Tropical Medicine and Infectious Disease最新文献_第9页

Presence of Intestinal Parasites in Patients with Chronic Non-Communicable Diseases in Masaya (Nicaragua). 马萨亚（尼加拉瓜）慢性非传染性疾病患者体内的肠道寄生虫。

IF 2.8 4区医学

Tropical Medicine and Infectious Disease Pub Date : 2024-07-30 DOI: 10.3390/tropicalmed9080171

Carla Muñoz-Antoli, Aleyda Pavón, Jacklyn Comas, Rafael Toledo, José Guillermo Esteban

{"title":"Presence of Intestinal Parasites in Patients with Chronic Non-Communicable Diseases in Masaya (Nicaragua).","authors":"Carla Muñoz-Antoli, Aleyda Pavón, Jacklyn Comas, Rafael Toledo, José Guillermo Esteban","doi":"10.3390/tropicalmed9080171","DOIUrl":"10.3390/tropicalmed9080171","url":null,"abstract":"Aims: A cross-sectional study was conducted in Masaya (Nicaragua) to estimate the prevalence of intestinal parasite (IP) infections in patients with non-communicable diseases (NCDs) and to determine the associations between the types of NCDs and patients' epidemiological characteristics of infection.Methods: A total of 157 preserved faecal samples were examined (direct wet mount, formalin/ethyl acetate concentration and modified Ziehl-Neelsen technique). Microscopically positive faecal sample identification was completed by conducting a molecular study.Results: The total prevalence of IP was 52% in NCD patients. Diabetic patients presented an IP prevalence of 42%. Blastocystis presented the highest prevalence (42%). A molecular analysis of Giardia intestinalis (prevalence of 1.3%) revealed 100% of sub-assemblage BIII and the Entamoeba complex (5%) was identified as E. dispar. Blastocystis ST1 appeared in 44% of those suffering from diabetes and ST3 in 66% of those suffering from hypertension, while ST2 only appeared in those suffering with several NCDs simultaneously. In diabetic patients, the risk of infection is associated with having pets (p = 0.021) and land-floor houses. The risk of infection appears to be statistically related (p = 0.019) in those with several NCDs having received a previous helminthic deworming treatment.Conclusions: Coordinated public health activities for IP and NCD screening and diagnosis are crucial to their successful control programmes.","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11359410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142081751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Awareness, Intention to Use Pre-Exposure Prophylaxis, and Factors Associated with Awareness among Men Who Have Sex with Men in the Republic of Korea 大韩民国男男性行为者对暴露前预防措施的认识、使用意向以及与认识相关的因素

IF 2.8 4区医学

Tropical Medicine and Infectious Disease Pub Date : 2024-07-25 DOI: 10.3390/tropicalmed9080170

Sarang Jang, Aeree Sohn

{"title":"Awareness, Intention to Use Pre-Exposure Prophylaxis, and Factors Associated with Awareness among Men Who Have Sex with Men in the Republic of Korea","authors":"Sarang Jang, Aeree Sohn","doi":"10.3390/tropicalmed9080170","DOIUrl":"https://doi.org/10.3390/tropicalmed9080170","url":null,"abstract":"This study assessed pre-exposure prophylaxis (PrEP) awareness, knowledge, and attitudes in a sample of 1389 men who have sex with men (MSM). Using a self-report survey, we measured PrEP knowledge mean scores, attitudes toward PrEP, and awareness rates to identify the key influences on PrEP uptake. PrEP awareness among participants was 66.3%, with 33.7% having never heard of PrEP. Approximately 4.5% had previous experience with PrEP but were not current users, while only 2.7% reported that they were currently taking it. Logistic regression analysis revealed that the significant predictors of PrEP awareness were educational attainment, marital status, prior HIV testing knowledge, and attitudes toward PrEP. Several demographic factors were not significant predictors of intention to use PrEP; however, using the internet to meet partners, number of partners, HIV testing, positive attitudes, and reduced perceived barriers played a critical role in shaping PrEP use intentions. These findings highlight the critical role of targeted educational strategies and tailored public health messaging in enhancing the awareness and intention to use PrEP among MSM.","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141803014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Defensin 5 Inhibits Plasmodium yoelii Development in Anopheles stephensi by Promoting Innate Immune Response 人类防御素 5 通过促进先天性免疫反应抑制疟原虫的发育

