Turkish journal of anaesthesiology and reanimation最新文献

{"title":"Comparison of the Blockbuster^TM and Air-Q^® Supraglottic Airway Devices as a Conduit to Blind Endotracheal Intubation in Paediatric Patients: A Randomised Control Trial.","authors":"Arunima Pattanayak, Abhyuday Kumar, Chandni Sinha, Neeraj Kumar, Ajeet Kumar, Bindey Kumar, Rajnish Kumar","doi":"10.4274/TJAR.2026.252084","DOIUrl":"10.4274/TJAR.2026.252084","url":null,"abstract":"<p><strong>Objective: </strong>Only two devices [air-Q^® intubating laryngeal airway (ILA) and AmbuAura-i] have been studied previously for blind endotracheal intubation (ETI) in paediatric patients. The aim of the study was to compare the success rate of blind ETI through Blockbuster^TM laryngeal mask (LM) and air-Q^® ILA in paediatric patients.</p><p><strong>Methods: </strong>Eighty patients with the American Society of Anesthesiologists' physical status I and II, aged between six months and 10 years, were enrolled in this randomised controlled trial. The patients were intubated through either of the supraglottic airway devices (SADs) by visualised, blind intubation. The primary outcome was the first- attempt success rate of ETI. Secondary outcomes were the overall success rate of ETI, the oropharyngeal leak pressure, the fiberoptic glottic view, the time to intubation, and the complication rate.</p><p><strong>Results: </strong>Blockbuster^TM LM was having significantly higher first attempt success rate without any manipulation as compared to air-Q^® ILA (55% vs. 32.5%; <i>P</i> value =0.042). Overall success rate was also significantly higher in Blockbuster^TM LM (77.5% vs. 55%; <i>P</i> value =0.03). In subgroup analyses, Blockbuster^TM LM demonstrated significantly higher first-attempt and overall intubation success rates in children aged 6 months to 5 years, while success rates were comparable between devices among children older than 5 years.</p><p><strong>Conclusion: </strong>Blockbuster^TM LM, having more than 50% success rate of first-attempt blind intubation through SAD, can be a helpful device in crises during airway management of children and, thus, an ideal SAD for difficult airway carts.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":"54 4","pages":"299-306"},"PeriodicalIF":1.2,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13529068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-Sepsis Outcomes: Risk Factors for 90-Day Mortality and Infection Site-Pathogen Similarity in Recurrent Sepsis.","authors":"Emine Arman Fırat, İlhami Çelik","doi":"10.4274/TJAR.2026.262525","DOIUrl":"10.4274/TJAR.2026.262525","url":null,"abstract":"<p><strong>Aim: </strong>Post-sepsis outcomes remain poorly defined, with recurrent infections and late mortality posing significant clinical challenges. To identify clinical and laboratory predictors of 90-day post-sepsis mortality and to evaluate infection site and pathogen similarity in recurrent sepsis.</p><p><strong>Methods: </strong>This retrospective cohort study included 300 adult patients hospitalized with sepsis or septic shock at a tertiary care center (2018-2022). Demographic, clinical, laboratory, and microbiological data were analyzed. Multivariate bootstrap logistic regression identified independent predictors of mortality, and receiver operating characteristic analysis assessed diagnostic performance. Recurrent episodes were examined for infection site and for microbial concordance with the index hospitalization.</p><p><strong>Results: </strong>Of 183 discharged patients, 60 (32.8%) died within 90 days. Non-survivors were older, had higher Charlson Comorbidity Index scores, had longer intensive care unit (ICU) stays, had lower albumin and procalcitonin levels, and were less likely to achieve microbiological clearance by day 7. In multivariate analysis, only hypoalbuminemia independently predicted mortality (P=0.012). Receiver operating characteristic analysis showed the highest area under the curve for 1/procalcitonin (0.694), followed by age (0.665) and 1/albumin (0.647). Among recurrent sepsis cases, 55.9% had infections at the same site, but identical pathogens were detected in only 5.9%.</p><p><strong>Conclusion: </strong>Advanced age, comorbidity burden, prolonged ICU stay, delayed microbiological response, and hypoalbuminemia are associated with increased 90-day post-sepsis mortality. Although pathogen concordance was uncommon, a low culture yield indicates that some recurrent episodes may be relapses caused by undetected similar pathogens. When culture-negative episodes are also considered, the true similarity rate between initial and recurrent infections is likely even higher.