肝移植受者移植前吸烟与5年生存率的社会心理预测因素：一项单中心回顾性队列研究

IF 0.8 4区医学 Q4 IMMUNOLOGY

Transplantation proceedings Pub Date : 2025-09-01 DOI:10.1016/j.transproceed.2025.05.008

Marco Miniotti , Alberto Olivero , Alessandra Torasso , Luca Giordanengo , Federico Genzano Besso , Paolo Leombruni

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引用次数: 0

摘要

背景：社会心理功能评估已成为评估移植候选人适用性的标准步骤。关于移植前心理社会评估在预测移植后预后方面的有效性的研究证据存在争议。在这种情况下，肝移植（LT）受者吸烟的社会心理预测因素被忽视。本研究旨在调查大样本肝移植受者吸烟和5年生存率的社会心理预测因素。方法：通过临床访谈对563例连续肝移植受者的临床报告进行回顾性分析。临床资料通过检查电子病历获得。结果：确定了心理社会评估临床报告的三个主要组成部分，即：组成部分1 =移植准备水平，心理稳定性和认知能力；成分2 =精神病史和药物使用史；第三部分是社会和家庭支持。组分1可显著预测移植后吸烟（P < 0.001）和5年生存率（P .010）。成分2显著预测移植后吸烟（P = 0.032）。酒精性肝炎和病毒性肝炎患者与不同原因的肝衰竭患者相比，移植后吸烟和未实现5年生存的风险更高。结论：本研究结果强调了心理社会评估的预测有效性，并支持其临床应用。需要进一步的研究来确定临床上最有用的方法来进行心理社会评估，并利用它来促进移植受者的最佳结果。

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Pre-transplant Psychosocial Predictors of Smoking and 5-year Survival in Liver Transplant Recipients: A Single-center Retrospective Cohort Study

Background

Assessment of psychosocial functioning has become a standard step in evaluating the suitability of transplant candidates. Research evidence about the validity of pre-transplant psychosocial assessment in predicting post-transplant outcomes is controversial. In this scenario, psychosocial predictors of smoking in liver transplant (LT) recipients are neglected. This study aims to investigate psychosocial predictors of smoking and 5-year survival in a large sample of LT recipients.

Methods

A retrospective analysis of clinical reports of psychosocial screening carried out through clinical interviews was performed on a sample of 563 consecutive LT recipients. Clinical data were obtained by inspection of digital medical records.

Results

Three main components underlying clinical reports of psychosocial assessment were identified, that is: component 1 = level of readiness to transplant, psychological stability, and cognitive abilities; component 2 = psychiatric and substance use history; and component 3 = social and family support. Component 1 significantly predicted post-transplant smoking (P < .001) and 5-year survival (P .010). Component 2 significantly predicted post-transplant smoking (P = .032). Patients with alcoholic and viral hepatitis showed a greater risk of smoking and non-achieving 5-year survival after transplantation when compared with patients with different causes of liver failure.

Conclusions

Findings of this study highlight the predictive validity of psychosocial assessment and support its clinical utility. Further research contributions are needed to define the most clinically useful way to perform psychosocial assessment and utilize it to facilitate the best outcomes for transplant recipients.

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来源期刊

Transplantation proceedings 医学-免疫学

CiteScore

1.70

自引率

0.00%

发文量

502

审稿时长

60 days

期刊介绍： Transplantation Proceedings publishes several different categories of manuscripts, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. The first type of manuscripts consists of sets of papers providing an in-depth expression of the current state of the art in various rapidly developing components of world transplantation biology and medicine. These manuscripts emanate from congresses of the affiliated transplantation societies, from Symposia sponsored by the Societies, as well as special Conferences and Workshops covering related topics. Transplantation Proceedings also publishes several special sections including publication of Clinical Transplantation Proceedings, being rapid original contributions of preclinical and clinical experiences. These manuscripts undergo review by members of the Editorial Board. Original basic or clinical science articles, clinical trials and case studies can be submitted to the journal?s open access companion title Transplantation Reports.