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Comparison of the expression of GATA-3 protein from the transcription factor family and pathological prognostic parameters in invasive ductal carcinomas of the breast 乳腺浸润性导管癌中转录因子家族GATA-3蛋白表达与病理预后指标的比较
Turkish Journal of Internal Medicine Pub Date : 2022-04-26 DOI: 10.46310/tjim.1090713
Leymune Parlak, O. Kandemir
{"title":"Comparison of the expression of GATA-3 protein from the transcription factor family and pathological prognostic parameters in invasive ductal carcinomas of the breast","authors":"Leymune Parlak, O. Kandemir","doi":"10.46310/tjim.1090713","DOIUrl":"https://doi.org/10.46310/tjim.1090713","url":null,"abstract":"Background GATA binding protein 3 (GATA-3) is one of the six transcription factor family members and is important for glandular development in the breast. Its expression becomes important in breast cancer. We aimed to compare GATA-3 immunoreactivity and pathological prognostic factors in patients with invasive ductal carcinoma. \u0000Material and Methods Our study was conducted retrospectively with 300 breast invasive ductal carcinoma patients who were operated on in our hospital between May 2013 and June 2014. Patient reports, slides and blocks in the pathology archive were scanned. GATA-3 immunohistochemical (IHC) staining was evaluated according to the nuclear staining, intensity and percentage. The relationship between clinicopathological prognostic parameters and GATA-3 IHC staining results was investigated. \u0000Results A positive staining was observed in 286 (95.3%) cases. According to the GATA-3 staining intensity and percentage, 210 (70%) cases stained strongly and 246 (82%) stained +4, respectively. There was a significant relationship between GATA-3 immunoreactivity with ER, PR, Cerb-B2, Ki-67, mitotic degree, mitotic count and histological grade. \u0000Conclusions There was a correlation between the high expression of GATA-3 and good prognostic markers. Hormone receptors can be evaluated with Cerb-B2 and Ki-67 and used as prognosis determinants in breast cancers. They can be used to identify both primary and secondary breast tumors.","PeriodicalId":23372,"journal":{"name":"Turkish Journal of Internal Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84654319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of relation between JAK2 gene and thrombosis in myeloproliferative neoplasms 骨髓增生性肿瘤中JAK2基因与血栓形成关系的研究
Turkish Journal of Internal Medicine Pub Date : 2022-04-21 DOI: 10.46310/tjim.1055305
S. Kahraman, F. Demirkan
{"title":"Assessment of relation between JAK2 gene and thrombosis in myeloproliferative neoplasms","authors":"S. Kahraman, F. Demirkan","doi":"10.46310/tjim.1055305","DOIUrl":"https://doi.org/10.46310/tjim.1055305","url":null,"abstract":"Background Thrombotic complications are the most considerable etiology causing morbidity and mortality in patients with philadelphia (Ph) negative myeloproliferative neoplasms (MPN). There are many studies evaluating the association of JAK2 mutation and risk of thrombosis in MPN with inconclusive results. We also investigated the relation between JAK2 mutation in all Ph negative MPN and thrombosis. \u0000Material and Methods Thrombotic events and demographic features of 177 patients with Ph negative MPN were evaluated retrospectively. \u0000Results JAK2 V617 F mutation was detected in 57% of patients with essential thrombocythemia (ET), %90.3 of pateints with polycythemia vera (PV), 100% of pateints with primary myelofibrosis (PMF). Thrombotic complications occured more frequently with JAK2 mutation in all MPN patients than without (p=0.014). In JAK 2 mutation positive groups, the median age, thrombosis risk scores and leucocyte values are higher, splenomegaly and arterial and/or venous thrombosis are detected more frequently (p","PeriodicalId":23372,"journal":{"name":"Turkish Journal of Internal Medicine","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82076429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HIV-Associated Opportunistic Pneumonia Case Mimicking Covid-19 Pneumonia 模拟Covid-19肺炎的hiv相关机会性肺炎病例
