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HSF1 Promotes T Cell Lymphoblastic Leukemia Progression by Controlling Cellular Energy Metabolism and mTORC1 Activation HSF1通过控制细胞能量代谢和mTORC1激活促进T淋巴细胞白血病进展
Thermal Medicine Pub Date : 2021-09-15 DOI: 10.3191/THERMALMED.37.95
K. Ohtsuka
{"title":"HSF1 Promotes T Cell Lymphoblastic Leukemia Progression by Controlling Cellular Energy Metabolism and mTORC1 Activation","authors":"K. Ohtsuka","doi":"10.3191/THERMALMED.37.95","DOIUrl":"https://doi.org/10.3191/THERMALMED.37.95","url":null,"abstract":"","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76990311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Direction for Development of Photothermal Therapy 光热疗法的发展方向
Thermal Medicine Pub Date : 2021-09-15 DOI: 10.3191/THERMALMED.37.108
Shinsuke Nomura, H. Tsujimoto, Y. Morimoto
{"title":"Direction for Development of Photothermal Therapy","authors":"Shinsuke Nomura, H. Tsujimoto, Y. Morimoto","doi":"10.3191/THERMALMED.37.108","DOIUrl":"https://doi.org/10.3191/THERMALMED.37.108","url":null,"abstract":"","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75806839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting of Collagen-specific Chaperone Heat Shock Protein 47 for Cancer Therapy 靶向胶原蛋白特异性伴侣热休克蛋白47用于癌症治疗
Thermal Medicine Pub Date : 2021-09-15 DOI: 10.3191/THERMALMED.37.79
A. Yoneda, Y. Tamura
{"title":"Targeting of Collagen-specific Chaperone Heat Shock Protein 47 for Cancer Therapy","authors":"A. Yoneda, Y. Tamura","doi":"10.3191/THERMALMED.37.79","DOIUrl":"https://doi.org/10.3191/THERMALMED.37.79","url":null,"abstract":"","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88253157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of Liquid-Liquid Phase Separation by Molecular Chaperones 分子伴侣对液-液分离的调控作用
Thermal Medicine Pub Date : 2021-07-05 DOI: 10.3191/thermalmed.37.31
Soichiro Kawagoe, Eiichiro Mori, T. Saio
{"title":"Regulation of Liquid-Liquid Phase Separation by Molecular Chaperones","authors":"Soichiro Kawagoe, Eiichiro Mori, T. Saio","doi":"10.3191/thermalmed.37.31","DOIUrl":"https://doi.org/10.3191/thermalmed.37.31","url":null,"abstract":"Molecular chaperones have been extensively studied as mediators in protein folding and quality control but are recently attracting increasing attention as regulators of liquid-liquid phase separation (LLPS). In this review, we summarize recent studies regarding molecular chaperones involved in LLPS regulation. We also provide a brief introduction of biophysical and structural studies on molecular chaperones in protein folding that depict how the molecular chaperones recognize client proteins and alter the folding process. Although little is known about the mechanism of regulation of LLPS, the understanding of molecular chaperones in protein folding will provide hints for LLPS regulation.","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82173962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Deep-Learning Approach for Non-Invasive Temperature Measurements Using Ultrasound Images 一种利用超声图像进行无创温度测量的深度学习方法
Thermal Medicine Pub Date : 2021-07-05 DOI: 10.3191/thermalmed.37.45
Y. Iseki, Tsugumi Nishidate
{"title":"A Deep-Learning Approach for Non-Invasive Temperature Measurements Using Ultrasound Images","authors":"Y. Iseki, Tsugumi Nishidate","doi":"10.3191/thermalmed.37.45","DOIUrl":"https://doi.org/10.3191/thermalmed.37.45","url":null,"abstract":"This paper proposes a deep-learning temperature measurement method using ultrasound images that is based on the thermal dependance of local changes in the speed of sound. In this method, the temperature distribution is measured using a non-invasive image analysis technique. In a previous study, we found a temperature measurement accuracy of 1.0 °C or less. However, our previous method has some disadvantages. First, the image analysis parameters (e.g., the size of the template and the cross-correlation threshold) are empirically determined. Second, it is necessary to obtain the thermal constant ktissue according to the type of tissue and the