Turkish Journal of Hematology最新文献

{"title":"Comparison of Capillary Zone Electrophoresis with High-pressure Liquid Chromatography in the Evaluation of Hemoglobinopathies","authors":"Özlem Çakır Madenci, Özlem Hürmeydan, Asuman Orçun, Fatma Erdoğmuş","doi":"10.4274/tjh.galenos.2023.2023.0114","DOIUrl":"10.4274/tjh.galenos.2023.2023.0114","url":null,"abstract":"<p><strong>Objective: </strong>The capillary zone electrophoresis (CZE) and high-performance liquid chromatography (HPLC) methods were compared in terms of HbA2 measurement for the assessment of hemoglobinopathies.</p><p><strong>Materials and methods: </strong>CZE was compared with HPLC for the evaluation of patients without hemoglobinopathy (n=321), with β-thalassemia trait (n=113), and with common (HbD-Punjab, E, C, S/A, and S/S) and rare (HbS/D, O-Arap, Lepore, G-Coushata, Setif, Hamadan, Q-Iran, and H) variants (n=21). The reference range for HbA2 was determined by CZE.</p><p><strong>Results: </strong>Among patients without hemoglobinopathy, the median (2.5^th-97.5^th percentiles) values were 97.4% (97.0-98.0%) and 97.5% (96.6-98.4%) for HbA (p=0.060) and 2.4% (1.6-3.0%) and 2.5% (1.6-3.1%) for HbA2 (p<0.001) by HPLC and CZE, respectively. The reference range for HbA2 was 1.6-3.1% by CZE. In the comparison of methods for HbA2, there was a constant error of 0.255 (confidence interval: 0.062-0.448) and bias of 0.10% (limit of agreement: 0.33-0.53), and higher values were obtained with CZE. A strong correlation was observed between the methods (r=0.782). Interrater agreement was almost perfect for clinical diagnosis (ϰ=0.911). The two methods detected and identified the common variants similarly. All rare variants, except HbH by HPLC and HbS/D by CZE, were detected as separate peaks by both methods.</p><p><strong>Conclusion: </strong>The two methods were in agreement regarding the preliminary identification of β-thalassemia patients. Different Hb variants were detected by both methods but with possible methodological interference for HbA2 measurements. CZE is a reliable and simple alternative for the evaluation of hemoglobinopathies. The standardization of HbA2 measurements should be prioritized as more techniques become available in routine laboratory practice.</p>","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"258-265"},"PeriodicalIF":2.6,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10314650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Analysis of Prekallikrein Deficiency in a Consanguineously Married Chinese Family.","authors":"Yuan Chen, Meina Liu, Mingshan Wang, Huilin Chen, Bile Chen","doi":"10.4274/tjh.galenos.2023.2023.0351","DOIUrl":"10.4274/tjh.galenos.2023.2023.0351","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":"40 4","pages":"286-287"},"PeriodicalIF":2.6,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138483107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ChatGPT as a Way to Enhance Parents’ Communication in Cases of Oncological Pediatric Diseases","authors":"Filipe Prazeres","doi":"10.4274/tjh.galenos.2023.2023.0326","DOIUrl":"10.4274/tjh.galenos.2023.2023.0326","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"275-277"},"PeriodicalIF":2.6,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10598691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change in Polycythemia Vera Treatment: Ropeginterferon Alfa-2b in Light of Current Trials","authors":"Heinz Gisslinger","doi":"10.4274/tjh.galenos.2023.2023.0419","DOIUrl":"10.4274/tjh.galenos.2023.2023.0419","url":null,"abstract":"<p><p>Ropeginterferon alfa-2b (RopegIFN) enables effective cytoreduction in polycythemia vera (PV). Recent analyses suggest that long-term RopegIFN therapy fulfills treatment goals important to patients with PV including good quality of life, the slowing of disease progression, and long event-free survival. Data support the use of RopegIFN in both early PV therapy and second-line and beyond.