Perineural invasion and parotid involvement in auricular cutaneous SCC: Which volumes to treat in postoperative radiotherapy?

IF 2 4区医学 Q3 ONCOLOGY

Tumori Pub Date : 2025-05-04 DOI:10.1177/03008916251334879

Paola Critelli, Silvana Parisi, Daniela Alterio, Melissa Scricciolo, Marta Maddalo, Pierluigi Bonomo, Domenico Romanello, Sara Ronchi, Daniela Sibio, Ida D'Onofrio, Clelia Di Carlo, Stefania Volpe, Lavinia Spinelli, Rachele Petrucci, Luca Frassinelli, Elisa D'Angelo, Anna Merlotti

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引用次数: 0

Abstract

Introduction: Postoperative radiotherapy is recommended for all patients with cutaneous and non-cutaneous squamous cell carcinoma of the head and neck in the presence of clinical and incidental perineural infiltration. Perineural infiltration represents one of the most important adverse prognostic factors and may impact negatively patient outcomes. While guidelines exist for defining radiotherapy treatment volumes in patients with cutaneous squamous cell carcinoma and clinical perineural infiltration, there is a notable gap in the literature regarding recommendations for cases with incidental perineural infiltration and parotid involvement.

Methods: A case of cutaneous squamous cell carcinoma of the auricular zone was proposed to an expert radiation oncologist panel.

Results: The main issues concerned the inclusion of the surgical bed alone or the extension to the adjacent zone.

Conclusion: This paper aims to provide a review of literature data and to propose a comprehensive approach to target volume definition in this setting of patients.

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耳廓皮肤鳞状细胞癌的周围神经侵犯和腮腺受累：术后放疗应治疗哪些体积？

简介：所有头颈部皮肤和非皮肤鳞状细胞癌患者，如果有临床和偶然的神经周围浸润，建议术后放疗。神经周围浸润是最重要的不良预后因素之一，可能会对患者的预后产生负面影响。虽然有关于皮肤鳞状细胞癌和临床神经周围浸润患者放射治疗量的指南，但对于偶发神经周围浸润和腮腺受累者的建议，文献中存在明显的空白。方法：向放射肿瘤学专家小组报告1例耳廓区皮肤鳞状细胞癌。结果：主要问题是手术床是否单独纳入或是否延伸至邻区。结论：本文旨在对文献资料进行回顾，并提出一种全面的方法来确定患者的靶体积。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tumori 医学-肿瘤学

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Tumori Journal covers all aspects of cancer science and clinical practice with a strong focus on prevention, translational medicine and clinically relevant reports. We invite the publication of randomized trials and reports on large, consecutive patient series that investigate the real impact of new techniques, drugs and devices inday-to-day clinical practice.