{"title":"低温プラズマおよびハイパーサーミア併用効果を用いたがん治療の可能性","authors":"TAKASHI KONDO, HIROSHI HASHIZUME, HIROMASA TANAKA, KENJI ISHIKAWA, JUN-ICHI SAITOH, MASARU HORI","doi":"10.3191/thermalmed.39.21","DOIUrl":"https://doi.org/10.3191/thermalmed.39.21","url":null,"abstract":"Low temperature plasma (LTP) has been proposed as a novel therapeutic method for its anti-cancer potential. However, its biological effects in combination with other physical modalities remain to be elusive. Therefore, this study was aimed to determine the effects of low temperature helium plasma (He-LTP) in combination with mild hyperthermia (HT, 42℃ for 20 min). Human lymphoma U937 cells were exposed to HT, immediately after He-LTP treatment. He-LTP in combination with HT showed enhanced cell death, which was accompanied by increased intracellular reactive oxygen species (ROS) production. These findings suggest that He-LTP can enhance the apoptotic effects of mild HT due to the increased in intracellular ROS generation as He-LTP has been known to caused marked induction of ROS in the aqueous medium. These findings would be helpful when establishing a therapeutic strategy for LTP in combination with mild HT. Here, the biological effects of LTP, and the combination with hyperthermia and LTP or LTP -activated solutions for cancer therapy have been summarized in this review.","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135132061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thermal MedicinePub Date : 2023-06-30DOI: 10.3191/thermalmed.39.3
K. Ohtsuka
{"title":"Discovery of Mammalian HSP40 and Subsequent Progress","authors":"K. Ohtsuka","doi":"10.3191/thermalmed.39.3","DOIUrl":"https://doi.org/10.3191/thermalmed.39.3","url":null,"abstract":"","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82109039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thermal MedicinePub Date : 2022-12-28DOI: 10.3191/thermalmed.38.72
R. Suzuki
{"title":"Engineering of Probiotic Bacteria System for the Temperature-sensitive Production of Immune Checkpoint Blockade Nanobodies by Intratumor Heating with Focused Ultrasound","authors":"R. Suzuki","doi":"10.3191/thermalmed.38.72","DOIUrl":"https://doi.org/10.3191/thermalmed.38.72","url":null,"abstract":"","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73548031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thermal MedicinePub Date : 2022-12-28DOI: 10.3191/thermalmed.38.71
K. Mitsudo
{"title":"Photoimmunotherapy for Head and Neck Cancer","authors":"K. Mitsudo","doi":"10.3191/thermalmed.38.71","DOIUrl":"https://doi.org/10.3191/thermalmed.38.71","url":null,"abstract":"","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73918363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thermal MedicinePub Date : 2022-12-28DOI: 10.3191/thermalmed.38.75
Y. Iseki
{"title":"Trends in Temperature Estimation around Main Blood Vessel","authors":"Y. Iseki","doi":"10.3191/thermalmed.38.75","DOIUrl":"https://doi.org/10.3191/thermalmed.38.75","url":null,"abstract":"","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76889364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thermal MedicinePub Date : 2022-10-01DOI: 10.3191/thermalmed.38.68
M. Kaneko, A. Ito
{"title":"Study on the Relationship between Structure and Function of Iron Oxide Nanoflowers for Efficient Hyperthermia","authors":"M. Kaneko, A. Ito","doi":"10.3191/thermalmed.38.68","DOIUrl":"https://doi.org/10.3191/thermalmed.38.68","url":null,"abstract":"","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79693444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thermal MedicinePub Date : 2022-10-01DOI: 10.3191/thermalmed.38.63
Takashi Kondo, J. Saitoh
{"title":"In Vivo Evaluation of Oxidized Multiwalled-carbon Nanotubes-mediated Hyperthermia Treatment for Breast Cancer","authors":"Takashi Kondo, J. Saitoh","doi":"10.3191/thermalmed.38.63","DOIUrl":"https://doi.org/10.3191/thermalmed.38.63","url":null,"abstract":"","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78863932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thermal MedicinePub Date : 2022-10-01DOI: 10.3191/thermalmed.38.66
N. Kawai
{"title":"Long-term Experience with RF-CHT for NMIMC","authors":"N. Kawai","doi":"10.3191/thermalmed.38.66","DOIUrl":"https://doi.org/10.3191/thermalmed.38.66","url":null,"abstract":"","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75263924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}