IF 2.8 4区医学

Tropical Medicine and Infectious Disease Pub Date : 2024-07-25 DOI: 10.3390/tropicalmed9080169

Tingting Liu, Jing Wang, Xin Li, Shasha Yu, Dan Zheng, Zhilong Liu, Xuesen Yang, Ying Wang

{"title":"Human Defensin 5 Inhibits Plasmodium yoelii Development in Anopheles stephensi by Promoting Innate Immune Response","authors":"Tingting Liu, Jing Wang, Xin Li, Shasha Yu, Dan Zheng, Zhilong Liu, Xuesen Yang, Ying Wang","doi":"10.3390/tropicalmed9080169","DOIUrl":"https://doi.org/10.3390/tropicalmed9080169","url":null,"abstract":"Malaria poses a serious threat to human health. Existing vector-based interventions have shortcomings, such as environmental pollution, strong resistance to chemical insecticides, and the slow effects of biological insecticides. Therefore, the need to develop novel strategies for controlling malaria, such as reducing mosquito vector competence, is escalating. Human defensin 5 (HD5) has broad-spectrum antimicrobial activity. To determine its effect on Plasmodium development in mosquitoes, HD5 was injected into Anopheles stephensi at various time points. The infection density of Plasmodium yoelii in An. stephensi was substantially reduced by HD5 treatment administered 24 h prior to infection or 6, 12, or 24 h post-infection (hpi). We found that HD5 treatment upregulated the expression of the innate immune effectors TEP1, MyD88, and Rel1 at 24 and 72 hpi. Furthermore, the RNA interference of MyD88, a key upstream molecule in the Toll signaling pathway, decreased the HD5-induced resistance of mosquitoes against Plasmodium infection. These results suggest that HD5 microinjection inhibits the development of malaria parasites in An. stephensi by activating the Toll signaling pathway.","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141803786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Characterization of Leptospira Species among Patients with Acute Undifferentiated Febrile Illness from the Municipality of Villeta, Colombia 哥伦比亚维莱塔市急性未分化热性病患者钩端螺旋体的分子特征描述

IF 2.8 4区医学

Tropical Medicine and Infectious Disease Pub Date : 2024-07-25 DOI: 10.3390/tropicalmed9080168

Carlos Ramiro Silva-Ramos, J. M. Matiz-González, Juliana Gil-Mora, Heidy-C. Martínez Díaz, Álvaro A. Faccini-Martínez, C. Cuervo, Peter C Melby, Patricia V. Aguilar, M. Cabada, Juan David Rodas, Marylin Hidalgo

{"title":"Molecular Characterization of Leptospira Species among Patients with Acute Undifferentiated Febrile Illness from the Municipality of Villeta, Colombia","authors":"Carlos Ramiro Silva-Ramos, J. M. Matiz-González, Juliana Gil-Mora, Heidy-C. Martínez Díaz, Álvaro A. Faccini-Martínez, C. Cuervo, Peter C Melby, Patricia V. Aguilar, M. Cabada, Juan David Rodas, Marylin Hidalgo","doi":"10.3390/tropicalmed9080168","DOIUrl":"https://doi.org/10.3390/tropicalmed9080168","url":null,"abstract":"Leptospira is a bacterial genus that includes several pathogenic species related to leptospirosis. In Colombia, leptospirosis is a mandatorily reported disease, widely distributed across the country. In the Villeta municipality, leptospirosis has been identified as an important cause of febrile illness; however, to date, no studies have been performed to identify the circulating species. A genus-specific qualitative qPCR was performed on DNA extracted from febrile patients’ acute-phase whole-blood samples targeting a fragment of the rrs gene. Positive qPCR samples were further amplified for the adk, icdA, LipL32, LipL41, rrs, and secY genes through conventional PCR for sequencing. All high-quality obtained sequences were further assessed through concatenated phylogenetic analysis. A total of 25% (14/56) of febrile patients’ acute blood samples were positive for Leptospira spp. High-quality sequences were obtained for only five genes, and analysis through concatenated phylogeny identified that all sequences clustered within the P1/pathogenic clade; some of them formed a robustly supported clade with Leptospira santarosai, and others were closely related with other Leptospira species but exhibited considerable genetic divergence. We describe the presence of pathogenic Leptospira species among febrile patients from the Villeta municipality and identify L. santarosai and other Leptospira species as causative agents of leptospirosis in the region.","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141805737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using a Knowledge and Awareness Survey to Engage and Inform a Community-Based Tuberculosis Intervention among Nomads in Adamawa State, Nigeria 在尼日利亚阿达马瓦州游牧民族中开展知识和意识调查，为基于社区的结核病干预措施提供参与和信息

