Tropical Medicine and Infectious Disease最新文献

A Case Report and Literature Review of Prostatic Tuberculosis Masquerading as Prostate Cancer: A Diagnostic Challenge in a Tuberculosis-Endemic Region. 前列腺结核伪装成前列腺癌的病例报告和文献综述：在结核病流行地区的诊断挑战。

IF 2.8 4区医学

Tropical Medicine and Infectious Disease Pub Date : 2025-05-21 DOI: 10.3390/tropicalmed10050145

Yonathan William, Marto Sugiono, Patricia Diana Prasetiyo, Adelbertus Erico, Gilbert Sterling Octavius

{"title":"A Case Report and Literature Review of Prostatic Tuberculosis Masquerading as Prostate Cancer: A Diagnostic Challenge in a Tuberculosis-Endemic Region.","authors":"Yonathan William, Marto Sugiono, Patricia Diana Prasetiyo, Adelbertus Erico, Gilbert Sterling Octavius","doi":"10.3390/tropicalmed10050145","DOIUrl":"10.3390/tropicalmed10050145","url":null,"abstract":"A male in his 60s presented with a four-month history of dysuria and lower urinary tract symptoms (LUTS). He had a history of elevated PSA and benign prostatic hyperplasia (BPH), previously treated with transurethral resection of the prostate (TURP). Multiparametric MRI (MP-MRI) revealed a PI-RADS 5 lesion, raising suspicion of malignancy. However, histopathological analysis from MRI fusion-targeted biopsies confirmed tuberculous prostatitis. The patient was treated with antituberculosis drugs, resulting in symptomatic improvement and a significant PSA decline. This case highlights the diagnostic challenge of distinguishing tuberculous prostatitis from prostate cancer, particularly in tuberculosis-endemic regions. Our literature review reveals that patients with tuberculous prostatitis undergoing MRI are at least 50 years old, originate from endemic areas, and exhibit PI-RADS scores ranging from 2 to 5, indicating inter-rater variability. Histopathological confirmation remains essential in cases with ambiguous imaging and clinical findings.","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":"10 5","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12115975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Tuan, D.A. Leveraging Climate Data for Dengue Forecasting in Ba Ria Vung Tau Province, Vietnam: An Advanced Machine Learning Approach. Trop. Med. Infect. Dis. 2024, 9, 250. 更正：Tuan， D.A.。利用气候数据预测越南巴里亚头省登革热：一种先进的机器学习方法。太。地中海,感染。2024, 9,250。

IF 2.8 4区医学

Tropical Medicine and Infectious Disease Pub Date : 2025-05-21 DOI: 10.3390/tropicalmed10050144

Dang Anh Tuan

引用次数: 0

Strongyloides Infection Presenting as E. coli Meningitis Post-Transplant. 移植后以大肠杆菌脑膜炎表现为类圆杆菌感染。

IF 2.8 4区医学

Tropical Medicine and Infectious Disease Pub Date : 2025-05-20 DOI: 10.3390/tropicalmed10050143

Anusha Belani, Chaitanya Mishra, Daniela Mihova, Todd Gleeson, Anita Nahar

引用次数: 0

Progress and Prospects of Triazoles in Advanced Therapies for Parasitic Diseases. 三唑类药物在寄生虫病先进治疗中的进展与展望。

IF 2.8 4区医学

Tropical Medicine and Infectious Disease Pub Date : 2025-05-20 DOI: 10.3390/tropicalmed10050142

