Tropical Journal of Pharmaceutical Research最新文献

{"title":"Effect of trimetazidine on ventricular remodeling, serum Cys C and ET-1 levels in patients with chronic heart failure","authors":"Xiaoyan Wu, Wenzhong Chen, Huiming Han","doi":"10.4314/tjpr.v22i8.24","DOIUrl":"https://doi.org/10.4314/tjpr.v22i8.24","url":null,"abstract":"Purpose: To evaluate the effect of trimetazidine on ventricular remodeling and serum levels of cystatin C and endothelin-1 in patients with chronic heart failure (CHF).Methods: A total of 96 patients with CHF were randomly divided into two groups, given either conventional treatment (control group) or conventional treatment plus trimetazidine (study group) for 6 months. Clinical efficacy was compared between the two groups. Left ventricular ejection fraction (LVEF), left ventricular end-systolic diameter (LVESD) and left ventricular end-diastolic diameter (LVEDD) were measured using cardiac echocardiography before and after treatment. Patients wererecorded at 6 MVT before and after treatment. An automatic biochemical analyzer was used to assay serum Cys C levels before and after treatment. Serum levels of ET-1, galactose agglutinin-3 (GAL-3), brain natriuretic peptide (BNP) and heart natriuretic peptide (ANP) were determined by enzyme-linked immunosorbent assay (ELISA) before and after treatment. Incidence of adverse events in CHF patients was compared between groups.Results: Study group had a significantly higher level of treatment effectiveness (91.67 %) and better improvement in left ventricular ejection fraction, left ventricular end-systolic diameter and left ventricular end-diastolic diameter than control group (p < 0.05). Serum levels of serum cystatin C, endothelin-1 and other biomarkers were also significantly lower (p < 0.05) in study group. Re-hospitalization rate was also lower in study group.Conclusion: Trimetazidine exerts a therapeutic effect on CHF patients, effectively improves cardiac function and reduces the rate of re-hospitalization.","PeriodicalId":23347,"journal":{"name":"Tropical Journal of Pharmaceutical Research","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135353551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sufentanil reduces myocardial apoptosis in rats with myocardial ischemia-reperfusion injury","authors":"Jianming Yao, Xiaoyue Zhang, Xuemei Hou","doi":"10.4314/tjpr.v22i8.13","DOIUrl":"https://doi.org/10.4314/tjpr.v22i8.13","url":null,"abstract":"Purpose: To determine the effect of sufentanil on myocardial apoptosis in rats with myocardial ischemia-reperfusion injury (MIRI).Methods: Fifty Sprague Dawley rats were randomly assigned to five groups: sham, model, low-dose, moderate-dose, and high-dose. The groups, except sham, underwent ligation of the left anterior descending coronary artery to establish the MIRI model. The low, moderate, and high-dose groups received intraperitoneal injections of sufentanil at different concentrations. Cardiac function, serum LDH, creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), superoxide dismutase (SOD) and malondialdehyde (MDA) content were evaluated. The mRNA expression levels of apoptosis genes and protein levels of p38 and p-p38 were assessed in myocardial tissues using various methods while apoptosis was assessed by TUNEL assay.Results: Compared to sham group, the model group exhibited significant decrease in fractional shortening (FS) and ejection fraction (EF), increase in CK activity, LDH, and MDA contents, lower SOD activity. Model group also showed increase in mRNA levels of B-cell lymphoma-2 (Bcl-2) and caspase- 3, higher apoptosis, significant increase in protein levels of p38 and p-p38, and higher level of myocardial apoptosis (p < 0.05). High-dose group demonstrated significant increase in FS and EF, decrease in LDH content and CK activity, lower MDA content, higher SOD activity, decrease in mRNA levels of Bcl-2 and caspase-3, lower apoptosis, decrease in protein levels of p38 and p-p38, and lower level of myocardial apoptosis (p < 0.05), when compared with model group.Conclusion: High-dose sufentanil reduces myocardial apoptosis and improves cardiac function, and thus can potentially be developed as a cardioprotective agent.","PeriodicalId":23347,"journal":{"name":"Tropical Journal of Pharmaceutical Research","volume":"149 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135484640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of