Turkish Journal of Internal Medicine最新文献_第5页

An unusual association of folic acid deficiency with gastric neuroendocrine tumor type I 叶酸缺乏与胃神经内分泌肿瘤I型的不寻常关联

Turkish Journal of Internal Medicine Pub Date : 2022-09-26 DOI: 10.46310/tjim.1098540

Victoria Gorciac, O. Bărboi, Ion Negură, L. Șorodoc, C. Lionte

{"title":"An unusual association of folic acid deficiency with gastric neuroendocrine tumor type I","authors":"Victoria Gorciac, O. Bărboi, Ion Negură, L. Șorodoc, C. Lionte","doi":"10.46310/tjim.1098540","DOIUrl":"https://doi.org/10.46310/tjim.1098540","url":null,"abstract":"The association of gastric neuroendocrine tumour type I with macrocytic anaemia due to vitamin B12 deficiency is commonly encountered. The etiological cause of macrocytic anaemia must always be precisely established for the subsequent treatment guidance. We present the case of a 63-year-old patient admitted for marked physical asthenia, palpitations, abdominal pain, flatulence, paresthesia in the upper and lower limbs and concentration difficulties. Clinical examination revealed pale, dry skin, Hunter's glossitis, and tachycardic heart sounds. Bloodwork showed pancytopenia with macrocytic normochromic anaemia, vitamin B12 within normal limits, but with low folic acid levels. The reticulocyte crisis was documented on day three after initiating folic acid treatment. Exploration by upper digestive endoscopy and colonoscopy described multiple polypoid tumours in the greater curvature of the stomach. The histopathological and immunohistochemical examination lead to the diagnosis of gastric neuroendocrine tumours (NET) type G1. To our knowledge, there are no reports about an association of this type of tumour with folate deficiency-induced anaemia.","PeriodicalId":23372,"journal":{"name":"Turkish Journal of Internal Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78826035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do Hormonal Disorders Contribute to the Pathology of Hereditary Angioedema? 激素紊乱与遗传性血管性水肿病理有关吗?

Turkish Journal of Internal Medicine Pub Date : 2022-09-26 DOI: 10.46310/tjim.1066357

G. Aytekin, H. Ozer, I. Baloglu, Fatih Çölkesen, Eray Yıldız, Ş. Arslan, A. Çalışkaner

{"title":"Do Hormonal Disorders Contribute to the Pathology of Hereditary Angioedema?","authors":"G. Aytekin, H. Ozer, I. Baloglu, Fatih Çölkesen, Eray Yıldız, Ş. Arslan, A. Çalışkaner","doi":"10.46310/tjim.1066357","DOIUrl":"https://doi.org/10.46310/tjim.1066357","url":null,"abstract":"Objective: Hereditary angioedema (HAE) is an autosomal dominant disorder characterized by recurrent episodes of angioedema without urticaria or pruritus. In this study, we compared the levels of anabolic hormones, such as insulin, insulin-like growth factor, growth hormone, and thyroid hormones (thyroid-stimulating hormone [TSH], triiodothyronine [T3], and thyroxine [T4]), and the levels of hormones that are considered catabolic, such as adrenocorticotrophic hormone (ACTH) and cortisol, between HAE patients and controls. We also discuss the contribution of these hormones to the pathophysiology of HAE. \u0000 \u0000Methods: The study included 18 patients (9 diagnosed with HAE type 1 and 9 with HAE type 2) who were followed in the immunology and allergy clinic between January 2013 and January 2020. The control group comprised 28 age- and gender-matched subjects. \u0000 \u0000Results: The HAE type 1, HAE type 2, and control groups showed no significant differences in insulin, insulin-like growth factor, ACTH, cortisol, TSH, or T4 levels. The C-peptide and T3 levels were significantly different between the groups (p = 0.011 and p = 0.027, respectively) (Table 3). Post-hoc pairwise comparison revealed no significant difference in C-peptide level among the groups, but a significant difference in the T3 level was detected between HAE type 1 patients and controls (p = 0.029) \u0000 \u0000Conclusions: Although no significant differences were observed in other anabolic hormone levels between the controls and HAE patients, T3 levels were significantly lower in type 1 HAE patients. Close monitoring of low T3 levels is required, particularly in patients with type 1 HAE.","PeriodicalId":23372,"journal":{"name":"Turkish Journal of Internal Medicine","volume":"278 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75113669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrospective Analysis of Follow-up and Results of Patients with High D-Dimer Value and Discharged without Emergency Pathology 高d -二聚体值出院无急诊病理患者随访及结果的回顾性分析

