Transplantation proceedings最新文献

{"title":"Catastrophic Outcome of Suspected Seventh-Day Syndrome After Liver Transplantation: Case Report and Literature Review","authors":"Xiao Wang ,&nbsp;Nianwei Xing ,&nbsp;Qiang Yang ,&nbsp;Peng Ding ,&nbsp;Yingdong Du","doi":"10.1016/j.transproceed.2025.07.023","DOIUrl":"10.1016/j.transproceed.2025.07.023","url":null,"abstract":"<div><h3>Background</h3><div>Seventh-Day Syndrome (7DS) is one of the early serious complications after liver transplantation (LT) with rapid deterioration and high mortality. The pathogenesis of such rare cases has not been clarified and effective intervention measures are lacking. This study describes the entire diagnosis and treatment process of a highly suspected 7DS patient, who ultimately died due to liver failure. In the rapidly developing information age of technology, we recommend exploring potential independent risk factors and establishing effective warning models based on clinical information to assist in clinical decision-making.</div></div><div><h3>Methods</h3><div>A 52-year-old patient with a recurrence of liver malignancy underwent LT after matching the liver source. The postoperative pathological results confirmed HCC and cirrhosis. Previous treatment history, test and examination results, surgical procedure, and postoperative treatments were evaluated comprehensively.</div></div><div><h3>Results</h3><div>The patient initially recovered smoothly after surgery, but developed a fever on postoperative day 6. Subsequently, liver enzyme levels sharply increased, and anti-immune rejection therapy was ineffective. Ultrasound examination showed a significant decrease in portal vein velocity or even no blood flow signal. These were consistent with previously reported clinical manifestations and also conformed to the currently proposed mechanisms of immune damage and ischemic injury theory. Treatment of the 7DS included steroid pulse therapy, thymoglobulin, intravenous immunoglobulin, and plasma exchange therapy. Unfortunately, with the rapid and irreversible damage to the graft function leading to liver failure, the patient ultimately died due to no chance of retransplantation.</div></div><div><h3>Conclusion</h3><div>7DS is a rare and highly lethal early serious complication after LT. Due to the unclear pathogenesis, rapid disease progression, and differences in cases, it presents significant challenges for prevention, diagnosis, and treatment. Utilizing big data analysis technology to identify potential risk factors and develop a warning system for the diagnosis and treatment of 7DS may enhance clinical decision-making in the future.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 7","pages":"Pages 1361-1368"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney Transplantation From a Brain-Dead Deceased Donor With Active Tuberculosis","authors":"Marta Kovacic ,&nbsp;Andro Koren ,&nbsp;Luciana Koren ,&nbsp;Anja Kovacic ,&nbsp;Lovro Krajina ,&nbsp;Nikolina Basic-Jukic","doi":"10.1016/j.transproceed.2025.07.018","DOIUrl":"10.1016/j.transproceed.2025.07.018","url":null,"abstract":"<div><div>Tuberculosis is one of the most common infections on a global scale. While in the 21st century it is practically endemic in some parts of the world, it poses as a constant threat to immunocompromised transplant patients. Apart from standards ways of transmission, transplant patients face another cause of transmission, infected donors. We present a case depicting two kidney transplantations from the same brain-dead deceased donor with active pulmonary tuberculosis.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 7","pages":"Pages 1344-1347"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144839582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Progression of a Child With Hypoplastic Left Heart Syndrome During the Waiting Period for Heart Transplantation: A Case Report","authors":"Pamela Galesso Lanza,&nbsp;Estela Azeka","doi":"10.1016/j.transproceed.2025.07.012","DOIUrl":"10.1016/j.transproceed.2025.07.012","url":null,"abstract":"<div><div>Congenital heart diseases, including hypoplastic left heart syndrome (HLHS), frequently lead to malnutrition, which can result in worse outcomes in critical and perioperative situations. This study presents a case report based on clinical and nutritional data