Tropical Medicine and Infectious Disease最新文献

{"title":"Biological and Molecular Characterization of Five <i>Trypanosoma cruzi</i> (Chagas, 1909) (Kinetoplastida, Trypanosomatidae) Isolates from the State of Hidalgo, Mexico.","authors":"Yessenia Montes-Vergara, Alberto Antonio-Campos, José Miguel Padilla-Valdez, Erick Abraham Contreras-López, Julio Cesar Noguez-García, Nancy Rivas, Ricardo Alejandre-Aguilar","doi":"10.3390/tropicalmed10050122","DOIUrl":"10.3390/tropicalmed10050122","url":null,"abstract":"<p><p><i>Trypanosoma cruzi</i>, the causal agent of Chagas disease, exhibits great genetic diversity, which has been related to its biological properties. However, these are poorly known in strains from the endemic area of Hidalgo. To assess the parasite's virulence, we evaluated parasitemia, mortality, and tropism in thirteen organs of CD1 mice during the acute phase of infection. For genotyping, we amplified the mini-exon gene from <i>T. cruzi</i> DNA using PCR. All five isolates were identified as belonging to DTU TcI. The peak of parasitemia occurred between 25 and 29 days post-infection. The Tultitlán and Olma isolates did not cause any mouse deaths, whereas Ixcatépec produced 100% mortality. Mice infected with the Barrio Hondo isolate exhibited the highest parasitemia, while those infected with Cuatecomaco had the lowest. The five isolates generated varying degrees of infection and chronic inflammation; only two isolates triggered acute pancreatitis and myocarditis. No amastigote nests were found in the hearts of mice infected with the Ixcatépec isolate. Our findings suggest that the damage caused by <i>T. cruzi</i> strains from Hidalgo may extend beyond cardiac lesions in the acute phase of Chagas disease regardless of their classification as TcI and variability in parasitemia levels.</p>","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":"10 5","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Outbreak of Multidrug-Resistant <i>Shigella flexneri</i> Serotype 2a Among People Experiencing Homelessness in Vancouver.","authors":"Victor Leung, Gordon Ritchie, Aleksandra Stefanovic, Colin Lee, Sam Chorlton, Nancy Matic, Marc G Romney, Althea Hayden, Christopher F Lowe","doi":"10.3390/tropicalmed10050120","DOIUrl":"10.3390/tropicalmed10050120","url":null,"abstract":"<p><p><b>Background</b>: We describe a community-based outbreak of multidrug-resistant <i>Shigella flexneri</i> serotype 2a among people experiencing homelessness (PEH) in Vancouver's Downtown Eastside during the COVID-19 pandemic. <b>Methods</b>: In this observational cohort study, we followed the Outbreak Reports and Intervention Studies of Nosocomial Infection (ORION) reporting guidelines. We identified cases by laboratory surveillance and collected demographic and clinical data from the medical charts or patient interviews. We implemented enhanced surveillance and disseminated testing and management guidelines. <i>Shigella flexneri</i> isolates were serotyped, and whole-genome sequencing was performed. <b>Results</b>: We identified 101 confirmed cases of <i>Shigella flexneri</i> 2a (80% male; median age 43) between 31 January and 16 December 2021. All the affected individuals experienced homelessness, and substance use disorder was the most common comorbidity (88%). Five patients required ICU hospitalization, and one death occurred within 30 days. Core-genome multilocus sequence typing analysis confirmed a clonal outbreak. All <i>S. flexneri</i> isolates were phenotypically and genotypically multidrug-resistant. <b>Conclusions</b>: COVID-19 exacerbated longstanding public health concerns around the dearth of hygiene and sanitation resources available to PEH. Preventing similar outbreaks will require addressing these risks and finding solutions to the crisis of homelessness in Canada.</p>","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":"10 5","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12115784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Ground and Aerial Ultra-Low Volume Applications Using ReMoa Tri Against Deltamethrin-Resistant <i>Aedes aegypti</i> from Collier County, Florida.","authors":"Decyo McDuffie, Sara Kacinskas, Suzanne Li, Casey Parker-Crockett, Keira J Lucas","doi":"10.3390/tropicalmed10050119","DOIUrl":"10.3390/tropicalmed10050119","url":null,"abstract":"<p><p>New intervention methods and product formulations are needed to better control pyrethroid-resistant <i>Aedes aegypti</i> populations and mitigate the risk of mosquito-borne disease. ReMoa Tri is a novel adulticidal space spray that utilizes a different mode of action than the commonly used adulticides: pyrethroids and organophosphates. As a triple-action space spray, ReMoa Tri combines three components: Fenpropathrin, a mixed-type I/II pyrethroid; abamectin, a macrocyclic lactone; and C8910, a patented fatty acid chain. Prior studies performed by Collier Mosquito Control District showed that ReMoa Tri is effective at controlling type I