Tropical Journal of Pharmaceutical Research最新文献_第6页

Effect of entecavir on IL-6/STAT3/SOCS3 pathway in patients with chronic hepatitis B-induced liver fibrosis 恩替卡韦对慢性乙型肝炎肝纤维化患者IL-6/STAT3/SOCS3通路的影响

4区医学

Tropical Journal of Pharmaceutical Research Pub Date : 2023-10-08 DOI: 10.4314/tjpr.v22i9.22

Shuqiao Wang, Ziqi Sui, Kaili Peng, Hefei Cheng

{"title":"Effect of entecavir on IL-6/STAT3/SOCS3 pathway in patients with chronic hepatitis B-induced liver fibrosis","authors":"Shuqiao Wang, Ziqi Sui, Kaili Peng, Hefei Cheng","doi":"10.4314/tjpr.v22i9.22","DOIUrl":"https://doi.org/10.4314/tjpr.v22i9.22","url":null,"abstract":"Purpose: To evaluate the impact of entecavir (ENT) on patients with liver fibrosis resulting from chronic hepatitis B (CHB) and its association with the interleukin (IL)-6/signal transducer and activator of transcription 3 (STAT3)/suppressor of cytokine signaling 3 (SOCS3) pathway.Methods: Thirty-one patients with liver fibrosis received ENT at a dose of 0.5 mg/day for 48 weeks. Relevant protein levels in patient’s serum before and after treatment were assayed using enzyme-linked immunosorbent assay (ELISA). Furthermore, human hepatic stellate cells (HSCs) were cultured in vitro and divided into three groups: control, transforming growth factor beta 1 (TGF-β1) induction (TGF-β1 group), and ENT treatment (TGF-β1 + ENT group). Protein levels in the supernatant were assayed using ELISA, while the expression levels of related genes were determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Expression of α-SMA was visualized using immunofluorescence assay and the relevant protein levels were determined by Western blotting.Results: Treatment with ENT significantly decreased (p < 0.01) IL-6 and STAT3 expression, increased SOCS3 expression and significantly reduced (p < 0.01) the concentrations of hyaluronic acid (HA), type IV collagen (IVC), laminin (LN) and pro-collagen type III (PCIII) in patients with liver fibrosis. TGF-β1 significantly (p < 0.01) elevated IL-6, STAT3 and Col-I expressions and a tissue inhibitor of metalloproteinases-1 (TIMP-1) suppressed the expression of SOCS3 in human HSCs and induced fibrosis. Entecavir mitigated TGF-β1-induced fibrogenesis in HSCs (p < 0.01).Conclusion: Entecavir has a positive effect on liver fibrosis resulting from CHB by regulating IL- 6/STAT3/SOCS3 pathway. Future research will focus on conducting larger clinical trials to further validate these findings and explore the long-term effects of ENT on liver fibrosis progression and patient outcomes.","PeriodicalId":23347,"journal":{"name":"Tropical Journal of Pharmaceutical Research","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135251528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Network pharmacology study on mechanism involved in the use of YuShu Soup for the treatment of exertional heatstroke 玉树汤治疗运动性中暑的网络药理学机制研究

4区医学

Tropical Journal of Pharmaceutical Research Pub Date : 2023-10-08 DOI: 10.4314/tjpr.v22i9.6

Jing Dong, Zheng Yang, Chen Fan

引用次数: 0

Utilizing cloud-based technology to construct a precise network management model for statin therapy in Alzheimer's disease - A meta-analysis 利用基于云的技术构建他汀类药物治疗阿尔茨海默病的精确网络管理模型-荟萃分析

4区医学

Tropical Journal of Pharmaceutical Research Pub Date : 2023-10-08 DOI: 10.4314/tjpr.v22i9.30

Chaosheng Zeng, Huaijie Xing, Min Chen, Lin Chen, Pengxiang Li, Xiaowen Wu, Shaozhu Huang

