低温プラズマおよびハイパーサーミア併用効果を用いたがん治療の可能性

TAKASHI KONDO, HIROSHI HASHIZUME, HIROMASA TANAKA, KENJI ISHIKAWA, JUN-ICHI SAITOH, MASARU HORI
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Abstract

Low temperature plasma (LTP) has been proposed as a novel therapeutic method for its anti-cancer potential. However, its biological effects in combination with other physical modalities remain to be elusive. Therefore, this study was aimed to determine the effects of low temperature helium plasma (He-LTP) in combination with mild hyperthermia (HT, 42℃ for 20 min). Human lymphoma U937 cells were exposed to HT, immediately after He-LTP treatment. He-LTP in combination with HT showed enhanced cell death, which was accompanied by increased intracellular reactive oxygen species (ROS) production. These findings suggest that He-LTP can enhance the apoptotic effects of mild HT due to the increased in intracellular ROS generation as He-LTP has been known to caused marked induction of ROS in the aqueous medium. These findings would be helpful when establishing a therapeutic strategy for LTP in combination with mild HT. Here, the biological effects of LTP, and the combination with hyperthermia and LTP or LTP -activated solutions for cancer therapy have been summarized in this review.
使用低温等离子体和hypersurmia联合治疗癌症的可能性
低温等离子体(LTP)因其抗癌潜力而被提出作为一种新的治疗方法。然而,其生物效应与其他物理模式的结合仍然是难以捉摸的。因此,本研究旨在探讨低温氦等离子体(He-LTP)联合轻度热疗(HT, 42℃,20 min)的效果。人淋巴瘤U937细胞在He-LTP治疗后立即暴露于HT。He-LTP联合HT可增强细胞死亡,并伴有细胞内活性氧(ROS)产生的增加。这些发现表明,He-LTP可以通过增加细胞内ROS的生成来增强轻度HT的凋亡作用,因为已知He-LTP在水介质中引起明显的ROS诱导。这些发现将有助于建立LTP联合轻度HT的治疗策略。本文就LTP的生物学效应以及与热疗、LTP或LTP活化溶液联合治疗癌症进行综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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