Turkish Journal of Internal Medicine Pub Date : 2022-09-25 DOI: 10.46310/tjim.1169467

Fulya Büşra Kaval, H. I. Çikriklar, V. Durak, Issa Omar, B. Kurtoğlu, E. Armağan

{"title":"Retrospective Analysis of Follow-up and Results of Patients with High D-Dimer Value and Discharged without Emergency Pathology","authors":"Fulya Büşra Kaval, H. I. Çikriklar, V. Durak, Issa Omar, B. Kurtoğlu, E. Armağan","doi":"10.46310/tjim.1169467","DOIUrl":"https://doi.org/10.46310/tjim.1169467","url":null,"abstract":"Background This study aimed to retrospectively examine the morbidity and mortality rates after discharge of patients who applied to the emergency department with high D-dimer values but had no pathology upon evaluation. \u0000Material and Methods Patients over the age of 18 who applied to Bursa Uludağ University Faculty of Medicine Emergency Department with preliminary diagnosis of pulmonary embolism in a two-year period between January 2018 and December 2019 were included in the study. The patient group consisted of cases with high D-dimer levels while the control group inluded patients with negative D-dimer and no pathology on discharge. \u0000Results A total of 594 cases; 297 D-dimer positive (+) and 297 D-dimer negative (-), were included in the study. A significant difference existed between the percentage of patients developing illness post-discharge in the D-dimer (+) 18.86% (n=56) and D-dimer (-) 1.68% (n=5) groups, respectively. The most common illness identified in the dimer (+) group after discharge up was pneumonia (n=11), followed by Coronary Artery Disease (n=5). Death rate was 1.68% (n=5) in the D-dimer (-) group and 11.78% (n=35) in the D-dimer (+) group; a statistically significant difference (p=0.001). \u0000Conclusions In conclusion, both morbidity and mortality rates were found to be significantly higher in the D-dimer positive group.","PeriodicalId":23372,"journal":{"name":"Turkish Journal of Internal Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85021866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-time ultrasound elastographic features and color doppler imaging of mitral valve prolapse 二尖瓣脱垂的实时超声弹性成像特征及彩色多普勒成像

Turkish Journal of Internal Medicine Pub Date : 2022-09-09 DOI: 10.46310/tjim.1167465

D. Topal, M. Can, Evrim KARADAĞ TEKİN, B. Uğuz, M. F. Kocamaz, M. E. Aslanci

{"title":"Real-time ultrasound elastographic features and color doppler imaging of mitral valve prolapse","authors":"D. Topal, M. Can, Evrim KARADAĞ TEKİN, B. Uğuz, M. F. Kocamaz, M. E. Aslanci","doi":"10.46310/tjim.1167465","DOIUrl":"https://doi.org/10.46310/tjim.1167465","url":null,"abstract":"Background: The aim of this study was to investigate the elasticity of ocular structures in patients with mitral valve prolapse (MVP). \u0000Material and Methods: This prospective study included a total of 35 patients with MVP (study group) and 35 healthy volunteers (control group). The elastography value of the ratio of orbital fat- sclera (ROF/S) was measured with real-time US elastography. For each eye, central retinal artery (CRA), posterior ciliary artery (PCA), and ophthalmic artery (OA) were evaluated, respectively. \u0000Results: The mean ages of the patients in the study and the control groups were 31.77 ± 11.40 years, and 30.65 ± 7.45 years, respectively (P =0.511). Mean ROF/S were 1.95 ± 0.81 and 1.37 ± 1.06 (P=0.001) in the study groups and control, respectively. The mean RI of the OA was 0.67 ± 0.05 in the control group, 0.67 ±0.05 (0.55; 0.87) in study group. The mean RI of the PCA was 0.66 ± 0.05 in the control group, 0.68 ±0.06 in study group. . The mean RI of the CRA was 0.66 ± 0.05 in the control group, 0.66 ±0.06 in study group. The RI value was not a significant difference between control and study group (p > 0.05). \u0000Conclusion: Scleral elasticity was significantly increased in MVP patients. These could be related to ocular pathologies such as glacouma, kerataconus in MVP.","PeriodicalId":23372,"journal":{"name":"Turkish Journal of Internal Medicine","volume":"197 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79945343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolated unconjugated hyperbilirubinemia in adults: the Gilbert’s versus Criggler Najar Syndrome Type 2 conundrum. 成人分离的非偶联高胆红素血症:吉尔伯特与克里格勒-纳贾尔综合征2型难题。

Turkish Journal of Internal Medicine Pub Date : 2022-08-23 DOI: 10.46310/tjim.1088059