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":"54 4","pages":"274-281"},"PeriodicalIF":1.2,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13529078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burnout in Anaesthesiology: A Nationwide Cross-sectional Study of Anaesthesiologists and Residents in Türkiye.","authors":"Orkun Kopac, Gökhan Sertçakacılar, Yasin Tire, Yutian Luo, Senem Urfalı, Sinem Sarı, Büşra Tok Çekmecelioğlu, Mohammad Khudirat, Sepideh Saroukhani, Ali Alper Kütük, Alparslan Turan","doi":"10.4274/TJAR.2026.252258","DOIUrl":"10.4274/TJAR.2026.252258","url":null,"abstract":"<p><strong>Objective: </strong>To determine the prevalence of burnout and to identify factors associated with it among anaesthesiology attendings and residents in Türkiye.</p><p><strong>Methods: </strong>We conducted a nationwide cross-sectional survey of anaesthesiology departments in Türkiye between September and December 2024. Burnout was assessed using the Maslach Burnout Inventory-Human Services Survey (Turkish version). Burnout syndrome was defined as high emotional exhaustion and depersonalization combined with low personal accomplishment; high-risk status was defined as high emotional exhaustion or depersonalization, regardless of personal accomplishment. Sociodemographic, occupational, and workplace factors were collected, and associations were analysed using univariable and multivariable logistic regression.</p><p><strong>Results: </strong>Among the 921 respondents (53% residents, 46% attendings; median age 33 years, interquartile range: 29-43; 53% female), 71.6% were at high-risk for burnout, and 36.7% met the criteria for burnout syndrome. Residents comprised a significantly greater proportion of physicians with burnout syndrome (68% vs. 45%; <i>P</i> < 0.001) and of those at high-risk for burnout (61% vs. 34%; <i>P</i> < 0.001). In the final multivariable model, younger age, female gender, low workplace satisfaction, perceived understaffing, and inadequate personal support were significantly associated with burnout syndrome. The combination of being female and being a resident is associated with higher odds of burnout (interaction <i>P</i>=0.034).</p><p><strong>Conclusion: </strong>The prevalence of burnout among the Turkish anaesthesiology workforce is extremely high and is especially pronounced among female residents and among those who are younger, work in understaffed settings, or experience job dissatisfaction. Targeted, system-level reforms that ensure fair pay, improved staffing, and supportive leadership, coupled with nationwide longitudinal monitoring, are needed to protect clinician well-being and patient safety.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":"54 4","pages":"262-273"},"PeriodicalIF":1.2,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13529074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a Structured Preoperative Educational Video on Maternal Anxiety in Elective Cesarean Section: A Randomized Controlled Trial Using EEG Biomarkers.","authors":"Ashutosh Kaushal, Tamonud Modak, Anuj Jain, Shikha Jain, L Pfokreni, Ujjwal Gupta","doi":"10.4274/TJAR.2026.262590","DOIUrl":"10.4274/TJAR.2026.262590","url":null,"abstract":"<p><strong>Objective: </strong>Preoperative anxiety is common in patients undergoing elective cesarean section and may worsen perioperative outcomes. This study evaluated whether a structured preoperative educational video (SPEV) reduces maternal anxiety, as measured by the Amsterdam Preoperative Anxiety and Information Scale (APAIS) and the quantitative electroencephalography (QEEG)-derived theta-beta ratio (TBR).</p><p><strong>Methods: </strong>Ninety primigravida women undergoing elective cesarean section with spinal anaesthesia were randomized to a video group (n = 45; SPEV plus routine counseling) or a control group (n = 45; routine counseling only). APAIS was measured at baseline and 30 minutes before surgery. Parietal TBR was recorded at baseline, 30 minutes before surgery, and 1 hour after surgery. Groups were compared using appropriate non-parametric tests, and the correlation between subjective and QEEG-derived measures was assessed.</p><p><strong>Results: </strong>Baseline characteristics were comparable between groups. At 30 minutes before surgery, APAIS scores were lower in the video group than in the control group [11.0 (9.0-12.0) vs. 14.0 (12.0-16.0); <i>P</i> < 0.001). TBR was also lower before surgery (1.20 vs. 1.90; <i>P</i> < 0.001) and at 1 hour postoperatively (1.20 vs. 1.80; <i>P</i> < 0.001). A positive correlation between APAIS scores and TBR was observed 30 minutes before surgery (<i>P</i>=0.48, <i>P</i> < 0.001). Intraoperative midazolam requirement was lower in the video group (11.1% vs. 33.3%, <i>P</i>=0.021).