发布求助
文献互助 智能选刊 最新文献

Trends in pharmacological sciences最新文献

筛选
英文 中文
Defeating MYC with drug combinations or dual-targeting drugs. 用药物组合或双靶向药物击败 MYC。
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-06-01 Epub Date: 2024-05-22 DOI: 10.1016/j.tips.2024.04.008
Philip E Thompson, Jake Shortt
{"title":"Defeating MYC with drug combinations or dual-targeting drugs.","authors":"Philip E Thompson, Jake Shortt","doi":"10.1016/j.tips.2024.04.008","DOIUrl":"10.1016/j.tips.2024.04.008","url":null,"abstract":"<p><p>Members of the MYC family of proteins are a major target for cancer drug discovery, but the development of drugs that block MYC-driven cancers has not yet been successful. Approaches to achieve success may include the development of combination therapies or dual-acting drugs that target MYC at multiple nodes. Such treatments hold the possibility of additive or synergistic activity, potentially reducing side effect profiles and the emergence of resistance. In this review, we examine the prominent MYC-related targets and highlight those that have been targeted in combination and/or dual-target approaches. Finally, we explore the challenges of combination and dual-target approaches from a drug development perspective.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":13.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141088679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune checkpoint blockade resistance in lung cancer: emerging mechanisms and therapeutic opportunities. 肺癌的免疫检查点阻断耐药性：新出现的机制和治疗机会。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-06-01 Epub Date: 2024-05-13 DOI: 10.1016/j.tips.2024.04.006
Jessica M Konen, Haoyi Wu, Don L Gibbons
{"title":"Immune checkpoint blockade resistance in lung cancer: emerging mechanisms and therapeutic opportunities.","authors":"Jessica M Konen, Haoyi Wu, Don L Gibbons","doi":"10.1016/j.tips.2024.04.006","DOIUrl":"10.1016/j.tips.2024.04.006","url":null,"abstract":"<p><p>Immune checkpoint blockade (ICB) therapy works by inhibiting suppressive checkpoints that become upregulated after T cell activation, like PD-1/PD-L1 and CTLA-4. While the initial FDA approvals of ICB have revolutionized cancer therapies and fueled a burgeoning immuno-oncology field, more recent clinical development of new agents has been slow. Here, focusing on lung cancer, we review the latest research uncovering tumor cell intrinsic and extrinsic ICB resistance mechanisms as major hurdles to treatment efficacy and clinical progress. These include genomic and non-genomic tumor cell alterations, along with host and microenvironmental factors like the microbiome, metabolite accumulation, and hypoxia. Together, these factors can cooperate to promote immunosuppression and ICB resistance. Opportunities to prevent resistance are constantly evolving in this rapidly expanding field, with the goal of moving toward personalized immunotherapeutic regimens.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":13.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11189143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140923442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TNIK's emerging role in cancer, metabolism, and age-related diseases. TNIK 在癌症、新陈代谢和老年相关疾病中的新作用。
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-06-01 Epub Date: 2024-05-21 DOI: 10.1016/j.tips.2024.04.010
Collin Y Ewald, Fadi E Pulous, Sarah Wing Yan Lok, Frank W Pun, Alex Aliper, Feng Ren, Alex Zhavoronkov
{"title":"TNIK's emerging role in cancer, metabolism, and age-related diseases.","authors":"Collin Y Ewald, Fadi E Pulous, Sarah Wing Yan Lok, Frank W Pun, Alex Aliper, Feng Ren, Alex Zhavoronkov","doi":"10.1016/j.tips.2024.04.010","DOIUrl":"10.1016/j.tips.2024.04.010","url":null,"abstract":"<p><p>Traf2- and Nck-interacting kinase (TNIK) has emerged as a key regulator of pathological metabolic signaling in several diseases and is a promising drug target. Originally studied for its role in cell migration and proliferation, TNIK possesses several newly identified functions that drive the pathogenesis of multiple diseases. Specifically, we evaluate TNIK's newfound roles in cancer, metabolic disorders, and neuronal function. We emphasize the implications of TNIK signaling in metabolic signaling and evaluate the translational potential of these discoveries. We also highlight how TNIK's role in many biological processes converges upon several hallmarks of aging. We conclude by discussing the therapeutic landscape of TNIK-targeting drugs and the recent success of clinical trials targeting TNIK.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":13.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing oncogenic signaling to kill cancer cells. 增强致癌信号，杀死癌细胞。
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-06-01 Epub Date: 2024-05-10 DOI: 10.1016/j.tips.2024.04.011
Maxim Noeparast, Oleg Timofeev, Martin Pichler