IF 2.8 4区医学

Tropical Medicine and Infectious Disease Pub Date : 2024-07-23 DOI: 10.3390/tropicalmed9080167

Stephen John, Suraj Abdulkarim, Thandi Katlholo, Caoimhe Smyth, Hunpiya Basason, Md. Toufiq Rahman, Jacob Creswell

{"title":"Using a Knowledge and Awareness Survey to Engage and Inform a Community-Based Tuberculosis Intervention among Nomads in Adamawa State, Nigeria","authors":"Stephen John, Suraj Abdulkarim, Thandi Katlholo, Caoimhe Smyth, Hunpiya Basason, Md. Toufiq Rahman, Jacob Creswell","doi":"10.3390/tropicalmed9080167","DOIUrl":"https://doi.org/10.3390/tropicalmed9080167","url":null,"abstract":"Background: Nomadic populations are frequently isolated and vulnerable to diseases including tuberculosis (TB) and human immunodeficiency virus (HIV) due to limited access to health-related information and services, poverty, and social exclusion. We designed and implemented community-driven and -based outreach for TB and HIV based on the results of a TB knowledge, attitude, and practices (KAP) survey in Adamawa, Nigeria. Methods: We conducted a cross-sectional study on KAP among nomads using an adapted WHO survey. A TB and HIV community-level active case-finding intervention among nomadic populations was planned and delivered based on the KAP survey results. Results: Among 81 respondents, 26 (32.1%) knew what caused TB. More than 60% reported no health facilities in their community. Radio and healthcare workers were primary sources of information on health. Using community input, we developed and broadcasted radio jingles to sensitize people to TB services. Outreach initiatives led to the verbal screening of 61,891 individuals and 306 were diagnosed with TB. Additionally, 4489 people underwent HIV testing, and 69 were HIV-positive, all of whom were linked to treatment. Conclusions: The results of KAP surveys can inform the design of evidence-based TB and HIV community-driven and -based case-finding interventions in rural Nigeria among nomadic populations.","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141810430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact on Aedes aegypti Mosquitoes Exposed to Honey-Impregnated Flinders Technology Associates (FTA^®) Cards. 浸过蜂蜜的弗林德斯技术协会 (FTA®) 卡对埃及伊蚊的影响。

IF 2.8 4区医学

Tropical Medicine and Infectious Disease Pub Date : 2024-07-20 DOI: 10.3390/tropicalmed9070165

Amandine Guidez, Albin Fontaine, Arnaud Cannet, Isabelle Dusfour, Romain Girod, Sébastien Briolant