pyrethroid-resistant <i>Ae. aegypti</i> mosquitoes. To further validate these results and the performance of ReMoa Tri, we conducted a semi-field evaluation using ground and aerial ULV (ultra-low volume) applications with field-caught deltamethrin-resistant <i>Ae. aegypti</i> and a susceptible <i>Ae. aegypti</i> laboratory strain. Ground evaluations tested ReMoa Tri and a type II pyrethroid-based product, DeltaGard. While ReMoa Tri was equally effective against Collier's deltamethrin-resistant <i>Ae. aegypti</i> and the susceptible laboratory strain, DeltaGard was effective against both strains, with reduced efficacy at farther distances. Similarly, aerial evaluations also showed that ReMoa Tri was equally effective against Collier's deltamethrin-resistant <i>Ae. aegypti</i> strain and susceptible laboratory strain. This study further confirms ReMoa Tri's potential as an effective alternative to pyrethroid-based adulticides, both in ground and aerial applications, for managing pyrethroid-resistant <i>Ae. aegypti</i>.</p>","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":"10 5","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12115956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yellow Fever Virus (YFV) Detection in Different Species of Culicids Collected During an Outbreak in Southeastern Brazil, 2016-2019.","authors":"Giovana Santos Caleiro, Lucila Oliveira Vilela, Karolina Morales Barrio Nuevo, Rosa Maria Tubaki, Regiane Maria Tironi de Menezes, Luis Filipe Mucci, Juliana Telles-de-Deus, Eduardo Sterlino Bergo, Emerson Luiz Lima Araújo, Mariana Sequetin Cunha","doi":"10.3390/tropicalmed10050118","DOIUrl":"10.3390/tropicalmed10050118","url":null,"abstract":"<p><p>Yellow fever virus (YFV) is an endemic arbovirus in parts of Africa and the Americas. In Brazil, following the eradication of the urban transmission cycle, YFV is maintained in a sylvatic cycle involving several species of neotropical primates and mosquitoes of the genera Haemagogus and Sabethes, which serve as primary and secondary vectors, respectively. During the 2016-2019 outbreak in São Paulo State, a total of 3731 mosquito pools were collected from sites with ongoing epizootic events in 192 municipalities. The RT-qPCR analysis detected YFV in 46 pools (1.4%) across nine mosquito species, including both primary and secondary vectors, as well as species from the genera Aedes and Psorophora. Differences in viral loads were observed among species. While Aedes aegypti was not found to be positive, the detection of natural YFV infection in other Aedes species raises concerns about potential virus reurbanization. Further studies are needed to clarify the role of additional mosquito species in YFV transmission in Brazil.</p>","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":"10 5","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12115348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary Metabolites from a New Antibiotic-Producing Endophytic Streptomyces Isolate Inhibited Pathogenic and Multidrug-Resistant <i>Mycobacterium tuberculosis</i> Strains.","authors":"Govinda Raju Vadankula, Arshad Rizvi, Haider Ali, Rakhi Khunjamayum, V V Ramprasad Eedara, Vijay Nema, Debananda Singh Ningthoujam, Katragadda Suresh Babu, Prakasham Reddy Shetty, Shekhar C Mande, Sharmistha Banerjee","doi":"10.3390/tropicalmed10050117","DOIUrl":"10.3390/tropicalmed10050117","url":null,"abstract":"<p><p>The long regimen of drug therapy, the emergence of drug-resistance (DR), and infections with non-tuberculous mycobacteria (NTMs) are alarming challenges in controlling tuberculosis (TB), a disease caused by <i>Mycobacterium tuberculosis</i> (<i>M.tb</i>), necessitating the pursuit of new, broad-spectrum anti-mycobacterials. With more than two-thirds of the clinically useful antibiotics originating from the bacterial phylum Actinomycetota, and their enormous diversity in India, we explored atypical environments for new bacterial strains with potential anti-<i>M.tb</i> activity. In this study, we the examined the secondary metabolites of soil and endophytic bacterial isolates from the wetland niches of Manipur, India, and determined their anti-mycobacterial properties using viability assays. The ethyl acetate culture filtrate extracts of one of the isolates, named <i>Streptomyces</i> sp. SbAr007, showed broad-spectrum anti-mycobacterial activity against laboratory <i>M.tb</i> strains H37Ra and H37Rv, a clinical drug-resistant <i>M.tb</i> and non-tuberculous mycobacteria (NTM). The isolate was characterized for its phenotype and genetic identity, which indicated its closeness to <i>Streptomyces samsunensis</i>, <i>Streptomyces malaysiensis</i>, and <i>Streptomyces solisilvae</i>. Further, macrophage infection assays showed that the extracts could effectively control the intracellular mycobacterial growth but had negligible cytotoxicity to PBMCs from healthy donors. LC-MS identified an unusual combination of antibiotics in these culture filtrate extracts, which can be further explored for specific active molecules or as a formulation against DR-TB.