{"title":"Utilizing cloud-based technology to construct a precise network management model for statin therapy in Alzheimer's disease - A meta-analysis","authors":"Chaosheng Zeng, Huaijie Xing, Min Chen, Lin Chen, Pengxiang Li, Xiaowen Wu, Shaozhu Huang","doi":"10.4314/tjpr.v22i9.30","DOIUrl":"https://doi.org/10.4314/tjpr.v22i9.30","url":null,"abstract":"Purpose: To investigate the use and applications of Internet cloud technology to construct a network management model for statin therapy in Alzheimer’s disease in Hainan Province.Method: Randomized controlled trials (RCTs) investigating the prevention and treatment of Alzheimer's disease (AD) with statins were employed in this study. Computerized searches were conducted using PubMed, EM-BASE, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), WANFANG Data, and Curriculum-Based Measurement (CBM) retrieval systems, with a retrieval timeframe of April 2012. After literature screening, data extraction, and quality evaluation, Meta-analysis was performed using Review Manager 5.1.0 software.Results: A total of 827 publications were obtained, and 3 RCTs were included after the full texts were studied. While there was no significant advantage of statin use at 3 and 6 months after intervention, the study group exhibited higher Mini-Mental State Examination (MMSE) scores than the control group one year later (p < 0.05). Also, statin use did not have a significant effect on Activities of Daily Living (ADL) scores one year after intervention (p < 0.05). The occurrence of adverse reactions in the two groups was not statistically significant (p > 0.05).Conclusion: The use of Internet cloud technology for building an Alzheimer’s disease network management system simplifies the process of Alzheimer’s disease diagnosis and treatment, and reduces the cost of Alzheimer’s disease services.","PeriodicalId":23347,"journal":{"name":"Tropical Journal of Pharmaceutical Research","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135251527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Jaceosidin inhibits NLRP3-mediated pyroptosis by activating SIRT1/NRF2 and ameliorating intestinal epithelial cell injury jacosidin通过激活SIRT1/NRF2和改善肠上皮细胞损伤来抑制nlrp3介导的焦亡

4区医学

Tropical Journal of Pharmaceutical Research Pub Date : 2023-10-08 DOI: 10.4314/tjpr.v22i9.2

Yifei Lv, Ting Qiu, Lu Niu

{"title":"Jaceosidin inhibits NLRP3-mediated pyroptosis by activating SIRT1/NRF2 and ameliorating intestinal epithelial cell injury","authors":"Yifei Lv, Ting Qiu, Lu Niu","doi":"10.4314/tjpr.v22i9.2","DOIUrl":"https://doi.org/10.4314/tjpr.v22i9.2","url":null,"abstract":"Purpose: To investigate the effect of Jaceosidin in ulcerative colitis (UC).Methods: An ulcerative colitis cell model was established by stimulating normal human colon mucosal epithelial cell lines (NCM460 cells) with lipopolysaccharide (LPS). The cells were treated with 5, 10, 20 or 40 μM Jaceosidin. Cell viability was performed using cell counting kit 8 (CCK8) assay. Oxidative stress was measured with superoxide dismutase (SOD), lipid peroxidation MDA, reduced glutathione (GSH), oxidized glutathione (GSSG), and human myeloperoxidase enzyme-linked immunoassay (ELISA) kits. The mRNA levels were determined by quantitative polymerase chain reaction (qPCR) assay, while protein levels of SIRT1, NRF2, NLRP3, caspase-1, TNF-α, IL-1β, and IL-6 were determined by western blotting.Results: Jaceosidin significantly inhibited oxidative stress and accumulation of inflammatory cytokines in LPS-induced NCM460 cells, as well as NLRP3-mediated cell pyroptosis (p < 0.05). Jaceosidin also inhibited activation of NLRP3 inflammasome by activating SIRT1/NRF2 pathway, thereby preventing NCM460 cell pyroptosis.Conclusion: Jaceosidin inhibits NLRP3-mediated pyroptosis, thus suggesting that jaceosidin is a potential lead for UC secondary to NLRP3 inflammasome.","PeriodicalId":23347,"journal":{"name":"Tropical Journal of Pharmaceutical Research","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135251533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness and safety of an ultrasound-guided injection of platelet-rich plasma versus sodium hyaluronate in patients with knee osteoarthritis 超声引导下富血小板血浆注射与透明质酸钠在膝关节骨关节炎患者中的有效性和安全性

4区医学

Tropical Journal of Pharmaceutical Research Pub Date : 2023-10-08 DOI: 10.4314/tjpr.v22i9.17

