曲安奈德口腔崩解膜的溶剂铸造法制备及评价

Turkish Journal of Pharmaceutical Sciences Pub Date : 2023-11-14 DOI: 10.4274/tjps.galenos.2023.37807

Özlem Çoban, Kutsal Özcan, Seçkin Engin, Buse Tatar, Mihriban Soylu

引用次数: 0

Prospective-Drug Utilization Evaluation Analysis in Ear, Nose, and Throat Outpatient Department: Incorporating Benchmarks and World Health Organization Indicators 耳鼻喉科门诊的前瞻性用药评估分析：纳入基准和世界卫生组织指标

IF 1.7

Turkish Journal of Pharmaceutical Sciences Pub Date : 2023-09-29 DOI: 10.4274/tjps.galenos.2022.50246

Vinodkumar Mugada, Blessy Jayamon, Bindu Krishna Kosireddy, Bhagya Sri Palisetty, Apoorva Pinisetti

{"title":"Prospective-Drug Utilization Evaluation Analysis in Ear, Nose, and Throat Outpatient Department: Incorporating Benchmarks and World Health Organization Indicators","authors":"Vinodkumar Mugada, Blessy Jayamon, Bindu Krishna Kosireddy, Bhagya Sri Palisetty, Apoorva Pinisetti","doi":"10.4274/tjps.galenos.2022.50246","DOIUrl":"https://doi.org/10.4274/tjps.galenos.2022.50246","url":null,"abstract":"Background : A drug utilization study is a tool for determining the effectiveness of drug use. Our research aims to evaluate the drug usage patterns in Ear, Nose, and Throat (ENT) outpatient settings by incorporating established benchmarks and World Health Organization (WHO) indicators. Methods : We conducted a drug utilization evaluation (DUE) study on 800 patients from the ENT outpatient department (OPD). Initially, we gathered data on the currently prescribed medications and, through careful analysis, identified discrepancies. To rectify any irrational prescribing patterns identified among physicians, we utilized continuing educational activities like 'Dear Doctor' letters and personal consultations. We applied the WHO's core indicators, specifically prescribing and patient care indicators, and established benchmarks to encourage rational prescribing. Results : The three most common diagnoses identified were pharyngitis (51.49%), allergic rhinitis (25.11%), and Acute Suppurative Otitis Media (21.17%). Montelukast, in combination with levocetirizine (13.77%) and amoxicillin paired with clavulanic acid (8.81%), were the most frequently prescribed medications. The study revealed prescribing indicators such as an excessive number of drugs per prescription (4.2), low usage of generic names (33.0%), and suboptimal reliance on the Essential Drugs List (76.7%). Furthermore, patient care indicators demonstrated room for improvement, particularly concerning consultation times (6mins","PeriodicalId":23378,"journal":{"name":"Turkish Journal of Pharmaceutical Sciences","volume":"139 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139334444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Inclusion of Sports & Exercise Related Module into Pharmacy Curriculum: Non-pharmacological Approach on Students’ Health Parameters 将体育锻炼相关模块纳入药学课程：非药物疗法对学生健康指标的影响

IF 1.7

Turkish Journal of Pharmaceutical Sciences Pub Date : 2023-09-20 DOI: 10.4274/tjps.galenos.2023.23428

Ahmad Rashidi Mohamed Tahir, Voon Jia Haw, Wan Sazrina Wan Zaid, M. Nizaruddin, Arimi Fitri Mat Ludin

{"title":"The Inclusion of Sports & Exercise Related Module into Pharmacy Curriculum: Non-pharmacological Approach on Students’ Health Parameters","authors":"Ahmad Rashidi Mohamed Tahir, Voon Jia Haw, Wan Sazrina Wan Zaid, M. Nizaruddin, Arimi Fitri Mat Ludin","doi":"10.4274/tjps.galenos.2023.23428","DOIUrl":"https://doi.org/10.4274/tjps.galenos.2023.23428","url":null,"abstract":"Objectives: To promote a holistic approach to healthcare, the University of Cyberjaya (UoC) introduced a unique elective course called sport pharmacy which incorporates components of lifestyle interventions. Customers are increasingly seeking guidance on lifestyle factors that impact their health. Pharmacists with expertise in sports and exercise can meet this demand. However, there is a lack of studies about the impact of non-pharmacological approaches on health parameters among healthcare professionals and pharmacy students in Malaysia. The objectives of this study were to compare students’ health parameters based on non-pharmacological approaches and identify the factors that motivate them to maintain their health. Materials and Methods: The study comprised of 47 Year 4 pharmacy students in pre and post practical phase (September 2018 and November 2018), followed by post-resting phase (May 2019). Data collection form in the Sport Pharmacy course was used for the data collection. Results: A little less than half of the students displayed normal Body Mass Index (BMI). After the post-resting period, there was a rise in the number of students classified as obese, as well as those with high TC and FBG. Around 23% continued to control their diet and 32% maintained their physical activity levels during the post-resting study.","PeriodicalId":23378,"journal":{"name":"Turkish Journal of Pharmaceutical Sciences","volume":"22 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139338665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Timolol Maleate In Situ Ophthalmic Mucoadhesive-Thermosensitive Gel: Development and Characterization 马来酸噻吗洛尔原位眼用粘胶-热敏凝胶：开发与表征

IF 1.7

Turkish Journal of Pharmaceutical Sciences Pub Date : 2023-09-19 DOI: 10.4274/tjps.galenos.2023.50723

Sibel İLBASMIŞ TAMER, Özlem Çulcu, Eda Turan, Fahriye Figen Tirnaksiz

引用次数: 0

Hemagglutinin from the Root Tuber of Dioscorea preussii Pax Exhibit Antioxidative Prowess and Haemolysis Inhibition 白果薯蓣块根中的血凝素具有抗氧化能力和溶血抑制作用

IF 1.7

Turkish Journal of Pharmaceutical Sciences Pub Date : 2023-09-19 DOI: 10.4274/tjps.galenos.2023.62293

O. Odekanyin, Sunday Isaiah Akanni

{"title":"Hemagglutinin from the Root Tuber of Dioscorea preussii Pax Exhibit Antioxidative Prowess and Haemolysis Inhibition","authors":"O. Odekanyin, Sunday Isaiah Akanni","doi":"10.4274/tjps.galenos.2023.62293","DOIUrl":"https://doi.org/10.4274/tjps.galenos.2023.62293","url":null,"abstract":"Objectives: In this research, Dioscorea preussii root tuber haemagglutinin was purified and its physicochemical properties determined. The antioxidative prowess and anti-haemolytic activities of the haemagglutinin were also investigated. Material and Methods: Hemagglutinating assay was used to detect the presence of lectin in the Phosphate Buffer Saline (PBS) extract of the D. preussii root tuber. The lectin was purified using ammonium sulphate fractionation and molecular sieve chromatography. Optimum pH and temperature were determined. So also, antioxidant activity was assessed using DPPH radical scavenging, metal chelating, FRAP and lipid peroxidation inhibition assays. Red blood cells subjected to oxidative damage caused by H 2 O 2 was employed to evaluate its antihemolytic ability. Results: Starch inhibited the haemagglutinating activity of the hemagglutinin. Dioscorea preussii haemagglutinin (DPH) maintained full haemagglutinating activity from 30 ºC to 60 ºC and pH 5-13. EDTA had no effect on the haemagglutinating activity of the haemagglutinin. All the denaturing agents (Guanidine-HCl, Urea and β-Mercaptoethanol","PeriodicalId":23378,"journal":{"name":"Turkish Journal of Pharmaceutical Sciences","volume":"38 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139338712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0