Devyani Thakur, Yogita Sharma

{"title":"Isolated unconjugated hyperbilirubinemia in adults: the Gilbert’s versus Criggler Najar Syndrome Type 2 conundrum.","authors":"Devyani Thakur, Yogita Sharma","doi":"10.46310/tjim.1088059","DOIUrl":"https://doi.org/10.46310/tjim.1088059","url":null,"abstract":"Gilbert’s syndrome is a genetic disorder characterised by non-hemolytic unconjugated hyperbilirubinemia. It is caused by mutations in the UGT1A1 gene which codes for the enzyme uridine diphosphate glucoronosyl transferase-1, which conjugates bilirubin for excretion. Affected individuals are usually asymptomatic apart from a mild jaundice and investigations reveal a mild isolated indirect hyperbilirubinemia. This may be exacerbated in the face of environmental and physical stressors. It is very similar in presentation to Criggler-Najjar syndrome (CNS) type 2. There is a small risk of kernicterus in patients with CNS type 2 needing daily phenobarbitone therapy. This risk is miniscule in Gilbert’s syndrome. Genetic testing for polymorphisms of the UGT1A1 gene is the diagnostic clincher for Gilbert’s syndrome, but it can also be picked up by evaluating the response to phenobarbitone and fasting, particularly in resource poor settings. Due to limited availability, case reports documenting the genetic mutational analysis are sparse. We reported one such rare case with an unusually high indirect hyperbilirubinemia in Gilbert’s syndrome confirmed by both phenobarbitone response and genetic analysis.","PeriodicalId":23372,"journal":{"name":"Turkish Journal of Internal Medicine","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86668618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Hemophagocytic Lymphohistiocytosis Diagnostic Criteria in Malignancy-Associated Hemophagocytic Lymphohistiocytosis Patients 恶性肿瘤相关噬血细胞淋巴组织细胞增多症诊断标准的比较

Turkish Journal of Internal Medicine Pub Date : 2022-08-23 DOI: 10.46310/tjim.1121064

H. Kırkızlar, Tuğcan ALP KIRKIZLAR, U. Demirci, Sedanur Karaman Gulsaran, V. Bas, E. Umit, A. Demir

{"title":"Comparison of Hemophagocytic Lymphohistiocytosis Diagnostic Criteria in Malignancy-Associated Hemophagocytic Lymphohistiocytosis Patients","authors":"H. Kırkızlar, Tuğcan ALP KIRKIZLAR, U. Demirci, Sedanur Karaman Gulsaran, V. Bas, E. Umit, A. Demir","doi":"10.46310/tjim.1121064","DOIUrl":"https://doi.org/10.46310/tjim.1121064","url":null,"abstract":"Background Fulfilling diagnostic criteria of hemophagocytic lymphohistiocytosis (HLH) is challenging due to unavailable laboratory tests. Hence, we aimed to reveal malignancy-associated-HLH (M-HLH) patients in our center, which can not be reached in all tests. \u0000Material and Methods Nine patients with M-HLH were analyzed retrospectively. \u0000Results The median age was 59 years. The distribution of the underlying diseases was like diffuse large B cell lymphoma in 3 patients, acute myeloid leukemia in 2 patients, Hodgkin lymphoma in 2 patients, T cell non-Hodgkin lymphoma in 1 patient, and small cell lung cancer in 1 patient. According to HLH-2004 diagnostic criteria except for soluble CD25 and natural killer activity tests; one patient had 3/6, six patients had 5/6, two patients had 6/6 criteria while the median H-score was 258 at diagnosis. According to Tamamyan et al’s criteria; at the diagnosis, all patients had ≥7 (between 7-12) of 18 parameters. Patients fulfilled ≥5 parameters a median of 15 days (3-52 days) before the diagnosis and on that time six patients had 3/6 criteria of HLH-2004. 88.8% of the patients died. The median duration of survival was 8.5 days (1-18 days). \u0000Conclusions Unavailability of the tests in some countries and centers as in ours results in complications to fulfill 5 of 8 criteria and being delayed in diagnosis and treatment. We need to develop more specific and accessible criteria, and grading systems for M-HLH diagnose.","PeriodicalId":23372,"journal":{"name":"Turkish Journal of Internal Medicine","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86660832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

C-reactive protein Lymphocyte Ratio in the Diagnosis of Pulmonary Tuberculosis c反应蛋白淋巴细胞比值在肺结核诊断中的价值

Turkish Journal of Internal Medicine Pub Date : 2022-06-09 DOI: 10.46310/tjim.1072714

