IF 3.1 4区医学

Tumori Pub Date : 2026-04-27 DOI: 10.1177/03008916261438276

Olga Nigro, Annarita Adduci, Luca Bergamaschi, Giovanna Gattuso, Giovanna Sironi, Monica Giovanetti, Maura Massimino, Paolo Grampa

{"title":"The \"empty speech bubbles\": Explaining cancer through play. A pediatric oncology unit pilot experience.","authors":"Olga Nigro, Annarita Adduci, Luca Bergamaschi, Giovanna Gattuso, Giovanna Sironi, Monica Giovanetti, Maura Massimino, Paolo Grampa","doi":"10.1177/03008916261438276","DOIUrl":"https://doi.org/10.1177/03008916261438276","url":null,"abstract":"Purpose: This pilot study aimed at evaluating the feasibility and acceptability of a structured psycho-educational intervention designed to increase disease awareness in children with tumors. The primary objective was to promote psychological adjustment by supporting children's understanding of their illness and facilitating open parent-child communication about cancer.Methods: Consecutive patients aged 6-11 years undergoing diagnosis or treatment for tumors at a single pediatric oncology center were invited to participate in a four-month period. The intervention consisted of three stages: (1) development of a mini guidebook for caregivers; (2) a psychologist-led meeting with parents focused on communication strategies; and (3) individual or group educational activities with children conducted by a multidisciplinary team. Child-centered, age-appropriate methods-including play, creative tasks, and anonymous \"empty speech bubbles\" for questions-were used to address disease etiology, diagnostic procedures, treatments, and terminology.Results: Eleven children participated in the intervention. All engaged actively in the sessions and expressed reassurance and satisfaction with the information received. The use of anonymous question tools facilitated open expression of fears and doubts. Parents reported increased confidence and reduced difficulty in communicating with their child about the illness, valuing the structured guidance provided.Conclusion: This preliminary experience suggests that structured, interactive interventions promoting illness awareness are feasible and well accepted in pediatric oncology. Such approaches may support psychological adjustment in children with tumors and improve parent-child communication, representing a valuable component of holistic cancer care.","PeriodicalId":23349,"journal":{"name":"Tumori","volume":" ","pages":"3008916261438276"},"PeriodicalIF":3.1,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethics in the evaluation of the quality of scientific research: An AIOM-TJ roundtable. 科学研究质量评价中的伦理：AIOM-TJ圆桌会议。

IF 3.1 4区医学

Tumori Pub Date : 2026-04-19 DOI: 10.1177/03008916261441119

Alessio Vittorio Adani, Paolo Crosetto, Laura Galbiati, Elena Giglia, Aldo Scarpa, Francesco Perrone

{"title":"Ethics in the evaluation of the quality of scientific research: An AIOM-TJ roundtable.","authors":"Alessio Vittorio Adani, Paolo Crosetto, Laura Galbiati, Elena Giglia, Aldo Scarpa, Francesco Perrone","doi":"10.1177/03008916261441119","DOIUrl":"https://doi.org/10.1177/03008916261441119","url":null,"abstract":"The current scientific ecosystem is characterized by a systemic crisis driven by the Publish or Perish culture and an exponential growth in publication volumes that outpaces the number of active researchers. Here, we highlight the limitations of traditional bibliometric indicators, such as the Impact Factor and H-index, which have become targets for manipulation and enable inflationary business models, including the proliferation of special issues. To address these distortions, we explore the transformative potential of Open Science and the adoption of FAIR data principles to move from a model based on blind trust to one rooted in verifiability. Furthermore, we examine innovative evaluation frameworks, such as the independent peer review model, and the integration of artificial intelligence through Technology Assisted Research Assessment (TARA), emphasizing that human judgment must remain central to ensuring research integrity. Ultimately, the transition from quantitative metrics to qualitative assessment is an ethical duty necessary to safeguard the credibility of oncological research and the quality of patient care.","PeriodicalId":23349,"journal":{"name":"Tumori","volume":" ","pages":"3008916261441119"},"PeriodicalIF":3.1,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification and selection of the best artificial intelligence methods developed for detection and diagnosis of breast cancer. 识别和选择用于检测和诊断乳腺癌的最佳人工智能方法。

