Turkish Journal of Hematology最新文献

{"title":"Round Promyelocyte Cells with Round Nuclei: Clues to the Diagnosis of <i>ZBTB16-RARA</i> Acute Promyelocytic Leukemia","authors":"Yang Su, Jiwei Zhao, Xiaoming Fan, Wei Yang, Jinlin Liu","doi":"10.4274/tjh.galenos.2023.2023.0181","DOIUrl":"10.4274/tjh.galenos.2023.2023.0181","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"273-274"},"PeriodicalIF":2.6,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9624660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of Serum Galactomannan Assay in Children with Acute Myeloid Leukemia: Effect of the Revised EORTC/MSGERC 2020 Criteria","authors":"Gülhadiye Avcu, Nihal Karadaş, Şebnem Önen Göktepe, Dilek Yeşim Metin, Deniz Yılmaz Karapınar","doi":"10.4274/tjh.galenos.2023.2023.0285","DOIUrl":"10.4274/tjh.galenos.2023.2023.0285","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"278-280"},"PeriodicalIF":2.6,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41155383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HNRNPC-RARA Fusion Gene in Acute Promyelocytic Leukemia Lacking PML-RARA Rearrangement Presented with Abundant Hemophagocytosis","authors":"Jing Tan, Gang Zhang","doi":"10.4274/tjh.galenos.2023.2023-0207","DOIUrl":"https://doi.org/10.4274/tjh.galenos.2023.2023-0207","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136081133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fungal Infections and Myeloma: Supports","authors":"İrfan Yavaşoğlu","doi":"10.4274/tjh.galenos.2023.2023.0255","DOIUrl":"https://doi.org/10.4274/tjh.galenos.2023.2023.0255","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":"206 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136161388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hb Andrew-Minneapolis Variant in a Turkish Family","authors":"Hamza Sümter, Soycan Mızrak, Serdar Ceylaner, Duran Canatan","doi":"10.4274/tjh.galenos.2023.2023.0239","DOIUrl":"https://doi.org/10.4274/tjh.galenos.2023.2023.0239","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135048562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying Risk Factors and Improving Preventive Strategies for Febrile Neutropenia in Children with Leukemia Receiving Ciprofloxacin Prophylaxis","authors":"Zühre Kaya, Nurettin Alıcı, Serap Kırkız, Ülker Koçak","doi":"10.4274/tjh.galenos.2023.2023-0116","DOIUrl":"https://doi.org/10.4274/tjh.galenos.2023.2023-0116","url":null,"abstract":"The purpose of this study was to identify risk factors and improve preventive strategies for febrile neutropenia (FEN) in children with leukemia who were receiving ciprofloxacin prophylaxis. The study included 100 children with leukemia [n=80 with acute lymphoblastic leukemia and n=20 with acute myeloblastic leukemia (AML)]. Patients were divided into two groups based on whether they had three or fewer FEN episodes (Group 1) or more than three FEN episodes (Group 2). Group 1 contained 63 (63%) of the 100 patients, while Group 2 contained 37 (37%). Older age (≥7 years), leukemia type, prolonged neutropenia (>10 days), and the presence of neutropenia and hypogammaglobulinemia at diagnosis were all risk factors for having more than three FEN episodes. Our findings suggest that, in addition to ciprofloxacin prophylaxis, identifying risk factors and improving preventive strategies could help reduce FEN episodes in children with leukemia.Bu çalışmanın amacı, siprofloksasin profilaksisi alan lösemili çocuklarda febril nötropeni (FEN) için risk faktörlerini belirlemek ve önleyici stratejileri geliştirmektir. Çalışmaya lösemili 100 çocuk dahil edildi (akut lenfoblastik lösemi n=80 ve akut myeloid lösemi (AML) n=20). Hastalar üç ve üçten az FEN atağı (Grup 1) veya üçten fazla FEN atağı (Grup 2) geçirmelerine göre 2 gruba ayrıldı. Yüz hastanın 63’ünü (%63) Grup 1, kalan 37’sini (%37) Grup 2 oluşturdu. İleri yaş (≥7 yaş), lösemi tipi, uzamış nötropeni (>10 gün), tanı anında nötropeni ve hipogamaglobulinemi varlığı üçten fazla FEN atağı için anlamlı risk faktörleriydi. Bulgularımız, siprofloksasin profilaksisine ek olarak, lösemili çocuklarda risk faktörlerinin belirlenmesinin ve önleyici stratejilerin geliştirilmesinin FEN atağını azaltmaya yardımcı olabileceğine işaret etmektedir.","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136081135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Venetoclax and Azacitidine Treatment in Relapsed Acute Myeloid Leukemia after Hematopoietic Stem Cell Transplantation: A Cohort Study in the Real-World Setting of a Tertiary Center","authors":"Hakan Göker, Olgu Erkin Çınar, Haluk Demiroğlu, Ümit Yavuz