the effectiveness of &lt;i&gt;Euodia rutaecarpa&lt;/i&gt; Benth acupressure and Wendan decoction in the treatment of vertigo","authors":"Tianying Wu, Qiang Zheng, Shuxian Niu","doi":"10.4314/tjpr.v22i8.29","DOIUrl":"https://doi.org/10.4314/tjpr.v22i8.29","url":null,"abstract":"Purpose: To systematically assess the efficacy and safety of combining Euodia rutaecarpa Benth acupressure with Wendan decoction for the treatment of vertigo, thereby establishing a theoretical framework for informed clinical practice.Methods: Computer-based search was conducted in PubMed, Embase, Scopus, Web of Science, and Cochrane databases to identify randomized controlled literature pertaining to efficacy and safety of Euodia rutaecarpa Benth acupressure in combination with Wendan decoction for management of vertigo. The experimental group received an intervention of Euodia rutaecarpa Benth acupressure combined with Wendan decoction. Articles that met set inclusion and exclusion criteria were screened and evaluated for quality based on Cochrane Quality Rating Scale. Baseline data, intervention data and outcome indicators of included studies were also extracted. Meta-analysis was performed using RevMan 5.4 software.Results: The difference in symptom scores between groups was statistically significant (RR = -0.04, 95 % CI (-0.3, 0.23), p = 0.78). Meta-analysis of the outcome indicators showed heterogeneity at p < 0.0001, I2 = 91 %. I2 = 91 > 50 %. There was a statistically significant difference (p < 0.05) between groups in terms of total treatment efficiency (RR = 0.31, 95 % CI (-0.25, 0.88), p = 0.28). Heterogeneity of vertigo degree score showed p < 0.0001, I2 = 98 %. I2 = 98 % > 50 %, SMD = 2.34, 95 % CI (0.69, 3.99), p = 0.53.Conclusion: The combination of clinical Euodia rutaecarpa Upright acupressure and Wendan decoction demonstrates significant clinical effectiveness in treating vertigo as evidenced by improvement of all indicators. Moreover, this treatment approach exhibits a high level of safety.","PeriodicalId":23347,"journal":{"name":"Tropical Journal of Pharmaceutical Research","volume":"140 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135484646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of ginkgo leaf tablets combined with compound carbidopa on patients with Parkinson’s disease","authors":"Yan Huang, Bo Du, Shiguang Zhu, Yingfeng Mu, Deqin Geng","doi":"10.4314/tjpr.v22i8.19","DOIUrl":"https://doi.org/10.4314/tjpr.v22i8.19","url":null,"abstract":"Purpose: To determine the effect of a combination of ginkgo leaf tablets with compound carbidopa tablets on cognitive function, serum homocysteine (Hcy), malondialdehyde (MDA) and neuron-specific enolase (NSE) levels in patients with Parkinson's disease (PD).Methods: A total of eighty (80) PD patients admitted to The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China between December 2020 and December 2022 were randomly divided into two groups: Western medicine group (n = 40, using compound carbidopa tablets alone) and combination group (n = 40, using ginkgo leaf tablets combined with compound carbidopa tablets), and orally treated for 3 months. Mini-mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA) were used to assess cognitive function before and after treatment. High-performance liquid chromatography was used to determine serum Hcy levels, while enzyme-linked immunosorbent assay (ELISA) was used to evaluate serum MDA and NSE levels. Adverse reactions were also recorded during treatment.Results: Total response rate following treatment in combination group was significantly higher than in Western medicine group (95.00 vs 80.00 %, p < 0.05). After treatment, MMSE and MoCA scores in combination group were significantly higher (p < 0.05) than those in Western medicine group, while serum Hcy, MDA and NSE levels in combination group were significantly lower than those in Western medicine group (p < 0.05). During treatment, there was no significant difference in incidence of adverse reactions between the two groups (p > 0.05).Conclusion: Ginkgo leaf tablets in combination with carbidopa significantly improve cognitive functions associated with PD with high safety, when compared to carbidopa tablets alone. However, further clinical trials are commended to validate these findings.","PeriodicalId":23347,"journal":{"name":"Tropical