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Synergistic Effects on Hyperthermic Cancer Therapy Using Plasma-activated Acetated Ringer’s Solution 血浆活化醋酸化林格氏液在高温癌症治疗中的协同作用
Thermal Medicine Pub Date : 2021-12-15 DOI: 10.3191/thermalmed.37.141
Hiromasa Tanaka, M. Hori
{"title":"Synergistic Effects on Hyperthermic Cancer Therapy Using Plasma-activated Acetated Ringer’s Solution","authors":"Hiromasa Tanaka, M. Hori","doi":"10.3191/thermalmed.37.141","DOIUrl":"https://doi.org/10.3191/thermalmed.37.141","url":null,"abstract":"ラズマ活性酢酸リンゲル液との併用 田中 宏昌・堀 勝 名古屋大学低温プラズマ科学研究センター 近年,低温プラズマによるがん治療研究が盛 んに行われるようになり,その中でもプラズマを 照射した溶液(プラズマ活性溶液と呼ばれる) による抗腫瘍効果が注目を集めている.2012年 に プ ラ ズ マ 活 性 培 養 液(Plasma-Activated Medium, PAM)と称されるプラズマ照射した細胞 培養液がアストロサイトの正常細胞に対しては影 響しないが,脳腫瘍培養細胞に対して選択的に細 胞毒性を示すが報告されて以来,様々な溶液や 様々ながん細胞に対してプラズマ活性溶液の抗腫 瘍効果が報告されてきた.2016年にはプラズマ 活性乳酸リンゲル液やプラズマ活性酢酸リンゲル 液による抗腫瘍効果が報告され,それらの溶液 内の成分,作用機序,動物実験など,プラズマ活 性溶液の臨床応用に向けた研究が広く進められて いる. ここではハイパーサーミアに加えてプラズマ活 性酢酸リンゲル液(Plasma-activated Ringer’s acetated solution, PAA)を併用し,相乗的に抗腫 瘍効果を高めることを証明した研究内容について 紹介する.A549ヒト非小細胞肺癌細胞株を用い て,ハイパーサーミア(42 °C)及び PAAの相乗 効果が調べられた.ハイパーサーミア単独やPAA 単独に比べ,ハイパーサーミアとPAAの併用は相 乗的に A549細胞に対して細胞毒性を示すことが 示された.更に,ハイパーサーミアと PAAの併用 によりA549細胞の細胞内Caの増加が確認され たため,Transient Receptor potential(TRP)チャ ネルの 1種である TRPM2(TRP metastatin 2)の 機能が調べられた.TRPM2の阻害剤(2-aminoethoxydiphenyl borate, 2APB)や siTRPM2による遺 伝子のノックダウンにより,ハイパーサーミアと PAAによる細胞内 Caの増加と抗腫瘍効果が抑 制されたことから,ハイパーサーミアとPAAの併 用による抗腫瘍効果には TRPM2が関与している ことが証明された.さらに,A549細胞における ハイパーサーミアとPAAの併用により,細胞内活 性酸素種の増加,DNAの断片化,poly(ADPribose)polymerase-1(PARP-1)の活性化の促進, アポトーシスの誘導が示された.以上より,PAA 処理とハイパーサーミアの併用により細胞内活性 酸素種が増大し,その結果 DNAの断片化と PARP-1の活性化が促進される.そのことによっ て TRPM2が活性化されて,細胞内 Ca2+がさら に増加することで細胞死が誘導されるというメカ ニズムが提唱された.つまりハイパーサーミアは, がん細胞の PAAに対する感受性を相乗的に増強 する.正常細胞として用いられた線維芽細胞にお いては,ハイパーサーミアとPAAの併用による細 胞毒性は認められなかった. 最近,ハイパーサーミアと低温プラズマの併用 による抗腫瘍効果の増大が U937リンパ腫細胞株 で報告されており,ハイパーサーミアと低温プ ラズマ/プラズマ活性溶液との併用療法は,有望 な治療法として期待される.","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75608814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current Study of Temperature Distribution Analysis Considering the Cooling Effect of Blood Flow 考虑血流冷却作用的温度分布分析研究现状
Thermal Medicine Pub Date : 2021-09-15 DOI: 10.3191/THERMALMED.37.98
Y. Shindo
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引用次数: 0
Enhancement of Abscopal Effects on Hyperthermic Cancer Therapy Using an Immune Checkpoint Blockade 利用免疫检查点阻断增强肿瘤热疗的体外效应
Thermal Medicine Pub Date : 2021-09-15 DOI: 10.3191/THERMALMED.37.109
T. Kondo, J. Saitoh
{"title":"Enhancement of Abscopal Effects on Hyperthermic Cancer Therapy Using an Immune Checkpoint Blockade","authors":"T. Kondo, J. Saitoh","doi":"10.3191/THERMALMED.37.109","DOIUrl":"https://doi.org/10.3191/THERMALMED.37.109","url":null,"abstract":"","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81498342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nano-Particle Imaging for Magnetic Hyperthermia 磁热疗的纳米粒子成像
Thermal Medicine Pub Date : 2021-09-15 DOI: 10.3191/THERMALMED.37.106
H. Hasegawa