IF 3.1 4区医学

Tumori Pub Date : 2026-04-16 DOI: 10.1177/03008916261434125

Xuan Zhou, Qi Fan, Dan Zhu, Jing Kang, Lijun Lv

{"title":"Identification and selection of the best artificial intelligence methods developed for detection and diagnosis of breast cancer.","authors":"Xuan Zhou, Qi Fan, Dan Zhu, Jing Kang, Lijun Lv","doi":"10.1177/03008916261434125","DOIUrl":"https://doi.org/10.1177/03008916261434125","url":null,"abstract":"Background: Comprehensive identification and prioritization of developed artificial intelligence methods for the detection and diagnosis of breast cancer can help to select proper techniques. This study aimed to introduce the best artificial intelligence techniques developed for the detection and diagnosis of breast cancer using microscopic images by fuzzy AHP-TOPSIS techniques.Methods: To identify the artificial intelligence techniques developed, a systematic search was performed in five reliable databases. After that, the Delphi method was applied to determine the proper criteria for selecting the best artificial intelligence techniques. To estimate the relative weights of the criteria, the fuzzy analytical hierarchy process (FAHP) method was used. In the next step, to prioritize the identified artificial intelligence techniques, the technique for order of preference by similarity to the ideal solution (TOPSIS) method was applied.Results: Forty-four artificial intelligence techniques were identified. Seven selection criteria, validity, accuracy, comprehensiveness, processing time, cost, simplicity, and executive capability, were introduced. Ensemble deep learning architectures integrated with web of things (weight = 0.8041), the computer-aided diagnosis method (weight = 0.7774), the ensemble strategy (VGG16 - ResNet34 - ResNet50) (weight = 0.7475), automated tumor-stroma interface zone detection (weight = 0.7475), and MultiNet/Computer-Aided Diagnosis (CAD)-based deep learning model (weight = 0.7262) were selected as the best methods, respectively.Conclusion: These findings represent a total approach to the developed techniques which can be used for designing methods with better performance in the future.","PeriodicalId":23349,"journal":{"name":"Tumori","volume":" ","pages":"3008916261434125"},"PeriodicalIF":3.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ten tips to reduce gaps in daily oncology practice. 减少日常肿瘤学实践差距的10个建议。

IF 3.1 4区医学

Tumori Pub Date : 2026-04-08 DOI: 10.1177/03008916261437958

Luca Moscetti, Antonella Ferro, Catia Angiolini, Ornella Garrone, Palma Fedele, Sara Donati, Lorenzo Gianni

引用次数: 0

Reforming Ethical Oversight in Italy: Challenges and Gaps in the Implementation of the New Ethics Committees Framework. 意大利伦理委员会改革两年后：是时候反思了。

IF 3.1 4区医学

Tumori Pub Date : 2026-04-01 Epub Date: 2025-11-11 DOI: 10.1177/03008916251392734

