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Identifying and Addressing the Barriers to Spasticity Management Across the Post-Stroke Continuum 识别和解决卒中后连续痉挛管理的障碍
IF 2.4 4区 医学
Toxicon Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108745
Gerard E. Francisco , Jörg Wissel , Raphaël Gross , Heather Walker , Francesca Bianchi , Steven Escaldi , Monica Verduzco-Gutierrez , Ganesh Bavikatte , Maximo Zimmerman
{"title":"Identifying and Addressing the Barriers to Spasticity Management Across the Post-Stroke Continuum","authors":"Gerard E. Francisco , Jörg Wissel , Raphaël Gross , Heather Walker , Francesca Bianchi , Steven Escaldi , Monica Verduzco-Gutierrez , Ganesh Bavikatte , Maximo Zimmerman","doi":"10.1016/j.toxicon.2025.108745","DOIUrl":"10.1016/j.toxicon.2025.108745","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108745"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Botulinum Neurotoxin Prophylaxis for Sialorrhea in Dementia: A Case Report on Preventing Recurrent Bronchopneumonia and Improving Clinical Outcomes 肉毒杆菌神经毒素预防痴呆患者唾液分泌：预防支气管肺炎复发和改善临床结果的一例报告
IF 2.4 4区 医学
Toxicon Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108730
Nicu Catalin Draghici , Dafin Fior Mureşanu
{"title":"Botulinum Neurotoxin Prophylaxis for Sialorrhea in Dementia: A Case Report on Preventing Recurrent Bronchopneumonia and Improving Clinical Outcomes","authors":"Nicu Catalin Draghici , Dafin Fior Mureşanu","doi":"10.1016/j.toxicon.2025.108730","DOIUrl":"10.1016/j.toxicon.2025.108730","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108730"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proteomic and biochemical characterization of Bothrops pubescens (Serpentes: Viperidae) venom 短毛蝮蛇毒液的蛋白质组学和生化特征。
IF 2.4 4区 医学
Toxicon Pub Date : 2026-03-01 Epub Date: 2025-12-15 DOI: 10.1016/j.toxicon.2025.108953
Patricia Berasain , Antonio Pinto , André Zelanis , Mikaela Cúparo , Silvana Baletta , Santiago Carreira , Charley Staats , Carlos Termignoni , Jolene K. Diedrich , John Yates III , Victor Morais
{"title":"Proteomic and biochemical characterization of Bothrops pubescens (Serpentes: Viperidae) venom","authors":"Patricia Berasain ,&nbsp;Antonio Pinto ,&nbsp;André Zelanis ,&nbsp;Mikaela Cúparo ,&nbsp;Silvana Baletta ,&nbsp;Santiago Carreira ,&nbsp;Charley Staats ,&nbsp;Carlos Termignoni ,&nbsp;Jolene K. Diedrich ,&nbsp;John Yates III ,&nbsp;Victor Morais","doi":"10.1016/j.toxicon.2025.108953","DOIUrl":"10.1016/j.toxicon.2025.108953","url":null,"abstract":"<div><div><em>Bothrops pubescens</em> is a clinically significant viperid snake species in Uruguay, accounting for over 60 cases of human envenomation annually, alongside <em>Bothrops alternatus</em>. Formerly classified within the <em>Bothrops neuwiedi</em> complex, recent taxonomic revisions now restrict its distribution to Rio Grande do Sul (Brazil) and Uruguay. This species is not very robust, with a body length ranging from 22 to 92 cm and displays a distinctive dorsolateral pattern consisting of dark brown trapezoidal blotches on each side.</div><div>The venom of <em>B. pubescens</em> exhibits toxicological properties typical of the <em>Bothrops</em> genus, including coagulopathy and severe local tissue damage, which may result in limb amputation in extreme cases. As in other <em>Bothrops</em> species, metalloproteinases are the most abundant toxins, accompanied by high levels of phospholipase A<sub>2</sub>, serine proteases, L-amino acid oxidases, and C-type lectins. Minor venom components include vascular endothelial growth factor (VEGF), nerve growth factor (NGF), hyaluronidases, and cysteine-rich secretory proteins (CRISPs).</div><div>Recent studies suggest that <em>B. pubescens</em> and <em>B. diporus</em> share a common evolutionary lineage and display highly similar venom compositions. In our study, biochemical and proteomic analyses revealed a venom profile in Uruguayan <em>B. pubescens</em> closely resembling that of <em>B. diporus</em> from Argentina yet differing slightly from <em>B. pubescens</em> specimens in Brazil.</div></div>","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108953"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145775845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Ultrasound Guidance in Botulinum Neurotoxin A Injections for Facial Nerve Neuropathy and Hemifacial Spasm: Improving Efficacy and Safety 超声引导下肉毒毒素A注射治疗面神经病变及面肌痉挛：提高疗效和安全性
IF 2.4 4区 医学
Toxicon Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108684