{"title":"Enhancing oncogenic signaling to kill cancer cells.","authors":"Maxim Noeparast, Oleg Timofeev, Martin Pichler","doi":"10.1016/j.tips.2024.04.011","DOIUrl":"10.1016/j.tips.2024.04.011","url":null,"abstract":"<p><p>Cancer-targeted therapies that inhibit oncogenic signaling often lead to resistance and recurrence. In a recent study, Dias et al. propose activating oncogenic pathways and inducing replication stress, resulting in cell death and tumor-suppressive mechanisms in colorectal cancer (CRC). This approach could spark a new wave of target discovery, and drug development and repurposing against cancer.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":13.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140909124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parvalbumin interneuron cell-to-network plasticity: mechanisms and therapeutic avenues 副突触中间神经元细胞对网络的可塑性：机制与治疗途径
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-05-18 DOI: 10.1016/j.tips.2024.04.003
Michael D. Hadler, Henrik Alle, Jörg R.P. Geiger
{"title":"Parvalbumin interneuron cell-to-network plasticity: mechanisms and therapeutic avenues","authors":"Michael D. Hadler, Henrik Alle, Jörg R.P. Geiger","doi":"10.1016/j.tips.2024.04.003","DOIUrl":"https://doi.org/10.1016/j.tips.2024.04.003","url":null,"abstract":"<p>Alzheimer’s disease (AD) and schizophrenia (SCZ) represent two major neuropathological conditions with a high disease burden. Despite their distinct etiologies, patients suffering from AD or SCZ share a common burden of disrupted memory functions unattended by current therapies. Recent preclinical analyses highlight cell-type-specific contributions of parvalbumin interneurons (PVIs), particularly the plasticity of their cellular excitability, towards intact neuronal network function (cell-to-network plasticity) and memory performance. Here we argue that deficits of PVI cell-to-network plasticity may underlie memory deficits in AD and SCZ, and we explore two therapeutic avenues: the targeting of PVI-specific neuromodulation, including by neuropeptides, and the recruitment of network synchrony in the gamma frequency range (40 Hz) by external stimulation. We finally propose that these approaches be merged under consideration of recent insights into human brain physiology.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":13.8,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141063672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eflornithine for treatment of high-risk neuroblastoma 依氟鸟氨酸治疗高危神经母细胞瘤
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-05-14 DOI: 10.1016/j.tips.2024.04.005
Jianxiong Jiang, Ying Yu
{"title":"Eflornithine for treatment of high-risk neuroblastoma","authors":"Jianxiong Jiang, Ying Yu","doi":"10.1016/j.tips.2024.04.005","DOIUrl":"https://doi.org/10.1016/j.tips.2024.04.005","url":null,"abstract":"No Abstract","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":13.8,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140925672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential for targeting small heat shock protein modifications 针对小型热休克蛋白修饰的潜力
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-05-03 DOI: 10.1016/j.tips.2024.04.002
Binyou Wang, Matthew R. Pratt
{"title":"Potential for targeting small heat shock protein modifications","authors":"Binyou Wang, Matthew R. Pratt","doi":"10.1016/j.tips.2024.04.002","DOIUrl":"https://doi.org/10.1016/j.tips.2024.04.002","url":null,"abstract":"<p>Small heat shock proteins (sHSPs) play key roles in cellular stress and several human diseases. The direct effects of some post-translational modifications (PTMs) on certain sHSPs have been characterized, raising the possibility that small molecules could be used to modulate these modifications and indirectly up- or downregulate sHSP activity.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":13.8,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140841750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-05-02 DOI: 10.1016/s0165-6147(24)00076-2
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s0165-6147(24)00076-2","DOIUrl":"https://doi.org/10.1016/s0165-6147(24)00076-2","url":null,"abstract":"No Abstract","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":13.8,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140841516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-05-02 DOI: 10.1016/s0165-6147(24)00072-5
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s0165-6147(24)00072-5","DOIUrl":"https://doi.org/10.1016/s0165-6147(24)00072-5","url":null,"abstract":"No Abstract","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":13.8,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140841544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging targets in lipid metabolism for cancer therapy 用于癌症治疗的脂质代谢新目标
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-05-01 DOI: 10.1016/j.tips.2024.04.007
Alexander R. Terry, Nissim Hay
{"title":"Emerging targets in lipid metabolism for cancer therapy","authors":"Alexander R. Terry, Nissim Hay","doi":"10.1016/j.tips.2024.04.007","DOIUrl":"https://doi.org/10.1016/j.tips.2024.04.007","url":null,"abstract":"","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":13.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141029448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信