Jaime A Isern, Renzo Carlucci, Guillermo R Labadie, Exequiel O J Porta

{"title":"Progress and Prospects of Triazoles in Advanced Therapies for Parasitic Diseases.","authors":"Jaime A Isern, Renzo Carlucci, Guillermo R Labadie, Exequiel O J Porta","doi":"10.3390/tropicalmed10050142","DOIUrl":"10.3390/tropicalmed10050142","url":null,"abstract":"Parasitic diseases represent a severe global burden, with current treatments often limited by toxicity, drug resistance, and suboptimal efficacy in chronic infections. This review examines the emerging role of triazole-based compounds, originally developed as antifungals, in advanced antiparasitic therapy. Their unique structural properties, particularly those of 1,2,3- and 1,2,4-triazole isomers, facilitate diverse binding interactions and favorable pharmacokinetics. By leveraging innovative synthetic approaches, such as click chemistry (copper-catalyzed azide-alkyne cycloaddition) and structure-based design, researchers have repurposed and optimized triazole scaffolds to target essential parasite pathways, including sterol biosynthesis via CYP51 and other novel enzymatic routes. Preclinical studies in models of Chagas disease, leishmaniasis, malaria, and helminth infections demonstrate that derivatives like posaconazole, ravuconazole, and DSM265 exhibit potent in vitro and in vivo activity, although their primarily static effects have limited their success as monotherapies in chronic cases. Combination strategies and hybrid molecules have demonstrated the potential to enhance efficacy and mitigate drug resistance. Despite challenges in achieving complete parasite clearance and managing potential toxicity, interdisciplinary efforts across medicinal chemistry, parasitology, and clinical research highlight the significant potential of triazoles as components of next-generation, patient-friendly antiparasitic regimens. These findings support the further optimization and clinical evaluation of triazole-based agents to improve treatments for neglected parasitic diseases.","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":"10 5","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a SYBR Green-Based Real-Time PCR Assay to Detect Oncomelania hupensis quadrasi DNA in Environmental Water Samples. 基于SYBR绿色的实时荧光定量PCR检测环境水样中湖北钉螺DNA的建立。

IF 2.8 4区医学

Tropical Medicine and Infectious Disease Pub Date : 2025-05-20 DOI: 10.3390/tropicalmed10050140

Daria L Manalo, Jude Karlo G Bolivar, Karl Ian T Ermino, Jeromir G Bondoc, Mark Joseph M Espino, Efraim P Panganiban, Kathyleen S Nogrado, Raffy Jay C Fornillos, Mario A Jiz, Lydia R Leonardo, Ian Kendrich C Fontanilla

{"title":"Development of a SYBR Green-Based Real-Time PCR Assay to Detect Oncomelania hupensis quadrasi DNA in Environmental Water Samples.","authors":"Daria L Manalo, Jude Karlo G Bolivar, Karl Ian T Ermino, Jeromir G Bondoc, Mark Joseph M Espino, Efraim P Panganiban, Kathyleen S Nogrado, Raffy Jay C Fornillos, Mario A Jiz, Lydia R Leonardo, Ian Kendrich C Fontanilla","doi":"10.3390/tropicalmed10050140","DOIUrl":"10.3390/tropicalmed10050140","url":null,"abstract":"Oncomelania hupensis quadrasi is the intermediate host of S. japonicum, the causative species of schistosomiasis in the Philippines. Conventionally, risk areas are identified by procedures requiring highly skilled personnel and constant surveillance efforts. Recent developments in disease diagnostics explore the utilization of environmental DNA as targets for polymerase chain reactions in disease surveillance. In this study, a low-cost, specific, and efficient SYBR Green-based real-time PCR assay to detect O. h. quadrasi DNA from water samples was developed, optimized, and validated. Primers were designed based on the A18 microsatellite region of O. h. quadrasi. The assay exhibited a detection limit of one copy number per microliter at 99.4% efficiency and R2 = 0.999, which specifically amplified O. h. quadrasi DNA only. Validation of this assay in environmental water samples demonstrated 100% PPV and NPV values, suggesting its potential as a tool for identifying risk areas, pathogen-directed surveillance, policy making, and disease control.","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":"10 5","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12115604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence, Conversion and Reversion of Tuberculosis Infection Among Healthcare Workers of Tertiary Care Centres in Puducherry, India: A Prospective Cohort Study. 印度普杜切里三级保健中心医护人员中结核病感染的流行、转化和逆转：一项前瞻性队列研究。

IF 2.8 4区医学

Tropical Medicine and Infectious Disease Pub Date : 2025-05-20 DOI: 10.3390/tropicalmed10050141

Sadhana Subramanian, Palanivel Chinnakali, Senbagavalli Prakashbabu, Guha Nandhini Visvanadane, Manju Rajaram, Vijay Viswanathan, Sonali Sarkar, Charles Robert Horsburgh

