{"title":"Fluid Selection in Renal Transplant Patients: Considerations for Hyperkalemia Management.","authors":"Furkan Tontu","doi":"10.4274/TJAR.2025.251963","DOIUrl":"10.4274/TJAR.2025.251963","url":null,"abstract":"","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":" ","pages":"138-140"},"PeriodicalIF":0.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ludmilla Candido Santos, Jingya Gao, Ronaldo C Fabiano Filho, Piero F Mejia, Lacey B Robinson, Carlos A Camargo
{"title":"National Trends in Hospitalizations for Appendectomy in Children, 2001-2017.","authors":"Ludmilla Candido Santos, Jingya Gao, Ronaldo C Fabiano Filho, Piero F Mejia, Lacey B Robinson, Carlos A Camargo","doi":"10.4274/TJAR.2025.241755","DOIUrl":"10.4274/TJAR.2025.241755","url":null,"abstract":"<p><strong>Objective: </strong>Appendectomy for acute appendicitis is the most common acute surgical procedure in children. Recent changes in appendicitis management have likely modified the nature and cost of hospitalizations for this condition.</p><p><strong>Methods: </strong>Using data from the National Inpatient Sample from 2001 to 2017, we performed a cross-sectional study and identified the temporal changes in hospitalization for appendectomy. Changes in relative hospitalization cost and length-of-stay were also studied to assess their associations with the changes in procedure incidence. Patient and hospital characteristics were considered to understand outcome disparities between groups. Geographic variation in the outcomes was also identified at the United States region and division levels.</p><p><strong>Results: </strong>The incidence of appendectomy hospitalization decreased from 11.2 to 6.4 per 10,000 person-years between 2001 and 2017. Conversely, the median procedure cost increased 61% during this same period. The temporal changes in appendectomy hospitalization varied according to patient and hospital characteristics, as well as geographic locations.</p><p><strong>Conclusion: </strong>The overall incidence of appendectomies in children decreased substantially from 2001 to 2017, yet the trend for costs was in the opposite direction. The data on the clinical factors driving these trends can be useful in guiding policies with evidence-based guidelines that help optimize clinical decisions and the effective use of resources in the management of appendicitis.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":" ","pages":"122-131"},"PeriodicalIF":0.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zeliha Aslı Demir, Emre Sertaç Bingül, Burhan Dost, Gamze Talih, Aslıhan Aykut, Muhammed Enes Aydın, Başak Akça, Ümit Karadeniz
{"title":"Foundations and Advancements in Hemodynamic Monitoring: Part I-Elements of Hemodynamics","authors":"Zeliha Aslı Demir, Emre Sertaç Bingül, Burhan Dost, Gamze Talih, Aslıhan Aykut, Muhammed Enes Aydın, Başak Akça, Ümit Karadeniz","doi":"10.4274/TJAR.2025.251925","DOIUrl":"10.4274/TJAR.2025.251925","url":null,"abstract":"<p><p>Standard monitoring guidelines by the American Society of Anesthesiologists and European Society of Anaesthesiology and Intensive Care have not been updated for over a decade, despite rapid advancements in monitoring technology and the growing complexity of surgical patients. Traditional parameters such as blood pressure and pulse oximetry often fail to detect critical intraoperative conditions, emphasizing the need for comprehensive hemodynamic assessment. This review, the first of a two-part series, explores the fundamental elements of hemodynamics, including cardiac output, stroke volume, blood pressure, and oxygen delivery, with a focus on their physiological basis, clinical significance, and perioperative applications. This article provides a detailed foundation for understanding hemodynamic monitoring, setting the stage for the second article, which addresses advanced monitoring tools and their applications in contemporary anaesthesia practice.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":" ","pages":"87-97"},"PeriodicalIF":0.