Tuberculosis and Respiratory Diseases最新文献_第4页

Comparison of Anticancer Effects of Histone Deacetylase Inhibitors CG-745 and Suberoylanilide Hydroxamic Acid in Non-small Cell Lung Cancer. HDAC抑制剂CG-745和SAHA对非小肺癌细胞的抗癌作用比较。

IF 2.5

Tuberculosis and Respiratory Diseases Pub Date : 2025-04-01 Epub Date: 2025-02-13 DOI: 10.4046/trd.2024.0090

Hyo Jin Kim, Ui Ri An, Han Jee Yoon, Hyun Lim, Ki Eun Hwang, Young Suk Kim, Hak Ryul Kim

{"title":"Comparison of Anticancer Effects of Histone Deacetylase Inhibitors CG-745 and Suberoylanilide Hydroxamic Acid in Non-small Cell Lung Cancer.","authors":"Hyo Jin Kim, Ui Ri An, Han Jee Yoon, Hyun Lim, Ki Eun Hwang, Young Suk Kim, Hak Ryul Kim","doi":"10.4046/trd.2024.0090","DOIUrl":"10.4046/trd.2024.0090","url":null,"abstract":"Background: Histone deacetylase (HDAC) inhibition offers potential anticancer effects across diverse cancers due to HDAC's significant role in cancer development and progression. Consequently, we demonstrated the therapeutic efficacy of the novel HDAC inhibitor, CG-745, in comparison with existing inhibitors such as suberoylanilide hydroxamic acid (SAHA) in non-small cell lung cancer (NSCLC) cells.Methods: CG-745's effect on apoptosis and reactive oxygen species (ROS)-dependent mitochondrial dysfunction was investigated using annexin V assay, MitoSoX, and Western blot in human A549 and H460 cells. Additionally, HDAC expression was analyzed through real-time polymerase chain reaction. We also evaluated the inhibitory effect of CG-745 on epithelial-mesenchymal transition (EMT) induced by transforming growth factor β1 (TGF-β1) via Western blot, scratch analysis, and matrigel invasion analysis.Results: Compared to SAHA, CG-745 inhibited cell viability and mRNA expression of HDACs such as HDAC1, HDAC2, HDAC3, and HDAC8. It also induced apoptosis, ROS, and mitochondrial dysfunction in a concentration-dependent manner. CG-745 reversed EMT triggered by TGF-β1 in A549 and H460 cells, and curtailed the migration and invasion enhanced by TGF-β1. CG-745 has demonstrably inhibited EMT and induced apoptosis in NSCLC cells.Conclusion: CG-745 may represent a novel therapeutic strategy for NSCLC treatment.","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"342-352"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maximal forced inspiratory flow dynamics and acute exacerbation in COPD patients with exacerbation history. 有急性加重史的COPD患者最大强迫吸气血流动力学与急性加重。

IF 2.5

Tuberculosis and Respiratory Diseases Pub Date : 2025-03-28 DOI: 10.4046/trd.2024.0156

Heemoon Park, Jung-Kyu Lee, Eun Young Heo, Deog Kyeom Kim, Hyun Woo Lee

{"title":"Maximal forced inspiratory flow dynamics and acute exacerbation in COPD patients with exacerbation history.","authors":"Heemoon Park, Jung-Kyu Lee, Eun Young Heo, Deog Kyeom Kim, Hyun Woo Lee","doi":"10.4046/trd.2024.0156","DOIUrl":"https://doi.org/10.4046/trd.2024.0156","url":null,"abstract":"Background: Chronic Obstructive Pulmonary Disease (COPD) is a significant global health burden characterized by progressive airflow obstruction and frequent exacerbations. Traditionally, COPD severity has been assessed using expiratory flow measurements like FEV1. However, the role of inspiratory flow, specifically maximal forced inspiratory flow (FIFmax), in predicting exacerbation risk is gaining attention.Methods: This retrospective cohort study evaluated COPD patients with a history of exacerbations, receiving inhaled therapy. The eligible patients were followed up for 3 years with spirometric assessments. Patients were categorized into quartiles based on the annual change in FIFmax, from the greatest decrease (Q1) to the greatest increase (Q4). Primary outcome was acute exacerbation, stratified by severity as moderate-to-severe and severe exacerbation.Results: A total of 180 patients were followed up for 3 years. While a greater increase in FIFmax was linearly associated with lower rates of both moderate-to-severe and severe exacerbations (P-value for trend <0.001 for both), time-to-event analysis revealed no significant association between FIFmax changes and moderate-to-severe exacerbations. In contrast, a significant association was observed with severe exacerbations (Log-Rank P-value=0.005). Even after adjusting for confounders, FIFmax remained an independent predictor of severe exacerbations (Q3: hazard ratio=0.506 [95% confidence interval=0.306-0.836], P-value=0.008; Q4: hazard ratio=0.491 [95% confidence interval=0.291-0.830], P-value=0.008).Conclusions: Changes in FIFmax were not significantly associated with moderate-to-severe exacerbations but were related with a reduced risk of severe exacerbations in COPD patients receiving inhaled therapy. These findings suggest that FIFmax may serve as a valuable prognostic marker for severe exacerbations in high-risk COPD patients.","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging Role of Molecular Testing in the Management of Non-Metastatic Non-Small Cell Lung Cancer. 分子检测在非转移性非小细胞肺癌治疗中的新作用。