{"title":"Nano-Particle Imaging for Magnetic Hyperthermia","authors":"H. Hasegawa","doi":"10.3191/THERMALMED.37.106","DOIUrl":"https://doi.org/10.3191/THERMALMED.37.106","url":null,"abstract":"","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91193819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HIVEC Treatment with an Intravesical Perfusion System for Bladder Cancer 膀胱灌注HIVEC治疗膀胱癌
Thermal Medicine Pub Date : 2021-09-15 DOI: 10.3191/THERMALMED.37.100
N. Kawai, T. Kondo
{"title":"HIVEC Treatment with an Intravesical Perfusion System for Bladder Cancer","authors":"N. Kawai, T. Kondo","doi":"10.3191/THERMALMED.37.100","DOIUrl":"https://doi.org/10.3191/THERMALMED.37.100","url":null,"abstract":"","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75710020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photothermal Therapy to Improve Immune Checkpoint Blockade for Controlling Cancer 光热疗法改善免疫检查点阻断以控制癌症
Thermal Medicine Pub Date : 2021-09-15 DOI: 10.3191/THERMALMED.37.105
S. Masunaga
{"title":"Photothermal Therapy to Improve Immune Checkpoint Blockade for Controlling Cancer","authors":"S. Masunaga","doi":"10.3191/THERMALMED.37.105","DOIUrl":"https://doi.org/10.3191/THERMALMED.37.105","url":null,"abstract":"","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76581024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hippo Pathway and Hyperthermia 河马通路和热疗
Thermal Medicine Pub Date : 2021-09-15 DOI: 10.3191/THERMALMED.37.102
K. Ohtsuka
{"title":"Hippo Pathway and Hyperthermia","authors":"K. Ohtsuka","doi":"10.3191/THERMALMED.37.102","DOIUrl":"https://doi.org/10.3191/THERMALMED.37.102","url":null,"abstract":"","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82377515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of Cell Death by Mortalin/HSPA9 and Strategy for Cancer Therapy 死亡素/HSPA9对细胞死亡的调控及肿瘤治疗策略
Thermal Medicine Pub Date : 2021-09-15 DOI: 10.3191/THERMALMED.37.97
T. Kondo, K. Ohtsuka
{"title":"Regulation of Cell Death by Mortalin/HSPA9 and Strategy for Cancer Therapy","authors":"T. Kondo, K. Ohtsuka","doi":"10.3191/THERMALMED.37.97","DOIUrl":"https://doi.org/10.3191/THERMALMED.37.97","url":null,"abstract":"","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89715333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperthermia-induced Cell Death: - From Apoptosis to New Stage on Cell Death - 高温诱导的细胞死亡:从细胞凋亡到细胞死亡的新阶段
Thermal Medicine Pub Date : 2021-09-15 DOI: 10.3191/THERMALMED.37.63
T. Kondo, Zhao Qing-li, T. Mizukami, J. Saitoh
{"title":"Hyperthermia-induced Cell Death: - From Apoptosis to New Stage on Cell Death -","authors":"T. Kondo, Zhao Qing-li, T. Mizukami, J. Saitoh","doi":"10.3191/THERMALMED.37.63","DOIUrl":"https://doi.org/10.3191/THERMALMED.37.63","url":null,"abstract":"","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87859996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Cancer Therapy by Histotripsy 组织病理学治疗癌症
Thermal Medicine Pub Date : 2021-09-15 DOI: 10.3191/THERMALMED.37.103
T. Kondo
{"title":"Cancer Therapy by Histotripsy","authors":"T. Kondo","doi":"10.3191/THERMALMED.37.103","DOIUrl":"https://doi.org/10.3191/THERMALMED.37.103","url":null,"abstract":"","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84226603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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