{"title":"Prevalence, Conversion and Reversion of Tuberculosis Infection Among Healthcare Workers of Tertiary Care Centres in Puducherry, India: A Prospective Cohort Study.","authors":"Sadhana Subramanian, Palanivel Chinnakali, Senbagavalli Prakashbabu, Guha Nandhini Visvanadane, Manju Rajaram, Vijay Viswanathan, Sonali Sarkar, Charles Robert Horsburgh","doi":"10.3390/tropicalmed10050141","DOIUrl":"10.3390/tropicalmed10050141","url":null,"abstract":"Healthcare workers (HCWs) face an increased risk of tuberculosis (TB) due to occupational exposure. This study aimed to estimate the point prevalence of TB infection (TBI) from the initial test performed, while the reversion and conversion were done by subsequent testing at one year among HCWs in Puducherry, India. A prospective cohort study was conducted among a sample of proportionately chosen HCWs based on their occupational strata of a tertiary hospital in 2022. TBI was assessed using IGRA (4th generation QuantiFeron-TB gold plus kits) after TB symptom screening. The IGRA test was repeated at the end of one year. Reversion was defined as a positive IGRA test at the baseline and had values < 0.2 IU/L in TB1 or TB2 tubes during follow-up. Conversion was defined as a negative IGRA result at the baseline and had values of >0.7 IU/L in TB1 or TB2 tubes during follow-up. Of the 400 HCWs included, the mean (SD) age was 37 (7) years. Median (IQR) work experience was 15.7 (10-21) years. TBI was seen in 150 HCWs (37.7%, 95% CI: 33.0-42.7), and one had active TB. A total of 128/150 HCWs with TBI at baseline were followed up, and 15 had TBI reversion (11.7 per 100 person-years; 95% CI: 6.7-18.5). Thirteen HCWs (5.6 per 100 person-years; 95% CI: 3.3-9.8) had TBI conversion.","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":"10 5","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12115517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mycoplasma genitalium Infections and Associated Antimicrobial Resistance in Canada, 1980-2023. 1980-2023年加拿大生殖道支原体感染及相关抗菌素耐药性

IF 2.8 4区医学

Tropical Medicine and Infectious Disease Pub Date : 2025-05-19 DOI: 10.3390/tropicalmed10050139

Angela Copete, Mariana Herrera, Camilo Suarez-Ariza, Zipporah Gitau, Maria Arango-Uribe, Rotem Keynan, Camila Oda, Ameeta E Singh, Stuart Skinner, Cara Spence, Will Riaño, Lauren J MacKenzie, Ken Kasper, Laurie Ireland, Irene Martin, Jared Bullard, Lucelly Lopez, Diana Marin, Margaret Haworth-Brockman, Yoav Keynan, Zulma Vanessa Rueda

{"title":"Mycoplasma genitalium Infections and Associated Antimicrobial Resistance in Canada, 1980-2023.","authors":"Angela Copete, Mariana Herrera, Camilo Suarez-Ariza, Zipporah Gitau, Maria Arango-Uribe, Rotem Keynan, Camila Oda, Ameeta E Singh, Stuart Skinner, Cara Spence, Will Riaño, Lauren J MacKenzie, Ken Kasper, Laurie Ireland, Irene Martin, Jared Bullard, Lucelly Lopez, Diana Marin, Margaret Haworth-Brockman, Yoav Keynan, Zulma Vanessa Rueda","doi":"10.3390/tropicalmed10050139","DOIUrl":"10.3390/tropicalmed10050139","url":null,"abstract":"Background: We aimed to describe trends in M. genitalium prevalence and associated resistance in Canada between 1980 and 2022.Methods: Ecological study and a scoping review. We collected publicly available data published by the governments of all Canadian provinces and territories. We also systematically searched PubMed, Medline, Embase, and grey literature using the keywords 'M. genitalium', 'Canada', and all provinces and territories. We reported M. genitalium prevalence, age, sex, gender, symptoms, coinfections, sample types used for diagnosis, and macrolide and fluoroquinolone resistance rates.Results: National or provincial surveillance systems for M. genitalium are absent. Eight studies reported the epidemiology of M. genitalium. The prevalence ranged between 3% in Quebec and 30.3% in Ontario. Half of the patients reported symptoms. The most collected sample for M. genitalium diagnosis was urine, followed by cervical and urethral swabs. Co-infection with Chlamydia trachomatis was reported in 3.3% to 16.4% of cases and with Neisseria gonorrhoeae in 0.0% to 24.0%. Macrolide resistance ranged between 25% and 82.1%, and fluoroquinolone resistance between 0.0% and 29.1%.Conclusions: M. genitalium prevalence and resistance rates varied by sex, gender, province, and specimen type. In the absence of routine surveillance, incomplete data hinders understanding the bacterium's natural history, its impact on some key groups, and the tracking of antibiotic resistance.","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":"10 5","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12115471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in Malaria Patterns in Comoros from 2010 to 2021: A Comparative Study with Sub-Saharan Africa. 2010年至2021年科摩罗疟疾模式变化：与撒哈拉以南非洲的比较研究。