extracted from the electronic medical record of a 1-year and 10-month-old male infant diagnosed with HLHS, hospitalized in a tertiary cardiology hospital while awaiting a heart transplant. The length of hospitalization while waiting for the organ was approximately 13 months. Upon hospital admission, the child presented with severe malnutrition according to the World Health Organization Child Growth Standards. Thus, the decision was made to initiate enteral nutritional therapy in combination with an oral diet. Despite being complementary, the enteral nutritional intake ranged from 35 to 100 kcal/kg/d and 1.6 to 2.7 g of protein/kg/d. As a result, the child presented progressive weight gain, reaching normal values, as per World Health Organization growth standards, by the time of transplantation. Although limited, there was also an improvement in the child’s length-for-age metric. Physical examination also revealed other improvements, such as in hair pigmentation and recovery of body reserves. Most notably, the child had a satisfactory recovery following heart transplant surgery. Therefore, it appears that the nutritional therapy applied was effective in improving the nutritional status of a child with severe malnutrition, which may have contributed to the surgical success and good postoperative recovery. Children with HLHS may benefit from alternative feeding methods to achieve higher nutritional intake.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 7","pages":"Pages 1305-1308"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 47th Congress of the Italian Society for Organ and Tissue Transplantation (SITO) Palermo, SicilyOctober 6-8, 2024Guest Editor: Luciano De Carlis","authors":"","doi":"10.1016/S0041-1345(25)00391-4","DOIUrl":"10.1016/S0041-1345(25)00391-4","url":null,"abstract":"","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 7","pages":"Page 1209"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144997684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Onset Systemic Lupus Erythematous After Kidney Transplant: Case Report","authors":"Alexandra Esteves ,&nbsp;Andreia Henriques ,&nbsp;Beatriz Fernandes ,&nbsp;Pedro Fragoso ,&nbsp;Clara Pardinhas ,&nbsp;Marina Reis ,&nbsp;Rita Leal ,&nbsp;Luís Rodrigues ,&nbsp;Maria Guedes Marques ,&nbsp;Lídia Santos ,&nbsp;Catarina Romãozinho ,&nbsp;Helena Sá ,&nbsp;Arnaldo Figueiredo","doi":"10.1016/j.transproceed.2025.07.015","DOIUrl":"10.1016/j.transproceed.2025.07.015","url":null,"abstract":"<div><div>The diagnosis of new onset autoimmune diseases in kidney transplant patients is challenging with new onset SLE after kidney transplant being a rare condition, with very few cases reported. We describe a case of a kidney transplant patient who, after 9 years presented with intermittent fever and diarrhea, inflammatory migratory polyarthralgia, myalgias, cramps and an erythematous rash in the cleavage area. Immunological testing revealed positive antinuclear antibodies (ANA 1:640), anti–double-stranded DNA antibodies (53.2 IU/mL), and elevated beta-2 microglobulin (105.59 U/mL), leading to the diagnosis of de novo SLE according to EULAR/ACR 2019 criteria. Notably, the patient exhibited no evidence of renal involvement from the onset, with stable kidney function and normal urinary sediment throughout follow-up. Ten months after undergoing treatment with corticosteroids and belimumab there was partial clinical and serological improvement. This case highlights a rare presentation of post-transplant SLE without renal involvement, reinforcing the need for a high index of suspicion in transplant recipients presenting with non-specific inflammatory symptoms.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 7","pages":"Pages 1300-1302"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ORIGINAL CONTRIBUTIONS ..