Turkish Journal of Hematology最新文献

{"title":"Erythrophagocytosis by Blasts and Numerous Cytoplasmic Granules in a Child with De Novo T-lymphoblastic Leukemia","authors":"Fang Long, Wenwen Song, Xue Li, Li Li, Ting Li, Yun Zhang","doi":"10.4274/tjh.galenos.2023.2023.0242","DOIUrl":"10.4274/tjh.galenos.2023.2023.0242","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"271-272"},"PeriodicalIF":2.6,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9895037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Thrombotic Thrombocytopenic Purpura in Elderly Patients: The Roles of PLASMIC and French Scores","authors":"Mehmet Baysal, Fehmi Hindilerden, Elif Gülsüm Ümit, Ahmet Muzaffer Demir, Fatma Keklik Karadağ, Güray Saydam, Seval Akpınar, Burhan Turgut, Vildan Özkocaman, Fahir Özkalemkaş, Rafiye Çiftçiler, Can Özlü, Sinan Demircioğlu, Yıldız İpek, Reyhan Diz Küçükkaya","doi":"10.4274/tjh.galenos.2023.2023.0295","DOIUrl":"10.4274/tjh.galenos.2023.2023.0295","url":null,"abstract":"<p><strong>Objective: </strong>In recent years, new developments have been incorporated into daily practice in the management of immune thrombotic thrombocytopenic purpura (iTTP). In particular, clinical scoring systems could help clinicians with clinical decision-making and early recognition. However, older patients frequently present with more organ involvement and in unusual ways. The ways in which age could affect these clinical prediction scoring systems remain unclear. We evaluated the use of PLASMIC and French scores in patients over 60 years of age.</p><p><strong>Materials and methods: </strong>We performed a retrospective cross-sectional analysis of patients over 60 years of age with a presumptive diagnosis of iTTP between 2014 and 2022 at 10 centers. We calculated PLASMIC and French scores and compared our data with a single-center analysis of younger patients presenting with thrombotic microangiopathy.</p><p><strong>Results: </strong>Our study included 30 patients over 60 years of age and a control group of 28 patients younger than 60 years. The diagnostic sensitivity and specificity of a French score of ≥1 were lower in older patients compared to the control group (78.9% vs. 100% and 18.2% vs. 57.1%, respectively). The diagnostic sensitivity and specificity of a PLASMIC score of ≥5 were 100% vs. 95% and 27.3% vs. 100% for the study group and control group, respectively. Our study showed a higher mortality rate in older patients compared to the control group (30% vs. 7.1%, p=0.043).</p><p><strong>Conclusion: </strong>For a limited number of patients (n=6), our results showed that rituximab can reduce mortality. Given that the reliability of clinical prediction scores for iTTP in older patients may be lower, more caution must be undertaken in interpreting their results.</p>","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"251-257"},"PeriodicalIF":2.6,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41137857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Biological Characteristics of 14 Adult Cases of <i>NUP98-NSD1⁺</i> Acute Myeloid Leukemia","authors":"Yan-Jun Sun, Wei Wang, Shen-Qi Lu, Li-Rong Li","doi":"10.4274/tjh.galenos.2023.2023.0340","DOIUrl":"10.4274/tjh.galenos.2023.2023.0340","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"281-283"},"PeriodicalIF":2.6,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10312583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Round Promyelocyte Cells with Round Nuclei: Clues to the Diagnosis of <i>ZBTB16-RARA</i> Acute Promyelocytic Leukemia","authors":"Yang Su, Jiwei Zhao, Xiaoming Fan, Wei Yang, Jinlin Liu","doi":"10.4274/tjh.galenos.2023.2023.0181","DOIUrl":"10.4274/tjh.galenos.2023.2023.0181","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"273-274"},"PeriodicalIF":2.6,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9624660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of Serum Galactomannan Assay in Children with Acute Myeloid Leukemia: Effect of the Revised EORTC/MSGERC 2020 Criteria","authors":"Gülhadiye Avcu, Nihal Karadaş, Şebnem Önen Göktepe, Dilek Yeşim Metin, Deniz Yılmaz