Journal of Pharmaceutical Research","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135484830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of early application of heparin on coronary blood flow during primary percutaneous coronary intervention","authors":"Shutian Shi, Lei Zhen, Mei Wang, Chunmei Wang, Hui Ai, Bin Que, Shaoping Nie","doi":"10.4314/tjpr.v22i8.21","DOIUrl":"https://doi.org/10.4314/tjpr.v22i8.21","url":null,"abstract":"Purpose: To investigate the efficacy and safety of unfractionated heparin (UFH) anticoagulant administered upstream in the ambulance or emergency room during primary percutaneous coronary intervention (pPCI) for patients with acute ST-segment elevation myocardial infarction (STEMI).Methods: The study included STEMI patients who received either early UFH subcutaneously (SC) (n = 163) or intraoperative UFH (SC) during pPCI (n = 476) between January 2017 to August 2018. Baseline characteristics, infarct-related artery (IRA) status, and procedural characteristics were analyzed. The primary endpoint was thrombolysis in myocardial infarction (TIMI) flow grade 2 - 3 before intervention. The secondary endpoints were time from first medical contact to guidewire passage, postoperative TIMI 3 flow grade, acute stent thrombosis, and in-hospital bleeding events.Results: Baseline characteristics were similar between the groups, with no significant difference in IRA location. Both groups underwent coronary angiography, with most patients receiving pPCI. The primary endpoint occurred in 18.1 % of patients in intraoperative UFH group and 27.6 % in the early UFH group, with a significant difference between the groups (p < 0.05). There was no significant difference in postoperative TIMI 3 flow grade or acute stent thrombosis, but bleeding events (BARC 2-5) were similar between groups (1.1 % in intraoperative group and 1.8 % in early UFH group, p > 0.05)Conclusion: Early upstream administration of UFH anticoagulation in STEMI patients improves coronary artery potency before pPCI, and early use of fixed-dose UFH is safe and does not increase major bleeding complications.","PeriodicalId":23347,"journal":{"name":"Tropical Journal of Pharmaceutical Research","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135485142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of enteral nutrition and factors influencing feeding intolerance in severely ill patients in the intensive care unit","authors":"Fen Tang, Pai Liu, Chunyan Wang","doi":"10.4314/tjpr.v22i8.22","DOIUrl":"https://doi.org/10.4314/tjpr.v22i8.22","url":null,"abstract":"Purpose: To investigate the use of enteral nutrition (EN) and factors influencing feeding intolerance (FI) in severely ill patients in intensive care unit (ICU).Methods: Retrospective data collection was performed on records of 247 severely ill patients admitted to ICU of the West China Hospital, Chengdu, China between January 2020 and December 2022. Data were divided into two groups: FI group (n = 107) and non-FI group (n = 140). Influencing factors of FI were analyzed by univariate and multivariate analysis, and the use of EN was analyzed.Results: Defined daily doses (DDDs) of enteral nutrition emulsion TPF-T (Ruineng), enteral nutrition suspension (Baipuli) and enteral nutrition emulsion TPF (Ruixian) were most prevalent. The DDDs of enteral nutrition suspension (Nengquanli 1.5) increased, while that of Nengquanli 1.0 decreased. Univariate analysis showed significant differences between FI and non-FI groups in start time of EN, addition of dietary fiber, Acute Physiology and Chronic Health Evaluation (APACHE) II score, use of sedatives, types of antibiotics used, use of vasoactive drugs and oral potassium preparation, mechanical ventilation and hypoalbuminemia (p < 0.05). Multivariate analysis showed that addition of dietary fiber, APACHE II score ≥ 20 points, sedatives use, types of antibiotics used ≥ 2, oral potassium preparation and hypoalbuminemia were independent risk factors of FI.Conclusion: Use of EN in ICU is consistent. Factors that influence FI in critically ill patients include dietary fiber, APACHE II score, use of sedatives, use of antibiotics, use oral potassium preparations and hypoalbuminemia. Knowledge of these risk factors and timely measures are of great significance in avoiding FI in ICU.","PeriodicalId":23347,"journal":{"name":"Tropical Journal of