I. Koc, Y. T. Gullu

{"title":"C-reactive protein Lymphocyte Ratio in the Diagnosis of Pulmonary Tuberculosis","authors":"I. Koc, Y. T. Gullu","doi":"10.46310/tjim.1072714","DOIUrl":"https://doi.org/10.46310/tjim.1072714","url":null,"abstract":"Background: Tuberculosis (TB) is still a severe problem in underdeveloped and developing countries. Diagnostic tests are unavailable in every health institution, and TB culture can take up to 45 days. Therefore, there is a need for cheaper, faster, and easily accessible diagnostic methods that can guide the diagnosis. This study aimed to determine whether red blood cell distribution width (RDW), C-reactive protein (CRP)-lymphocyte ratio (CLR), platelet-lymphocyte ratio (PLR), and lymphocyte-monocyte ratio (LMR) can be used as biomarkers in the diagnosis of pulmonary TB in patients with no comorbidities. \u0000Material and Methods: Files of microbiologically confirmed 122 patients with pulmonary TB and 153 patients in whom pulmonary TB was excluded were retrospectively reviewed. Out of them, patients with comorbidities were excluded from the study. Eighty-one patients with TB and 100 controls were included in the study. \u0000Results: The lymphocyte, eosinophil, and LMR levels remained significantly lower in the TB group, while neutrophil, monocyte, RDW, platelet, and PLR levels were higher in the same group. \u0000Conclusion: In those patients suspicious of pulmonary TB, higher levels of RDW, PLR, and CLR, whereas lower levels of eosinophil, PDW, and LMR may predict the diagnosis of pulmonary TB in previously healthy individuals.","PeriodicalId":23372,"journal":{"name":"Turkish Journal of Internal Medicine","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84817070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Persistent Stomach Pain In The young Age Patient: A Case Of Primary Gastric Burkitt's Lymphoma 年轻患者持续性胃痛:原发性胃伯基特淋巴瘤1例

Turkish Journal of Internal Medicine Pub Date : 2022-06-08 DOI: 10.46310/tjim.1073581

Hatice Hamarat, Berrin Yalinbaş, H. Simsek

引用次数: 0

Sulfasalazine related nephrolithiasis in patients with rheumatoid arthritis and ankylosing spondylitis 类风湿性关节炎和强直性脊柱炎患者与柳氮磺胺嘧啶相关的肾结石

Turkish Journal of Internal Medicine Pub Date : 2022-05-22 DOI: 10.46310/tjim.1058021

Gulsah Şaşak Kuzgun, S. Murat, Serçin Özkök, E. Kasapoğlu

{"title":"Sulfasalazine related nephrolithiasis in patients with rheumatoid arthritis and ankylosing spondylitis","authors":"Gulsah Şaşak Kuzgun, S. Murat, Serçin Özkök, E. Kasapoğlu","doi":"10.46310/tjim.1058021","DOIUrl":"https://doi.org/10.46310/tjim.1058021","url":null,"abstract":"Background Sulfasalazine (SSZ) is an anti-inflammatory and immunomodulatory drug used to treat many inflammatory diseases. Bacteria in the gut metabolize SSZ to active 5-aminosalicylic acid and inactive sulfapyridine. Sulfapyridine can crystallize in the kidney. We aimed to investigate the frequency of nephrolithiasis in patients who were diagnosed with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and who received SSZ treatment retrospectively. \u0000Material and Methods We retrospectively analyzed the files of AS and RA patients in the rheumatology outpatient clinic between 2009 and 2018. We identified patients who underwent kidney ultrasonography at least six months after initiation of SSZ. One hundred six patients and 50 healthy adults were included in the study. \u0000Results Only eight patients (6 AS, 2 RA) had nephrolithiasis on ultrasonography, but none in the control group (p=0.046). In logistic regression analysis, no correlation was found between gender, age, vitamin D, parathyroid hormone, and urinary calcium excretion with SSZ use (p>0.05). \u0000Conclusion Although, it is noteworthy that these patients are prone to stone formation for various reasons. Therefore, paying attention to the patient’s hydration while using these drugs may prevent such side effects.","PeriodicalId":23372,"journal":{"name":"Turkish Journal of Internal Medicine","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80192655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Painless cervical lymphadenopathy in an elderly patient – a rare case of Rosai-Dorfman disease and Hodgkin's lymphoma 老年患者无痛性宫颈淋巴结病-罕见的罗赛-多夫曼病和霍奇金淋巴瘤病例

Turkish Journal of Internal Medicine Pub Date : 2022-05-10 DOI: 10.46310/tjim.1057647

S. Tan, P. Telisinghe, J. Keasberry

引用次数: 0