Celeste Cagnazzo, Giorgia Rocca, Franca Fagioli

{"title":"Reforming Ethical Oversight in Italy: Challenges and Gaps in the Implementation of the New Ethics Committees Framework.","authors":"Celeste Cagnazzo, Giorgia Rocca, Franca Fagioli","doi":"10.1177/03008916251392734","DOIUrl":"10.1177/03008916251392734","url":null,"abstract":"The recent reform of Italian Ethics Committees (ECs), formalized between 2022 and 2023, aimed to streamline ethical oversight in clinical research by transitioning from a fragmented local system to a coordinated national framework. The new structure includes 40 Territorial Ethics Committees (CETs) and three National Committees (CENs), under the supervision of the National Coordination Centre (CCNCE). While the reform aligned Italy with European Regulation (EU) No 536/2014, significant implementation gaps remain. Many CETs face operational delays, non-compliance with legal composition requirements, inconsistent procedures, and limited resources. Technical-Scientific Secretariats (STS)-crucial to committee function-often lack adequate staffing and training, leading to geographic disparities in review efficiency. Financial sustainability is also a major concern, especially for committees handling unfunded non-commercial studies. Furthermore, the limited mandate of ECs excludes a large portion of ethically complex but non-regulated research. The CCNCE's coordinating role is constrained by scarce resources and insufficient authority. To ensure effective, equitable, and independent ethical review, the article calls for regulatory harmonization, organizational investment, financial support, and broader recognition of ECs' roles in all areas of health research.","PeriodicalId":23349,"journal":{"name":"Tumori","volume":" ","pages":"92-96"},"PeriodicalIF":3.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145490520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nuclear expression of AIRE in lung squamous cell carcinoma correlates with immune microenvironment remodeling and poor prognosis. AIRE在肺鳞状细胞癌中的核表达与免疫微环境重塑和不良预后相关。

IF 3.1 4区医学

Tumori Pub Date : 2026-04-01 Epub Date: 2026-03-01 DOI: 10.1177/03008916261423494

Chengyan Wang, Chuhuai Wang, Yuhan Jia, Fangfang Liu, Xun Yuan, Qian Chu

{"title":"Nuclear expression of AIRE in lung squamous cell carcinoma correlates with immune microenvironment remodeling and poor prognosis.","authors":"Chengyan Wang, Chuhuai Wang, Yuhan Jia, Fangfang Liu, Xun Yuan, Qian Chu","doi":"10.1177/03008916261423494","DOIUrl":"10.1177/03008916261423494","url":null,"abstract":"Objective: The autoimmune regulator (AIRE), an atypical transcriptional regulator, exhibits aberrant expression in multiple tumor types. However, its significance in lung squamous cell carcinoma (LUSC) is still uncertain. This study investigated AIRE's expression, immune microenvironment association, and prognostic value in LUSC.Method: AIRE expression was analyzed using TCGA database, validated via RT-qPCR/Western blot in LUSC (H1703, SK-MES-1, EBC-1) vs. normal (BEAS-2B) cells. Tissue microarray immunohistochemistry (IHC) quantified nuclear/cytoplasmic AIRE in clinical samples. Clinicopathological correlations, immune infiltration (CIBERSORT), and survival outcomes were assessed. A nomogram integrating nuclear AIRE and clinical factors predicted 1/3/5-year survival (C-index evaluation).Result: AIRE was upregulated in LUSC. Nuclear AIRE was tumor-specific (absent in normal tissue), elevated in inflammatory stroma (6.29 ± 4.57 vs. 3.10 ± 3.66, P < 0.001), and correlated with lymphocyte infiltration (R = 0.437, P < 0.001). High AIRE linked to increased Tregs (P< 0.001) and reduced dendritic cells (P< 0.01). No association with age, stage, or Ki-67 (P > 0.05) was observed. Patients with high AIRE had worse survival (HR = 2.00 [1.02 - 3.93], P = 0.043). The nomogram incorporating nuclear AIRE achieved a C-index of 0.814 for outcome estimation in our cohort.Conclusion: In a LUSC cohort, nuclear AIRE expression is associated with immune microenvironment features and poorer overall survival. However, its incremental prognostic value beyond established clinicopathological variables appears modest, and further external validation and functional studies are warranted.","PeriodicalId":23349,"journal":{"name":"Tumori","volume":" ","pages":"134-144"},"PeriodicalIF":3.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147327127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of body mass index on the treatment response to neoadjuvant chemotherapy in patients with breast cancer: A systematic review and meta-analysis. 体重指数对乳腺癌患者新辅助化疗治疗反应的影响：系统回顾和荟萃分析。