</p><p><strong>Conclusion: </strong>A SPEV significantly reduced preoperative anxiety in women undergoing elective cesarean section, as demonstrated by both subjective and QEEG-derived measures, and was associated with reduced intraoperative anxiolytic requirements.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":"54 4","pages":"307-314"},"PeriodicalIF":1.2,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13529077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ilioinguinal-Iliohypogastric Block for Open Inguinal Hernia Repair: A Prospective Observational Study.","authors":"Silvia De Pinto, Alessandro De Cassai, Margherita Iuzzolino, Giovanni Zecchino, Annalisa Boscolo, Giacomo Sarzo, Burhan Dost, Giuseppe Franco, Marina Munari","doi":"10.4274/TJAR.2026.252356","DOIUrl":"10.4274/TJAR.2026.252356","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the effectiveness of the ultrasound-guided ilioinguinal-iliohypogastric (II-IH) nerve block under mild intravenous sedation as a sole anaesthetic technique for open inguinal hernia repair and to identify factors independently associated with clinical inadequacy. The central research question was whether the II-IH block alone, when combined with intravenous sedation, could provide adequate anaesthesia for this procedure in a day-case setting.</p><p><strong>Methods: </strong>In this prospective observational study conducted at a university hospital, 342 adult patients undergoing unilateral open inguinal hernia repair with II-IH block were enrolled. The primary outcome was a composite of the need for intraoperative opioid supplementation, additional local anaesthetic, or conversion to general anaesthesia. Logistic regression was used to assess predefined predictors of clinical inadequacy.</p><p><strong>Results: </strong>Out of 342 patients, 233 (68.2%) successfully completed surgery with an II-IH block and mild intravenous sedation as the sole anaesthetic technique. In the remaining 109 patients (31.8%), only 9 (2.6%) required conversion to general anaesthesia. Logistic regression identified anaesthetic volume-but not dose-as significantly associated with clinical inadequacy (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>The II-IH block, when combined with sedation, is a feasible and effective anaesthetic approach for a substantial proportion of appropriately selected patients undergoing open inguinal hernia repair. This approach may represent a practical alternative to spinal or general anaesthesia.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":"54 4","pages":"315-322"},"PeriodicalIF":1.2,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13529081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anaesthetic Management of Hermansky-Pudlak Syndrome with Major Hemorrhage: Based on a Case Report.","authors":"Akın Akbulut, Doruk Yaylak, Yasemin Sincer, Yavuz Gürkan","doi":"10.4274/TJAR.2026.252131","DOIUrl":"10.4274/TJAR.2026.252131","url":null,"abstract":"<p><p>Hermansky-Pudlak Syndrome (HPS) is a rare autosomal recessive disorder characterized by oculocutaneous albinism, platelet dysfunction, and bleeding diathesis. This case discusses the anaesthetic and hemostatic management of a paediatric patient with HPS undergoing scoliosis surgery, which has not been previously documented. A 15-year-old female patient with HPS presented with scoliosis requiring surgical correction. Key clinical findings included albinism, neutropenia, cardiovascular abnormalities, and prolonged platelet function test results. Preoperative assessments identified significant risks of bleeding and pulmonary complications, necessitating multidisciplinary planning. Intraoperative interventions included the administration of 1-desamino-8 D-arginine vasopressin, tranexamic acid, and blood product transfusions to manage intraoperative hemorrhage. Postoperatively, the patient required intensive care support and was discharged without further complications. This case emphasizes the importance of early diagnosis, preoperative optimization, and individualized anaesthetic and hemostatic management for patients with HPS undergoing major surgery. Multidisciplinary collaboration and vigilance are essential to mitigating bleeding risks and ensuring favorable outcomes in this high-risk population.