Wenxing Ding, Qinghua Zhao, Dexiang Zhang, Xiao Zhong

{"title":"Effectiveness and safety of an ultrasound-guided injection of platelet-rich plasma versus sodium hyaluronate in patients with knee osteoarthritis","authors":"Wenxing Ding, Qinghua Zhao, Dexiang Zhang, Xiao Zhong","doi":"10.4314/tjpr.v22i9.17","DOIUrl":"https://doi.org/10.4314/tjpr.v22i9.17","url":null,"abstract":"Purpose: To examine the effectiveness and safety of ultrasound-guided platelet-rich plasma (PRP) injection versus sodium hyaluronate injection in patients with knee osteoarthritis (KOA).Methods: The clinical data of 92 patients treated at the West China Hospital Sichuan University-Ziyang Hospital between May 2020 and December 2021 were retrospectively analyzed. Patients were allocated to PRP group (ultrasound-guided PRP injection) and a hyaluronic acid (HA) group (sodium hyaluronate injection) with each group containing 46 patients. Before and after treatment, the two groups were compared in terms of visual analog scale (VAS) score, Lysholm score, levels of serum inflammatory factors, insulin-like growth factor (IGF)-1, fibroblast growth factor (FGF)-2 and WOMAC score.Results: After treatment, PRP group exhibited significantly lower pain scores and higher function scores than HA group. Furthermore, PRP group exhibited lower levels of inflammation markers, higher levels of growth factors as well as better treatment efficiency and incidence of adverse reactions when compared with HA group (p < 0.05).Conclusion: Ultrasound-guided PRP therapy ameliorates pains and joint functions in KOA patients. The therapeutic effect may be associated with the regulation of cartilage performance and alleviation of inflammatory state. Therefore, PRP injection therapy combined with ultrasound guidance might also have clinical potential for other applications.","PeriodicalId":23347,"journal":{"name":"Tropical Journal of Pharmaceutical Research","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135250942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Linarin attenuates oxaliplatin-induced neuropathic pain by inhibiting NF-κB/NLRP3 signaling pathway Linarin通过抑制NF-κB/NLRP3信号通路减轻奥沙利铂诱导的神经性疼痛

4区医学

Tropical Journal of Pharmaceutical Research Pub Date : 2023-10-08 DOI: 10.4314/tjpr.v22i9.5

Siyu Zeng, Chenming Ling, Hao Chen, Yu Wang

{"title":"Linarin attenuates oxaliplatin-induced neuropathic pain by inhibiting NF-κB/NLRP3 signaling pathway","authors":"Siyu Zeng, Chenming Ling, Hao Chen, Yu Wang","doi":"10.4314/tjpr.v22i9.5","DOIUrl":"https://doi.org/10.4314/tjpr.v22i9.5","url":null,"abstract":"Purpose: To assess the therapeutic effects of linarin on chemotherapy-induced peripheral neuropathy (CINP) in rats.Methods: A CINP rat model was established using oxaliplatin. The rats were divided into control, CINP, and two linarin treatment groups (20 mg/kg/day and 40 mg/kg/day). Observations were made at various time points, assessing weight gain, mechanical withdrawal thresholds, cold allodynia response, and thermal pain sensitivity. Additionally, the expression levels of various inflammatory factors (IL-1β, IL-6, IL-10, and IL-17), proteins related to glial and neuronal activation (IBA-1, GFAP, c-fos), and proteins linked to NF-κB/NLRP3 signaling (ASC, caspase-1, p65, and p-p65) were evaluated in rat spinal cord tissue.Results: Linarin treatment resulted in improved weight gain, mechanical threshold, decreased withdrawal response, and enhanced paw withdrawal latency (p < 0.001) compared to the CINP group. These improvements or mitigations were more pronounced in the 40 mg/kg/day linarin group. Linarin inhibited the expression of inflammatory factors IL-1β, IL-6, and IL-17 (p < 0.001) but enhanced IL-10 expression (p < 0.001). The activation of microglia, astrocytes, and neurons, as indicated by IBA-1, GFAP, and c-fos (p < 0.001) proteins, was significantly reduced with linarin, especially at the higher dose. Linarin also suppressed the expression of ASC, caspase-1, p65, and p-p65 (p < 0.001) proteins, associated with the NF-κB/NLRP3 signaling pathway.Conclusion: Our study indicates that linarin may serve as a potential therapeutic agent for managing CINP. The beneficial effects of linarin are likely mediated through its immunomodulatory effects and the inhibition of the NF-κB/NLRP3 signaling pathway. Further research is needed to confirm these findings in clinical settings.","PeriodicalId":23347,"journal":{"name":"Tropical Journal of Pharmaceutical Research","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135251525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and efficacy of arterial injection of tirofiban in treating ischemic stroke beyond the window period 动脉注射替罗非班治疗窗期外缺血性脑卒中的安全性和有效性

4区医学

Tropical Journal of Pharmaceutical Research Pub Date : 2023-10-08 DOI: 10.4314/tjpr.v22i9.28