ç.. CASE REPORTSJohnny C Hong, MD, FACSEditor-in-Chief","authors":"","doi":"10.1016/S0041-1345(25)00402-6","DOIUrl":"10.1016/S0041-1345(25)00402-6","url":null,"abstract":"","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 7","pages":"Page 1309"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144997588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"De-Novo Hepatic Angiosarcoma in a Liver Transplant Recipient","authors":"Alp Serhat Kahveci ,&nbsp;Aysha Aslam ,&nbsp;Yiqin Xiong ,&nbsp;Tomohiro Tanaka","doi":"10.1016/j.transproceed.2025.03.031","DOIUrl":"10.1016/j.transproceed.2025.03.031","url":null,"abstract":"<div><div>Angiosarcoma (AS) is a rare and highly aggressive soft tissue tumor. Cases of de-novo hepatic angiosarcoma after liver transplantation have not been described in the literature. Here, we present an exceedingly rare case of hepatic AS developing in a patient with a liver transplant (LT). A 72-year-old male with a history of orthotopic LT presented with cholestatic pattern of liver enzyme elevation for 3 months. Six years prior, he had undergone LT for treatment of alcohol-associated cirrhosis. He was on everolimus (1 mg twice daily) and low-dose tacrolimus (0.5 mg twice daily) for immunosuppression without evidence of allograft rejection. At presentation, his ALP and GGT were elevated to 1-2 times the upper limit of normal. He endorsed a 20-pound weight loss, anorexia, abdominal pain, and distention. A right upper quadrant ultrasound with doppler revealed a 14 cm liver mass and moderate ascites. This was followed by a multiphasic abdominal MRI, which revealed a 14.9 cm central hepatic mass involving the right and left hepatic lobes with extension into the hepatic veins and the inferior vena cava. The patient underwent a core biopsy of the tumor, which was suggestive of high-grade liver AS. A follow-up PET/CT scan was concerning for right adrenal gland and bilateral pulmonary metastasis. Patient was discussed at multidisciplinary tumor board and started on palliative chemotherapy with a single agent (docetaxel). Due to medication intolerance, patient discontinued the regimen after 1 cycle, and opted to transition to comfort care. He passed away 3 months after initial diagnosis.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 7","pages":"Pages 1348-1351"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Management of a Lung Transplant Patient With an Anaphylactic Reaction to Methylprednisolone Sodium Succinate: A Case Report","authors":"Gouji Toyokawa ,&nbsp;Mitsuaki Kawashima ,&nbsp;Koji Aze ,&nbsp;Nobuyuki Yoshiyasu ,&nbsp;Yue Cong ,&nbsp;Haruaki Hino ,&nbsp;Ikuo Takazawa ,&nbsp;Masanori Kono ,&nbsp;Hiroaki Harada ,&nbsp;Chihiro Konoeda ,&nbsp;Keishi Fujio ,&nbsp;Masaaki Sato","doi":"10.1016/j.transproceed.2025.05.024","DOIUrl":"10.1016/j.transproceed.2025.05.024","url":null,"abstract":"<div><h3>Background</h3><div>Methylprednisolone sodium succinate (MPS) is one of the key immunosuppressive drugs in the management of patients undergoing solid organ transplantation, and is known to rarely induce anaphylaxis. Several case reports describe an anaphylactic reaction to MPS in kidney and liver transplant patients; however, there have been no reports of an anaphylactic reaction to MPS in a lung transplant patient.</div></div><div><h3>Case report</h3><div>A female patient was diagnosed with mixed connective tissue disease and Sjögren’s syndrome when she was 10 years old. When the patient was 19 years old, she developed interstitial pneumonia, which gradually worsened despite treatment with oral prednisolone, mycophenolate mofetil, and tacrolimus. Therefore, lung transplantation was planned. The patient had previously developed an anaphylactic reaction when being administered steroid pulse therapy using MPS, while no other drugs had induced any allergic reaction. Therefore, a drug provocation test was performed to identify suitable alternative steroids to MPS before lung transplantation. Dexamethasone was shown to be safe and was thus administered during a lung transplant operation and the early postoperative period. The dexamethasone was then switched to oral prednisolone, and the patient was discharged approximately one month after the operation without having had any anaphylactic reactions to dexamethasone and oral prednisolone and without experiencing allograft rejection.</div></div><div><h3>Conclusion</h3><div>This case underscores the importance of using dexamethasone and oral prednisolone as an alternative therapeutic approach in the management of lung transplant recipients with an anaphylactic reaction to MPS.