Pharmaceutical Research","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135485283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abietic acid ameliorates pancreatic injury in acute pancreatitis by modulating MAPK pathway","authors":"Hailin Ye, Jun Wang, Jiaodan Mao, Debiao Pan","doi":"10.4314/tjpr.v22i8.7","DOIUrl":"https://doi.org/10.4314/tjpr.v22i8.7","url":null,"abstract":"Purpose: To examine the effect of abietic acid (AA) in the treatment of acute pancreatitis (AP) in mice.Methods: C57BL/6J mice were randomly assigned to 4 groups: sham, AP, AP + 20 mg/kg AA, and AP + 40 mg/kg AA groups. To induce AP mouse model, the mice received intraperitoneal (IP) injections of cerulein. The extent of pancreatic tissue damage was evaluated by histological examination. Serum ALT, lipase, and amylase levels were determined by commercial kits while TUNEL assay was used to assess the apoptosis of pancreatic cells. The contents of Bax, Caspase-3, Bcl-2, p-ERK/ERK, p-JNK/JNK, and p-P38/P38 in pancreatic tissues were evaluated by western blot while the contents of IL-6, TNF-α, IL-1β, nitrite, MDA, and GSH in the tissues were evaluated by enzyme-linked immunosorbent assay (ELISA) kits.Results: AA relieved pancreatic damage and reduced ALT, lipase, and amylase levels in ceruleintreated AP mouse (p < 0.001). AA repressed apoptosis of pancreatic cells in cerulein-induced AP mouse, and inhibited oxidative stress and inflammatory response in the mice by reducing IL-6, TNF-α, IL-1β, nitrite, and MDA contents; it also enhanced the levels of GSH in the tissues (p < 0.001). In addition, AA inhibited MAPK pathway activity in the mice (p < 0.001).Conclusion: AA ameliorates pancreatic damage, pancreatic cell apoptosis, oxidative stress, and inflammation in cerulein-induced AP mouse by inhibiting MAPK pathway. This study offers a new potential drug for the management of AP and expands the relevant molecular regulatory mechanisms.","PeriodicalId":23347,"journal":{"name":"Tropical Journal of Pharmaceutical Research","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135485725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of co-administration of pranoprofen/emedastine difumarate eye drops on efficacy, inflammatory factors, tear film stability and immune function in children with allergic conjunctivitis","authors":"Shasha Zhang, Leiyan Su, Zefeng Kang, Shoukang Zhang, Jing Wang","doi":"10.4314/tjpr.v22i7.20","DOIUrl":"https://doi.org/10.4314/tjpr.v22i7.20","url":null,"abstract":"Purpose: To investigate the clinical efficacy of pranoprofen eye drops when combined with emedastinedifumarate eye drops for the treatment of children with allergic conjunctivitis.Methods: A total of 96 children with allergic conjunctivitis admitted to Eye Hospital, China Academy of Chinese Medical Sciences from January 2020 to 2022 were enrolled in this study. They were divided into study group (treated with both pranoprofen eye drops and emedastine difumarate eye drops), and control group (treated with emedastine difumarate eye drops alone), with 48 children in each group. The control group was given emedastine fumarate eye drops 1 drop twice a day. The study group was given pranoprofen eye drops 2 drops 4 times a day in addition to the treatment administered to control group. Patients in both groups were observed and compared after one week of treatment. Efficacy, incidence of adverse reactions, symptom scores, inflammatory factors, tear film stability indicators and immune function indicators were assessed and recorded.Results: Prior to treatment, there was no significant difference in symptom score, inflammatory factors, tear film stability indicators and immune function indicators between study and control groups. Although the above indicators improved in both groups after treatment, the study group showed significantly greater improvement than control group (p < 0.05). Overall clinical response rate in the study group (95.83 %) was higher than in the control group (77.08 %), while the incidence of adverse reaction in the study group (6.25 %) was lower than that of control group (27.08 %, p < 0.05).Conclusion: Pranoprofen eye drops, when combined with emedastine difumarate eye drops for treatment of children with allergic conjunctivitis, is more effective than the use of emedastine difumarate eye drops alone. However, further clinical trials are required to