Qiongwen Rong, Fenglei Chen, Yuanyuan Ma, Yi Cai

{"title":"Safety and efficacy of arterial injection of tirofiban in treating ischemic stroke beyond the window period","authors":"Qiongwen Rong, Fenglei Chen, Yuanyuan Ma, Yi Cai","doi":"10.4314/tjpr.v22i9.28","DOIUrl":"https://doi.org/10.4314/tjpr.v22i9.28","url":null,"abstract":"Purpose: To investigate the efficacy of intraarterial administration of tirofiban for stroke treatment beyond the conventional window period and evaluate its impact on prognosis.Methods: A retrospective study was conducted on ninety (90) acute ischemic stroke patients admitted to The First Affiliated Hospital of Hainan Medical University, Haikou, China from July 2021 to October 2022. The patients were divided into Tirofiban group (50) and non-Tirofiban group (40) based on whether the patients received arterial clopidogrel. National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS) and Barthel index (BI) scores were used to evaluate adverse drug reactions and its impact on prognosis for patients with symptoms onset within 6 - 24 h.Results: No significant differences were observed between the groups in terms of age, gender, medical history, personal history, blood indicators and neurologic function scores (p > 0.05). The median NIHSS score on admission and after 24 h of treatment was 4 in both groups and 3 in both groups after 72 h of treatment. However, after 7 days of treatment, the median NIHSS score was lower in Tirofiban group (2.0) than in non-Tirofiban group (2.5; p > 0.05). Tirofiban group demonstrated higher rates of effective treatment and good prognosis compared to non-Tirofiban group. Importantly, there was no significant difference in the occurrence of adverse reactions between the two groups (p > 0.05).Conclusion: Tirofiban, given via the arteries, improves neurological functions following hyper-acute stroke even beyond the window period and without adverse reactions. It is a safe and effective antiplatelet drug for late-life treatment. For future studies, it will be necessary to broaden the treatment scope and gather more robust and reliable data in order to enhance data quality.","PeriodicalId":23347,"journal":{"name":"Tropical Journal of Pharmaceutical Research","volume":"162 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135251666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin D: An effective therapy against methotrexateinduced cardiotoxicity 维生素D:抗甲氨蝶呤引起的心脏毒性的有效疗法

4区医学

Tropical Journal of Pharmaceutical Research Pub Date : 2023-10-08 DOI: 10.4314/tjpr.v22i9.10

Tuba Ozcan Metin, Alper Yalcin

{"title":"Vitamin D: An effective therapy against methotrexateinduced cardiotoxicity","authors":"Tuba Ozcan Metin, Alper Yalcin","doi":"10.4314/tjpr.v22i9.10","DOIUrl":"https://doi.org/10.4314/tjpr.v22i9.10","url":null,"abstract":"Purpose: To determine the potential cardioprotective effect of vitamin D (VD) against methotrexate (MTX) induced cardiotoxicity.Methods: A total of thirty-five (35) rats were randomly assigned to five equal groups. Control groupreceived no treatment; MTX group received intraperitoneal (IP) injection of MTX in a single dose of 20 mg/kg on day 8; VD group received 200 IU/kg VD daily dissolved in sunflower oil orally; sunflower oil (SO) group received 1 mL/kg/day SO orally; MTX + VD group received a single dose of MTX (20 mg/kg, IP) on day 8 and VD (200 IU/kg, orally) for 21 days. Myocardial tissue samples were harvested and used for clinical chemistry, histopathological, and ultrastructural evaluation.Results: Histopathological damage in MTX group was more severe than in control group under both light and electron microscopy. Expression of transient receptor potential melastatin 2 (TRPM2) and caspase-3 markers was significantly higher in MTX group (p < 0.05). Glutathione peroxidase (GSH-Px) enzyme activity in cardiac tissue was lower in MTX group, whereas malondialdehyde (MDA) levels increased significantly (p < 0.05). In MTX + VD group, VD treatment alleviated histopathological damage and significantly lowered TRPM2 and caspase-3 expressions (p < 0.05). Vitamin D also reduced tissue MDA levels, and increased GSH-Px activity albeit non-significantly (p > 0.05),Conclusion: These findings suggest that VD exerts an ameliorative effect on MTX-induced cardiotoxicity in rats. Therefore, TRPM2 channel affords a novel therapeutic approach for treatment of diseases related to chemotherapy-induced oxidative stress.","PeriodicalId":23347,"journal":{"name":"Tropical Journal of Pharmaceutical Research","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135250943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the mechanism of <i>Astragalus membranaceus</i> in the treatment of lumbar disc herniation using network pharmacology 黄芪的作用机理研究<应用网络药理学治疗腰椎间盘突出症