Malkan, Elifcan Aladağ Karakulak, Yahya Büyükaşık","doi":"10.4274/tjh.galenos.2023.2023-0089","DOIUrl":"https://doi.org/10.4274/tjh.galenos.2023.2023-0089","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136081132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aleukemic Variant of Mast Cell Leukemia with del (7)(q31): Rare Case Report of an Elderly Chinese Man","authors":"Xiaoying Song, Yiping Yang, Zhanlong Wang, Jihong Hao","doi":"10.4274/tjh.galenos.2023.2022-0456","DOIUrl":"https://doi.org/10.4274/tjh.galenos.2023.2022-0456","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136081134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hb Andrew-Minneapolis Variant in a Turkish Family","authors":"Hamza Sümter,&nbsp;Soycan Mızrak,&nbsp;Serdar Ceylaner,&nbsp;Duran Canatan","doi":"10.4274/tjh.galenos.2023.2023-0239","DOIUrl":"10.4274/tjh.galenos.2023.2023-0239","url":null,"abstract":"There are a total of 1864 known structural hemoglobin (Hb) variants [1] and Hb Andrew-Minneapolis is a rare variant. Hb Andrew-Minneapolis is a beta-chain variant of hemoglobin, which is formed with the replacement of lysine at position 144 with asparagine (HGVS name: HBB:c.435G>C, beta 144(HC1) Lys>Asn), and it was first identified in 1973 by Zak et al. [2]. This variant is inherited in an autosomal dominant manner [2,3]. The first case in Türkiye was published by Aykut et al. [4]. Here we present the Hb Andrew-Minneapolis variant in two siblings whose parents were not alive.","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":"40 3","pages":"234-235"},"PeriodicalIF":2.6,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e5/c2/TJH-40-234.PMC10476262.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10531292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of GCET1, HGAL (GCET2), and LMO2 in the Determination of Germinal Center Phenotype in Diffuse Large B-cell Lymphoma","authors":"Neslihan Berker,&nbsp;Gülçin Yegen,&nbsp;Yasemin Özlük,&nbsp;Öner Doğan","doi":"10.4274/tjh.galenos.2023.2023.0110","DOIUrl":"https://doi.org/10.4274/tjh.galenos.2023.2023.0110","url":null,"abstract":"<p><strong>Objective: </strong>Diffuse large B-cell lymphoma (DLBCL) is a biologically heterogeneous disease that is classified into germinal center B-cell (GCB) and non-GCB subtypes, which are prognostically different. The Hans algorithm is the most widely used tool based on CD10, BCL6, and MUM1 expression, but some cases with the non-GCB phenotype are still known to be misclassified. In this study, we investigate the extent to which GCET1, HGAL, and LMO2 protein expressions reflect GCB phenotype together with their roles in determining the GCB phenotype of DLBCL and their contributions to the performance of the Hans algorithm.</p><p><strong>Materials and methods: </strong>Sixty-five cases of DLBCL-not otherwise specified, 40 cases of follicular lymphoma (FL), and 19 non-GC-derived lymphoma cases were included in this study. The DLBCL cases were grouped as CD10⁺ (Group A) or only MUM1⁺ (Group B), and the remaining cases constituted the intermediate group (Group C). GCET1, HGAL, and LMO2 expressions were evaluated.</p><p><strong>Results: </strong>In the FL group, GCET1, HGAL, and LMO2 were positive in 85%, 77.5%, and 100% of the cases, respectively. Among the non-GC-derived lymphoma cases, all three markers were negative in cases of small lymphocytic lymphoma, plasmablastic lymphoma, peripheral T-cell lymphoma, and anaplastic large cell lymphoma. GCET1 and HGAL were negative in cases of marginal zone lymphoma (MZL) and mantle cell lymphoma (MCL). Two of the 3 MZL and 2 of the 4 MCL cases were positive for LMO2. In the DLBCL group, the number of cases with GCET1, HGAL, and LMO2 positivity was 18 (90%), 17 (85%), and 20 (100%), respectively, in Group A and 0 (0%), 2 (13.3%), and 2 (13.3%), respectively, in Group B. Considering these rates, when the cases in the intermediate group were evaluated, it was concluded that 13 cases typed as non-GCB according to the Hans algorithm may have the GCB phenotype.</p><p><strong>Conclusion: </strong>GCET1, HGAL, and LMO2 are highly sensitive markers for determining the germinal center cell phenotype and can increase the accuracy of the subclassification of DLBCL cases, especially for cases that are negative for CD10.</p>","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":"40 3","pages":"162-173"},"PeriodicalIF":2.6,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6a/38/TJH-40-162.PMC10476251.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10513005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}