Turkish Journal of Pharmaceutical Sciences最新文献

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Resveratrol-Loaded Microsponge Gel for Wound Healing: In Vitro and In Vivo Characterization. 白藜芦醇微海绵凝胶用于伤口愈合:体外和体内表征。
IF 1.7
Turkish Journal of Pharmaceutical Sciences Pub Date : 2023-03-02 DOI: 10.4274/tjps.galenos.2022.93275
Vinita Chandrakant Patole, Devyani Awari, Shilpa Chaudhari
{"title":"Resveratrol-Loaded Microsponge Gel for Wound Healing: <i>In Vitro</i> and <i>In Vivo</i> Characterization.","authors":"Vinita Chandrakant Patole,&nbsp;Devyani Awari,&nbsp;Shilpa Chaudhari","doi":"10.4274/tjps.galenos.2022.93275","DOIUrl":"https://doi.org/10.4274/tjps.galenos.2022.93275","url":null,"abstract":"<p><strong>Objectives: </strong>The study was aimed to formulate resveratrol (RSV) loaded microsponges to deliver drug at the wound site and incorporate it in the <i>Moringa oleifera</i> Lam. (Moringaceae) gel base to provide an appropriate moist environment for wound management. RSV, a stilbenoid that activates sirtuins and cell-signaling regulators involved in the process of wound healing.</p><p><strong>Materials and methods: </strong>Microsponges were prepared by oil in oil emulsion solvent diffusion method by optimizing the independent variables; drug: polymer ratio and volume of internal phase solvent and their effects on entrapment efficiency and particle size. Formulation batches were evaluated for drug content, production yield, entrapment efficiency, and <i>in vitro</i> drug release. The microsponges were further incorporated into <i>M. oleifera</i> gum gel, which was then evaluated for spreadability, viscosity, <i>ex vivo</i> diffusion study and <i>in vivo</i> studies using an excision wound model in rats.</p><p><strong>Results: </strong>Scanning electron microscopy revealed spherical and porous nature of the microsponges <i>in vitro</i>-release study of the optimized batch of RSV microsponges showed 80.88% drug release within 8 h. Differential scanning calorimetry results revealed no drug and polymer interaction during the formation of microsponges. An <i>ex vivo</i> diffusion study through goat skin revealed sustained release of RSV through porous microsponges embedded in the gel base at the wound site. An <i>in vivo</i> study performed using an excision wound model showed wound healing and closure within day 8. Histopathology showed increased re-epithelization and reduced ulceration in RSV microsponge gel-treated group compared with sham operated.</p><p><strong>Conclusion: </strong>RSV microsponge gel delivered the drug at the wound site and the gel base provided a moist environment and influenced cell adhesion, thereby promoting faster wound healing.</p>","PeriodicalId":23378,"journal":{"name":"Turkish Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986941/pdf/TJPS-20-23.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10859881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Genistein Enhances TRAIL-Mediated Apoptosis Through the Inhibition of XIAP and DcR1 in Colon Carcinoma Cells Treated with 5-Fluorouracil 染料木黄酮通过抑制XIAP和DcR1增强5-氟尿嘧啶诱导的结肠癌细胞凋亡
IF 1.7
Turkish Journal of Pharmaceutical Sciences Pub Date : 2023-02-23 DOI: 10.4274/tjps.galenos.2023.69649
T. Çal, S. Aydın Dilsiz, H. Canpınar, Ülkü Ündeğer Bucurgat