analysis parameters. To overcome these problems, we propose a new method using deep-learning. This new method is divided into three steps. The first step is to determine the image analysis parameters from the ultrasound images using a convolutional neural network (CNN). The second step is to analyze the image using the estimated analysis parameters to obtain a normalized temperature distribution. The third step is to determine the thermal constant ktissue to calibrate the temperature increase using multi-layered perceptron (MLP). In this paper, first, we propose three types of image fusion methods to input the ultrasound images into the CNN. Comparing the results of the three methods, we determine the optimal CNN structure. Second, we determine the optimal MLP structure by changing the number of hidden layers and neurons. Finally, as described above, we obtain the temperature distribution. Our results indicate that the proposed deep-learning method can effectively provide non-invasive temperature measurements.","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84567885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Significance of Category Classification of Novel Medical Products Originated from Japanese Academic Researches with Regards to Its Industrialization 源自日本学术研究的新型医疗产品类别分类对其产业化的意义
Thermal Medicine Pub Date : 2021-03-31 DOI: 10.3191/THERMALMED.37.25
T. Morino, N. Kawai, T. Yasui
{"title":"Significance of Category Classification of Novel Medical Products Originated from Japanese Academic Researches with Regards to Its Industrialization","authors":"T. Morino, N. Kawai, T. Yasui","doi":"10.3191/THERMALMED.37.25","DOIUrl":"https://doi.org/10.3191/THERMALMED.37.25","url":null,"abstract":"This communication to chief editor discussed category classification process of medical products originated from Japanese academic researches, showing that of authorsʼ product for example. US guideline in 2017, “Classification of Products as Drugs and Devices & Additional Products. Classification Issues: Guidance for Industry and FDA Staff. Final Guidance”, was refereed and key provisions for device definition were introduced. In US, medical products were defined as device when primary intended purpose of the product was not achieved through chemical action. Examples of FDAʼs device definition of two kinds of heat generating nanoparticles were shown as gold nanoparticles illustrated in the guideline and magnetite cationic lipid composite particles (formerly named magnetite cationic liposomes) originated from Japanese academic research. Concerning category classification process in Japan, necessity of detailed discussion between academia and administrative agency was issued in order to facilitate its technology transfer to Japanese industry.","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86285512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
“Oncothermia” (Modulated electro-hyperthermia) “肿瘤热疗”(调制电热疗)
Thermal Medicine Pub Date : 2021-03-31 DOI: 10.3191/THERMALMED.37.1
M. Kanamori, Tsutomu Sato, T. Shima, J. Saitoh, G. Andócs, T. Kondo
{"title":"“Oncothermia” (Modulated electro-hyperthermia)","authors":"M. Kanamori, Tsutomu Sato, T. Shima, J. Saitoh, G. Andócs, T. Kondo","doi":"10.3191/THERMALMED.37.1","DOIUrl":"https://doi.org/10.3191/THERMALMED.37.1","url":null,"abstract":"","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80790107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heat Dose Based Large Tumor Treatment with Multiple Site Injections of Heat-generating Nanoparticles Dispersible within Tumor Tissue 基于热剂量的大肿瘤治疗:多部位注射可分散于肿瘤组织内的发热纳米颗粒
Thermal Medicine Pub Date : 2020-12-25 DOI: 10.3191/THERMALMED.36.101
T. Morino, A. Ito, T. Etani, T. Naiki, N. Kawai, T. Yasui