IF 3.1 4区医学

Tumori Pub Date : 2026-04-01 Epub Date: 2026-02-19 DOI: 10.1177/03008916251410090

Lirong Zhang, Dongmei Lu, Pan Geng, Gang Chen, Yaqing Wang, Juanqin Niu

{"title":"The impact of body mass index on the treatment response to neoadjuvant chemotherapy in patients with breast cancer: A systematic review and meta-analysis.","authors":"Lirong Zhang, Dongmei Lu, Pan Geng, Gang Chen, Yaqing Wang, Juanqin Niu","doi":"10.1177/03008916251410090","DOIUrl":"10.1177/03008916251410090","url":null,"abstract":"Objective: Many studies have highlighted that elevated body mass index (BMI) not only correlates with an elevated likelihood of developing breast cancer (BC) but may also influence patients' responsiveness to therapeutic regimens and long-term survival outcomes. The impact of BMI on therapeutic response to neoadjuvant chemotherapy (NAC) in patients with BC remains inconclusive. This study seeks to evaluate the effect of BMI on treatment response in the BC population undergoing NAC via a meta-analysis, thereby providing evidence-based support for clinical decision-making.Methods: PubMed, Embase, Web of Science, and the Cochrane Library were thoroughly searched until July 29, 2024. Eligible studies were selected as per predefined eligibility criteria. Data extraction and quality assessment were executed via the Newcastle-Ottawa Scale (NOS). Statistical analyses were enabled by R 4.4.1 and Stata 17.Results: Fifteen studies encompassing 15,235 patients were incorporated. The meta-analysis revealed that in contrast to patients with a normal or low BMI, those who were overweight or obese had a significantly reduced pathlological complete response (pCR) rate (OR: 0.79, p = 0.040). The underweight cohort demonstrated a higher pCR rate in comparison to those with normal BMI (OR: 1.56, p=0.015). Moreover, overweight and obese cohorts displayed a lower pCR rate in contrast to those having normal BMI (OR: 0.83, p < 0.0001).Conclusion: This study indicates that overweight and obese patients tend to exhibit a reduced pCR, highlighting the need for standardized BMI definitions. Future well-designed prospective studies are necessitated to validate these observations.","PeriodicalId":23349,"journal":{"name":"Tumori","volume":" ","pages":"102-117"},"PeriodicalIF":3.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence, mortality and risk factors of hematologic malignancies in China from 1990 to 2021: A systematic analysis for the GBD 2021. 1990 - 2021年中国血液恶性肿瘤发病率、死亡率及危险因素：GBD 2021的系统分析

IF 3.1 4区医学

Tumori Pub Date : 2026-04-01 Epub Date: 2026-01-23 DOI: 10.1177/03008916251410092