{"title":"Genistein Enhances TRAIL-Mediated Apoptosis Through the Inhibition of XIAP and DcR1 in Colon Carcinoma Cells Treated with 5-Fluorouracil","authors":"T. Çal, S. Aydın Dilsiz, H. Canpınar, Ülkü Ündeğer Bucurgat","doi":"10.4274/tjps.galenos.2023.69649","DOIUrl":"https://doi.org/10.4274/tjps.galenos.2023.69649","url":null,"abstract":"Objectives: Colorectal cancer is one of the most common cancers in the world. However, surgical intervention and chemotherapy provide only limited benefits for the recovery and survival of patients. The anti-carcinogenic effect of genistein has attracted attention due to epidemiological studies showing that soybean consumption is associated with a decrease in incidence of cancer. There are limited studies on the effects of genistein in colorectal carcinoma cells. We aimed to investigate the cytotoxic, genotoxic, and apoptotic effects of genistein in SW480 and SW620 colon adenocarcinoma cells treated with 5-fluorouracil, the basis of chemotherapy, and TRAIL ligand, the mediator of apoptosis, both alone and in combination. Materials and Methods: The cytotoxicity and genotoxicity were determined by MTT assay and comet assay, respectively. The apoptotic effects were evaluated by RT-PCR assay, with the additional use of Annexin V FITC, mitochondrial membrane potential, caspase 3, 8 and 9 activity, reactive oxygen species assay kits. Results: According to our findings, genistein, 5-fluorouracil and TRAIL had synergistic apoptotic effects as a result of DR5 up-regulation, ROS production, and DNA damage, which was mediated by increased caspase 3, 8 and 9 activity and decreased mitochondrial membrane potential. Conclusion: The applied combinations of these compounds may contribute to the resistance problem that may occur in the treatment of colorectal cancer, with the decrease in DcR1 and XIAP genes.","PeriodicalId":23378,"journal":{"name":"Turkish Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42116508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell Therapy and Investigation of Angiogenesis of Fibroblastswith Collagen Hydrogel on the Healing of Diabetic Wounds 胶原水凝胶对成纤维细胞治疗及血管生成的研究
IF 1.7
Turkish Journal of Pharmaceutical Sciences Pub Date : 2022-12-28 DOI: 10.4274/tjps.galenos.2022.62679
Abbas Zabihi, Sanaz Pashapour, M. Mahmoodi
{"title":"Cell Therapy and Investigation of Angiogenesis of Fibroblastswith Collagen Hydrogel on the Healing of Diabetic Wounds","authors":"Abbas Zabihi, Sanaz Pashapour, M. Mahmoodi","doi":"10.4274/tjps.galenos.2022.62679","DOIUrl":"https://doi.org/10.4274/tjps.galenos.2022.62679","url":null,"abstract":"INTRODUCTION: A diabetic ulcer is a common disease in diabetic patients. Due to antibiotic resistance, new therapeutic alternatives are being considered in diabetic foot patients to reduce complications and mortality. This study aimed to evaluate the effect of collagen hydrogel on wound healing process in diabetic rats. METHODS: Diabetic wounds were induced with streptozotocin in all 42 male Wistar rats. The rats were divided into four groups: (a) treated with fibroblast cells, (b) collagen hydrogel, (c) collagen cultured with fibroblast cells, and (d) control group. Microscopic and histological (H&E staining and Mason trichrome staining), measurement of wound surface with Image J, skin density and thickness by the ultrasound probe, and skin elasticity with cutometer tool was used to evaluate the wound healing in a days , 14, and 21 after the treatment. RESULTS: The results showed that the treatment of diabetic wounds with fibroblast cells cultured in collagen hydrogel greatly reduces inflammatory responses in the skin tissue and significantly accelerates the healing process. Also, 21 days after the start of treatment, skin elasticity, thickness and density were higher in the collagen + fibroblast group than in the control group.","PeriodicalId":23378,"journal":{"name":"Turkish Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48275892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deiodinase Type III Polymorphism (Rs1190716) Affects The Therapeutic Response to Levothyroxine Short Title: Deiodinase Type III Gene and Hypothyroidism 脱碘酶III型多态性(Rs190716)对左旋甲状腺素治疗反应的影响
IF 1.7
Turkish Journal of Pharmaceutical Sciences Pub Date : 2022-12-28 DOI: 10.4274/tjps.galenos.2022.04876
A. H. Mohmmed, Suzanne Jubair, B. Khalaf