</p>","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":"10 5","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12115879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Desiccation Tolerance of <i>Aedes aegypti</i> and <i>Aedes albopictus</i> Eggs of Northeastern Argentina Origin.","authors":"Mía E Martín, Elizabet L Estallo, Luis G Estrada, Carolina Matiz Enriquez, Marina Stein","doi":"10.3390/tropicalmed10040116","DOIUrl":"https://doi.org/10.3390/tropicalmed10040116","url":null,"abstract":"<p><p>This study examines the desiccation tolerance of <i>Aedes aegypti</i> and <i>Aedes albopictus</i> eggs, two major arbovirus vectors, in a subtropical region of Argentina to understand their survival under varying relative humidity (RH) conditions (35%, 68%, and 82%). Laboratory experiments revealed that <i>Ae. aegypti</i> eggs exhibited significantly higher survival rates across all RH levels and exposure times compared to <i>Ae. albopictus</i>. After 1 month, <i>Ae. aegypti</i> eggs maintained 88% survival at 35% RH, while <i>Ae. albopictus</i> survival dropped to 38%. This disparity was more pronounced at low RH, where <i>Ae. albopictus</i> eggs experienced a rapid decline in survival over time. The results highlight the importance of RH as a key factor influencing the persistence of both species in the environment. The coexistence of <i>Ae. aegypti</i> and <i>Ae. albopictus</i> in Puerto Iguazú suggests that microhabitats with distinct humidity conditions may favor one species over the other. These findings provide crucial insights for predicting mosquito population dynamics under changing climate conditions and developing more effective vector control strategies to reduce arbovirus transmission in subtropical regions.</p>","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":"10 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative Study of Nutritional Support-Related Perceptions and Preferences Among Persons Affected by TB, Family Caregivers, and Healthcare Providers in India.","authors":"Balaji Ramraj, Karikalan Nagarajan, Debjani Ram Purakayastha, Major Madhukar, Makesh Kumar, Neha Raj, Sarath Kumar, Banappa S Unger, Nithin Rajamani, Sampada Dipak Bangar, Murugesan Periyasamy, Hansraj Choudhary, Yasaswany Santhoshkumar, Ramesh Kumar, Seema Sahay, Nivedita Gupta, Chandrasekaran Padmapriyadarsini","doi":"10.3390/tropicalmed10040114","DOIUrl":"https://doi.org/10.3390/tropicalmed10040114","url":null,"abstract":"<p><p>Evidence on the implementation aspects of nutritional support interventions for persons with TB in India is limited. This qualitative study employed focus group discussions with persons with TB (n = 71), their family caregivers (n = 17), and healthcare providers (n = 18). The study was conducted from August 2023 to April 2024 in five states in India. Participants' knowledge, perceptions, and practices about nutritional intake, experiences, and expectations when accessing nutritional support were explored. Four nutrition-related themes emerged: (a) the experiences and perceptions of persons with tuberculosis and their caregivers, explained by their understanding of the importance of adequate nutrition and TB cures; (b) changes in food practices, explained by protein food adoption, alongside food insecurity experienced by those in poverty; (c) Direct Benefit Transfer (DBT)-related issues, explained by insufficiency and access-related gaps; and (d) preferred choices for nutrition support delivery, explained by less preference towards the involvement of intermediaries and a public distribution system alongside preference for the provision of nutrition through treatment facilities. Our findings underscore the importance of the provision of protein-rich food and an increase in financial support based on needs assessments. Mitigating the linkage and access gaps in DBT is needed. The delivery of ready-to-consume food through tuberculosis treatment facilities could be prioritized.</p>","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":"10 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The State of Antimicrobial Resistance of Gram-Negative Bacilli in Canada.","authors":"Jeremy Li, Andrew Walkty, Philippe Lagacé-Wiens, James Karlowsky, George Zhanel","doi":"10.3390/tropicalmed10040115","DOIUrl":"https://doi.org/10.3390/tropicalmed10040115","url":null,"abstract":"<p><p>In the last two decades, there has been an increase in resistance among Gram-negative bacteria in Canada. From 2007 to 2016, the proportion of ESBL-producing isolates among <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> isolates increased from 3.5% to 11.1%. There has also been an increase in carbapenem use over this time period, which may be contributing to the increasing prevalence of carbapenemase-producing Enterobacterales (CPE) in Canada. CPE, which were historically associated with travel, are now mostly acquired domestically. The prevalence of multi-drug resistant (MDR) <i>Pseudomonas aeruginosa</i> has decreased slightly, possibly due to decreasing use of fluoroquinolones and aminoglycosides. Many of the most effective antimicrobials for the treatment of infections with resistant Gram-negative organisms, including many of the novel β-lactam/β-lactamase inhibitors (βL/βLIs), are not marketed in Canada. A coordinated focus on antimicrobial stewardship and infection control is necessary to slow the spread of resistance and to preserve the efficacy of our current antimicrobials for future generations.