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Ulcerative colitis: clinical biomarkers, therapeutic targets, and emerging treatments 溃疡性结肠炎：临床生物标记物、治疗目标和新兴疗法
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-09-10 DOI: 10.1016/j.tips.2024.08.003
Phurpa Wangchuk, Karma Yeshi, Alex Loukas
{"title":"Ulcerative colitis: clinical biomarkers, therapeutic targets, and emerging treatments","authors":"Phurpa Wangchuk, Karma Yeshi, Alex Loukas","doi":"10.1016/j.tips.2024.08.003","DOIUrl":"https://doi.org/10.1016/j.tips.2024.08.003","url":null,"abstract":"<p>Ulcerative colitis (UC) is one of the two forms of inflammatory bowel disease. It affects 5 million people globally, and is a chronic and recurring inflammation of the gastrointestinal tract with clinical presentation of abdominal pain, chronic diarrhea, rectal bleeding, and weight loss. The cause and the etiology of UC remain poorly understood. There is no cure and no ‘gold standard diagnostic’ for UC. The existing treatments are ineffective, and UC patients have a lower life expectancy with a risk of colorectal cancer. Recent studies in pathophysiology, clinical presentation, and biomarkers have significantly improved our understanding of UC. In this review we summarize recent advances in identifying novel clinical biomarkers, diagnostics, treatment targets, and emerging therapeutics. These insights are expected to assist in developing effective treatments for UC.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":"12 1","pages":""},"PeriodicalIF":13.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142203097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ensifentrine (Ohtuvayre™) for chronic obstructive pulmonary disease 治疗慢性阻塞性肺病的 Ensifentrine (Ohtuvayre™)
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-09-10 DOI: 10.1016/j.tips.2024.08.002
Sandra Hubert, Ayrin Kök-Carrière, Frédéric De Ceuninck
{"title":"Ensifentrine (Ohtuvayre™) for chronic obstructive pulmonary disease","authors":"Sandra Hubert, Ayrin Kök-Carrière, Frédéric De Ceuninck","doi":"10.1016/j.tips.2024.08.002","DOIUrl":"https://doi.org/10.1016/j.tips.2024.08.002","url":null,"abstract":"No Abstract","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":"20 1","pages":""},"PeriodicalIF":13.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142203094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-09-05 DOI: 10.1016/s0165-6147(24)00175-5
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s0165-6147(24)00175-5","DOIUrl":"https://doi.org/10.1016/s0165-6147(24)00175-5","url":null,"abstract":"No Abstract","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":"20 1","pages":""},"PeriodicalIF":13.8,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142203099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-09-05 DOI: 10.1016/s0165-6147(24)00171-8
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s0165-6147(24)00171-8","DOIUrl":"https://doi.org/10.1016/s0165-6147(24)00171-8","url":null,"abstract":"No Abstract","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":"55 1","pages":""},"PeriodicalIF":13.8,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142203101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging chemophysiological diversity of gut microbiota metabolites. 肠道微生物群代谢物新出现的化学生理学多样性。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-09-01 Epub Date: 2024-08-10 DOI: 10.1016/j.tips.2024.07.006
Xiaorong Lin, Kaixin He, Zhen Gu, Xiaohui Zhao
{"title":"Emerging chemophysiological diversity of gut microbiota metabolites.","authors":"Xiaorong Lin, Kaixin He, Zhen Gu, Xiaohui Zhao","doi":"10.1016/j.tips.2024.07.006","DOIUrl":"10.1016/j.tips.2024.07.006","url":null,"abstract":"<p><p>Human physiology is profoundly influenced by the gut microbiota, which generates a wide array of metabolites. These microbiota-derived compounds serve as signaling molecules, interacting with various cellular targets in the gastrointestinal tract and distant organs, thereby impacting our immune, metabolic, and neurobehavioral systems. Recent advancements have unveiled unique physiological functions of diverse metabolites derived from tryptophan (Trp) and bile acids (BAs). This review highlights the emerging chemophysiological diversity of these metabolites and discusses the role of chemical and biological tools in analyzing and therapeutically manipulating microbial metabolism and host targets, with the aim of bridging the chemical diversity with physiological complexity in host-microbe molecular interactions.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"824-838"},"PeriodicalIF":13.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structures reveal how SGLT inhibitors work. 结构揭示了 SGLT 抑制剂的工作原理。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-09-01 Epub Date: 2024-06-18 DOI: 10.1016/j.tips.2024.05.009
Zejian Sun, Wenhao Cui, Lei Chen