{"title":"Deiodinase Type III Polymorphism (Rs1190716) Affects The Therapeutic Response to Levothyroxine Short Title: Deiodinase Type III Gene and Hypothyroidism","authors":"A. H. Mohmmed, Suzanne Jubair, B. Khalaf","doi":"10.4274/tjps.galenos.2022.04876","DOIUrl":"https://doi.org/10.4274/tjps.galenos.2022.04876","url":null,"abstract":"Objectives : Levothyroxine (LT4) is the commonly used treatment for hypothyroidism. Deiodinases enzymes control the metabolism and homeostasis of thyroid hormones (THs). Deiodinases type III (DIO3) gene encodes deiodinase type 3 enzyme (D3), the genetic polymorphisms of this gene could affect the levels of THs and then the response to LT4 treatment. This study aims to investigate the single nucleotide polymorphism (SNP), rs1190716; C>T, of DIO3 as a candidate genetic variant that might affect the clinical response to LT4 treatment. Materials and Methods: Two hundred Iraqi hypothyroid female patients who were aged 40 years or older were enrolled in this cross-sectional study. All of them were already on the LT4 treatment for at least 4 months. Thyroid hormones (thyroxin (T4), triiodothyrionine (T3), revers riiodothyrionine (rT3) and diiodothyrionine (T2)) were estimated. Allele specific-polymerase chain reaction technique was performed to detect the rs1190716; C>T SNP. Results: The genotypes distribution of rs1190716; C>T SNP was 10 (4.5%) for the wild type (CC), 50 (22.7%) for the heterozygous mutant type (TC), and 160 (72.7%) for the homozygous mutant type (TT). The patients were divided into three groups according to their genotypes. Significant differences were found in the levels of T4, T3 and T2 among the groups of the patients (P=0.019, P=0.039, P= 0.032, respectively) Conclusion: The rs1190716; C>T SNP could affect the activity of the D3 enzyme and the metabolic homeostasis of the THs, therefore rs1190716; C>T SNP could have an impact in the therapeutic response to LT4 in Iraqi female patients with primary hypothyroidism. Regarding the DIO3 gene, this is a novel finding, hence further studies are needed to conform it.","PeriodicalId":23378,"journal":{"name":"Turkish Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43301743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Cross-Sectional Survey of Knowledge, Attitude, and Practices Regarding Influenza Vaccination Among Jordanians Aged 18–64 With Chronic Diseases 约旦18-64岁慢性病患者流感疫苗接种知识、态度和实践的横断面调查
IF 1.7
Turkish Journal of Pharmaceutical Sciences Pub Date : 2022-12-28 DOI: 10.4274/tjps.galenos.2022.61798
Ola A Bdair, Izzeddin A. Bdair, Esraa Gogazeh, Ola Al-fawares, M. Alwadi, Rawan Badaineh, Fatima Al-tarawneh
{"title":"A Cross-Sectional Survey of Knowledge, Attitude, and Practices Regarding Influenza Vaccination Among Jordanians Aged 18–64 With Chronic Diseases","authors":"Ola A Bdair, Izzeddin A. Bdair, Esraa Gogazeh, Ola Al-fawares, M. Alwadi, Rawan Badaineh, Fatima Al-tarawneh","doi":"10.4274/tjps.galenos.2022.61798","DOIUrl":"https://doi.org/10.4274/tjps.galenos.2022.61798","url":null,"abstract":"Background : Influenza is a frequent infectious disease that can be prevented and is linked to significant mortality and morbidity. The most economical way to prevent influenza is through vaccination, although this method is not widely used. This study aimed to assess the seasonal influenza vaccination rates and the knowledge and attitudes of Jordanian adults with chronic illnesses toward the influenza vaccine. Methods : A cross-sectional design was employed. A 26-item online survey was utilized to gather data about the patients' knowledge of and attitudes toward the influenza vaccine as well as their status as influenza vaccine recipients. Results : A total of 19% of the 564 study participants had an influenza vaccination. The majority (81%) of individuals reported inconsistent vaccination