IF 2.8 4区医学

Tropical Medicine and Infectious Disease Pub Date : 2025-05-19 DOI: 10.3390/tropicalmed10050138

Sheng Zhou, Linxin Yu, Jianming Liang, Wei Xie, Guoming Li, Changsheng Deng, Jianping Song, Guanyang Zou, Yinhuan Chen

{"title":"Changes in Malaria Patterns in Comoros from 2010 to 2021: A Comparative Study with Sub-Saharan Africa.","authors":"Sheng Zhou, Linxin Yu, Jianming Liang, Wei Xie, Guoming Li, Changsheng Deng, Jianping Song, Guanyang Zou, Yinhuan Chen","doi":"10.3390/tropicalmed10050138","DOIUrl":"10.3390/tropicalmed10050138","url":null,"abstract":"Background: Recent setbacks in malaria control in Comoros demand a reassessment of its evolving epidemiology.Methods: Using the Global Burden of Disease (GBD) Study 2021 data, we analyzed malaria trends from 2010 to 2021, stratified by sex. We quantified the contributions of demographic and epidemiological factors to these trends and identified risk factors for malaria-related disability-adjusted life years (DALYs).Results: From 2010 to 2021, malaria cases, deaths, and DALYs in Comoros fell by -90.22%, -94.44%, and -94.88%; and the corresponding age-standardized rates declined with EAPCs of -18.70% (95% CI: -33.77 to -0.20), -23.89% (95% CI: -36.58 to -8.66), and -24.49% (95% CI: -36.88 to -9.66), with steeper declines in males. Nevertheless, all indicators increased in 2018 and again in 2021. In sub-Saharan Africa, only cases increased, while other metrics declined slightly. In Comoros, incidence shifted mainly to adults ≥25 years, unlike sub-Saharan Africa, where children < 5 years were most affected. Population growth drove increases in cases, deaths and DALYs, whereas epidemiological shifts had the opposite effect. Child underweight was the leading risk factor for malaria DALYs.Conclusions: Existing interventions can achieve malaria control in Comoros; however, rebounds in 2018 and 2021 highlight the need to identify and address drivers of resurgence.","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":"10 5","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12115432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visceral Leishmaniasis in Pediatrics: A Case Series and a Narrative Review with Global Insights. 内脏利什曼病在儿科：一个案例系列和叙事回顾与全球视野。

IF 2.8 4区医学

Tropical Medicine and Infectious Disease Pub Date : 2025-05-17 DOI: 10.3390/tropicalmed10050136

Valentina Andreottola, Chiara Santucci, Tommaso Bellini, Simona Matarese, Francesca Canzoneri, Gianluca Dell'Orso, Martina Finetti, Francesca Fioredda, Alessio Mesini, Emanuela Piccotti