{"title":"Impact on Aedes aegypti Mosquitoes Exposed to Honey-Impregnated Flinders Technology Associates (FTA®) Cards.","authors":"Amandine Guidez, Albin Fontaine, Arnaud Cannet, Isabelle Dusfour, Romain Girod, Sébastien Briolant","doi":"10.3390/tropicalmed9070165","DOIUrl":"10.3390/tropicalmed9070165","url":null,"abstract":"Programs to control viruses transmitted by mosquitoes requires the implementation of surveillance tools. Over the past decade, Flinders Technology Associates (FTA®) cards, which preserve nucleic acids, have emerged as an innovating surveillance system for collecting arboviruses expectorated during mosquito sugar feeding. In this study, we evaluate the survival rates of two strain of Aedes aegypti (New Orleans (NO) and Cayenne (CAY)) in the laboratory after exposing to either honey-impregnated FTA® cards or untreated filter paper (UFP) card. Experimental exposure of mosquitoes to FTA® cards during sugar feeding significantly negatively impacted their survival, as compared to untreated filter paper. The median survival time was 2 days (95% confidence interval [CI] 1 day, 3 days) for mosquitoes exposed to FTA cards from strain NO and 3 days (95% CI 2 days, 3 days) for mosquitoes exposed to FTA cards from strain CAY. Mosquitoes exposed to UFP did not survive until the end of the experiment (4 days for strain NO and 7 days for strain CAY). Although this finding does not preclude the use of FTA® cards in surveillance, it is crucial to consider and incorporate this factor into study designs.","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11281320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Update on the Entomology, Virology, Pathogenesis, and Epidemiology Status of West Nile and Dengue Viruses in Europe (2018-2023). 欧洲西尼罗河病毒和登革热病毒的昆虫学、病毒学、发病机制和流行病学现状更新（2018-2023 年）》。

IF 2.8 4区医学

Tropical Medicine and Infectious Disease Pub Date : 2024-07-20 DOI: 10.3390/tropicalmed9070166

Federica Frasca, Leonardo Sorrentino, Matteo Fracella, Alessandra D'Auria, Eleonora Coratti, Luca Maddaloni, Ginevra Bugani, Massimo Gentile, Alessandra Pierangeli, Gabriella d'Ettorre, Carolina Scagnolari

{"title":"An Update on the Entomology, Virology, Pathogenesis, and Epidemiology Status of West Nile and Dengue Viruses in Europe (2018-2023).","authors":"Federica Frasca, Leonardo Sorrentino, Matteo Fracella, Alessandra D'Auria, Eleonora Coratti, Luca Maddaloni, Ginevra Bugani, Massimo Gentile, Alessandra Pierangeli, Gabriella d'Ettorre, Carolina Scagnolari","doi":"10.3390/tropicalmed9070166","DOIUrl":"10.3390/tropicalmed9070166","url":null,"abstract":"In recent decades, increases in temperature and tropical rainfall have facilitated the spread of mosquito species into temperate zones. Mosquitoes are vectors for many viruses, including West Nile virus (WNV) and dengue virus (DENV), and pose a serious threat to public health. This review covers most of the current knowledge on the mosquito species associated with the transmission of WNV and DENV and their geographical distribution and discusses the main vertebrate hosts involved in the cycles of WNV or DENV. It also describes virological and pathogenic aspects of WNV or DENV infection, including emerging concepts linking WNV and DENV to the reproductive system. Furthermore, it provides an epidemiological analysis of the human cases of WNV and DENV reported in Europe, from 1 January 2018 to 31 December 2023, with a particular focus on Italy. The first autochthonous cases of DENV infection, with the most likely vector being Aedes albopictus, have been observed in several European countries in recent years, with a high incidence in Italy in 2023. The lack of treatments and effective vaccines is a serious challenge. Currently, the primary strategy to prevent the spread of WNV and DENV infections in humans remains to limit the spread of mosquitoes.","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11281579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One Health, One Future: A Unified Approach to a Balanced Ecosystem. 一个健康，一个未来：实现平衡生态系统的统一方法》。

IF 2.8 4区医学

Tropical Medicine and Infectious Disease Pub Date : 2024-07-20 DOI: 10.3390/tropicalmed9070164

Santanu Sasidharan, Claire J Standley

引用次数: 0

The Diagnostic Challenge of Cystic Echinococcosis in Humans: First Assessment of Underreporting Rates in Mongolia. 人类囊性棘球蚴病的诊断挑战：首次评估蒙古的漏报率

IF 2.8 4区医学

Tropical Medicine and Infectious Disease Pub Date : 2024-07-19 DOI: 10.3390/tropicalmed9070163