uptake. The most important factor affect vaccination is the belief the flu is not a threat (39%) and they were not advised by their doctors about the vaccination (32%). Participants with no health insurance and with public insurance had a lower level of vaccination in comparison with private insurance (p = 0.008). Conclusions : The adult population of Jordan with chronic diseases have subpar immunization rates. Also revealed is a blatant misunderstanding about the value of routine influenza vaccination. These findings emphasize how urgently the public needs to be made aware of the effectiveness of the influenza vaccine.","PeriodicalId":23378,"journal":{"name":"Turkish Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49502048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Development and Full Validation of a Novel Liquid Chromatography Electrochemical Detection Method for Simultaneous Determination of Nine Catecholamines in Rat Brain 一种同时测定大鼠脑中9种儿茶酚胺的新型液相色谱-电化学检测方法的建立和充分验证
IF 1.7
Turkish Journal of Pharmaceutical Sciences Pub Date : 2022-12-28 DOI: 10.4274/tjps.galenos.2022.06606
Saniye Özcan, Murat Kozanlı, Aysun Geven, Nafiz Öncü Can
{"title":"Development and Full Validation of a Novel Liquid Chromatography Electrochemical Detection Method for Simultaneous Determination of Nine Catecholamines in Rat Brain","authors":"Saniye Özcan, Murat Kozanlı, Aysun Geven, Nafiz Öncü Can","doi":"10.4274/tjps.galenos.2022.06606","DOIUrl":"https://doi.org/10.4274/tjps.galenos.2022.06606","url":null,"abstract":"INTRODUCTION: Chemical neurotransmission, managed by neurotransmitters, has a crucial role in brain processes such as fear, memory, learning, and pain, or neuropathologies such as schizophrenia, epilepsy, anxiety/depression, and Parkinson’s disease. The measurement of these compounds is to elucidate the disease mechanisms and evaluate the outcomes of therapeutic interventions. However, this can be quite difficult due to various matrix effects and the problems of chromatographic separation of analytes. In the current study; for the first time, an optimized and fully validated fully according to FDA and EMA Bioanalytical Validation Guidance HPLC-EC method was developed for the simultaneous analysis of nine neurotransmitter compounds which are dopamine (DA), homovanilic acid (HVA), vanilmandelic acid (VA) serotonin (SER), 5-hydroxyindole-3-acetic acid (5-HIAA), 4-hydroxy-3-methoxyphenylglycol (MHPG), norepinephrine (NE), 3,4 dihydroxyphenylacetic acid (DOPAC) and 3-methoxytyramine (3-MT) and simultaneously determined in rat brain samples. METHODS: The separation was achieved with 150 mm × 4.6 mm, 2.6 μm F5 Kinetex (Phenomenex, USA) column isocratically, and analysis was carried out HPLC equipped with DECADE II electrochemical detector. RESULTS: The method exhibited good selectivity and correlation coefficient values for each analyte’s calibration curves were >0.99. The detection and quantification limits ranged from 0.01 to 0.03 ng/mL and 3.04 to 9.13 ng/mL, respectively. The stability of the analytes and method robustness were also examined in detail in the study, and the obtained results are also presented statistically. DISCUSSION AND CONCLUSION: The developed fully validated method has been successfully applied to real rat brain samples and important results have been obtained. In the rat brain sample analysis, the least amount of SER and the highest amount of NA were found.","PeriodicalId":23378,"journal":{"name":"Turkish Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45169243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advantages and Disadvantages of Two In Vitro Assays in Evaluating Aromatase Activity: "A Cell-Based and a Cell-Free Assay". 评价芳香酶活性的两种体外测定法的优缺点:“基于细胞和无细胞测定法”。
IF 1.7
Turkish Journal of Pharmaceutical Sciences Pub Date : 2022-12-21 DOI: 10.4274/tjps.galenos.2021.85530