Alexander Balbert , Svetlana Khatkova , Ekaterina Moroshek
{"title":"The Role of Ultrasound Guidance in Botulinum Neurotoxin A Injections for Facial Nerve Neuropathy and Hemifacial Spasm: Improving Efficacy and Safety","authors":"Alexander Balbert ,&nbsp;Svetlana Khatkova ,&nbsp;Ekaterina Moroshek","doi":"10.1016/j.toxicon.2025.108684","DOIUrl":"10.1016/j.toxicon.2025.108684","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108684"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blepharospasm Presenting as Facial Pain and “Sinus” Headache: A Case Series 眼睑痉挛表现为面部疼痛和“窦性”头痛：一个病例系列
IF 2.4 4区 医学
Toxicon Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108680
Julius Anang
{"title":"Blepharospasm Presenting as Facial Pain and “Sinus” Headache: A Case Series","authors":"Julius Anang","doi":"10.1016/j.toxicon.2025.108680","DOIUrl":"10.1016/j.toxicon.2025.108680","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108680"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Botulinum Neurotoxin Therapy in the Treatment of Prolonged Hemifacial Spasm in Combination With Facial Neuropathy 肉毒杆菌神经毒素治疗面神经病变合并长时间面肌痉挛
IF 2.4 4区 医学
Toxicon Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108677
M.A. Akulov , V.N. Shimansky , V.K. Poshataev , O.R. Orlova , V.O. Zakharov
{"title":"Botulinum Neurotoxin Therapy in the Treatment of Prolonged Hemifacial Spasm in Combination With Facial Neuropathy","authors":"M.A. Akulov ,&nbsp;V.N. Shimansky ,&nbsp;V.K. Poshataev ,&nbsp;O.R. Orlova ,&nbsp;V.O. Zakharov","doi":"10.1016/j.toxicon.2025.108677","DOIUrl":"10.1016/j.toxicon.2025.108677","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108677"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological Differences Between Botulinum Toxin Type A 900 kDa Complex and 150 kDa Neurotoxin Protein A型肉毒毒素900 kDa复合物与150 kDa神经毒素蛋白的药理差异
IF 2.4 4区 医学
Toxicon Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108706
Ron S. Broide , Greg Nicholson , Michelle Cano , Dave Canty , Terry Boodhoo , Amy D. Brideau-Andersen , Mitchell F. Brin
{"title":"Pharmacological Differences Between Botulinum Toxin Type A 900 kDa Complex and 150 kDa Neurotoxin Protein","authors":"Ron S. Broide ,&nbsp;Greg Nicholson ,&nbsp;Michelle Cano ,&nbsp;Dave Canty ,&nbsp;Terry Boodhoo ,&nbsp;Amy D. Brideau-Andersen ,&nbsp;Mitchell F. Brin","doi":"10.1016/j.toxicon.2025.108706","DOIUrl":"10.1016/j.toxicon.2025.108706","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108706"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phenomenological Approach To Spastic Movement Disorders 痉挛性运动障碍的现象学研究
IF 2.4 4区 医学
Toxicon Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108696
Bo Biering-Sørensen , Jörg Wissel , Raymond Rosales , Rajiv Reebye , Jorge Jacinto , Gerard E. Francisco , Peter Sanderson , Per Ertzgaard
{"title":"Phenomenological Approach To Spastic Movement Disorders","authors":"Bo Biering-Sørensen ,&nbsp;Jörg Wissel ,&nbsp;Raymond Rosales ,&nbsp;Rajiv Reebye ,&nbsp;Jorge Jacinto ,&nbsp;Gerard E. Francisco ,&nbsp;Peter Sanderson ,&nbsp;Per Ertzgaard","doi":"10.1016/j.toxicon.2025.108696","DOIUrl":"10.1016/j.toxicon.2025.108696","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108696"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Longitudinal Comparison of BoNT Dose Development Across Different Preparations in Patients With Cervical Dystonia 不同制剂对颈肌张力障碍患者BoNT剂量发展的纵向比较
IF 2.4 4区 医学
Toxicon Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108694
Vera Bertsch , Mandana Mirshakkeh , Thomas Gasser , Ebba Lohmann
{"title":"Longitudinal Comparison of BoNT Dose Development Across Different Preparations in Patients With Cervical Dystonia","authors":"Vera Bertsch ,&nbsp;Mandana Mirshakkeh ,&nbsp;Thomas Gasser ,&nbsp;Ebba Lohmann","doi":"10.1016/j.toxicon.2025.108694","DOIUrl":"10.1016/j.toxicon.2025.108694","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108694"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-COVID Cervical Dystonia: A Case Report covid - 19后颈肌张力障碍1例报告
IF 2.4 4区 医学
Toxicon Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108714
Maria Chondrogiorgi, Spiridon Konitsiotis
{"title":"Post-COVID Cervical Dystonia: A Case Report","authors":"Maria Chondrogiorgi,&nbsp;Spiridon Konitsiotis","doi":"10.1016/j.toxicon.2025.108714","DOIUrl":"10.1016/j.toxicon.2025.108714","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108714"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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