DongHui Gan, Jun Lin, JinFang Zeng, JinQing Fan, ZhiQun Pan

{"title":"Incidence, mortality and risk factors of hematologic malignancies in China from 1990 to 2021: A systematic analysis for the GBD 2021.","authors":"DongHui Gan, Jun Lin, JinFang Zeng, JinQing Fan, ZhiQun Pan","doi":"10.1177/03008916251410092","DOIUrl":"10.1177/03008916251410092","url":null,"abstract":"Objective: This study aimed to systematically analyze the incidence, mortality, and risk factors of hematologic malignancies and their subtypes in China from 1990-2021.Methods: The study utilized data from the Global Burden of Disease 2021 database. Trends in incidence and mortality rates of hematologic malignancies from 1990-2021 were measured using estimated annual percentage change (EAPC) with 95% confidence intervals. Future burden in China up to 2035 was projected using Bayesian age-period-cohort modeling.Results: Between 1990 and 2021, China saw rising age-standardized incidence rates for multiple myeloma, non-Hodgkin lymphoma, and leukemia, but a decline for Hodgkin lymphoma. Mortality decreased for leukemia, Hodgkin lymphoma, and non-Hodgkin lymphoma, while increasing for multiple myeloma. Among leukemia subtypes, incidence fell for acute myeloid, chronic myeloid, and other leukemias but rose for acute and chronic lymphoid leukemias. Mortality declined across all five subtypes. Males had higher incidence and mortality than females for all hematologic malignancies. The 65-69 age group had the highest number of cases and deaths. Children under 5 years of age were most affected by leukemia, mainly acute lymphoid leukemia. High BMI was a significant risk factor. Projections to 2035 suggest continued increases in incidence and mortality for multiple myeloma, but declining leukemia mortality. Incidence of acute lymphoblastic and other leukemias is expected to fall, with mortality improving for all leukemia subtypes.Conclusions: China's hematologic malignancy burden remained high in 2021 and is projected to persist through 2035. BMI is a key driver, highlighting the need for targeted control measures to reduce this burden.","PeriodicalId":23349,"journal":{"name":"Tumori","volume":" ","pages":"145-156"},"PeriodicalIF":3.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attitudes and beliefs of Italian palliative care experts regarding cachexia: A Delphi study. 意大利姑息治疗专家对恶病质的态度和信念：德尔菲研究。

IF 3.1 4区医学

Tumori Pub Date : 2026-04-01 Epub Date: 2026-02-08 DOI: 10.1177/03008916261418900

Matteo Moroni, Eduardo Bruera, Luca Ghirotto, Gianmarco Priori, Simone Veronese

{"title":"Attitudes and beliefs of Italian palliative care experts regarding cachexia: A Delphi study.","authors":"Matteo Moroni, Eduardo Bruera, Luca Ghirotto, Gianmarco Priori, Simone Veronese","doi":"10.1177/03008916261418900","DOIUrl":"10.1177/03008916261418900","url":null,"abstract":"Introduction: Cachexia is a multifactorial syndrome prevalent in advanced illness. Guidelines rarely integrate the relational, multidimensional perspective of palliative care (PC). Addressing this gap is essential to optimize care. To achieve this, national consensus among PC physicians and nurses on principles and priorities for managing cachexia within PC settings is necessary.Methods: A two-round Delphi study was conducted with 43 Italian PC experts (29 physicians, 14 nurses) meeting ⩾10 years' experience criteria. In Round 1, participants answered open-ended questions informed by literature and a prior exploratory study. Qualitative Framework Method analysis generated 28 statements. In Round 2, statements were rated on a 5-point Likert scale; consensus was defined as ⩾90% agreement (scores 4 or 5).Results: Response rates were 82.2% (Round 1) and 95.5% (Round 2). High consensus (⩾90%) from both physicians and nurses was reached for 14 of 28 statements. Unanimous agreement (100%) supported the need for multiprofessional management, assessment of symptom clusters, and reframing the meaning of food in relation to illness stage. Strong agreement was found for dyadic care planning (97.7%), oral care (97.7%), and body image assessment (95.3%). Lower consensus occurred for prioritizing nutritional deficits (55.8%) and routine CRP/prealbumin testing (34.5%), reflecting contextual and prognostic considerations.Conclusions: This study defines core PC-oriented principles for cachexia management: interprofessional collaboration, dyadic engagement, early holistic assessment, and goal-concordant interventions. Findings can inform future clinical guidelines, training, and policy development to address cachexia in advanced illness.","PeriodicalId":23349,"journal":{"name":"Tumori","volume":" ","pages":"176-182"},"PeriodicalIF":3.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forceful survivorship: The desire to procreate in parents of cancer patients. 强生存：癌症患者父母的生育欲望。

IF 3.1 4区医学

Tumori Pub Date : 2026-04-01 Epub Date: 2026-02-08 DOI: 10.1177/03008916251414313

Annarita Adduci, Giovanna Sironi, Andrea Ferrari, Paolo Grampa, Luca Bergamaschi, Cristina Meazza, Marta Podda, Susanna Castelli, Maura Massimino

引用次数: 0

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