Turkish Journal of Internal Medicine Pub Date : 2022-03-17 DOI: 10.46310/tjim.926630
Sedat Celikci, E. Yılmaz
{"title":"HIV-Associated Opportunistic Pneumonia Case Mimicking Covid-19 Pneumonia","authors":"Sedat Celikci, E. Yılmaz","doi":"10.46310/tjim.926630","DOIUrl":"https://doi.org/10.46310/tjim.926630","url":null,"abstract":"Cytomegalovirus (CMV) pneumonia is a rare opportunistic infection in the progression of human immunodeficiency virus (HIV) infection. Also, COVID-19 has been named a pandemic since the beginning of 2020. During this period, physicians were exposed to many COVID-19 cases, and it was challenged to consider different diagnoses in patients who applied to the emergency room with lung complaints and bilateral pneumonia. Here we reported a 30-year-old man diagnosed with HIV- associated opportunistic CMV pneumonia mimicking COVID-19. The diagnosis of CMV pneumonia was obtained through consistent clinical, radiological, microbiological and cytologic examinations. The patient made a complete clinical recovery after being initialized on anti-CMV treatment.","PeriodicalId":23372,"journal":{"name":"Turkish Journal of Internal Medicine","volume":"225 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77451587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Single Center Retrospective Analysis of Patients with Recurrent Papillary Thyroid Carcinoma Undergoing Radiofrequency Ablation 射频消融治疗复发性甲状腺乳头状癌患者的单中心回顾性分析
Turkish Journal of Internal Medicine Pub Date : 2022-03-09 DOI: 10.46310/tjim.1073526
Erhan Hocaoğlu, E. Aydemir, C. Ateş, Filiz MERCAN SARIDAŞ, O. F. Nas, M. F. Inecikli, S. Cander, Özen Öz Gül, E. Ertürk, C. Ersoy
{"title":"A Single Center Retrospective Analysis of Patients with Recurrent Papillary Thyroid Carcinoma Undergoing Radiofrequency Ablation","authors":"Erhan Hocaoğlu, E. Aydemir, C. Ateş, Filiz MERCAN SARIDAŞ, O. F. Nas, M. F. Inecikli, S. Cander, Özen Öz Gül, E. Ertürk, C. Ersoy","doi":"10.46310/tjim.1073526","DOIUrl":"https://doi.org/10.46310/tjim.1073526","url":null,"abstract":"Background Radiofrequency ablation (RFA) is used in selected patients with recurrent or metastatic thyroid cancer who have high surgical risk or do not accept surgical treatment. However, long-term follow-up data are limited. Here, we present our single-center experience with the use of RFA in the treatment of recurrent or metastatic papillary thyroid carcinoma (PTC). Material and Methods Patients","PeriodicalId":23372,"journal":{"name":"Turkish Journal of Internal Medicine","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74070819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the relationship between dehydroepiandrosterone sulfate-total testosterone ratio and metabolic parameters in patients with polycystic ovary syndrome 多囊卵巢综合征患者脱氢表雄酮-总睾酮比值与代谢参数关系的评价
Turkish Journal of Internal Medicine Pub Date : 2022-03-09 DOI: 10.46310/tjim.1070164
Özen Öz Gül, S. Cander
{"title":"Evaluation of the relationship between dehydroepiandrosterone sulfate-total testosterone ratio and metabolic parameters in patients with polycystic ovary syndrome","authors":"Özen Öz Gül, S. Cander","doi":"10.46310/tjim.1070164","DOIUrl":"https://doi.org/10.46310/tjim.1070164","url":null,"abstract":"Background In this study we aimed to evaluate the correlations between dehydroepiandrosterone sulfate-total testosterone (DHEAS/TT) ratio and insulin resistance, glycemic and lipid parameters. Material and Methods A total of 35 patients with polycystic ovary syndrome (PCOS) and 34 healthy volunteers were included in the study. Anthropometric, clinical, biochemical, lipid and glycemic measurements were performed according to routine standards. Patients’ demographic, clinical, anthropometric, biochemical, glycemic, lipid and hormonal parameters were measured and recorded. DHEAS/TT ratio was calculated in all patients. DHEAS/TT ratio and metabolic parameters were compared between the PCOS and control groups. Results There were significant differences between the PCOS and control groups in terms of fasting blood glucose, total cholesterol, high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c), triglycerides, insulin and homeostatic model assessment-insulin resistance (HOMA-IR)","PeriodicalId":23372,"journal":{"name":"Turkish Journal of Internal Medicine","volume":"177 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76873191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A finding that is not clear what will emerge when you see it: Hypoalbuminemia 这个发现还不清楚当你看到它的时候会发生什么:低白蛋白血症