IF 2.5

Tuberculosis and Respiratory Diseases Pub Date : 2025-03-26 DOI: 10.4046/trd.2024.0159

Hidenori Kage

引用次数: 0

Challenges and the Future of Pulmonary Function Testing in COPD: Toward Earlier Diagnosis of COPD. COPD肺功能检测的挑战和未来：COPD的早期诊断。

IF 2.5

Tuberculosis and Respiratory Diseases Pub Date : 2025-03-25 DOI: 10.4046/trd.2025.0009

Sang Hyuk Kim, MeiLan K Han

引用次数: 0

Efficacy and safety of YJP-40 in patients with acute bronchitis: a randomized, double-blind, parallel group study. YJP-40治疗急性支气管炎的疗效和安全性：一项随机、双盲、平行组研究

IF 2.5

Tuberculosis and Respiratory Diseases Pub Date : 2025-03-20 DOI: 10.4046/trd.2024.0177

Chin Kook Rhee

{"title":"Efficacy and safety of YJP-40 in patients with acute bronchitis: a randomized, double-blind, parallel group study.","authors":"Chin Kook Rhee","doi":"10.4046/trd.2024.0177","DOIUrl":"https://doi.org/10.4046/trd.2024.0177","url":null,"abstract":"Pelargonium sidoides has been known to be effective in treating respiratory diseases. Pelargonium sidoides extract (Umckamin®) was approved in Korea for acute bronchitis. YJP-40 (Umckamin plus®) is formulated with extract of Pelargonium sidoides and ivy leaf. Ivy leaf extract has an expectorant effect and has been used to treat bronchitis. The aim of this study was to compare the efficacy of YJP-40 syrup with Umckamin® syrup in patients with acute bronchitis. This was a multicenter, randomized, double-blind, active-controlled, non-inferiority, phase III clinical trial. Patients were randomized 1:1 to either the test (YJP-40) or the control (Umckamin®) group. The primary endpoint was the change in bronchitis severity score (BSS) total score 7 days after administration. A total of 240 subjects (test group: 121, control group: 119) from 7 hospitals were enrolled in this clinical trial. The average change in BSS total score 7 days after administration compared to before was -4.31±2.09 and -4.36±1.71 in the test group and the control group, respectively. The non-inferiority of the test group to the control group was demonstrated. The response rate at 7 days after administration was 87.16% (95/109) in the test group and 86.92% (93/107) in the control group (P = 0.9778). There was no statistically significant difference between the groups in the incidence of adverse events. YJP-40 can be a safe and effective treatment option for acute bronchitis.","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Korean Guidelines for Diagnosis and Management of Interstitial Lung Disease: Cryptogenic organizing pneumonia. 韩国间质性肺疾病诊断和管理指南：隐源性组织性肺炎。

IF 2.5

Tuberculosis and Respiratory Diseases Pub Date : 2025-03-13 DOI: 10.4046/trd.2024.0167

Yong Suk Jo, Jong Sun Park, Sun Hyo Park, Joon Sung Joh, Hye Jin Jang, Hyun-Kyung Lee

引用次数: 0

Korean Guidelines for the Diagnosis and Management of Interstitial Lung Disease: Part 5-Other Forms of Interstitial Lung Disease. 韩国间质性肺疾病诊断和治疗指南：第5部分：其他形式的间质性肺疾病。

IF 2.5

Tuberculosis and Respiratory Diseases Pub Date : 2025-03-13 DOI: 10.4046/trd.2024.0181

Hyung Koo Kang, Sun Mi Choi, Hong-Joon Shin, Hae In Jung, Uiri An, Sei Hoon Yang

{"title":"Korean Guidelines for the Diagnosis and Management of Interstitial Lung Disease: Part 5-Other Forms of Interstitial Lung Disease.","authors":"Hyung Koo Kang, Sun Mi Choi, Hong-Joon Shin, Hae In Jung, Uiri An, Sei Hoon Yang","doi":"10.4046/trd.2024.0181","DOIUrl":"https://doi.org/10.4046/trd.2024.0181","url":null,"abstract":"Rare forms of interstitial lung diseases (ILDs) present with unique clinical features and require different treatment strategies. Respiratory bronchiolitis-associated ILD mainly affects smokers, showing ground-glass opacities on chest computed tomography (CT) scans and pigmented macrophages in the bronchoalveolar lavage fluid. Smoking cessation is essential for treatment, with corticosteroids used for severe cases. Desquamative interstitial pneumonia, also related to smoking, is characterized by exertional dyspnea, dry cough, restrictive lung function, and ground-glass opacities on high-resolution CT. Lymphoid interstitial pneumonia involves lymphocytic proliferation and is associated with autoimmune diseases or infections, treated with corticosteroids. Acute interstitial pneumonia resembles acute respiratory distress syndrome but occurs without a clear cause and is managed with supportive care. Idiopathic pleuroparenchymal fibroelastosis results in fibrosis in the upper lobes, primarily in nonsmokers, and is diagnosed through clinical and imaging findings, with no effective treatment to improve survival. Each condition has distinct pathological features, clinical presentations, and treatment approaches, along with variable prognoses.","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-pharmacologic Prevention of AECOPD. AECOPD的非药物预防。