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neonatal Severe Hyperparathyroidism: Anaesthetic Considerations for Removal of Pea-size Glands in Children.","authors":"Uditi Parmar, Raylene Dias, Gayathri P, Madhuri Bamnote","doi":"10.4274/TJAR.2025.241409","DOIUrl":"10.4274/TJAR.2025.241409","url":null,"abstract":"<p><p>Neonatal severe hyperparathyroidism (NSHPT) is an extremely rare disorder with uncontrolled severe hypercalcemia and its clinical manifestations. It is caused by a mutation in the <i>calcium-sensing receptor (CaSR)</i> gene, which modulates the negative feedback of parathormone. We present anaesthetic management of two children with NSHPT who were posted for total parathyroidectomy as a life saving procedure. Both patients presented with lethargy, failure to thrive, and hypotonia. Intraoperative anaesthetic challenges include susceptibility to bradycardia, prolonged QT interval, precipitation of hypercalcemic crisis in the form of renal failure, hyperkalemia and electrocardiography changes, unpredictable response to neuromuscular blockade, susceptibility to recurrent laryngeal nerve injury, refractory hypocalcemia, which may start developing within six hours after surgery. Anaesthetic goals include preoperative optimisation of serum calcium with subcutaneous. Calcitonin, intravenous pamidronate and tablet cinacalcet, which are calcimimetics, maintenance of hydration and readiness to deal with intraoperative hypercalcemic crises. Anaesthetic management of NSHPT posted for total parathyroidectomy is challenging. To the best of our knowledge, there is no anaesthetic literature published to this day and only four surgical cases have been reported. Genome sequencing in both patients showed a <i>CaSR</i> gene mutation that is homozygous for a suspected pathogenic variant. Management requires a preoperative multidisciplinary approach for severe hypercalcemia and postoperative refractory hypocalcemia. These patients need lifelong calcium and vitamin D supplementation.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":" ","pages":"132-135"},"PeriodicalIF":0.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on \"Can Artificial Intelligence Be Successful as an Anaesthesiology and Reanimation Resident?\"","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.4274/TJAR.2025.252040","DOIUrl":"10.4274/TJAR.2025.252040","url":null,"abstract":"","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":" ","pages":"136-137"},"PeriodicalIF":0.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hemachander Sridharan, Nikhil Kesarkar, Raylene Dias
{"title":"Optimizing Paediatric Hypospadias Surgical Repair: Pudendal Nerve Block Versus Caudal Block for Superior Analgesia.","authors":"Hemachander Sridharan, Nikhil Kesarkar, Raylene Dias","doi":"10.4274/TJAR.2025.241773","DOIUrl":"10.4274/TJAR.2025.241773","url":null,"abstract":"<p><strong>Objective: </strong>Postoperative pain control after hypospadias surgery can be challenging, and the effectiveness of caudal block (CB) for analgesia is limited. This study evaluated the analgesic efficacy of pudendal nerve block (PNB) using both ultrasound and a peripheral nerve stimulator (PNS), compared to a CB performed using landmark guidance, in paediatric patients undergoing hypospadias surgical repair.</p><p><strong>Methods: </strong>A total of 40 patients scheduled for hypospadias surgery were included in this prospective, randomized, double-blind controlled trial, who received either a PNB or a CB. Patients in the pudendal group received an ultrasound- and PNS-guided, PNB with a combination of bupivacaine (0.25%) at a dose of 0.5 mL kg<sup>-1</sup> and clonidine at a dose of 1 μg kg<sup>-1</sup>, whereas those in the caudal group received a landmark-guided CB with bupivacaine (0.25%) at a dose of 1 mL kg<sup>-1</sup> along with clonidine at a dose of 1 μg kg<sup>-1</sup>. The objective pain scale (OPS) was used to assess pain intensity in each group within 24 hours post-surgery. Perioperative hemodynamic changes and analgesic requirements were also recorded.</p><p><strong>Results: </strong>The CB provided effective analgesia, lasting an average of 6 hours. OPS scores at 6, 12, 18, and 24 hours after surgery were significantly lower in the PNB group than in the CB group. The PNB group had a significantly longer time to the need for initial analgesia, while the CB group required a significantly greater dose of paracetamol after surgery (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>Findings from this study suggest that, at these doses, PNB is more effective than CB in providing longer-lasting pain relief, significantly lower pain scores, and a reduced need for postoperative analgesics.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":" ","pages":"114-121"},"PeriodicalIF":0.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vildan Kölükçü, Mehtap Gürler Balta, Ahmet Tuğrul Şahin, Ali Genç, Velid Unsal, Fatih Fırat, Fikret Gevrek, Asiye Yancı, Ahmet Burak Gürpınar