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":" ","pages":"221-224"},"PeriodicalIF":1.2,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13308580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148278984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Ultrasound-guided Erector Spinae Plane Block Versus Rhomboid Intercostal Block for Perioperative Analgesia in Breast Cancer Surgery.","authors":"Satish Kumar, Shagufta Naaz, Nishant Sahay, Sarfaraz Ahmad, Chandan Kumar Jha, Akhil V P, George Paul","doi":"10.4274/TJAR.2026.252149","DOIUrl":"10.4274/TJAR.2026.252149","url":null,"abstract":"<p><strong>Objective: </strong>Over 75% of women who have post-mastectomy reconstruction feel significant pain right away, and about 50% endure chronic pain. Thus, increasing the efficiency of postoperative pain management is crucial. Our study investigated the effects of ultrasound-guided erector spinae plane blocks (ESPB) and rhomboid intercostal blocks (RIB) on perioperative fentanyl use and pain scores in patients undergoing radical mastectomy surgery.</p><p><strong>Methods: </strong>This was a double-blind, randomised controlled trial conducted at a tertiary care hospital. Patients with breast cancer aged 18-70 years and American Society of Anaesthesiologists status I-II who were scheduled for unilateral modified radical mastectomy were included. They were randomly assigned to two groups. ESPB was performed in the ESPB group, and RIB was performed in the RIB group, using ultrasound guidance. Total postoperative fentanyl usage in the first 24 hours was the primary outcome indicator of the study. Intraoperative fentanyl requirements and numerical rating scale (NRS) scores at seven distinct time points were used as secondary outcome measures.</p><p><strong>Results: </strong>The difference between the mean of total postoperative fentanyl consumption in 24 hours in Group ESPB (2.67±0.68 μg kg^-1) and Group RIB (3.68±1.22 μg kg^-1) was statistically significant (t value: -4.183, df:66, <i>P</i> value: < 0.001). There was no difference in intraoperative opioid consumption between the groups (<i>P</i>=0.7). However, NRS scores were not significantly different between the ESPB group and the RIB group.</p><p><strong>Conclusion: </strong>Our study's outcome demonstrates ultrasound-guided ESPB to be more effective than RIB in terms of lower perioperative fentanyl consumption.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":" ","pages":"176-184"},"PeriodicalIF":1.2,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13308582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148279007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating a Novel Regional Technique: Serratus Posterior Superior Intercostal Plane Block Reduces Opioid Consumption and Pain Scores after Breast-conserving Surgery: A Randomized Controlled Trial.","authors":"Bahadır Çiftçi, Burak Ömür, Birzat Emre Gölboyu, Selçuk Alver, Pelin Basim, Tumay Uludağ Yanaral, Bayram Ufuk Sakul","doi":"10.4274/TJAR.2026.252202","DOIUrl":"10.4274/TJAR.2026.252202","url":null,"abstract":"<p><strong>Objective: </strong>Serratus posterior superior intercostal plane block (SPSIPB) provides thoracic analgesia. Our objective was to assess the analgesic effectiveness of SPSIPB in reducing pain scores and opioid consumption in patients undergoing breast-conserving surgery (BCS) with axillary dissection or sentinel lymph node biopsy.</p><p><strong>Methods: </strong>Participants were individuals aged 18-65 years with American Society of Anesthesiologists physical status I-II who were scheduled for elective BCS under general anaesthesia. Participants were randomly assigned to Group SPSIPB (n = 30) or Group Control (n = 30); the control group received local infiltration anaesthesia. A total of 30 milliliters of 0.25% bupivacaine was during the SPSIPB procedure. The primary outcome of the study was the numerical rating scale (NRS) score at 1 hour postoperatively. Secondary outcomes included 24-hour opioid consumption, need for rescue analgesia, and adverse effects.</p><p><strong>Results: </strong>During the first 24 hours after surgery, the median static and dynamic NRS scores were lower in the SPSIPB group than in the control group (<i>P</i> < 0.005). Fewer patients in the SPSIPB group required rescue analgesia than in the control group (3 vs. 26 patients, <i>P</i>=0.001), and opioid consumption was lower in the SPSIPB group (<i>P</i>=0.001). The incidence of adverse effects was significantly lower in the SPSIPB group (<i>P</i> < 0.005).</p><p><strong>Conclusion: </strong>Opioid consumption and pain scores in the SPSIPB group were significantly lower compared with those in the control group. SPSIPB provides effective analgesia and reduces opioid requirements, offering a valuable opioid-sparing alternative for anaesthesia in breast surgery.