{"title":"Structures reveal how SGLT inhibitors work.","authors":"Zejian Sun, Wenhao Cui, Lei Chen","doi":"10.1016/j.tips.2024.05.009","DOIUrl":"10.1016/j.tips.2024.05.009","url":null,"abstract":"<p><p>Sodium glucose cotransporters (SGLTs) transport glucose against its concentration gradient by harnessing the electrochemical potential gradient of sodium ions. SGLT inhibitors are widely prescribed to treat diabetes and other conditions. Recent structural studies have uncovered how chemically diverse SGLT inhibitors bind and inhibit the transporter at the atomic level.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"760-763"},"PeriodicalIF":13.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frontiers in CAR-T cell therapy for autoimmune diseases. CAR-T 细胞疗法治疗自身免疫性疾病的前沿。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-09-01 Epub Date: 2024-08-14 DOI: 10.1016/j.tips.2024.07.005
Yan-Ruide Li, Zibai Lyu, Yuning Chen, Ying Fang, Lili Yang
{"title":"Frontiers in CAR-T cell therapy for autoimmune diseases.","authors":"Yan-Ruide Li, Zibai Lyu, Yuning Chen, Ying Fang, Lili Yang","doi":"10.1016/j.tips.2024.07.005","DOIUrl":"10.1016/j.tips.2024.07.005","url":null,"abstract":"<p><p>Chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapy has demonstrated significant success in treating cancers. The potential of CAR-T cells is now being explored in the context of autoimmune diseases. Recent clinical trials have shown sustained and profound elimination of autoreactive B cells by CAR-T cells, leading to promising autoimmune disease control with minimal safety concerns. These encouraging results have inspired further investigation into CAR-T cell applications for a broader range of autoimmune diseases and the development of advanced cell products with improved efficacy and safety. In this review, we discuss the mechanisms by which CAR-T cells target autoimmune conditions, summarize current preclinical models, and highlight ongoing clinical trials, including CAR-T therapy design, clinical outcomes, and challenges. Additionally, we discuss the limitations and future directions of CAR-T therapy in the treatment of autoimmune diseases.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"839-857"},"PeriodicalIF":13.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting epigenetic enzymes for autism treatment. 针对表观遗传酶治疗自闭症。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-09-01 Epub Date: 2024-07-20 DOI: 10.1016/j.tips.2024.06.009
Zhen Yan
{"title":"Targeting epigenetic enzymes for autism treatment.","authors":"Zhen Yan","doi":"10.1016/j.tips.2024.06.009","DOIUrl":"10.1016/j.tips.2024.06.009","url":null,"abstract":"<p><p>Emerging preclinical autism research has shown the therapeutic promise of pharmacological inhibitors for epigenetic enzymes, such as histone deacetylases (HDAC), euchromatic histone methyltransferases (EHMT), and lysine-specific histone demethylase 1A (LSD1). These interventions restore gene expression, synaptic function, and behavioral performance in autism models, highlighting a new strategy for autism treatment.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"764-767"},"PeriodicalIF":13.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11380587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
'Living drugs' target CD70 in advanced renal tumors. 针对晚期肾肿瘤CD70的 "活药物
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-09-01 Epub Date: 2024-07-29 DOI: 10.1016/j.tips.2024.07.002
Kilian Wagner, Peter J Siska
{"title":"'Living drugs' target CD70 in advanced renal tumors.","authors":"Kilian Wagner, Peter J Siska","doi":"10.1016/j.tips.2024.07.002","DOIUrl":"10.1016/j.tips.2024.07.002","url":null,"abstract":"<p><p>Cellular therapies against solid tumors face three major barriers: low persistence, insufficient specificity, and high costs. In a recent study, Pal et al. tackle these challenges in kidney cancer by using novel, 'persistence-tuned' allogeneic chimeric antigen receptor (CAR) T cells directed against a stable antigen.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"757-759"},"PeriodicalIF":13.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting the STAT3 pathway with STAT3 degraders. 用 STAT3 降解剂靶向 STAT3 通路。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-09-01 Epub Date: 2024-08-07 DOI: 10.1016/j.tips.2024.07.003
Zhijie Wang, Xiaotong Liao, Haiqi He, Xia Guo, Jianjun Chen
{"title":"Targeting the STAT3 pathway with STAT3 degraders.","authors":"Zhijie Wang, Xiaotong Liao, Haiqi He, Xia Guo, Jianjun Chen","doi":"10.1016/j.tips.2024.07.003","DOIUrl":"10.1016/j.tips.2024.07.003","url":null,"abstract":"<p><p>Signal transducer and activator of transcription 3 (STAT3) has been widely considered as a therapeutic target for various diseases, especially tumors. Thus far, several STAT3 inhibitors have been advanced to clinical trials; however, the development of STAT3 inhibitors is hindered by numerous dilemmas. Fortunately, STAT3 degraders represent an alternative and promising strategy to block STAT3, attracting extensive research interest. Here, we analyze the recent advancements of STAT3 degraders, including proteolysis targeting chimeras (PROTACs) and small-molecule natural products, focusing on their structures, mechanisms, and biological activities. We discuss the potential opportunities and challenges for developing STAT3 degraders. It is hoped that this Review will provide insights into the discovery of potent STAT3-targeting drugs.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"811-823"},"PeriodicalIF":13.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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