</p>","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":"10 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infectivity and Dissemination of Dengue Virus-1 in Different <i>Aedes aegypti</i> Populations Throughout Brazil.","authors":"Amanda Cupertino de Freitas, Ellen Santos, Lívia Baldon, Silvana de Mendonça, Fernanda Oliveira Rezende, Rafaela Moreira, Viviane Sousa, Mariana Lima, Emanuele Silva, Flávia Ferreira, João Paulo Pereira de Almeida, Siad Amadou, Bruno Marçal, Sara Comini, Marcele Rocha, Yaovi Todjro, Thiago Jiran Leite, Viviane Santos, Isaque João da Silva de Faria, Marta Giovanetti, Luiz Carlos Junior Alcantara, Luciano A Moreira, Alvaro Ferreira","doi":"10.3390/tropicalmed10040112","DOIUrl":"https://doi.org/10.3390/tropicalmed10040112","url":null,"abstract":"<p><p>Dengue virus, one of the most prevalent mosquito-borne flaviviruses affecting humans globally, is primarily transmitted by the <i>Aedes aegypti</i> mosquito, which thrives in densely populated urban environments. Dengue incidence has surged in recent decades, becoming a major public health concern in many regions, particularly in Brazil, which has experienced recurrent outbreaks and reported over 6.6 million probable cases in the year of 2024. While the link between the mosquito vector and dengue transmission is well understood, the effects of different DENV types and their interactions with the vector capacity of natural mosquito populations are crucial for understanding disease dynamics. Here we report findings from experiments designed to analyze and compare the infectivity and dissemination of the DENV-1 strain among five <i>Ae. aegypti</i> populations collected from different regions of Brazil. When exposed to DENV-infected AG129 mice for blood feeding, these populations exhibited variations in infection rates and dissemination efficiency. Eight days post-infection, all populations demonstrated high infection rates, underscoring the substantial capacity of Brazilian <i>Ae. aegypti</i> populations to support the locally circulating DENV-1 strain. Our results demonstrate variation in <i>Ae. aegypti</i> vector competence across Brazil, revealing distinct patterns of DENV transmission efficiency. These findings highlight the necessity for geographically tailored control strategies, particularly in high-risk urban areas where outbreak potential is greatest.</p>","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":"10 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12030886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of <i>Trichomonas vaginalis</i> Among Women in the Chinese Population: A Systematic Review and Meta-Analysis.","authors":"Shuang Li, Jiahui Xu, Sisi Ru, Changjun Hu, Chongyang Liu, Xingquan Sun, Heteng Guo, Xi Zhang","doi":"10.3390/tropicalmed10040113","DOIUrl":"https://doi.org/10.3390/tropicalmed10040113","url":null,"abstract":"<p><p><i>Trichomonas vaginalis</i> (TV) is the most common non-viral sexually transmitted infection (STI) among women worldwide. However, there is little information available regarding the burden of trichomoniasis infection among Chinese women. The aim of the present study is to assess the status of trichomoniasis in China. To address this gap, we searched seven databases for relevant studies published from their inception to June 2024. The overall prevalence of <i>T. vaginalis</i> in China was determined to be 6.31% with a high level of heterogeneity (<i>I</i>² = 99.68%). Subgroup analysis also demonstrated a statistically significant association between the <i>T. vaginalis</i> prevalence in the type of population, age range, year, residential status, and province. Among these, sex workers are the most prominent with 12.16%. Meta-regression analysis indicated that the infection rate of <i>T. vaginalis</i> among Chinese women had not shown a significant decline over time (<i>p</i> = 0.2919). Therefore, it continues to be a public health issue that should not be overlooked. Sex workers and rural women have a relatively higher infection rate of trichomoniasis, and this is largely associated with sexual safety awareness and hygiene conditions. Our findings provide crucial information for healthcare authorities and can shed light on the prevention strategies for trichomoniasis in China.</p>","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":"10 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}