4区医学

Tropical Journal of Pharmaceutical Research Pub Date : 2023-10-08 DOI: 10.4314/tjpr.v22i9.7

WenJie Ke, Chengwei Yu, Wei Liu, Haifeng Liu

{"title":"Investigation of the mechanism of <i>Astragalus membranaceus</i> in the treatment of lumbar disc herniation using network pharmacology","authors":"WenJie Ke, Chengwei Yu, Wei Liu, Haifeng Liu","doi":"10.4314/tjpr.v22i9.7","DOIUrl":"https://doi.org/10.4314/tjpr.v22i9.7","url":null,"abstract":"Purpose: To determine the underlying mechanisms of action of Astragalus membranaceus in lumbar disc herniation (LDH) treatment.Methods: This study utilized network pharmacology analysis and STRING database to identify compound targets and visualize PPI network. Furthermore, an LDH model was induced in human nucleus pulposus cells using lipopolysaccharide (LPS), and then the vital target genes were evaluated in this model treated with active components of Astragalus membranaceus.Results: Network pharmacology analysis indicates that several key proteins, including vascular endothelial growth factor A (VEGF A), AKT1, JUN, prostaglandin-endoperoxide synthase 2 (PTGS2), interleukin-6 (IL-6), matrix metallopeptidase 9 (MMP9), interleukin-1β (IL-1β), C-X-C motif chemokine ligand 8 (CXCL8), epidermal growth factor (EGF) and matrix metallopeptidase 2 (MMP2) may play essential roles in LDH treated with Astragalus membranaceus. The active components in Astragalus membranaceus suppressed the production of IL-1β and IL-6, and increased the expressions of VEGF A, MMP9 and MMP2 in LPS-induced LDH model.Conclusion: The active components of Astragalus membranaceus effectively inhibits inflammation in LPS-induced LDH model, indicating that Astragalus membranaceus is a potential therapeutic candidate for LDH treatment.","PeriodicalId":23347,"journal":{"name":"Tropical Journal of Pharmaceutical Research","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135250936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analgesic and safety analysis of dexmedetomidine combined with ropivacaine in ultrasound-guided brachial plexus nerve block 右美托咪定联合罗哌卡因用于超声引导下臂丛神经阻滞的镇痛及安全性分析

4区医学

Tropical Journal of Pharmaceutical Research Pub Date : 2023-10-08 DOI: 10.4314/tjpr.v22i9.21

Jiayu Lu, Taihao Cui, Zhaoxiang Yu, Wei Zheng, Wei He

{"title":"Analgesic and safety analysis of dexmedetomidine combined with ropivacaine in ultrasound-guided brachial plexus nerve block","authors":"Jiayu Lu, Taihao Cui, Zhaoxiang Yu, Wei Zheng, Wei He","doi":"10.4314/tjpr.v22i9.21","DOIUrl":"https://doi.org/10.4314/tjpr.v22i9.21","url":null,"abstract":"Purpose: To investigate analgesic effect and safety of dexmedetomidine combined with ropivacaine in ultrasound-guided brachial plexus block in intercostal space.Methods: A total of 90 patients were scheduled to undergo upper limb surgery and divided into control and study groups, respectively. Patients in control group were given ropivacaine nerve block, while those in study group were given ropivacaine combined with dexmedetomidine mixture nerve block. The efficiency of sensory and motor block, secondary evaluation of block effect, visual analogue scale (VAS) scores at different postoperative moments, remedial analgesia and adverse reactions were compared between the two groups after 30 min of drug injection.Results: The success rate of sensory block was not significantly different between control group (91.11 %) and study group (93.33 %; χ2 = 0.155, p > 0.05) but success rate of the motor block was significantly higher in study group (93.33 %) than in control group (71.11 %; χ2 = 7.601, p < 0.05). Compared with control group, onset of sensory block and motor block were significantly shorter in study group, while the duration of sensory block and motor block was significantly longer (p < 0.05). The VAS scores at 12, 24, and 48 h postoperatively were significantly lower in study group than control group (p < 0.05). The number of self-administered analgesia, number of patients, dose used, and overall incidence of adverse reactions in study group were significantly lower than in control group (p < 0.05).Conclusion: Dexmedetomidine and ropivacaine, when administered together, have a significant anesthetic effect during nerve block, which is safe and enhances their analgesic effect. However, the mechanism of improving analgesic effect of the combined plan, using a larger number of samples should be further investigated.","PeriodicalId":23347,"journal":{"name":"Tropical Journal of Pharmaceutical Research","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135250940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0