</p>","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":"40 4","pages":"266-268"},"PeriodicalIF":1.5,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138483106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythrophagocytosis by Blasts and Numerous Cytoplasmic Granules in a Child with De Novo T-lymphoblastic Leukemia","authors":"Fang Long, Wenwen Song, Xue Li, Li Li, Ting Li, Yun Zhang","doi":"10.4274/tjh.galenos.2023.2023.0242","DOIUrl":"10.4274/tjh.galenos.2023.2023.0242","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"271-272"},"PeriodicalIF":2.6,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9895037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Thrombotic Thrombocytopenic Purpura in Elderly Patients: The Roles of PLASMIC and French Scores","authors":"Mehmet Baysal, Fehmi Hindilerden, Elif Gülsüm Ümit, Ahmet Muzaffer Demir, Fatma Keklik Karadağ, Güray Saydam, Seval Akpınar, Burhan Turgut, Vildan Özkocaman, Fahir Özkalemkaş, Rafiye Çiftçiler, Can Özlü, Sinan Demircioğlu, Yıldız İpek, Reyhan Diz Küçükkaya","doi":"10.4274/tjh.galenos.2023.2023.0295","DOIUrl":"10.4274/tjh.galenos.2023.2023.0295","url":null,"abstract":"<p><strong>Objective: </strong>In recent years, new developments have been incorporated into daily practice in the management of immune thrombotic thrombocytopenic purpura (iTTP). In particular, clinical scoring systems could help clinicians with clinical decision-making and early recognition. However, older patients frequently present with more organ involvement and in unusual ways. The ways in which age could affect these clinical prediction scoring systems remain unclear. We evaluated the use of PLASMIC and French scores in patients over 60 years of age.</p><p><strong>Materials and methods: </strong>We performed a retrospective cross-sectional analysis of patients over 60 years of age with a presumptive diagnosis of iTTP between 2014 and 2022 at 10 centers. We calculated PLASMIC and French scores and compared our data with a single-center analysis of younger patients presenting with thrombotic microangiopathy.</p><p><strong>Results: </strong>Our study included 30 patients over 60 years of age and a control group of 28 patients younger than 60 years. The diagnostic sensitivity and specificity of a French score of ≥1 were lower in older patients compared to the control group (78.9% vs. 100% and 18.2% vs. 57.1%, respectively). The diagnostic sensitivity and specificity of a PLASMIC score of ≥5 were 100% vs. 95% and 27.3% vs. 100% for the study group and control group, respectively. Our study showed a higher mortality rate in older patients compared to the control group (30% vs. 7.1%, p=0.043).</p><p><strong>Conclusion: </strong>For a limited number of patients (n=6), our results showed that rituximab can reduce mortality. Given that the reliability of clinical prediction scores for iTTP in older patients may be lower, more caution must be undertaken in interpreting their results.</p>","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"251-257"},"PeriodicalIF":2.6,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41137857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Biological Characteristics of 14 Adult Cases of <i>NUP98-NSD1⁺</i> Acute Myeloid Leukemia","authors":"Yan-Jun Sun, Wei Wang, Shen-Qi Lu, Li-Rong Li","doi":"10.4274/tjh.galenos.2023.2023.0340","DOIUrl":"10.4274/tjh.galenos.2023.2023.0340","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"281-283"},"PeriodicalIF":2.6,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10312583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Round Promyelocyte Cells with Round Nuclei: Clues to the Diagnosis of <i>ZBTB16-RARA</i> Acute Promyelocytic Leukemia","authors":"Yang Su, Jiwei Zhao, Xiaoming Fan, Wei Yang, Jinlin Liu","doi":"10.4274/tjh.galenos.2023.2023.0181","DOIUrl":"10.4274/tjh.galenos.2023.2023.0181","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"273-274"},"PeriodicalIF":2.6,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9624660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of Serum Galactomannan Assay in Children with Acute Myeloid Leukemia: Effect of the Revised EORTC/MSGERC 2020 Criteria","authors":"Gülhadiye Avcu, Nihal Karadaş, Şebnem Önen Göktepe, Dilek Yeşim Metin, Deniz Yılmaz Karapınar","doi":"10.4274/tjh.galenos.2023.2023.0285","DOIUrl":"10.4274/tjh.galenos.2023.2023.0285","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"278-280"},"PeriodicalIF":2.6,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41155383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HNRNPC-RARA Fusion Gene in Acute Promyelocytic Leukemia Lacking PML-RARA Rearrangement Presented with Abundant Hemophagocytosis","authors":"Jing Tan, Gang Zhang","doi":"10.4274/tjh.galenos.2023.2023-0207","DOIUrl":"https://doi.org/10.4274/tjh.galenos.2023.2023-0207","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136081133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}