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":" ","pages":"161-168"},"PeriodicalIF":1.2,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13308567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145990852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative Management of Patients using GLP-1 Receptor Agonists Current Evidence, Risks, and Practical Recommendations-A Narrative Review.","authors":"Uğur Serkan Çitilcioğlu, Hatice Kaya Özdoğan","doi":"10.4274/TJAR.2026.262459","DOIUrl":"10.4274/TJAR.2026.262459","url":null,"abstract":"<p><p>Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual glucose-dependent insulinotropic polypeptide GLP-1 RAs are increasingly prescribed for diabetes and obesity, leading to a growing number of surgical patients receiving these agents. Their ability to delay gastric emptying has raised concerns about residual gastric contents (RGCs) and potential aspiration during anaesthesia. Available evidence from mechanistic studies, clinical investigations, and case reports indicates that GLP-1-based therapies consistently impair solid-phase gastric emptying and may increase RGC, particularly during early treatment and dose escalation, with effects that can persist despite standard fasting and short-term drug interruption. Although clinically apparent aspiration events remain uncommon, multiple reports have described perioperative regurgitation or unexpected solid gastric contents at induction. Early guidance favoured routine preoperative drug interruption; however, more recent multisociety recommendations increasingly support continuation of therapy in most asymptomatic patients and endorse enhanced perioperative mitigation strategies, such as dietary modification, strict adherence to fasting, selective use of point-of-care gastric ultrasound, preference for regional anaesthesia when feasible, and tailored airway management. Overall, current data support an individualised, risk-adapted approach rather than uniform interruption of GLP-1 therapy. Continuation of structured mitigation appears reasonable for many patients, whereas heightened caution and full-stomach precautions remain appropriate in higher-risk situations. Further prospective studies are required to define true perioperative aspiration risk and to establish evidence-based management pathways.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":" ","pages":"150-160"},"PeriodicalIF":1.2,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13308581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148303314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Intranasal Dexmedetomidine Premedication as an Adjunct on Intubation Process in Paediatric Patients: A Randomized, Double-blind, Placebo-controlled Trial.","authors":"Octava Prima Arta, Raihanita Zahra, Christopher Kapuangan, Indro Mulyono, Arif H M Marsaban, Aldy Heriwardito","doi":"10.4274/TJAR.2026.252306","DOIUrl":"10.4274/TJAR.2026.252306","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of a single intranasal dose of dexmedetomidine (2 μg kg^-1) on intubation efficacy, mask acceptance, sedation quality, intubation duration, and intraoperative fentanyl consumption in children undergoing elective surgery.</p><p><strong>Methods: </strong>A randomized, double-blind, placebo-controlled trial was conducted in 40 American Society of Anaesthesiologists I-II children aged 1-6 years who were scheduled for elective surgery. Participants were randomized to receive either dexmedetomidine (n = 20) or 0.9% sodium chloride placebo (n = 20). All patients received intravenous midazolam as a routine premedication. Primary outcomes were mean arterial pressure (MAP) and heart rate (HR), measured at baseline and post-intubation; these were compared to assess intubation efficacy. Secondary outcomes included mask acceptance, sedation quality, intubation time, and total fentanyl consumption. Data were analyzed using the independent-samples t-test or the Mann-Whitney U test (<i>P</i> <0.05).</p><p><strong>Results: </strong>Dexmedetomidine maintained MAP (1.34±19.59%) versus a significant rise with placebo (21.95±26.36%; P=0.008) and limited HR increase (1.6% vs. 22.2%; <i>P</i> <0.001).Mask acceptance and adequate sedation were significantly higher (<i>P</i> <0.001). Intubation duration did not differ (median 39 seconds vs. 44 seconds; P=0.267). Fentanyl consumption was significantly lower (1.10 vs. 2.15 μg kg^-1; <i>P</i> <0.001).</p><p><strong>Conclusion: </strong>A single intranasal dose of dexmedetomidine provides superior intubation efficacy, improves mask acceptance and sedation quality, and yields a significant opioid-sparing effect.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":" ","pages":"169-175"},"PeriodicalIF":1.2,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13308583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148279035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}