Turkish Journal of Internal Medicine Pub Date : 2022-03-09 DOI: 10.46310/tjim.1073366
E. Simdi, Mirac Vural Keskinler, Ender İğneci
{"title":"A finding that is not clear what will emerge when you see it: Hypoalbuminemia","authors":"E. Simdi, Mirac Vural Keskinler, Ender İğneci","doi":"10.46310/tjim.1073366","DOIUrl":"https://doi.org/10.46310/tjim.1073366","url":null,"abstract":"","PeriodicalId":23372,"journal":{"name":"Turkish Journal of Internal Medicine","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82537696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Rare Cause of Hypokalemia: Ectopic ACTH Syndrome 低钾血症的罕见原因:异位ACTH综合征
Turkish Journal of Internal Medicine Pub Date : 2022-03-09 DOI: 10.46310/tjim.1078178
Merve Tekinyildiz, S. Kayhan, M. Çalapkulu, R. Özkan, I. Akdag
{"title":"A Rare Cause of Hypokalemia: Ectopic ACTH Syndrome","authors":"Merve Tekinyildiz, S. Kayhan, M. Çalapkulu, R. Özkan, I. Akdag","doi":"10.46310/tjim.1078178","DOIUrl":"https://doi.org/10.46310/tjim.1078178","url":null,"abstract":"in the presence of hypokalemia accompanying hypertension and proximal muscle weakness, if the patient also has progressive weight loss","PeriodicalId":23372,"journal":{"name":"Turkish Journal of Internal Medicine","volume":"13 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82592019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ground Glass Appearance During the Pandemic Period: Everolimus Induced Interstitial Pneumonia 大流行期间的磨玻璃外观:依维莫司诱导的间质性肺炎
Turkish Journal of Internal Medicine Pub Date : 2022-03-09 DOI: 10.46310/tjim.1078775
Sidelya Ecem Yi̇ği̇t, İffet Beril Gökmen, Y. Okuturlar
{"title":"Ground Glass Appearance During the Pandemic Period: Everolimus Induced Interstitial Pneumonia","authors":"Sidelya Ecem Yi̇ği̇t, İffet Beril Gökmen, Y. Okuturlar","doi":"10.46310/tjim.1078775","DOIUrl":"https://doi.org/10.46310/tjim.1078775","url":null,"abstract":"to","PeriodicalId":23372,"journal":{"name":"Turkish Journal of Internal Medicine","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73078494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-COVID ANCA-Associated Vasculitis: A Case Report 冠状病毒后anca相关性血管炎1例报告
Turkish Journal of Internal Medicine Pub Date : 2022-03-09 DOI: 10.46310/tjim.1073603
Kübra Özeri̇k, Mehmet Sezen, A. Yildiz, K. Dilek, M. Güllülü, M. Yavuz, A. Oruc, S. Güllülü, A. Ersoy
{"title":"Post-COVID ANCA-Associated Vasculitis: A Case Report","authors":"Kübra Özeri̇k, Mehmet Sezen, A. Yildiz, K. Dilek, M. Güllülü, M. Yavuz, A. Oruc, S. Güllülü, A. Ersoy","doi":"10.46310/tjim.1073603","DOIUrl":"https://doi.org/10.46310/tjim.1073603","url":null,"abstract":"","PeriodicalId":23372,"journal":{"name":"Turkish Journal of Internal Medicine","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74190225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Rare Cause Of Anemia Etiology: Gastrointestinal Stromal Tumors 一种罕见的贫血病因:胃肠道间质瘤
Turkish Journal of Internal Medicine Pub Date : 2022-03-09 DOI: 10.46310/tjim.1072659
H. Şen, A. Kırık, Erdoğan Bülbül, T. Doğru
{"title":"A Rare Cause Of Anemia Etiology: Gastrointestinal Stromal Tumors","authors":"H. Şen, A. Kırık, Erdoğan Bülbül, T. Doğru","doi":"10.46310/tjim.1072659","DOIUrl":"https://doi.org/10.46310/tjim.1072659","url":null,"abstract":"","PeriodicalId":23372,"journal":{"name":"Turkish Journal of Internal Medicine","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84112627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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