{"title":"The Potential Renoprotective Effect of Sugammadex in Renal Ischemia-reperfusion Injury.","authors":"Vildan Kölükçü, Mehtap Gürler Balta, Ahmet Tuğrul Şahin, Ali Genç, Velid Unsal, Fatih Fırat, Fikret Gevrek, Asiye Yancı, Ahmet Burak Gürpınar","doi":"10.4274/TJAR.2025.251887","DOIUrl":"10.4274/TJAR.2025.251887","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to evaluate the effectiveness of sugammadex on renal tissue for against ischemia-reperfusion injury.</p><p><strong>Methods: </strong>Twenty-one Wistar albino strain female rats were divided into three groups. The first group functioned as the control cohort for comparison. In Groups 2 and 3, a renal ischemia-reperfusion model was established. Moreover, following the cessation of ischemia, the rats in Group 3 were intravenously administered sugammadex at a dose of 4 mg kg<sup>-1</sup>. Blood and tissue samples were subsequently collected for analysis.</p><p><strong>Results: </strong>Biochemical analyses revealed a notable increase in the enzymatic activities of glutathione peroxidase and superoxide dismutase in Group 3 relative to Group 2 (<i>P</i> < 0.001 and <i>P</i>=0.015, respectively). Additionally, the concentration of malondialdehyde was found to be significantly reduced in Group 3 relative to Group 2 (<i>P</i>=0.004). Group 3 exhibited a substantial decrease in tumor necrosis factor-alpha, interleukin 6, and interleukin 1 beta levels when compared to Group 2 (<i>P</i>=0.021, <i>P</i>=0.006, and <i>P</i>=0.016 respectively). Group 2 exhibited the highest concentrations of neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 (<i>P</i> < 0.001 and <i>P</i>=0.015, respectively). Similarly, the histopathologic tissue damage was the most prominent in Group 2 (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>Sugammadex plays a protective role against ischaemia-reperfusion injury in renal tissue.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Application of Regional Anaesthesia in Türkiye: National Survey Study.","authors":"Elvin Kanat, Zeynep Çağıran, Nezih Sertöz","doi":"10.4274/TJAR.2025.251900","DOIUrl":"https://doi.org/10.4274/TJAR.2025.251900","url":null,"abstract":"<p><strong>Objective: </strong>This study was designed to determine why anaesthesiologists working in various institutions in our country prefer current regional anaesthesia methods and to evaluate the use and prevalence of ultrasonography in these methods.</p><p><strong>Methods: </strong>A questionnaire created on SurveyMonkey.com was sent electronically or face-to-face to anaesthesiology and reanimation physicians working in different provinces of our country, and they were asked to fill it out. The survey was intended to be administered to at least 200 volunteer anaesthesiologists. The questionnaire consisted of 34 questions, including demographic characteristics, neuraxial block and peripheral nerve block (PNB) applications, drug choices, preferences in paediatric cases, training, and safety measures.</p><p><strong>Results: </strong>A total of 215 anaesthesiologists participated in our questionnaire. 39.2% were working in a university hospital, and 38.2% were working in a training and research hospital. PNB training was received by 89.2% of the participants during specialty training. For analgesic purposes, the interscalene block was preferred for shoulder surgery (57.4%), the axillary block for elbow, forearm, and hand surgery (49.8%), the erector spinae plane block for thoracic surgery (33.8%), and the transverse abdominis and rectus block for open abdominal surgery (51.5%).</p><p><strong>Conclusion: </strong>Regional anaesthesia is an essential part of multimodal analgesia and is used both as an anaesthetic and analgesic in routine practice. In recent years, many new techniques have been utilized as a result of advancements. However, for these to be implemented in practice, up-to-date information should be closely followed, and anaesthetists should be supported in terms of training and equipment.