validate the findings of this study prior to adoption of the combination treatment in clinical practice.","PeriodicalId":23347,"journal":{"name":"Tropical Journal of Pharmaceutical Research","volume":"76 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86782152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between traditional Chinese medicine constitution and pregnancy outcome in elderly primiparae","authors":"Junxin Qiu, Juan Zhao, Ping Feng, Huiqin Zhou, Haiyang Li","doi":"10.4314/tjpr.v22i7.12","DOIUrl":"https://doi.org/10.4314/tjpr.v22i7.12","url":null,"abstract":"Purpose: To investigate the correlation between traditional Chinese medicine (TCM) constitution and pregnancy outcomes in elderly primiparae.Methods: A cross-sectional case-control study was conducted on 113 elderly primiparae who were delivered in Jinshan Hospital of Fudan University, Shanghai, China from January 2019 to December 2019. The elderly primiparae was the study group. Using a random ratio of 1:3, 393 primiparous women of suitable age who were delivered in the hospital at the same period were selected as the control group. A traditional Chinese medicine (TCM) questionnaire was used to collect clinical data, and differences between the two groups were compared.Results: The incidence of gestational diabetes mellitus was significantly higher in the study group (elderl y primiparae) with phlegm dampness constitution and qi stagnation constitution than in control group (appropriate-age primiparae) (p < 0.05). The incidence of hypertension was significantly higher in the study group with yin deficiency constitution and special constitution than in control group (p < 0.05). The frequency of selective cesarean section in study group with a biased qi-deficiency constitution, yang-deficiency constitution, and yin-deficiency constitution were significantly higher than control group (p < 0.05).Conclusion: There is a correlation between pregnancy outcomes in old age and TCM constitution. Individualized diet and exercise programs may be formulated in early pregnancy (based on the type of physique) to improve pregnancy outcomes in elderly primiparae.","PeriodicalId":23347,"journal":{"name":"Tropical Journal of Pharmaceutical Research","volume":"42 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84982990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of zinc on weight gain, hematological parameters and tissue structure of the liver, kidney and spleen in albino mice","authors":"Tri Truong Van, Nhi Ho Linh Kieu, Huyen Nguyen Thi Thuong","doi":"10.4314/tjpr.v22i7.7","DOIUrl":"https://doi.org/10.4314/tjpr.v22i7.7","url":null,"abstract":"Purpose: To investigate the effect of varying zinc concentrations on weight gain, hematological parameters, and tissue structure of the liver, kidney, and spleen in albino mice.Methods: The mice were administered daily zinc at 50, 70, and 90 mg/kg body weight. Weight gain was measured every two weeks. Hematological parameters were evaluated after 4 and 8 weeks, while biomolecular parameters were assessed after 8 weeks. Liver, kidney, and spleen were also assessed after 8 weeks using H & E staining procedures.Results: Albino mice exhibited reduced weight gain, and altered hematological parameters after 8 weeks of exposure to varying zinc concentrations, with the highest dose of 90 mg/kg body weight having the most significant impact. Hematological parameters including blood cells, hemoglobin, hematocrit, blood clotting time, aspartate aminotransferase, and alanine transaminase decreased, while bilirubin, urea, and mean corpuscular hemoglobin concentration increased. Liver and kidney tissues exhibited widespread destruction such as necrosis and hemorrhage, while red pulp invaded white pulp activity in the spleen.Conclusion: High levels of zinc from zinc chloride (90 mg/kg) affect body weight, and hematological parameters, as well as liver and kidney histology in albino mice. The most significant negative effects include the potential toxicity and adverse health consequences of excessive zinc intake. Consequently, this study provides the groundwork for investigating natural compounds that inhibit zinc toxicity.","PeriodicalId":23347,"journal":{"name":"Tropical Journal of Pharmaceutical Research","volume":"25 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82014930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}