Elif İnce Ergüç, Senem Özcan Sezer, Hande Gürer Orhan
{"title":"Advantages and Disadvantages of Two <i>In Vitro</i> Assays in Evaluating Aromatase Activity: \"A Cell-Based and a Cell-Free Assay\".","authors":"Elif İnce Ergüç,&nbsp;Senem Özcan Sezer,&nbsp;Hande Gürer Orhan","doi":"10.4274/tjps.galenos.2021.85530","DOIUrl":"https://doi.org/10.4274/tjps.galenos.2021.85530","url":null,"abstract":"<p><strong>Objectives: </strong>Aromatase is an enzyme that catalyzes the conversion of androgens to estrogens. While inhibition of aromatase is a useful approach for treating breast cancer, it may also have toxicological consequences due to its endocrine disrupting/modulating effect. In this study, sensitivity and performance of two <i>in vitro</i> assays -a cell free and a cell-based- for evaluating aromatase activity were investigated by testing known aromatase inhibitors and partial validation of the methods was performed. Advantages and disadvantages of these methods are also discussed.</p><p><strong>Materials and methods: </strong>Aromatase activity was evaluated <i>via</i> two <i>in vitro</i> models; direct measurement with a cell-free assay using a fluorescent substrate and recombinant human enzyme and indirect evaluation with a cell-based assay where cell proliferation was determined in estrogen receptor positive human breast cancer cells (MCF-7 BUS) in the absence of estrogen and the presence of testosterone.</p><p><strong>Results: </strong>In the cell-free direct measurement assay, reference compounds ketoconazole and aminoglutethimide have been shown to inhibit the aromatase enzyme with half-maximal inhibitory concentration (IC<sub>50</sub>) values concordant with literature. In cell-based indirect measurement assay, only ketoconazole dose-dependently inhibited cell proliferation with 3.47 x 10<sup>-7</sup> M IC<sub>50</sub>. Inter-assay and intra-assay reproducibility of both methods was found to be within acceptable deviation levels.</p><p><strong>Conclusion: </strong>Both methods can be successfully applied. However, to evaluate the potential aromatase activity of the novel compounds <i>in vitro</i>, it seems better to perform both the cell-based and the cell-free assays that allows low-moderate biotransformation and eliminate cytotoxicity potential, respectively.</p>","PeriodicalId":23378,"journal":{"name":"Turkish Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780571/pdf/TJPS-19-626.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10799612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging Role of Biopharmaceutical Classification and Biopharmaceutical Drug Disposition System in Dosage form Development: A Systematic Review. 生物药品分类和生物药品处置系统在剂型开发中的新作用:系统综述。
IF 1.7
Turkish Journal of Pharmaceutical Sciences Pub Date : 2022-12-21 DOI: 10.4274/tjps.galenos.2021.73554
Ramu Samineni, Jithendra Chimakurthy, Sathish Konidala
{"title":"Emerging Role of Biopharmaceutical Classification and Biopharmaceutical Drug Disposition System in Dosage form Development: A Systematic Review.","authors":"Ramu Samineni,&nbsp;Jithendra Chimakurthy,&nbsp;Sathish Konidala","doi":"10.4274/tjps.galenos.2021.73554","DOIUrl":"https://doi.org/10.4274/tjps.galenos.2021.73554","url":null,"abstract":"<p><p>Biopharmaceutical classification system (BCS) is an advanced tool used for classifying medicines based on dissolution, water solubility, and intestinal permeability, which affect the absorption of active pharmaceutical ingredients (API) from immediate-release solid oral forms. It is useful to the formulation researchers to develop novel dosage forms based on modernistic rather than experimental approaches. The current review focuses on the fundamentals, objectives, guidance of BCS, characteristics of BCS drugs, their importance and applications of BCS. This review explains the challenges in drug development in terms of solubility and in vivo disposition. In the current review, new strategies for improving BCS II drug solubility as well as biopharmaceutical drug disposition properties which are utilized throughout the early stages of drug development and commercialization are mainly discussed.