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Impact of Preoperative Duration of Fasting on the Intravascular Volume Status of Children Older than 5 Years of Age: A Prospective, Observational Study.","authors":"Beliz Bilgili, Tümay Umuroğlu","doi":"10.4274/TJAR.2025.251934","DOIUrl":"https://doi.org/10.4274/TJAR.2025.251934","url":null,"abstract":"<p><strong>Objective: </strong>Preoperative fasting is a common practice aiming to reduce the risk of pulmonary aspiration during anaesthesia. It is advised to avoid fasting times longer than 6 hours in all children, whenever possible. Prolonged fasting can be uncomfortable for children and may lead to dehydration and other negative outcomes. The primary outcome of the study was the relationship between preoperative duration of fasting and cardiac index (CI) variability, used as a surrogate for intravascular volume status after the induction of anaesthesia, in paediatric patients undergoing surgery.</p><p><strong>Methods: </strong>Prospective, observational study that included patients over 5 years of age, scheduled for surgery. Passive leg-raising-induced CI variability was evaluated for fluid responsiveness and intravascular volume after anaesthesia induction. Patients were termed fluid responders (Rs) if an increase in CI of >10% was obtained after passive leg raising, and non-responders (NRs) if the CI variability was <10%. CI and aortic peak velocity (V<sub>peak</sub>) were measured through the suprasternal notch via an ultrasonic cardiac output monitor.</p><p><strong>Results: </strong>There were 32 Rs and 53 (NRs). The mean duration of fasting for Rs was 11.53±2.61, while NR had a mean duration of fasting of 10.6±2.93 hours, showing an insignificant difference. Aortic V<sub>peak</sub> change was significantly higher in Rs (0.24±0.17) compared to NRs (0.03±0.13) (<i>P</i> < 0.001). Duration of fasting showed no significant correlation with CI variability and peak aortic velocity.</p><p><strong>Conclusion: </strong>With this study method, it was observed that preoperative fasting time had no effect on intraoperative intravascular volume.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gülseli Berivan Sezen, Osman Boyalı, Burak Karip, Selman Aktaş, Eyüp Can Savrunlu, Mourat Chasan, Necati Kaplan, Erdinç Civelek, Serdar Kabataş
{"title":"Retrospective Clinical and Radiological Comparison of Intradiscal Ozone and Ozone + PRP Therapy Results in Patients with Intervertebral Disc Degeneration.","authors":"Gülseli Berivan Sezen, Osman Boyalı, Burak Karip, Selman Aktaş, Eyüp Can Savrunlu, Mourat Chasan, Necati Kaplan, Erdinç Civelek, Serdar Kabataş","doi":"10.4274/TJAR.2025.241831","DOIUrl":"https://doi.org/10.4274/TJAR.2025.241831","url":null,"abstract":"<p><strong>Objective: </strong>This retrospective study aimed to evaluate and compare the clinical efficacy of intradiscal ozone therapy (OT) against a combination therapy of ozone and platelet-rich plasma (PRP) in patients diagnosed with intervertebral disc degeneration (IVDD).</p><p><strong>Methods: </strong>The study included a cohort of 50 patients, divided equally into two groups of 25, who received either intradiscal OT or ozone + PRP combination therapy between February 2022 and February 2023. The sample comprised 20 females and 30 males, with ages ranging from 19 to 76 years (mean age 48.8). Pain intensity was measured using the visual analog scale (VAS), while disability levels were assessed using the oswestry disability index (ODI) prior to treatment and at 1, 3, and 6 months post-treatment. Additionally, lumbar magnetic resonance imaging was conducted at the 3-month mark post-treatment, with evaluations based on the Pfirrmann disc degeneration classification.</p><p><strong>Results: </strong>Significant improvement in both VAS and ODI scores was observed in both treatment groups (<i>P</i> < 0.001). The ozone + PRP combination therapy group exhibited no statistically significant difference in VAS and ODI scores compared to the ozone-only group (<i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>Intradiscal OT and the ozone + PRP combination therapy represent effective minimally invasive treatment options for patients suffering from IVDD, yielding substantial clinical benefits with minimal side effects. That is why it is suggested as a potential preferred therapeutic approach prior to the consideration of surgical interventions.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}