Bolor Bold, Christian Schindler, Uranshagai Narankhuu, Agiimaa Shagj, Erdenebileg Bavuujav, Sonin Sodov, Tsogbadrakh Nyamdorj, Jakob Zinsstag

{"title":"The Diagnostic Challenge of Cystic Echinococcosis in Humans: First Assessment of Underreporting Rates in Mongolia.","authors":"Bolor Bold, Christian Schindler, Uranshagai Narankhuu, Agiimaa Shagj, Erdenebileg Bavuujav, Sonin Sodov, Tsogbadrakh Nyamdorj, Jakob Zinsstag","doi":"10.3390/tropicalmed9070163","DOIUrl":"10.3390/tropicalmed9070163","url":null,"abstract":"Cystic echinococcosis (CE), caused by the larval stage of Echinococcus granulosus, is significantly underreported in Mongolia due to geographical remoteness, a lack of early diagnostics, and poor clinical management. This study aimed to provide a more accurate estimate of CE in Mongolia by comparing data from surgical (reported) and diagnosed (unreported) cases and assessing the challenges faced by rural doctors in disease management and surveillance. We collected data on surgical cases hospitalized between 2006 and 2016 and newly diagnosed CE cases in 2016 from eight provinces. Using a quasi-Poisson regression model, we extrapolated the collected data to estimate the number of diagnosed cases for the entire country. Additionally, forty health professionals from all 21 provinces rated local clinical management for CE through a questionnaire. The results reveal that surgical cases (2.2 per year) represent only one-eighth of diagnosed cases (15.9 per year). The laboratory facilities, disease reporting, and cyst classification usage scored below 2. These results highlight the significant underreporting of CE in Mongolia and urge human and animal health experts, along with policymakers, to invest in combating CE, particularly in remote provincial areas. This study also emphasizes the need for standard clinical management involving cyst classification according to the WHO-IWGE and seamless integration of CE reporting and monitoring mechanisms, which can significantly contribute to the national and global burden estimation of CE.","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11281321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can Support Groups Improve Treatment Adherence and Reduce Sexual Risk Behavior among Young People Living with HIV? Results from a Cohort Study in South Africa. 互助小组能否改善感染艾滋病毒的年轻人坚持治疗的情况并减少其性风险行为？南非队列研究的结果。

IF 2.8 4区医学

Tropical Medicine and Infectious Disease Pub Date : 2024-07-19 DOI: 10.3390/tropicalmed9070162

Tonya R Thurman, Brian Luckett, Babalwa Zani, Johanna Nice, Tory M Taylor

{"title":"Can Support Groups Improve Treatment Adherence and Reduce Sexual Risk Behavior among Young People Living with HIV? Results from a Cohort Study in South Africa.","authors":"Tonya R Thurman, Brian Luckett, Babalwa Zani, Johanna Nice, Tory M Taylor","doi":"10.3390/tropicalmed9070162","DOIUrl":"10.3390/tropicalmed9070162","url":null,"abstract":"Adolescents and young adults living with HIV (AYLHIV) in sub-Saharan Africa experience poorer HIV outcomes than adults, including lower ART adherence and virologic suppression. They also have high rates of unprotected sex, increasing the risk of adverse sexual health outcomes and onward transmission. This one-arm, pre-post study investigates a structured 14-session support group aiming to boost treatment adherence and sexual protective behavior for AYLHIV in South Africa. Logistic and Poisson regression analyses were performed on self-reported pre- and post-intervention survey data collected approximately 7.5 months apart from a cohort of 548 AYLHIV. Participants were significantly more likely to report at least 95% adherence at follow-up and rate their health as \"good;\" they also demonstrated greater treatment knowledge and had fewer absences from school overall and due to illness. Among sexually active AYLHIV, contraception use at last sex increased significantly, while condom use did not. Effects were small, and greater programmatic emphasis on adherence and multifaceted service packages is likely necessary to promote viral suppression. Nonetheless, the intervention addresses an important gap in service provision for AYLHIV in South Africa. Findings denote the potential for incorporating care and treatment components into sexual and reproductive health interventions tailored for AYLHIV.","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11281618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0