Karapınar","doi":"10.4274/tjh.galenos.2023.2023.0285","DOIUrl":"10.4274/tjh.galenos.2023.2023.0285","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"278-280"},"PeriodicalIF":2.6,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41155383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HNRNPC-RARA Fusion Gene in Acute Promyelocytic Leukemia Lacking PML-RARA Rearrangement Presented with Abundant Hemophagocytosis","authors":"Jing Tan, Gang Zhang","doi":"10.4274/tjh.galenos.2023.2023-0207","DOIUrl":"https://doi.org/10.4274/tjh.galenos.2023.2023-0207","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136081133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fungal Infections and Myeloma: Supports","authors":"İrfan Yavaşoğlu","doi":"10.4274/tjh.galenos.2023.2023.0255","DOIUrl":"https://doi.org/10.4274/tjh.galenos.2023.2023.0255","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":"206 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136161388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hb Andrew-Minneapolis Variant in a Turkish Family","authors":"Hamza Sümter, Soycan Mızrak, Serdar Ceylaner, Duran Canatan","doi":"10.4274/tjh.galenos.2023.2023.0239","DOIUrl":"https://doi.org/10.4274/tjh.galenos.2023.2023.0239","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135048562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying Risk Factors and Improving Preventive Strategies for Febrile Neutropenia in Children with Leukemia Receiving Ciprofloxacin Prophylaxis","authors":"Zühre Kaya, Nurettin Alıcı, Serap Kırkız, Ülker Koçak","doi":"10.4274/tjh.galenos.2023.2023-0116","DOIUrl":"https://doi.org/10.4274/tjh.galenos.2023.2023-0116","url":null,"abstract":"The purpose of this study was to identify risk factors and improve preventive strategies for febrile neutropenia (FEN) in children with leukemia who were receiving ciprofloxacin prophylaxis. The study included 100 children with leukemia [n=80 with acute lymphoblastic leukemia and n=20 with acute myeloblastic leukemia (AML)]. Patients were divided into two groups based on whether they had three or fewer FEN episodes (Group 1) or more than three FEN episodes (Group 2). Group 1 contained 63 (63%) of the 100 patients, while Group 2 contained 37 (37%). Older age (≥7 years), leukemia type, prolonged neutropenia (>10 days), and the presence of neutropenia and hypogammaglobulinemia at diagnosis were all risk factors for having more than three FEN episodes. Our findings suggest that, in addition to ciprofloxacin prophylaxis, identifying risk factors and improving preventive strategies could help reduce FEN episodes in children with leukemia.Bu çalışmanın amacı, siprofloksasin profilaksisi alan lösemili çocuklarda febril nötropeni (FEN) için risk faktörlerini belirlemek ve önleyici stratejileri geliştirmektir. Çalışmaya lösemili 100 çocuk dahil edildi (akut lenfoblastik lösemi n=80 ve akut myeloid lösemi (AML) n=20). Hastalar üç ve üçten az FEN atağı (Grup 1) veya üçten fazla FEN atağı (Grup 2) geçirmelerine göre 2 gruba ayrıldı. Yüz hastanın 63’ünü (%63) Grup 1, kalan 37’sini (%37) Grup 2 oluşturdu. İleri yaş (≥7 yaş), lösemi tipi, uzamış nötropeni (>10 gün), tanı anında nötropeni ve hipogamaglobulinemi varlığı üçten fazla FEN atağı için anlamlı risk faktörleriydi. Bulgularımız, siprofloksasin profilaksisine ek olarak, lösemili çocuklarda risk faktörlerinin belirlenmesinin ve önleyici stratejilerin geliştirilmesinin FEN atağını azaltmaya yardımcı olabileceğine işaret etmektedir.","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136081135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Venetoclax and Azacitidine Treatment in Relapsed Acute Myeloid Leukemia after Hematopoietic Stem Cell Transplantation: A Cohort Study in the Real-World Setting of a Tertiary Center","authors":"Hakan Göker, Olgu Erkin Çınar, Haluk Demiroğlu, Ümit Yavuz Malkan, Elifcan Aladağ Karakulak, Yahya Büyükaşık","doi":"10.4274/tjh.galenos.2023.2023-0089","DOIUrl":"https://doi.org/10.4274/tjh.galenos.2023.2023-0089","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136081132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}