发布求助
文献互助 智能选刊 最新文献

微小但强大：作为疫苗佐剂的小分子。

IF 13.9 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Trends in pharmacological sciences Pub Date : 2024-12-01 Epub Date: 2024-11-08 DOI:10.1016/j.tips.2024.10.011
Ari Joffe, Nancy Vázquez-Maldonado, Kentner L Singleton, Wolfgang W Leitner
{"title":"微小但强大：作为疫苗佐剂的小分子。","authors":"Ari Joffe, Nancy Vázquez-Maldonado, Kentner L Singleton, Wolfgang W Leitner","doi":"10.1016/j.tips.2024.10.011","DOIUrl":null,"url":null,"abstract":"<p><p>Screening small molecule (SM) libraries now replaces traditional methods for vaccine adjuvant discovery. A study by Soni et al. highlights the use of primary human cells in high-throughput screening (HTS), leading to the discovery of a novel SM TLR7/8 agonist, PVP-037. This compound successfully restored vaccine-induced immune responses in aged mice.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"1097-1099"},"PeriodicalIF":13.9000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624981/pdf/","citationCount":"0","resultStr":"{\"title\":\"Tiny but mighty: small molecules as vaccine adjuvants.\",\"authors\":\"Ari Joffe, Nancy Vázquez-Maldonado, Kentner L Singleton, Wolfgang W Leitner\",\"doi\":\"10.1016/j.tips.2024.10.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Screening small molecule (SM) libraries now replaces traditional methods for vaccine adjuvant discovery. A study by Soni et al. highlights the use of primary human cells in high-throughput screening (HTS), leading to the discovery of a novel SM TLR7/8 agonist, PVP-037. This compound successfully restored vaccine-induced immune responses in aged mice.</p>\",\"PeriodicalId\":23250,\"journal\":{\"name\":\"Trends in pharmacological sciences\",\"volume\":\" \",\"pages\":\"1097-1099\"},\"PeriodicalIF\":13.9000,\"publicationDate\":\"2024-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624981/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Trends in pharmacological sciences\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.tips.2024.10.011\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/11/8 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in pharmacological sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.tips.2024.10.011","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/8 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0

摘要

筛选小分子 (SM) 库现已取代了发现疫苗佐剂的传统方法。Soni 等人的一项研究强调了在高通量筛选 (HTS) 中使用原代人体细胞，从而发现了一种新型 SM TLR7/8 激动剂 PVP-037。这种化合物成功地恢复了疫苗诱导的老年小鼠的免疫反应。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
分享
查看原文 本刊更多论文
Tiny but mighty: small molecules as vaccine adjuvants.

Screening small molecule (SM) libraries now replaces traditional methods for vaccine adjuvant discovery. A study by Soni et al. highlights the use of primary human cells in high-throughput screening (HTS), leading to the discovery of a novel SM TLR7/8 agonist, PVP-037. This compound successfully restored vaccine-induced immune responses in aged mice.

求助全文
通过发布文献求助，成功后即可免费获取论文全文。 去求助
来源期刊
Trends in pharmacological sciences
Trends in pharmacological sciences 医学-药学
CiteScore
23.90
自引率
0.70%
发文量
132
审稿时长
6-12 weeks
期刊介绍： Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research. The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics. Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles. Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信