{"title":"Visceral Leishmaniasis in Pediatrics: A Case Series and a Narrative Review with Global Insights.","authors":"Valentina Andreottola, Chiara Santucci, Tommaso Bellini, Simona Matarese, Francesca Canzoneri, Gianluca Dell'Orso, Martina Finetti, Francesca Fioredda, Alessio Mesini, Emanuela Piccotti","doi":"10.3390/tropicalmed10050136","DOIUrl":"10.3390/tropicalmed10050136","url":null,"abstract":"Visceral leishmaniasis (VL) is a severe parasitic disease caused by Leishmania spp., with a significant impact on pediatric populations, particularly in endemic regions. The diagnosis of VL in children requires a high index of suspicion, as clinical manifestations-such as prolonged fever, hepatosplenomegaly, and pancytopenia-overlap with other infectious and hematologic diseases. While serological and molecular tests aid in detection, bone marrow aspiration remains the gold standard for definitive diagnosis. In this case series, we describe five pediatric patients diagnosed with VL in Italy, emphasizing the importance of a timely and accurate diagnostic approach. Liposomal amphotericin B (LAmB) is the first-line treatment in Southern Europe due to its high efficacy and reduced toxicity. Our patients received a standard regimen of 3 mg/kg daily for five days, plus an additional dose on day 10, leading to rapid clinical improvement. However, some cases required supportive care, such as red blood cell transfusions, particularly in patients with co-infections. Despite being a neglected disease, VL is re-emerging in Europe, influenced by climate change, increased pet ownership, and migration from endemic regions. Prevention strategies focus on vector control, canine vaccination, and public health awareness. The global rise in pediatric VL highlights the need for improved surveillance, access to affordable treatments, and the development of effective vaccines to mitigate the disease burden in both endemic and non-endemic areas.","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":"10 5","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12115772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patterns, Barriers and Facilitators of Responsiveness to Text Message Medication Reminders Among Youth Living with HIV in Southwest Nigeria. 尼日利亚西南部感染艾滋病毒的青年对短信药物提醒的反应模式、障碍和促进因素。

IF 2.8 4区医学

Tropical Medicine and Infectious Disease Pub Date : 2025-05-17 DOI: 10.3390/tropicalmed10050137

Mobolanle Balogun, Aniekan E Ulor, Mayowa Odofin, Olufunmilola Idowu, Mmeli V Chukwu, Abiola Aina, Oluwanifemi Adeshina, Hameed Adelabu, Lisa M Kuhns, Amy K Johnson, Kehinde M Kuti, Nadia A Sam-Agudu, Titilope Badru, Marbella Cervantes, Robert Garofalo, Babafemi Taiwo, Alani S Akanmu

{"title":"Patterns, Barriers and Facilitators of Responsiveness to Text Message Medication Reminders Among Youth Living with HIV in Southwest Nigeria.","authors":"Mobolanle Balogun, Aniekan E Ulor, Mayowa Odofin, Olufunmilola Idowu, Mmeli V Chukwu, Abiola Aina, Oluwanifemi Adeshina, Hameed Adelabu, Lisa M Kuhns, Amy K Johnson, Kehinde M Kuti, Nadia A Sam-Agudu, Titilope Badru, Marbella Cervantes, Robert Garofalo, Babafemi Taiwo, Alani S Akanmu","doi":"10.3390/tropicalmed10050137","DOIUrl":"10.3390/tropicalmed10050137","url":null,"abstract":"The iCARE Nigeria study is evaluating a daily text message medication reminder intervention (TXTXT) to improve viral suppression and medication adherence among youth living with HIV (YLH), aged 15-24 years. In this sub-study, we evaluated text message responsiveness (text-back) at 24 weeks of the intervention as an indicator of engagement, as well as barriers and facilitators at one of six clinical study sites. Differences in responses by age group, birth sex, schooling status, education, mode of infection, and weekend/weekday and holiday/non-holiday periods were analyzed using t-test and multiple linear regression. Focus group discussions were conducted among three groups (low, average, and high text message responsiveness) and analyzed using a rapid content analysis approach. Overall, TXTXT responsiveness was 26.5% (4606/17,367); older age (18-24 years) and weekdays (versus weekends) were significantly associated with higher responsiveness. Facilitators included being comfortable receiving personalized text messages. Barriers included a lack of airtime and messages received late. Overall, text-back responsiveness to daily medication adherence messages among YLH was low, better among older participants, and higher on weekdays. Addressing barriers and promoting facilitators may improve responsiveness.","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":"10 5","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12115468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0