{"title":"Heat Dose Based Large Tumor Treatment with Multiple Site Injections of Heat-generating Nanoparticles Dispersible within Tumor Tissue","authors":"T. Morino, A. Ito, T. Etani, T. Naiki, N. Kawai, T. Yasui","doi":"10.3191/THERMALMED.36.101","DOIUrl":"https://doi.org/10.3191/THERMALMED.36.101","url":null,"abstract":": Solid cancer therapy based on necrosis induction with heat-generating nanoparticles has been developed in Japan. Heat was induced from intratumorally injected magnetite cationic lipid composite particles (MCL particles) by alternating magnetic field irradiations to kill cancer cells nearby located. In our previous report we have showed importance of heat dose index in vivo (J / cm 3 tumor volume) for tumor regression when 45 mg MCL particles were injected at a single site of 1.36 cm 3 tumor. Purpose of this study is to show rationale and utility of multiple site injections of MCL particles for treatment of large tumors more than 1.36 cm 3 . Rat mammary tumors were induced by 7,12-dimethylbenz ［ a ］ anthracene (DMBA) and tumors in range of 2.19 ～ 3.81 cm 3 were applied to treatment experiment. Treatment condition was designed to reproduce the heat generation condition of the 1.36 cm 3 tumor treatment at every multiple injection site in rat mammary tumors. Tumor volume divided by number of injection sites (cm 3 / site) was set to close to 1.36 cm 3 / site and 45 mg MCL particles were administered at multiple sites to keep even spaces among injection sites. Three irradiation conditions were set to give close heat dose in vivo (J / cm 3 ) of the 1.36 cm 3 tumor treatment. Treatment under designed conditions resulted in complete regression of rat tumors at 21 days after the treatment, showing theoretical validity of design procedures for the multiple site injections. Novel concept of necrosed tumor volume from an injection site (cm 3 / site) and its actual value under a standard injection condition of 45 mg-MCL / site were described and its use in clinic was discussed.","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79009706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can be Hikeshi a Potential Target for Hyperthermic Therapy? Hikeshi能成为热疗的潜在靶点吗?
Thermal Medicine Pub Date : 2020-12-25 DOI: 10.3191/THERMALMED.36.91
Y. Tabuchi, Tatsuya Yunoki
{"title":"Can be Hikeshi a Potential Target for Hyperthermic Therapy?","authors":"Y. Tabuchi, Tatsuya Yunoki","doi":"10.3191/THERMALMED.36.91","DOIUrl":"https://doi.org/10.3191/THERMALMED.36.91","url":null,"abstract":": While hyperthermia (HT) is a promising modality for cancer therapy, major difficulty with the use of HT is the development of thermotolerance due to the elevation of heat shock proteins (HSPs), which function as molecular chaperons. Among the HSPs, Hsp70 possesses cytoprotective activity and plays a critical role in the acquisition of thermotolerance. Upon heat stress, Hsp70 rapidly translocates from the cytoplasm to nucleus. Recently, the protein Hikeshi, also known as the gene product of C11orf73, has been shown to function as a nuclear import carrier of Hsp70 under heat-stress conditions. Knockdown of Hikeshi significantly enhances sensitivity to HT and mild HT in the presence — but not the absence — of heat-stress in human cancer cells. Moreover, upregulation of Hikeshi expression is observed in human gastric or renal cancer. It has also been suggested that functional defects leading to homozygosity for a missense mutation, p. Cys4Ser or p. Val54Leu, in Hikeshi cause leukoencephalopathy in Finnish or Ashkenazi-Jewish patients, respectively. This review summarizes the physiological and pathological roles of Hikeshi and discusses its potential as a target in HT therapy.","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88224536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Development of Ultrasonic Cancer Therapy 超声治疗癌症的新进展
Thermal Medicine Pub Date : 2020-09-25 DOI: 10.3191/thermalmed.36.75
T. Kondo, R. Suzuki, N. Sasaki, M. Takiguchi
{"title":"New Development of Ultrasonic Cancer Therapy","authors":"T. Kondo, R. Suzuki, N. Sasaki, M. Takiguchi","doi":"10.3191/thermalmed.36.75","DOIUrl":"https://doi.org/10.3191/thermalmed.36.75","url":null,"abstract":"","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84161300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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