IF 2.5

Tuberculosis and Respiratory Diseases Pub Date : 2025-03-07 DOI: 10.4046/trd.2024.0155

Joon Young Choi

{"title":"Non-pharmacologic Prevention of AECOPD.","authors":"Joon Young Choi","doi":"10.4046/trd.2024.0155","DOIUrl":"https://doi.org/10.4046/trd.2024.0155","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD) is a major global health issue, with acute exacerbations (AECOPD) significantly worsening outcomes and increasing healthcare burden. This review explores non-pharmacologic strategies aimed at preventing AECOPD. Pulmonary rehabilitation consistently demonstrates its effectiveness in reducing exacerbations and mortality while improving exercise capacity and quality of life. Lung volume reduction, through both surgical and bronchoscopic methods, has shown promise in select patient groups, leading to improved lung function and reduced exacerbation risk. Smoking cessation remains a critical intervention, while the role of electronic cigarettes is still debated; some evidence suggests they may help patients unable to quit tobacco smoking. Vitamin D supplementation has shown potential in reducing exacerbations, particularly in patients with severe deficiency, though conflicting results warrant further research. Furthermore, shielding measures, such as mask-wearing and social distancing, have gained attention during the COVID-19 pandemic for their role in reducing exacerbation risk. Lastly, vaccination, diet and nutrition, and non-invasive ventilation (NIV) may have important role in the prevention of AECOPD. These non-pharmacologic approaches should be integrated into comprehensive COPD management to improve outcomes and prevent AECOPD.","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of suboptimal peak inspiratory flow in patients with acute exacerbation of chronic obstructive pulmonary disease in real clinical practice. 实际临床实践中慢性阻塞性肺疾病急性加重患者的次优吸气峰流量预测因素

IF 2.5

Tuberculosis and Respiratory Diseases Pub Date : 2025-03-06 DOI: 10.4046/trd.2024.0154

Natalia V Trushenko, Baina B Lavginova, Svetlana Yu Chikina, Natalia E Obukhova, Iuliia A Levina, Fedor D Tkachenko, Galina V Nekludova, Zamira M Merzhoeva, Sergey N Avdeev

{"title":"Predictors of suboptimal peak inspiratory flow in patients with acute exacerbation of chronic obstructive pulmonary disease in real clinical practice.","authors":"Natalia V Trushenko, Baina B Lavginova, Svetlana Yu Chikina, Natalia E Obukhova, Iuliia A Levina, Fedor D Tkachenko, Galina V Nekludova, Zamira M Merzhoeva, Sergey N Avdeev","doi":"10.4046/trd.2024.0154","DOIUrl":"https://doi.org/10.4046/trd.2024.0154","url":null,"abstract":"Background: Incorrect inhalation technique is one of the most common reasons for the ineffectiveness of Chronic Obstructive Pulmonary Disease (COPD) therapy, increasing the frequency of exacerbations. Selection of treatment based on Peak Inspiratory Flow (PIF) measurements or predictors of suboptimal PIF (sPIF) could optimize therapy in patients with COPD. The goal of this study was to investigate a prevalence and predictors of sPIF in hospitalized patients with acute exacerbation of COPD in clinical practice.Methods: The study involved 72 patients hospitalized with acute COPD exacerbation. The analysis included demographic, clinical and lung function parameters. PIF was measured at the resistance level of patients' inhalation device using In-Check DIAL G16 before and after explaining the inhalation technique, as well as at medium-low resistance (R2) and high resistance (R5) at admission and on discharge.Results: Upon admission and before explaining the inhalation technique, sPIF was observed in 52.7% of patients, while after the explanation, the proportion of patients with sPIF decreased to 19.4% (p < 0.0001). ROC analysis revealed that independent predictors of suboptimal PIF were age >70 years; FVC <73% pred.; FEV1< 35% pred.; RV > 194% pred.; RV/TLC > 70%; DLco < 36% pred. The most significant predictors of sPIF were age (OR 0.89) and FEV1 (OR 0.59).Conclusion: When choosing dry powder inhaler for the maintenance therapy in patients with acute exacerbation of COPD, it is important to consider the patient's ability to generate the optimal PIF taking into account the patient's age and the severity of functional impairments.","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Korean guidelines for diagnosis and management of interstitial lung diseases: Hypersensitivity pneumonitis. 韩国间质性肺疾病诊断和治疗指南：超敏性肺炎。

IF 2.5

Tuberculosis and Respiratory Diseases Pub Date : 2025-03-06 DOI: 10.4046/trd.2024.0190

Byoung Soo Kwon, Sooim Sin, Kyung Hoon Kim, Jinkyeong Park, Beomsu Shin, Hongseok Yoo, Yong Hyun Kim

引用次数: 0