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 7","pages":"Pages 1373-1375"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-transplant Psychosocial Predictors of Smoking and 5-year Survival in Liver Transplant Recipients: A Single-center Retrospective Cohort Study","authors":"Marco Miniotti ,&nbsp;Alberto Olivero ,&nbsp;Alessandra Torasso ,&nbsp;Luca Giordanengo ,&nbsp;Federico Genzano Besso ,&nbsp;Paolo Leombruni","doi":"10.1016/j.transproceed.2025.05.008","DOIUrl":"10.1016/j.transproceed.2025.05.008","url":null,"abstract":"<div><h3>Background</h3><div>Assessment of psychosocial functioning has become a standard step in evaluating the suitability of transplant candidates. Research evidence about the validity of pre-transplant psychosocial assessment in predicting post-transplant outcomes is controversial. In this scenario, psychosocial predictors of smoking in liver transplant (LT) recipients are neglected. This study aims to investigate psychosocial predictors of smoking and 5-year survival in a large sample of LT recipients.</div></div><div><h3>Methods</h3><div>A retrospective analysis of clinical reports of psychosocial screening carried out through clinical interviews was performed on a sample of 563 consecutive LT recipients. Clinical data were obtained by inspection of digital medical records.</div></div><div><h3>Results</h3><div>Three main components underlying clinical reports of psychosocial assessment were identified, that is: component 1 = level of readiness to transplant, psychological stability, and cognitive abilities; component 2 = psychiatric and substance use history; and component 3 = social and family support. Component 1 significantly predicted post-transplant smoking (<em>P</em> &lt; .001) and 5-year survival (<em>P</em> .010). Component 2 significantly predicted post-transplant smoking (<em>P</em> = .032). Patients with alcoholic and viral hepatitis showed a greater risk of smoking and non-achieving 5-year survival after transplantation when compared with patients with different causes of liver failure.</div></div><div><h3>Conclusions</h3><div>Findings of this study highlight the predictive validity of psychosocial assessment and support its clinical utility. Further research contributions are needed to define the most clinically useful way to perform psychosocial assessment and utilize it to facilitate the best outcomes for transplant recipients.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 7","pages":"Pages 1219-1226"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular Recanalization of Late Venous Thrombosis After Kidney Transplantation by Off-Label Application of Ultrasound Mechanical Thrombolysis (EKOS): A Case Report","authors":"Alessandro Baggi ,&nbsp;Leonardo Centonze ,&nbsp;Angela Alfonsi ,&nbsp;Federico De Stefano ,&nbsp;Francesco Morelli ,&nbsp;Marco Solcia ,&nbsp;Andrea Lauterio","doi":"10.1016/j.transproceed.2025.07.011","DOIUrl":"10.1016/j.transproceed.2025.07.011","url":null,"abstract":"<div><h3>Background</h3><div>Kidney transplantation (KT) represents the best treatment option for patients with end-stage renal disease (ESTD). Graft venous thrombosis is a rare but serious complication. Early diagnosis and prompt treatment are crucial to preserve graft function and survival.</div></div><div><h3>Case Presentation</h3><div>The patient underwent DBD KT for stage V ESRD. The postoperative course was uneventful, without medical or surgical complications. Fifteen days after surgery, the patient presented to the emergency department with anuria. A CT scan demonstrated a complete thrombosis of the renal vein. The thrombosis was managed with an off-label application of the EKOS device.</div></div><div><h3>Discussion</h3><div>There are currently no established guidelines for the management of RVTPT. Surgical intervention, including thrombectomy by renal venotomy, anastomotic repair, or graft explant is the recommended approach in early VT. In contrast, thrombolytic therapy is generally the preferred treatment for thrombosis occurring in the late post-transplant period. The off-label application of ultrasound-mechanical thrombolysis (EKOS) for late renal vein thrombosis after kidney transplantation offers a promising, minimally invasive alternative.</div></div><div><h3>Conclusions</h3><div>This experience highlights the importance of a multidisciplinary approach in the management of surgical and transplant patients.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 7","pages":"Pages 1238-1241"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}