</p>","PeriodicalId":23378,"journal":{"name":"Turkish Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780568/pdf/TJPS-19-706.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10452333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Risk Perception and Acceptability of the COVID-19 Vaccine in Nigeria. 尼日利亚COVID-19疫苗的风险认知和可接受性
IF 1.7
Turkish Journal of Pharmaceutical Sciences Pub Date : 2022-12-21 DOI: 10.4274/tjps.galenos.2021.75710
Chinonyerem Ogadi Iheanacho, Okechukwu Harrison Enechukwu, Chinelo Nneka Aguiyi-Ikeanyi
{"title":"Risk Perception and Acceptability of the COVID-19 Vaccine in Nigeria.","authors":"Chinonyerem Ogadi Iheanacho,&nbsp;Okechukwu Harrison Enechukwu,&nbsp;Chinelo Nneka Aguiyi-Ikeanyi","doi":"10.4274/tjps.galenos.2021.75710","DOIUrl":"https://doi.org/10.4274/tjps.galenos.2021.75710","url":null,"abstract":"<p><strong>Objectives: </strong>Vaccines are anticipated to control the ongoing coronavirus disease-2019 (COVID-19) pandemic, however, their acceptance is critical for the desired benefit. This study assessed risk perceptions of COVID-19, acceptability of its vaccine and socio-demographic associations of its acceptability in Nigeria.</p><p><strong>Materials and methods: </strong>A cross-sectional web-based study was conducted among 420 participants in Nigeria's six geopolitical regions, using a three-part questionnaire. The questionnaire link was distributed <i>via</i> snowball method to consenting participants through online platforms. Study outcome measures were acceptance of COVID-19 vaccine, and risk perception of COVID-19 by study participants. Descriptive and inferential statistics were performed using Microsoft Excel and SPSS version 24. <i>p</i> values ≤0.05 were considered statistically significant.</p><p><strong>Results: </strong>A total of 410 respondents participated in the study and high-risk perception of severe acute respiratory syndrome-coronavirus-2 infection (COVID-19) was seen in 127 (66.1%) respondents. Vaccine acceptance was high in 233 (56.8%) respondents and was significantly associated with geo-political region (<i>p</i>=0.028). A moderate positive relationship (r: 0.3) was found between risk perception and acceptability of COVID-19 vaccine and the correlation was statistically significant (<i>p</i>=0.000).</p><p><strong>Conclusion: </strong>High-risk perception of COVID-19 was found in over half of the respondents, and COVID-19 vaccine acceptance rate was a little more than 50%. However, the study noted regional association with vaccine acceptance among study participants. Therefore, strategic and targeted messaging on vaccine acceptance should be prioritized by stakeholders, to ensure successful vaccine implementation.</p>","PeriodicalId":23378,"journal":{"name":"Turkish Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780578/pdf/TJPS-19-686.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10452334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Lentinus squarrosulus Mont. Mushroom: Molecular Identification, In vitro Anti-Diabetic, Anti-Obesity, and Cytotoxicity Assessment. 大香菇蘑菇:分子鉴定、体外抗糖尿病、抗肥胖和细胞毒性评估。
IF 1.7
Turkish Journal of Pharmaceutical Sciences Pub Date : 2022-12-21 DOI: 10.4274/tjps.galenos.2021.72798
Oyindamola Olajumoke Abiodun, Adenike Martha Alege, Precious Ulonnam Ezurike, Abraham Nkumah, Oluwatosin Adelowo, Tolulope Aderinola Oke
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引用次数: 2
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